Dietary methionine restriction (MR) is associated with a spectrum of health‐promoting benefits. Being conducive to prevention of chronic diseases and extension of life span, MR can activate integrated responses at metabolic, transcriptional, and physiological levels. However, how the mitochondria of MR influence metabolic phenotypes remains elusive. Here, we provide a summary of cellular functions of methionine metabolism and an overview of the current understanding of effector mechanisms of MR, with a focus on the aspect of mitochondria‐mediated responses. We propose that (...) mitochondria can sense and respond to MR through a modulatory role of lipoylation, a mitochondrial protein modification sensitized by MR. (shrink)

The concept of matter is the cornerstone of philosophical materialism. In each of the nations and cultures of the world it has undergone a long historical process of change and development. To study these concepts of matter from a comparative perspective will undoubtedly help to clarify the general laws governing human philosophical thinking and their various characteristics in the many cultural traditions of the peoples of the world.

The target article presented a plausible argument that females' susceptibility to threats might be self-protection for staying alive, but some evidence requires scrutiny. We need to consider the biases of narrative reviews, subjective life quality, and the shadow side of extreme reactions to threats before concluding that females' threat-based response is a self-protection mechanism that promotes survival.

本书概述现代西方价值观的形成、演变和特征,西方哲学思潮对不同国家和民族在价值上的不同体现。.

In this paper, we propose a new predator-prey nonlinear dynamic evolutionary model of real estate enterprises considering the large, medium, and small real estate enterprises for three different prey teams. A 5D predator-prey nonlinear dynamic evolutionary system in the real estate market is established, where the large, medium, and small real estate enterprises correspond to three differential equations, provincial and local officials, and the central government correspond to the other two differential equations. Nonlinear dynamic analysis on a 5D predator-prey evolutionary (...) system in the real estate market, containing the analysis of equilibrium points and stabilities, is made. The corresponding discrete system is simulated, and the simulation results about Lyapunov spectrum, bifurcation diagram, sequence diagram, and phase diagram are given. Compared with the work of Yang et al. in which all real estate enterprises corresponded to one differential equation, in our proposed model, the large, medium, and small real estate enterprises correspond to three differential equations which is more accordant with the specific circumstance of real estate companies. (shrink)

The present study aims to examine the relationship between the cortical midline structures (CMS), which have been regarded to be associated with selfhood, and moral decision making processes at the neural level. Traditional moral psychological studies have suggested the role of moral self as the moderator of moral cognition, so activity of moral self would present at the neural level. The present study examined the interaction between the CMS and other moral-related regions by conducting psycho-physiological interaction analysis of functional images (...) acquired while 16 subjects were solving moral dilemmas. Furthermore, we performed Granger causality analysis to demonstrate the direction of influences between activities in the regions in moral decision-making. We first demonstrate there are significant positive interactions between two central CMS seed regions—i.e., the medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC)—and brain regions associated with moral functioning including the cerebellum, brainstem, midbrain, dorsolateral prefrontal cortex, orbitofrontal cortex and anterior insula (AI); on the other hand, the posterior insula (PI) showed significant negative interaction with the seed regions. Second, several significant Granger causality was found from CMS to insula regions particularly under the moral-personal condition. Furthermore, significant dominant influence from the AI to PI was reported. Moral psychological implications of these findings are discussed. The present study demonstrated the significant interaction and influence between the CMS and morality-related regions while subject were solving moral dilemmas. Given that, activity in the CMS is significantly involved in human moral functioning. (shrink)

Recent years have witnessed an increasing academic interest in Chinese homosexuality; however, linguistic-oriented research on this topic is scant and multimodal inquiry on it is even rarer. To address the gap, this article conducts a discourse analysis of how tongzhi in mainland China are represented by news media. Specifically, we examine both linguistic and visual representations of tongzhi by utilizing two influential English-language newspapers in mainland China published between 2009 and 2019. Our data consist of 221 news articles totaling 117,407 (...) words; 44 of the articles are accompanied with pictures. Methodologically, we draw on Halliday’s transitivity structure coupled with van Leeuwen’s classification of social actors. Our findings reveal that Chinese tongzhi are mainly represented in a negative fashion, and that there is little positive news representation of this invisible community. In addition, socio-cultural factors contributing to media representations of Chinese tongzhi are considered. (shrink)

Journal of Chinese Philosophy, EarlyView.

