HIV stigma and fears surrounding the disease pose a challenge for public health interventions, particularly those that target pregnant women. In order to reduce stigma and improve the lives of vulnerable populations, researchers have recognized a need to integrate different types of support at various levels. To better inform HIV interventions, the current study draws on social-ecological and evolutionary theories of reproduction to predict stigma and fear of contracting HIV among pregnant women in South India. The aims of this study (...) were twofold: compare the social-ecological model to a modified maternal-fetal protection model and test a combined model that included strong predictors from each model. The study took place in 2008–2011 in Mysore District, Karnataka, India. Using data from a cross-sectional survey and biological indicators of health, we statistically modeled social-ecological variables representing individual, interpersonal, and community/institutional levels. Participants were 645 pregnant women. The social-ecological and combined models were the best-fitting models for HIV-related stigma, and the combined model was the best fit for HIV-related fear. Our findings suggest that combining reproductive life history factors along with individual, interpersonal, and community/institutional factors are significant indicators of HIV-related stigma and fear. Results of this study support a multifaceted approach to intervention development for HIV-related stigma and fear. The combined model in this study can be used as a predictive model for future research focused on HIV stigma and fear, with the intent that dual consideration of social-ecological and evolutionary theories will improve public health communication efforts. (shrink)

This article examines the discourses of the Indian state and of community élites during battles for the custody of a young Muslim girl, Ameena, who was ‘rescued’ from a marriage with an elderly Arab. The battles for Ameena's custody were fought as much in news reports, opinion columns, and letters to the editor of metropolitan and vernacular newspapers, as in courts. Questions were raised about Ameena's age, the viability of her marriage, the applicability of secular laws to Muslim communities, and (...) the political economy of the sexuality of girl-children. In these representations, Ameena became a symbol of minority identity, and was transformed into an unwilling and unwitting object of protection. Why did Ameena's story attract so much attention? What were the different positions underlying the arguments made for Ameena's ‘protection’? Without dismissing the protection of children and the advocacy of their rights, this article analyses the agendas shaping the discourses of the Indian state and national and community élites during the battles for Ameena's custody. The article situates the controversies surrounding Ameena in the wider context of the increasing polarization between Hindu and Muslim communities in India in the early 1990s, and focuses on the relationship between notions of childhood and discourses of community, gender and nation. The article argues that there was a synecdochic relationship between the purity of girl-children and the purity of the Indian nation: far from being ‘pre-cultural’ or apolitical, discourses of childhood were profoundly implicated in the politics of gender, sexuality, community and nation. What are the implications of Ameena's predicament for feminist epistemology and praxis? In pointing to the ways in which feminist critiques of modernist regimes of power and knowledge can enable us to understand the multiple positionalities of children in the contemporary world, the article explores the spaces available for feminist theorists and activists to engage in a politics of vigilance and intervention with regard to the state's positions towards children. (shrink)

The two waves of COVID-19 in India have had severe consequences for the lives of people. The Indian State-imposed various regulatory mechanisms like lockdowns, encouraged remote work, online teaching in academic institutions, and enforced adherence to the COVID protocols. The use of various technologies especially digital/online technologies not only helped to adapt to the “new normal” and cope with the disruptions in pursuing everyday activities but also to manage one’s well-being. However, the availability and accessibility of digital technologies to various (...) sections of the population were not uniform. This paper reports a series of three studies examining the nature of pandemic stress, the impact of technology use on people’s emotional well-being during turbulent times, and the effects of technology use on psychological resources like resilience, self-efficacy, motivation to work, and emotional well-being. The differences in the residential background and SES in the extent of the use of technology and strength of psychological resources were assessed. The findings indicated that the most common causes of concern included worrying about family, friends, partners, fears of getting and giving the viral infection to someone; frustration and or boredom; and changes in normal sleep patterns. It was noted that technology was a double-edged sword and created barriers as well as opportunities for the people. Also, self-efficacy mediated the relationship between the use of technology and emotional wellbeing. The results have policy implications for building resilient communities in the post COVID period. (shrink)

Flap EndoNuclease‐1 (FEN‐1) is a multifunctional and structure‐specific nuclease involved in nucleic acid processing pathways. It plays a critical role in maintaining human genome stability through RNA primer removal, long‐patch base excision repair and resolution of dinucleotide and trinucleotide repeat secondary structures. In addition to its flap endonuclease (FEN) and nick exonuclease (EXO) activities, a new gap endonuclease (GEN) activity has been characterized. This activity may be important in apoptotic DNA fragmentation and in resolving stalled DNA replication forks. The multiple (...) functions of FEN‐1 are regulated via several means, including formation of complexes with different protein partners, nuclear localization in response to cell cycle or DNA damage and post‐translational modifications. Its functional deficiency is predicted to cause genetic diseases, including Huntington's disease, myotonic dystrophy and cancers. This review summarizes the knowledge gained through efforts in the past decade to define its structural elements for specific activities and possible pathological consequences of altered functions of this multirole player. BioEssays 27:717–729, 2005. © 2005 Wiley Periodicals, Inc. (shrink)