In this paper I address issues related to the problem of future contingents and the metaphysical doctrine of fatalism. Two classical responses to the problem of future contingents are the third truth value view and the all-false view. According to the former, future contingents take a third truth value which goes beyond truth and falsity. According to the latter, they are all false. I here illustrate and discuss two ways to respectively argue for those two views. Both ways are similar (...) in spirit and intimately connected with fatalism, in the sense that they engage with the doctrine of fatalism and accept a large part of a standard fatalistic machinery. (shrink)

This paper addresses a particular interpretation of quantum mechanics, i.e. superdeterminism. In short, superdeterminism i) takes the world to be fundamentally deterministic, ii) postulates hidden variables, and iii) contra Bell, saves locality at the cost of violating the principle of statistical independence. Superdeterminism currently enjoys little support in the physics and philosophy communities. Many take it to posit the ubiquitous occurrence of hard-to-digest conspiratorial and coincidental events; others object that violating the principle of statistical independence implies the death of the (...) scientific methodology. In this paper, we offer a defense to these and other objections. To counter the conspiracy objection, we draw upon the philosophical literature on time travel, and conclude that the picture of the world offered by the superdeterminist does not need to be particularly surprising or conspiratorial. We then move on to other recent objections, in particular those that focus on the methodology of science and the nature of the physical laws compatible with superdeterminism. A key ingredient of our arguments is that the principle of statistical independence may be violated in theory, but valid for practical purposes. Our overarching goal is to offer a defense of superdeterminism with respect to its main objections, so that it can earn its keep as a legitimate contender among the possible interpretations of quantum mechanics. (shrink)

Branching time is a popular theory of time that is intended to account for the openness of the future. Generally, branching-time models the openness of the future by positing a multiplicity of concrete alternative futures mirroring all the possible ways the future could unfold. A distinction is drawn in the literature among branching-time theories: those that make use of moment-based structures and those that employ history-based ones. In this paper, I introduce and discuss a particular kind of openness relative to (...) the possibility that time ends (doomsday). I then show that whereas moment-based branching structures cannot represent this kind of openness, history-based structures can account for it. The conclusion is that history-based structures have an advantage over moment-based ones. (shrink)

The goal of this paper is to defend the general tenet that time travelers cannot change the past within B-theoretical models of time, independently of how many temporal dimensions there are. Baron Pacific Philosophical Quarterly, 98, 129–147 offered a strong argument intended to reach this general conclusion. However, his argument does not cover a peculiar case, i.e. a B-theoretical one-dimensional model of time that allows for the presence of internal times. Loss Pacific Philosophical Quarterly, 96, 1–11 used the latter model (...) to argue that time travelers can change the past within such model. We show a way to debunk Loss’s argument, so that the general tenet about the impossibility of changing the past within B-theoretical models is maintained. (shrink)

This paper explores mutable futurism, the view according to which the future can literally change—that is, it can happen that a future time t changes from containing an event E to lacking it. Mutable futurism has received little attention so far, and the details and implications of the view are underexplored in the literature. For instance, it currently lacks a precise metaphysical model and a formal semantics. Although we do not endorse mutable futurism, our goal here is to strengthen the (...) case for mutable futurism and help establish it as a worthy contender in the debate on the philosophy of time. To attain this goal, we try to make mutable futurism, along with its metaphysical and inferential commitments, as clear as possible, by providing it with a coherent metaphysical model and a plausible semantics, and we show that it can be backed by theoretical reasons. (shrink)

The future is different from the past. What is past is fixed and set in stone. The future, on the other hand, is open insofar as it holds numerous possibilities. Branching-tree models of time account for this asymmetry by positing an ontological difference between the past and the future. Given a time t, a unique unified past lies behind t, whereas multiple alternative existing futures lie ahead of t. My goal in this paper is to show that there is an (...) incompatibility between the way branching-tree models account for the open future and the possibility of time travel. That is, I argue that once time travel enters the picture, branching time fails to model the openness of the future by means of alternative future branches. I show how this holds independently of whether branching-time models are cashed out in A-theoretic or B-theoretic terms. (shrink)