تتميز هذه الدراسة عن صوفية الغزالي. رحمة الله. بأنها حققت النظرة المعرفية التي يتبناها، ومناهج البحث التي تسندها وتبعاً لهذا فإنها وفقت في ملاحقة واستنباط معالجة العديد من القضايا التي حفل بها فكره، وهي متشعبة ونجحت في وضعها في مكانها المناسب من البنية المنطقية والمنهجية في فكره. فأثبتت، من غير شك.بأن خطاب الغزالي متماسك الرؤى متلاحم الأجزاء، على عكس ما أشيع عنه الأمر الذي خفف حدة الإشكالية التي اصطبغ بها وساعد، وبالتالي، على تخليصه مما ألحق به من أوهام أو الصق (...) به من مثالب. وفضلا على هذا فقد لفتت الدراسة الانتظار إلى أهمية ( سياسة العلم) التي أخذ بها الغزالي وصمم على أساس منه خطابه، وبينت دورها الخطير في تشكله. كما أنها حللت مفهوم (النور) عنده وهو مفهوم مركزي في خطابه. حيث بينت أنه لا يخرج عن العقلانية بحال. وكذلك تحققت من ركون الغزالي إلى الظاهر البرهاني والتزامه به. قبل أن يتجاوزه في محاولة الارتياد وتأسيس عقلانية أرحب وأرقى كان الغزالي رحمه الله يتطلع إليها وبهذا فقد جاءت هذه الدراسة جديدة حقاً على مستوى الدراسات التي عالجت فكر عالجت فكر الغزالي. واستطاعت أن تغير مفاهيم عدة أشاعتها تلك الدراسات. وبينت تهافت بعض الآراء التي تضمنتها، الأمر الذي يوضح ما قام به الباحث. وإذا نضع بين يديك عزيزنا القارئ هذه الدراسة، فإننا نسأل الله عز وجل أن يوفق الباحث في إعداد دراسات أخرى تنحو ذات المنحى، فتستخرج البنى المعرفية والمنهجية لمفكرين آخرين متميزين في تراثنا العظيم، لتعميق وعينا به، وتدبر آفاقه والله نسأل التوفيق والسداد. (shrink)

Resumen: Este artículo sostiene que algunas Meta-Picto-Poesías del Paisaje compuestas por el poeta estadounidense Gary Snyder toman como tema la pintura china del paisaje con las características de la antigua poesía china, resplandeciente de incomparable encanto artístico y sustancia cultural. La poesía de este tipo es una combinación perfecta de elementos orientales y occidentales, que integra las culturas, los pensamientos y las artes de ambas partes, cuya apreciación crea una experiencia compleja con un híbrido de formas artísticas y espacios estéticos. (...) Gary Snyder no es sólo un eco-poeta, sino también un estilista y un hombre de práctica. Sus obras poéticas revelan la relación de fomento entre literatura, cultura y naturaleza. El artículo pretende hacer un intento transcultural, interdisciplinar y multidisciplinar en la crítica de Snyder, con métodos analíticos que incluyen culturas orientales y occidentales, visiones antiguas y actuales, así como experiencias dinámicas y estáticas. (shrink)

