During brain development, neural precursor cells (NPCs) in different brain regions produce different types of neurons, and each of these regions plays a different role in the adult brain. Therefore, precise regionalization is essential in the early stages of brain development, and irregular regionalization has been proposed as the cause of neurodevelopmental disorders. The mechanisms underlying brain regionalization have been well studied in terms of morphogen‐induced expression of critical transcription factors for regionalization. NPC potential in different brain regions is defined (...) by chromatin structures that regulate the plasticity of gene expression. Herein, we present recent findings on the importance of chromatin structure in brain regionalization, particularly with respect to its regulation by Polycomb‐group proteins and chromatin accessibility. (shrink)

Commentary on a beloved ancient philosopher of Zen by a beloved contemporary master of Zen. Eihei Dogen was a thirteenth-century Buddhist poet-philosopher and founder of the Soto school of Zen. Famously insightful and famously complex, his writings have been studied and puzzled over by generations of students. Kosho Uchiyama was a beloved twentieth-century Zen teacher and author of over twenty books, who here addressed himself head-on to unpacking Dogen's wisdom for a modern audience. Translators Tom Wright and Shohaku Okumura present (...) three fascicles of Dogen's monumental Shobogenzo, or Treasury of the True Dharma Eye: "Shoaku Makusa" or "Refraining from Evil," "Maka Hannya Haramitsu" or "Practicing Deepest Wisdom," and "Uji" or "Living Time." For each one, they lovingly translate Uchiyama's thoughtful commentary on the piece. At turns poetic and funny, always insightful, this is Zen wisdom for the ages. (shrink)

A story for all ages about interconnection and learning to live in harmony amid differences, from a leading light of contemporary Zen-based on a parable from Kosho Uchiyama's classic bestseller Opening the Hand of Thought. Features a contextualizing afterword by Shohaku Okumura. [Amplify what kids will benefit from reading this book] "It's true that we are all different squashes... some are bigger and some are smaller... some are rounder and some are longer. But even if we are different, we are (...) all connected. We are all growing together. We don't have to be such squabbling squashes.". (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 22 (2002) 93-99 [Access article in PDF] Jesus Prayer and the Nembutsu Taitetsu Unno Smith College As a Shin Buddhist of the Pure Land tradition, I find the practice of Jesus Prayer in Eastern Orthodox Christianity fascinating, because so much of it resonates with my own experience in the saying of Nembutsu or the Name—namu-amida-butsu. 1 One calls on the Name of Jesus, and the other on (...) the Name of Amida, the Buddha of Immeasurable Light and Life. Both may be called the "Way of the Name." 2 Some appreciation of the Jesus Prayer may help us understand the depth of Nembutsu experience, for the similarities are striking, but there are also fundamental differences.We begin with four definitions of prayer as given by the Orthodox scholar Kallistos Ware. 3 The first may be called external prayer, which includes some form of verbally addressing God, including petitions for favors to be granted. Second is prayer understood simply as standing before God. Here there is only silence, negating all discursive activities. In both of these cases the focus is on the human and not on the divine.In Buddhist terms these two forms of prayer are dualistic, the subject standing apart from the object and the act centered on the human subject. In Pure Land language both are acts of self-power. In the case of Nembutsu it may also begin as a self-generated act, but it must be superseded. True prayer, as we shall see, is nondualistic with the initiative coming from the side of the divine. In Pure Land terms it is the manifestation of the working of Other Power.Buddhist meditative practice may also begin in a dualistic mode with personal benefits as the goal, but ultimately it becomes a nondualistic experience, whereby conceptual distinctions of subject and object disappear, so that a deeper reality is realized. The Soto Zen teacher Kosho Uchiyama sums up this awareness: 4 In our zazen, it is precisely at the point where our small, foolish self remains unsatisfied, or completely bewildered, that immeasurable natural life beyond the thought of the self functions. It is precisely at the point where we become completely lost that life operates and the power of Buddha is realized. The third and fourth definitions of prayer, based on Saint Gregory of Sinai, highlight the core experience in Jesus Prayer. The third sense of prayer, according to Ware, is [End Page 93] an inner act. In his words, "True inner prayer is to stop talking and to listen to the wordless voice of God within our heart; it is to cease doing things on our own, and to enter into the action of God." 5 Here, silence is not mere silence but the openness to hear the wordless voice of God. The initiative comes from the divine: "I have been crucified with Christ and I no longer live, but Christ lives in me" (Gal. 2:20) and "He must become greater, I must become less" (John 3:30).Fourth is prayer as "the manifestation of Baptism," not baptism as a ritual act but as the embodying of the divine. This is the state of grace that is brought "to the point of full spiritual perception and conscious awareness when we experience and feel the activity of the Spirit directly and immediately." 6These two connotations of prayer may be helpful in understanding the writings of Shinran, the founder of Shin Buddhism, who lived in thirteenth-century Japan. 7 The English translations of his works, coming from an entirely different cultural tradition and written in an alien language, sometimes defy easy comprehension. To take one important example, Shinran states at the beginning of the Chapter of Practice in his major opus, translated as "True Teaching, Practice, and Realization of the Pure Land Way," as follows: 8 The great practice is to say the Name of the Tathagata of unhindered light. This practice, embodying all good acts and possessing all roots of virtue, is perfect and most rapid in bringing them to fullness. It is the treasure ocean of virtues that is... (shrink)

How are the teachings of a thirteenth-century master relevant today? Twenty contemporary writers unpack Dogen's words and show how we can still find meaning in his teachings. Engaging Dogen's Zen is a practice oriented study of Shushogi (a canonical distillation of Dogen's thought used as a primer in the Soto School of Zen) and Fukanzazengi (Dogen's essential text on the practice of "just sitting," a text recited daily in the Soto School of Zen). It is also a study of the (...) entire self. Here, the principles of Soto Zen practice are unpacked and explained by leading contemporary Buddhists from the living tradition--monks, priests, academics, and community teachers. Tackling Dogen's approach to key issues, such as the preeminence of shikantaza, universal buddha nature, and what it means to be a Mahayana Buddhist, the contributors to the volume help Zen practitioners and any who are trying to deepen their lives to appreciate better the teachings of Soto Zen and make these teachings part of their lives. By revisiting what remains precious in Shushogi and Fukanzazengi, we let them breathe just as we learn to breathe in zazen. We find that Soto practice not only engages Dogen and Sakyamuni, but all of our sisters and brothers, and indeed the great earth itself. Includes essays from Kosho Itagaki, Taigen Dan Leighton, Tenshin Charles Fletcher, Shudo Brian Schroeder, Glen A. Mazis, David Loy, Drew Leder, Steven DeCaroli, Steve Bein, John Maraldo, Michael Schwartz, Tetsuzen Jason M. Wirth, Leah Kalmanson, Erin Jien McCarthy, Dainen David Putney, Steven Heine, Graham Parkes, Mark Unno, Shudo Brian Schroeder, and Kanpu Bret W. Davis. (shrink)