This paper introduces a new kind of explanation that we describe as ‘purely theoretical’. We first present an example, E, of what we take to be a case of purely theoretical explanation. We then show that the explanation we have in mind does not fit neatly into any of the existing categories of explanation. We take this to give us prima facie motivation for thinking that purely theoretical explanation is a distinctive kind of explanation. We then argue that it can (...) earn its keep via application to two existing literatures: the literature on how we explain the truth of true negative existential propositions and the literature on how we explain the truth of true propositions about the past. We reply to some possible concerns regarding the introduction of purely theoretical explanations. We conclude that there is nothing obviously wrong with them and explore the ramifications for particular debates in metaphysics. (shrink)

Review of Patrick Todd's The Open Future (2021, OUP).

Book review of Wasserman, R. (2017), Paradoxes of Time Travel, OUP.

While growing empirical evidence suggests a continuity between human and non-human psychology, many philosophers still think that only humans can act and form beliefs rationally. In this paper, we challenge this claim. We first clarify the notion of rationality. We then focus on the rationality of beliefs and argue that, in the relevant sense, humans are not the only rational animals. We do so by first distinguishing between unreflective and reflective responsiveness to epistemic reasons in belief formation and revision. We (...) argue that unreflective responsiveness is clearly within the reach of many animals. We then defend that a key demonstration of reflective responsiveness would be the ability to respond to undermining defeaters. We end by presenting some empirical evidence that suggests that some animal species are capable of processing these defeaters, which would entail that even by the strictest standards, humans are not the only rational animals. (shrink)

Dispositionalism is the theory of modality according to which all (metaphysical and natural) modal truths are made true by some actual irreducibly dispositional property. The relationship between Dispositionalism and time is yet to be satisfactorily explored. In this paper we contribute to this task by examining how Dispositionalism deals with ‘dated truths’: propositions involving a specific time, e.g. “It might rain at 12.30”. We examine two possible accounts: the first, 'Dated Manifestations Strategy', is the idea that powers are very fine-grained, (...) and tend towards temporally very specific manifestations. We argue that such strategy should not be adopted, for it leads to unnecessary violations of ontological parsimony; it is unable to accommodate an ontology of platonic universals; and it is incapable of offering a principled explanation of the forward-looking nature of powers. We offer an alternative account, the "Duration Strategy", which relies on an independently determined arrow of time and the existence of some “duration facts” that specify how long a power takes to bring about its manifestation. We argue that the Duration Strategy is to be preferred. We then flesh out the account by exploring the connection between powers, duration facts, and processes. (shrink)

A lot of attention has recently been devoted to the notion of Trustworthy AI (TAI). However, the very applicability of the notions of trust and trustworthiness to AI systems has been called into question. A purely epistemic account of trust can hardly ground the distinction between trustworthy and merely reliable AI, while it has been argued that insisting on the importance of the trustee’s motivations and goodwill makes the notion of TAI a categorical error. After providing an overview of the (...) debate, we contend that the prevailing views on trust and AI fail to account for the ethically relevant and value-laden aspects of the design and use of AI systems, and we propose an understanding of the notion of TAI that explicitly aims at capturing these aspects. The problems involved in applying trust and trustworthiness to AI systems are overcome by keeping apart trust in AI systems and interpersonal trust. These notions share a conceptual core but should be treated as distinct ones. (shrink)

Nowadays, almost everyone seems to agree that science is facing an epistemological crisis – namely the replicability crisis – and that we need to take action. But as to precisely what to do or how...

When we witness a great actor, musician, or sportsperson performing, we share something of their experience. Only recently has it become clear just how this sharing of experience is realised within the human brain. 'Mirrors in the brain' provides an accessible overview of mirror neurons, written by the man who first discovered them.

_Demonstrates how the ethical underpinning of Hegel’s political and social philosophy has relevance for contemporary democratic life._.