This article discusses Abū Isḥāq al-Naẓẓām’s (d. 231/845) (one of the first Muʽtazilī thinkers); understanding of Allah-world relationship, his theory of nature (tab‘) and his view on miracles. In a proposal form, Muʽtazilī scholars accept that the miracle, which is the actual confirmation, must occur, since it is not possible for Allah to confirm His messenger (prophet) in a way that everyone can hear and in a direct word. Since the Prophet's message can be authenticated only by a miracle, Muʽtazilī (...) thinkers paid great attention to this issue, organized and formed natural theories about the universe in a way that miracles can occur. Naẓẓām explains a kind of miracle that occurs under the power of Allah, by his theory of nature called latency and occurrence (kumūn-ẓuhūr). His view of miracles is rooted in the Muʽtazilī classification of miracles. Naẓẓām argues that in the theory of nature, things are infinitely divided. He also argues that all qualities considered accident (aʽrāḍ) by other Muslim theologians are different objects as only motion and rest are the only accidents. According to him, the universe consists of objects and accidents of motion only. In each object in the universe, an unlimited number of opposing objects (sub-components) that have different effects on each other is located in the same space. Those objects in the same space are intervened (tadākhul) with each other. Kumūn refers to sub-components that are located inside the object in a state of passing into each other, and a state of balancing each other through the push-pull motion (i‘timād). Ẓuhūr is an outward movement of the sub-component from where it is located when an impact imposed outside the object interacts with one of the sub-components contained in it. Naẓẓām says that too many opposing sub-components, such as heaviness-lightness, heat-coldness contained in the object, form an internal dynamic by providing balancing each other through inside the object with the push-pull motion. The state of balance inside the object is disrupted by an external factor affecting one of the sub-components. An external thing approaching the object interacts with one of the sub-components contained in the object. Then, the affected sub-component moves out of the object and thus the state of balance inside the object is disrupted. According to the theory of kumūn-ẓuhūr, change in objects occurs when the balance within the object is disturbed. The change in the balance also occurs not by the direct intervention of Allah and the creation of accidents, but by the disruption in the balance of natures within the object. Naẓẓām, who advocates the intrinsic natures in things, has been criticized for not leaving any room for Allah’s influence on objects at least through miracles. This criticism is not correct. Naẓẓām says that the nature of objects depends on God, and it is possible for God to intervene in them at any time. According to him, Allah can force opposing objects into a union that is not in their natures. In their natures, unification can separate those by applying pull and push. In this way, Naẓẓām sees the intervention of Allah as possible in the occurrence of a situation that is the opposite of what is present in the nature of objects. In Naẓẓām's theory of kumūn-ẓuhūr, there are suppressed natures and sub-components that are in a weak state inside the actual object. Furthermore, they cannot go out in any way from the actual object. One of these suppressed natures found in the object is removed from the nature of the object by the intervention of Allah when a miracle occurs in the hands of theProphet. In this case, the miracle is not something new that Allah has created, but that Allah has disclosed a hidden sub-component that is hidden in that thing that has never appeared before. Naẓẓām’s view of miracle is something occurring under the power of the created, which Muʽtazilī scholars accept in the classification of miracles in relation to, the theory of sarfa. He suggests that the Qur'an, which he accepts under the power of the created, would not be a miracle, if the Arabs could dispute it. However, according to him, the Qur'an is a miracle because Allah prevents them from the dispute. In his understanding of sarfa, the miracles occur directly as an act of God’s divine intervention with human beings. This study investigates Naẓẓām’s view of miracles along with his theory of nature and his understanding of sarfa. (shrink)