Over the last decade, philosophers of science have extensively criticized the epistemic superiority of randomized controlled trials for testing safety and effectiveness of new drugs, defending instead various forms of evidential pluralism. We argue that scientific methods in regulatory decision-making cannot be assessed in epistemic terms only: there are costs involved. Drawing on the legal distinction between rules and standards, we show that drug regulation based on evidential pluralism has much higher costs than our current RCT-based system. We analyze these (...) costs and advocate for evaluating any scheme for drug regulatory tests in terms of concrete empirical benchmarks, like the error rates of regulatory decisions. (shrink)

Taking the inspiration from some points made by Scott Sturgeon and Albert Casullo, I articulate a view according to which an important difference between undermining and overriding defeaters is that the former require the subject to engage in some higher-order epistemic thinking, while the latter don’t. With the help of some examples, I argue that underminers push the cognizer to reflect on the way she formed a belief by challenging the epistemic worthiness of either the source of justification or the (...) specific justificatory process. By contrast, overriders needn’t pose any such challenge. I also consider some problems for the proposed view, and I put forward some possible solutions. Finally, I provide some details on how undermining defeat works in different cases. (shrink)

There is a tension between Dispositionalism––the view that all metaphysical modality is grounded in actual irreducible dispositional properties––and the possibility of time travel. This is due to the fact that Dispositionalism makes it much harder to solve a potentiality-based version of the grandfather paradox. We first present a potentiality-based version of the grandfather paradox, stating that the following theses are inconsistent: 1) time travel is possible, 2) powers fully ground modality, 3) self-defeating actions are impossible, 4) time-travellers retain their intrinsic (...) powers upon time-travelling, and 5) time-travellers are ordinary agents with basic intrinsic potentialities. We then consider a number of potential solutions, and find them wanting. We argue that the metaphysical impossibility of performing a self-defeating action acts as a necessary perfect mask––while time-travel lets us “slip” the potentiality under the mask, thus generating the contradiction. We conclude considering what are the options for the dispositionalist. (shrink)

This paper investigates the epistemic assumptions that David Lewis makes in his account of social conventions. In particular, I focus on the assumption that the agents have common knowledge of the convention to which they are parties. While evolutionary analyses show that the common knowledge assumption is unnecessary in certain classes of games, Lewis’ original account (and, more recently, Cubitt and Sugden’s reconstruction) stresses the importance of including it in the definition of convention. I discuss arguments pro et contra to (...) argue that, although the assumption might be relevant to a descriptively adequate account of social convention, it is not required for its rational reconstruction. I then point out that Lewis’ account, properly speaking, is of common reason to believe, rather than of common knowledge, and argue that, in order to formalize aptly the distinction between reason to believe and belief, standard formal epistemic models need to be supplemented with so-called awareness structures. Finally, I stress that the notion of knowledge implicit in Lewis’ text involves interesting elements that cannot be captured in the standard propositional formalizations, but need the full expressive force of quantified epistemic logic. (shrink)

Famously, Kripke has argued that the central portion of the Philosophical Investigations describes both a skeptical paradox and its skeptical solution. Solving the paradox involves the element of the community, which determines correctness conditions for rule-following behavior. What do such conditions precisely consist of? Is it accurate to say that there is no fact to the matter of rule following? How are the correctness conditions sustained in the community? My answers to these questions revolve around the idea that a rule (...) is followed insofar as a convention is in place. In particular, I consider the game-theoretic definition of convention offered by David Lewis and I show that it illuminates essential aspects of the communitarian understanding of rule-following. Make the following experiment: say “It’s cold here” and mean “It’s warm here”. Can you do it?Ludwig Wittgenstein, Philosophical Investigations, 1953, §510.I can’t say “it’s cold here” and mean “it’s warm here”—at least, not without a little help from my friends.David Lewis, Convention. (shrink)