This article discusses Abū ʽUthmān al-Jāḥiẓ (d. 255/869) (one of the first Muʽtazilī scholars) Allah-world relationship, his understanding of custom, and his view on miracles. The Muʻtazilī thinkers examined the problem of miracles within their concept of prophethood. They divide miracles, which they accept as the only proof of prophethood, into two: those under the power of Allah and under the power of the created. Jāḥiẓ explains these two sorts of miracles with the order in the universe established by Allah (...) and people and expresses this order with the concept of custom (ʻāda). Jāḥiẓ divides custom into three. The first of these is the “qā’im (constant) custom”, which is based on the theory of kumūn-ẓuhūr and expresses the general rules that occur as a requirement of the general functioning in the universe. According to Jāḥiẓ “qā’im (constant) custom” is that knowledgeable people are aware of the custom of the universe. This custom is an order created by Allah in the eyes of intelligent and knowledgeable people, which is continuous and therefore cannot be interrupted, and in which there is no chaos. He states that this order is realized through the natures in the objects, which are knowable to everyone. But rarely a nature in this order can be interrupted due to a situation that takes it out of the natural flow and cannot be explained by natural causes. According to him, this is proof that nature, which has the defining feature of the object, is created by the creator, and maintains its continuity based on an arranged program. However, the creator can involve in this order when necessary. In this type of custom, God’s intervention occurs by breaking the qā’im custom that continues on a regular basis. The second of these is the “regional custom”, which is not known to everyone but only known to people living in a certain area. Jāḥiẓ states that the miracle in this type of custom occurred when Allah broke the custom known to the people in the region. The third of these is “social custom” which is established by people. For Jāḥiẓ, the miracles of this kind are under the power of people. He argues that the miracle in this type of custom occurs with sarfa, that is, by God’s intervention with human’s motive or knowledge. In this study, Jāḥiẓ’s view of miracles is discussed together with his theory of nature, his understanding of custom and sarfa. (shrink)

The aim is to deeply understand the current situation of College English Teaching. By consulting the theories of Deep Learning and Edge Computing, this work designs a Questionnaire Survey to understand the current situation of college English learning and teaching. Then, Adaptive Deep Learning and EC are introduced into CET. Finally, the corresponding conclusions and suggestions are drawn. Specifically, the purpose and time of college students’ vocabulary learning are investigated. The results suggest that students’ English vocabulary learning is shallow. They (...) have not really mastered the meaning and usage of vocabulary. Simultaneously, teachers’ vocabulary teaching methods are analyzed from three aspects: root affixes, vocabulary collocation, or repeated reading and memory. The teaching method is excellent from the teacher’s perspective but far from perfect from the students’ perspective. Introducing ADL and EC into CET enhances students’ class concentration time, homework submission efficiency, and academic performance. More than half of the students believe that the new teaching method introducing ADL and EC can make them more confident and motivated in English learning. Therefore, it has great reference significance for applying ADL and EC in CET. (shrink)