One important distinction in the debate over the nature of epistemic justification is the one between propositional and doxastic justification. Roughly, while doxastic justification is a property of beliefs, propositional justification is a property of propositions. On a rather common view, which accounts for doxastic justification in terms of propositional justification plus the so-called ‘basing relation’, propositional justification is seen as the prior notion, and doxastic justification is explained in terms of it. According to the opposing view, the direction of (...) explanation needs to be reversed, and doxastic justification should be seen as primary. I distinguish between two notions of priority, and I argue that they give different verdicts with respect to the issue of which notion of justification comes first. The lesson may be taken to be that propositional and doxastic justification are in a relation of intertwinement. (shrink)

This article argues that Plotinus wrote Ennead VI 8 (39) to direct his students to see that our freedom is founded on the One, a goal pursued by means of a polemic against Alexander of Aphrodisias’ De fato and De anima. The first part aims to establish that the “rash discourse” introduced in chapter 7 is an interpretation of De fato’s position on the freedom of the gods. Plotinus reads his opponent’s thesis by transferring to the level of the One (...) a tripartite structure made up of nature, reason, and chance, a structure that Alexander used to explain events on the level of Becoming. The second part proposes to see the treatise as a dialectical process. Plotinus starts his inquiry at the levels of soul and Intellect. He later arrives at the discourse about the One, in which he tries to progressively overcome the limits of language by analyzing alternative positions from the viewpoint of discourse, words, and finally thought. In doing this, he insists on his reversal of Alexander’s theses: the One is simple and therefore not constrained by its nature; it is free thanks to a will incapable of choosing between the contraries and directed metaphorically toward itself. (shrink)

This paper develops a novel theory of the meaning of moral equality. This theory has two original and significant implications: first, it shows—contra what is commonly held in the literature—that adults and children are not always each other’s equals; rather, the former are sometimes inferior and sometimes superior to the latter, depending on the interest at stake. Second, it reveals that human beings’ comparative moral status changes across time, and what matters is that they are each other’s equals at simultaneous (...) segments of their lives. (shrink)

The principle of moral equality is one of the cornerstones of any liberal theory of justice. It is usually assumed that persons’ equal moral status should be grounded in the equal possession of a status-conferring property. Call this the property-first approach to the basis of moral equality. This approach, however, faces some well-known difficulties: in particular, it is difficult to see how the possession of a scalar property can account for persons’ equal moral status. A plausible way of circumventing such (...) difficulties is to explore another avenue for the justification of persons’ equal moral status: moral equality should be grounded in the wrongness of treating others as inferiors. Call this the relation-first approach to the basis of moral equality. This paper aims at providing some reasons as to why this approach should be rejected and clarifying why the property-first approach still represents the most promising way of justifying our commitment to moral equality. Two objections will be pressed against the relation-first approach: first, grounding moral equality in the wrongness of treating others as inferiors gives rise to some disturbing normative implications; second, relation-first accounts cannot vindicate the idea that a range of beings has equal fundamental rights. This, however, is precisely what an account of moral equality is meant to justify. The paper, then, concludes that the relation-first approach fails to provide a plausible answer to the question of the basis of moral equality. Property-first accounts, whatever problems they encounter, are still more viable in principle. (shrink)

Replicability is widely regarded as one of the defining features of science and its pursuit is one of the main postulates of meta-research, a discipline emerging in response to the replicability crisis. At the same time, replicability is typically treated with caution by philosophers of science. In this paper, we reassess the value of replicability from an epistemic perspective. We defend the orthodox view, according to which replications are always epistemically useful, against the more prudent view that claims that it (...) is useful in very limited circumstances. Additionally, we argue that we can learn more about the original experiment and the limits of the discovered effect from replications at different levels. We hold that replicability is a crucial feature of experimental results and scientists should continue to strive to secure it. (shrink)

The symplectic quantization scheme proposed for matter scalar fields in the companion paper (Gradenigo and Livi, arXiv:2101.02125, 2021) is generalized here to the case of space–time quantum fluctuations. That is, we present a new formalism to frame the quantum gravity problem. Inspired by the stochastic quantization approach to gravity, symplectic quantization considers an explicit dependence of the metric tensor gμν\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$g_{\mu \nu }$$\end{document} on an additional time variable, named intrinsic time at variance (...) with the coordinate time of relativity, from which it is different. The physical meaning of intrinsic time, which is truly a parameter and not a coordinate, is to label the sequence of gμν\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$g_{\mu \nu }$$\end{document} quantum fluctuations at a given point of the four-dimensional space–time continuum. For this reason symplectic quantization necessarily incorporates a new degree of freedom, the derivative g˙μν\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\dot{g}}_{\mu \nu }$$\end{document} of the metric field with respect to intrinsic time, corresponding to the conjugated momentum πμν\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\pi _{\mu \nu }$$\end{document}. Our proposal is to describe the quantum fluctuations of gravity by means of a symplectic dynamics generated by a generalized action functional A[gμν,πμν]=K[gμν,πμν]-S[gμν]\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathcal {A}}[g_{\mu \nu },\pi _{\mu \nu }] = {\mathcal {K}}[g_{\mu \nu },\pi _{\mu \nu }] - S[g_{\mu \nu }]$$\end{document}, playing formally the role of a Hamilton function, where S[gμν]\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$S[g_{\mu \nu }]$$\end{document} is the standard Einstein–Hilbert action while K[gμν,πμν]\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathcal {K}}[g_{\mu \nu },\pi _{\mu \nu }]$$\end{document} is a new term including the kinetic degrees of freedom of the field. Such an action allows us to define an ensemble for the quantum fluctuations of gμν\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$g_{\mu \nu }$$\end{document} analogous to the microcanonical one in statistical mechanics, with the only difference that in the present case one has conservation of the generalized action A[gμν,πμν]\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathcal {A}}[g_{\mu \nu },\pi _{\mu \nu }]$$\end{document} and not of energy. Since the Einstein–Hilbert action S[gμν]\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$S[g_{\mu \nu }]$$\end{document} plays the role of a potential term in the new pseudo-Hamiltonian formalism, it can fluctuate along the symplectic action-preserving dynamics. These fluctuations are the quantum fluctuations of gμν\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$g_{\mu \nu }$$\end{document}. Finally, we show how the standard path-integral approach to gravity can be obtained as an approximation of the symplectic quantization approach. By doing so we explain how the integration over the conjugated momentum field πμν\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\pi _{\mu \nu }$$\end{document} gives rise to a cosmological constant term in the path-integral approach. (shrink)

We focus on Timothy Williamson’s recent attack on the epistemological significance of the a priori–a posteriori distinction, and offer an explanation of why, fundamentally, it does not succeed. We begin by setting out Williamson’s core argument, and some of the background to it and move to consider two lines of conciliatory response to it—conciliatory in that neither questions the central analogy on which Williamson's argument depends. We claim, setting aside a methodological challenge to which Williamson owes an answer, that no (...) satisfactory such reconciliation is in prospect. Rather, as we then argue, —and it is on this that we base our overall negative assessment of his argument—Williamson’s core analogy is flawed by an oversight. We conclude with some brief reflections on Williamson’s ideas about the imagination as a source of knowledge. Our principal conclusion is only that Williamson’s argument fails to perform as advertised. A constructive case for confidence, to the contrary, that the intuitive contrast between a priori and a posteriori reflects something of fundamental epistemological significance is prefigured in our final section, but will not be elaborated here. (shrink)

Among the many possible approaches to dealing with logical omniscience, I consider here awareness and impossible worlds structures. The former approach, pioneered by Fagin and Halpern, distinguishes between implicit and explicit knowledge, and avoids logical omniscience with respect to explicit knowledge. The latter, developed by Rantala and by Hintikka, allows for the existence of logically impossible worlds to which the agents are taken to have access; since such worlds need not behave consistently, the agents’ knowledge is fallible relative to logical (...) omniscience. The two approaches are known to be equally expressive in propositional systems interpreted over Kripke semantics. In this paper I show that the two approaches are equally expressive in propositional systems interpreted over Montague-Scott (neighborhood) semantics. Furthermore, I provide predicate systems of both awareness and impossible worlds structures interpreted on neighborhood semantics and prove the two systems to be equally expressive. (shrink)