Bilişsel Din Bilimi (CSR), dini inanç ve uygulamaların nedensel açıklamalarını sağlamayı amaçlayan din araştırmalarına bilimsel bir yaklaşımdır. CSR savunucuları, insan zihninin doğal özelliklerini ve nasıl işlediğini açıklayarak dini inançların oluşumu, kabulü, aktarımı ve yaygınlığı sürecini açıklamaya çalışırlar. Tüm insan kültürlerinde var olan ve son on yılda birçok CSR akademisyeninin dikkatini çeken dini inançlardan biri de öbür dünyaya olan inançtır. CSR araştırmacılarına göre, bu inanç, insan zihninin doğal yapılarına dayanmaktadır. Ölümden sonraki hayata olan inancı, zihinsel araçların işleyişinden kaynaklanan, yansıtıcı olmayan veya (...) sezgisel bir inanç olarak görürler. Ölümden sonra hayata inancın oluşumunu, gelişimini, yayılmasını ve aktarılmasını açıklamak için çeşitli teoriler önerdiler. Ancak bu teoriler arasında, iki teori daha geniş kabul görmüştür, sezgisel düalizm teorisi ve simülasyon kısıtlama teorisi. Sezgisel düalizm teorisi, tüm insanların iki zihinsel araca sahip olduğunu söyler: Sezgisel Biyoloji ve Sezgisel Psikoloji. Sezgisel Biyoloji, ölü bir kişinin karşısına geçip hareket edemediği için artık hayatta olmadığına inanmamızı sağlar. Sezgisel Psikoloji, ölü kişiye otomatik olarak görünmez özellikleri (arzular, düşünceler, inançlar ve duygular gibi) atfetmeye devam eder. Yukarıdaki iki zihinsel aracın aynı anda işleyişi, insan zihnini ölü kişinin bir kısmının önemsiz olduğuna ve fiziksel ölümden sonra kaldığına inandırır. Simülasyon kısıtlama teorisi, tüm insanların çevreden gelen bilgileri işlemek ve dini inançlar edinmek için zihinsel araçlara sahip olduğunu söyler. Zihinsel araçların hiçbiri, kişinin arzularının, düşüncelerinin, inançlarının ve duygularının var olmadığını hayal edemez veya simüle edemez. Bu nedenle ölü kişinin karşısındaki insan zihni, fiziksel ölümünü kolayca hayal etmesine rağmen, kişinin başka bir bölümünün (düşünceler, arzular vb.) Varlığına inanmaya devam eder. Bu teorilerin her ikisi de, öbür dünyaya inancın oluşumunu açıklamada zorluklar ve sınırlamalarla karşı karşıya görünüyor. Bunlar arasında nedensel açıklama yapamama, ölümden sonraki hayata olan inancın doğal ve rasyonel temelleri arasındaki ayrım eksikliği ve öbür dünya inancının doğaüstü temellerini göz ardı etme yer alır. İki teoriden hiçbiri öbür dünyaya inancın oluşumu için yeterli nedensel açıklama sağlamıyor gibi görünmektedir. Her iki teori de zihinsel araçların nasıl işlediğine bağlı olarak öbür dünya inançlarının oluşumu hakkında olası bir hikaye sunmaya çalışır. Ölümden sonraki hayata inanmaya yol açan sürecin yalnızca makul bir hikayesini sunarlar. Bu iki teorinin sunduğu şey, insan zihninin ve araçlarının ve bunların nasıl işlediğinin bir açıklamasıdır (nedensel açıklama değil). Bu, kendi başına, bu aletlerin öbür dünyaya bir inanç ürettiğini açıklamaz. Dolayısıyla ahirete olan inancın zihinsel araçların işleyişinin bir sonucu olduğu iddiası, zihinsel araçlar ile bu inanç arasında nedensel bir ilişki gerektirir. Bu iki teoriden hiçbiri bu nedensel ilişkiyi açıklayamaz ve yalnızca aralarındaki ilişkinin makul bir hikayesini açıklarlar. Dahası, dini inancın rasyonel temelleri ile dini inancın doğal temelleri arasındaki ayrım, ahirete inanmak veya onunla ilişkili bilişsel mekanizmaları tanımlamak için doğal bir köken bulmanın hiçbir şekilde bu inancı reddetmek veya itibarını sarsmak anlamına gelmediğini göstermektedir. Ahirete olan inancın doğal kökenleri hakkındaki bilişsel teoriler bize bu inancın rasyonel mi irrasyonel mi olduğunu gösteremez. Bu açıklamalar ancak (eğer yapabilirlerse) bize bu inancın oluşumunun ve yaygınlığının doğal köklerini gösterebilir. Ayrıca Dinsel inanç karmaşık bir kavramdır. Birincisi, doğal bir kavramdır, bu anlamda insan doğasına dayanır ve insanın bilişsel sistemleri ve zihinsel araçlarıyla ilgilidir. İkincisi, kültürel ve sosyal bir kavramdır, bu anlamda hem kültürel ve sosyal değişimden etkilenir hem de onu etkiler. Üçüncüsü, doğaüstü bir kavramdır, bu anlamda hem vahiy hem de kehanet ve insanın maddi olmayan yönüyle derinden bağlantılıdır. Öbür dünyaya inanç, her üç düzeyde açıklamayı gerektiriyor gibi görünüyor. (shrink)

A group of Sogdian documents from the area of Khotan was recently acquired by Renmin University of China, Beijing. Four economic documents were edited in JAOS 130/4 ; the present article, comprising the edition of one complete letter and several fragments of letters, completes the publication of this collection, which adds to a growing body of evidence for the presence of Sogdian-speakers on the trade routes to the south of the Taklamakan desert.

Introducere în istoria filozofiei -- Problema cunoașterii -- Problema libertății -- Valoare și umanism.