This essay gives an account of epistemic deference for agents with imprecise credences. I look at the two main imprecise deference principles in the literature, known as Identity Reflection and Pointwise Reflection (Moss, 2021). I show that Pointwise Reflection is strictly weaker than Identity Reflection, and argue that, if you are certain you will update by conditionalisation, you should defer to your future self according to Identity Reflection. Then I give a more general justification for Pointwise and Identity Reflection from (...) the assumption that you defer to someone whenever you consider their doxastic state to be better than yours, in the sense of leading to better decision-making. (shrink)

In his recent book, Humanity without Dignity: Moral Equality, Respect, and Human Rights, Andrea Sangiovanni argues that the principle of moral equality should be grounded in the wrongness of treating others as inferiors insofar as this constitutes an act of social cruelty. In this short piece, I will raise two concerns about the rejection of social cruelty as the basis of moral equality: first, Sangiovanni’s account seems to give rise to disturbing implications as to how those beings that have basic (...) moral status relate to each other. Second, grounding moral equality in the rejection of social cruelty may fail to capture some wrongs qua violation of moral equality. (shrink)

Statistical evidence is pervasive in medicine. In this chapter we will focus on the reliability of randomized clinical trials (RCTs) conducted to test the safety and efficacy of medical treatments. RCTs are scientific experiments and, as such, we expect them to be replicable: if we repeat the same experiment time and again, we should obtain the same outcome (Norton 2015). The statistical design of the test should guarantee that the observed outcome is not a random event, but rather a real (...) effect of the treatments administered. However, for more than a decade now, we have been discussing a replicability crisis across different experimental disciplines including medicine: the outcomes of trials published in very prestigious journals often disappear when the experiment is repeated (see, e.g., Lehrer 2010, Begley and Ellis 2012, Horton 2015). -/- There are different accounts of the reason for this replicability crisis, ranging from scientific fraud to lack of institutional incentives to double-check someone else’s results. In this chapter we will use the replicability crisis as a thread to introduce some central issues in the design of scientific experiments in medicine. First, in section 1, we will see how replicability and statistical significance are connected: we can only make sense of the p-value of a trial outcome within a series of replications of the test. But in order to conduct these replications properly, we need to agree on the proper design of the experiment we are going to repeat. In particular, we need to prevent the preferences of the experimenters from biasing the outcome of the experiment. If there is such a bias, when the experiment is replicated by a third party, the observed outcome will vanish. In section 2, we will argue that trialists need to agree on the debiasing procedures and the statistical quality controls that feature in the trial protocol, if they want the outcome to be replicable. In section 3, we will make two complementary points. On the one hand, replicability per se is not everything: we need trial outcomes that are not only statistically significant but also clinically relevant. On the other hand, trials are not everything: the experts analyzing the evidence can improve the reliability of statistical evidence, although they sometimes fail; we need to further study how they make their decisions. In section 4, we will use a controversy about the overprescription of statins to show how non-replicable effects are obtained in trials and how experts may fail at detecting such flaws, if the commercial interests are big enough. (shrink)

Hybrid organisations combine different elements from the for-profit and non-profit domains, and they usually operate in a resource-scarce environment. For these reasons, they continuously face various resources constraints, yet their hybrid nature could be translated into an opportunity. The purpose of our study was to investigate how a hybrid organisation can overcome resource constraints in developing countries by exploiting their own hybrid nature. In the unique research setting offered by Kenyan social enterprises, we identified five creative approaches implemented by social (...) enterprises. Finally, we present a grounded model that clearly explains which hybrid harvesting strategies can be implemented to overcome resource constraints, exploiting their hybrid potential. Our work contributes to knowledge about resource constraints in the social entrepreneurship literature and extends social bricolage theory. Limitations and future research approaches are also presented. (shrink)

This paper generalises an argument for probabilism due to Lindley [9]. I extend the argument to a number of non-classical logical settings whose truth-values, seen here as ideal aims for belief, are in the set $\{0,1\}$, and where logical consequence $\models $ is given the “no-drop” characterization. First I will show that, in each of these settings, an agent’s credence can only avoid accuracy-domination if its canonical transform is a (possibly non-classical) probability function. In other words, if an agent values (...) accuracy as the fundamental epistemic virtue, it is a necessary requirement for rationality that her credence have some probabilistic structure. Then I show that for a certain class of reasonable measures of inaccuracy, having such a probabilistic structure is sufficient to avoid accuracy-domination in these non-classical settings. (shrink)

I extend the Higher-Order View of Undermining Defeat (HOVUD) defended in Melis (2014) to account for the defeat of propositional justification. In doing so, I clarify the important notion of higher-order commitment, and I make some considerations concerning the defeat of externalist epistemic warrants.

Accuracy-first epistemologists argue that rational agents have probabilistically coherent credences. But why should we care, given that we can’t help being incoherent? A common answer: probabilistic coherence is an ideal to be approximated as best one can. De Bona (in: Philos Sci 84(2), 189–213, 2017) and Staffel (in: Unsettled thoughts: a theory of degrees of rationality, Oxford University Press, 2019) show how accuracy-firsters can spell out this answer by adopting an appropriate notion of approximate coherence. In this essay, I argue (...) that De Bona and Staffel’s proposal is not entirely satisfactory, because it does not show whether, or why, it’s generally better to be more rather than less approximately coherent from an accuracy-first perspective. To address this point, I give a characterisation of their notion of approximate coherence in terms of accuracy. This shows that accuracy-firsters should maintain that more approximately coherent credences are better than less approximately coherent ones _if and only if_ they accept that it’s better to miss out on less rather than more guaranteed accuracy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Canti VI, Bruto Minore GIACOMO LEOPARDI (Translated by Steven J. Willett) To Peter Green After Italian Valor, lying in Thracian dust an immense ruin, had been uprooted, then in the valleys of green Hesperia, on Tiber’s shore, Fate prepares the tramp of barbarian horse, and from naked forests oppressed by the freezing Bear, calls forth the Gothic swords to overthrow Rome’s renowned walls; sitting alone, soaked in (...) brothers’ blood, through black night in a desolate site, Brutus is determined to die, and the implacable gods and Hell itself he accuses with savage cries and strikes the somnambulant air in vain. Fatuous Valor, the empty mists, the fields of unquiet phantoms are your schools, and behind you strides remorse. To you, marmoreal gods, (whether you reside in Phlegethon or the clouds), to you a laughingstock and mockery is the miserable race from whom you extort temples and a fraudulent law insulting to mortals. Is heaven’s wrath, then, so provoked by terrestrial piety? and do you then sit, Jove, impiety’s protector? and when storm clouds exult through the air, and when arion 27.1 spring/summer 2019 you hurl the swift thunderbolt, do you cast the sacred fire on the just and faithful? Invincible destiny and iron necessity crush the sickly slaves of death: and if nothing avails to end their indignities, the common man takes comfort in their necessity. Is the evil without cure less harsh? Does he feel no grief who’s stripped naked of hope? War to the death, eternal, o ignoble fate, the valorous man wages, incapable of surrender; and your tyrannical right hand, victorious as it bears him down, indomitable he shrugs off with a valiant show, when in his noble side the bitter blade runs with blood, and malignly he smiles at the darkening shadows. He displeases the gods who violently breaks into Tartarus. No such courage could be found in their feeble, eternal breasts. Perhaps our torments, perhaps our bitter accidents and wretched passions heaven created as a pleasing spectacle for their idle hours? Not between calamities and crimes, but free in the forests and pure Nature appointed us, once our queen and goddess. But since on earth impious custom has destroyed the blessed realms and subjected our miserable life to other laws; when a virile soul rejects his luckless days does Nature return, and accuse the arrow that’s not hers? 166 CANTI VI, bruto minore Ignorant of guilt and their own misfortunes are the fortunate beasts; serene old age guides them to an unforeseen passage. But if they dash their foreheads on rough tree-trunks or from a mountain cliff cast bodies headlong to the winds, moved by their anguish, against that miserable desire would stand no arcane law or shadowy conception. You alone, among the numerous progeny that heaven created, alone among all, children of Prometheus, regret life. Alone o wretched ones, to you Jove bans, if sluggish fate delays, the shores of death. And you, from the sea stained by our blood, you rise bright moon, and explore the unquiet night and the deadly battlefield of Italian Valor. The victor tramples on kinsmen’s breasts, the hills shudder, from her highest summits ancient Rome collapses— and are you so placid? You saw the birth of Lavinia’s offspring, and their years of happiness, and the memorable victories; and on the mountain peaks you pour your immutable silent light when, in the wreck of the servile Italian name, this solitary place will echo beneath the barbarian tramp. Giacomo Leopardi 167 Here among naked rocks or on green boughs, beast and bird, breasts heavy with their habitual oblivion, ignore the profound ruin and the altered destiny of the world: and as the rooftop of the industrious peasant first glows red, with its morning song the one will wake the valleys, while through high slopes the other will startle the helpless multitude of smaller creatures. Oh destiny! oh insensate race! we are an abject part of things; neither the bloodstained soil nor the howling caves has our calamity ever perturbed, and no human cares stain the stars. Neither to Olympus’ or Cocytus’ deaf kings, or to the unworthy earth, and... (shrink)

Standard liberal theories of justice rest on the assumption that only those beings that hold the capacity for moral personality have moral status and therefore are right-holders. As many pointed out, this has the disturbing implication of excluding a wide range of entities from the scope of justice. Call this the under-inclusiveness objection. This paper provides a response to the under-inclusiveness objection and illustrates its implications for liberal theories of justice. In particular, the paper defends two claims: first, it argues (...) that both the CMP and the potential capacity for moral personality are bases of moral status. This pluralist account of the basis of moral status can broaden the scope of justice and provide a solid philosophical justification for the common-sense intuition that almost all human beings have a moral status that is different and superior to that of nonhuman animals. Second, contra what is commonly suggested, it contends that potential and actual moral persons have different and unequal rights, other things being equal. (shrink)

The question of the basis of human equality has recently gained increasing attention. However, much of the literature has focused on whether persons—understood as fully competent adults—have equal moral status, while relatively less attention has been devoted to the analysis of what grounds the equal moral status of those human beings who are not fully competent adults. This paper contributes to this debate by addressing the question of the equality of moral status between adults and children. Specifically, this paper has (...) three aims. First, it provides a conceptual map of this complex issue. Second, it argues that the challenges that have been raised against standard accounts of persons’ equal moral status are even more forceful when applied to the question of adults and children’s moral equality. Finally, it examines what a commitment to adults and children’s moral _inequality_ entails and what it does not, thereby showing that the justificatory role of the principle of moral equality is not as far-reaching as commonly assumed. (shrink)

Nowadays, physicalism is arguably the received view on the nature of mental states. Among the arguments that have been provided in its favour, the inductive one seems to play a pivotal role in the debate. Leveraging the past success of materialistic science, the physicalist argues that a materialistic account of consciousness will eventually be provided, hence that physicalism is true. This article aims at evaluating whether this strategy can provide support for physicalism. According to the standard objection raised against the (...) inductive line of reasoning, the argument would beg the question by assuming some sort of metaphysical uniformity between consciousness and the rest of the natural domain. Here, I concede that there is a way to avoid this criticism. However, I argue that the argument still fails to support physicalism due to a structural problem of justification transmission. (shrink)

Among the philosophies of special sciences, Philosophy of Medicine is an emerging field, even though the relationship between philosophy and medicine dates back to ancient times. Since the 1980s, t...

Hooks et al. note that microbiota-gut-brain research suffers from serious methodological flaws and interpretative issues. We suggest two corrective measures: first, taking more seriously the need of interdisciplinary work; second, interpreting some of the methodological issues as ordinary challenges of standardization, typical of emerging disciplines.