During brain development, neural precursor cells (NPCs) in different brain regions produce different types of neurons, and each of these regions plays a different role in the adult brain. Therefore, precise regionalization is essential in the early stages of brain development, and irregular regionalization has been proposed as the cause of neurodevelopmental disorders. The mechanisms underlying brain regionalization have been well studied in terms of morphogen‐induced expression of critical transcription factors for regionalization. NPC potential in different brain regions is defined (...) by chromatin structures that regulate the plasticity of gene expression. Herein, we present recent findings on the importance of chromatin structure in brain regionalization, particularly with respect to its regulation by Polycomb‐group proteins and chromatin accessibility. (shrink)

Apathy and depression are frequently observed as behavioral and psychological symptoms of dementia, respectively, and are important for ensuring adequate care. This study aims to explore effective non-pharmacological interventions for apathy and depression with mild cognitive impairment and dementia. Five search engines including PubMed, Scopus, CINAHL, PsycInfo, and Web of Science were used to extract relevant studies. Inclusion criteria were studies that involved participants who were diagnosed with MCI or dementia, included quantitative assessments of each symptom, and employed randomized controlled (...) trials. Twenty studies were extracted, with interventions have been conducted in care facilities, the community, and hospitals. Participants in many studies had MCI or mild-to-moderate dementia but were not diagnosed with the subtypes of dementia. Few studies had set apathy and depression as the primary outcomes of non-pharmacological interventions. The findings suggested that emotional and stimulation-oriented approaches to apathy and depression would be useful for people with MCI or mild-to-moderate dementia. It would be helpful for therapists to assess the clinical features of the target symptoms for selecting suitable interventions. Additionally, increasing the number of randomized controlled trials focusing on apathy or depression as primary outcomes would offer a more definite conclusion for future systematic reviews. (shrink)

‘Gender ’ is a troublesome loanword in Japan. While this term has been prevalent in feminist and scholarly circles, it has evoked confusion in the government and stimulated a backlash from the ultra-conservatives against gender equality. Japanese reactionaries have attacked the concept of gender because of their anxiety about cultural destruction – I thus call them the ‘old guard’. Focusing on a dispute over the term ‘gender’ between feminists and the old guard, this paper examines the changes in the term's (...) usage and meanings in the Japanese political context. I first shed light on Japan's reaction to the newly arrived term ‘gender’, outlining different attitudes towards gender between the feminist/scholarly circles and the government. Secondly, I discuss the old guard's condemnation of the concept of gender, in which they distort its significance in order to diminish its positive impact on society. I then scrutinize the old guard's reasons behind their attack on the concept of gender. My findings reveal that the old guard, whose political cause is to protect traditional Japanese culture, asserts that gender equality damages this culture. Moreover, I refute their emphasis on Japan's uniqueness, demonstrating that Japanese women's traditional virtues under the patriarchal family system are not peculiar to Japan. To gauge how the concept of gender has been interpreted politically, I highlight legislative debates about the term ‘gender’. In doing so, I elucidate the extent to which the concept of gender has infiltrated Japanese society through the dispute.Export citation Request permission. (shrink)

西が中心に据える〈虚〉という概念に注目し、「平和・和解」理論としての可能性を問うた。.

SUPERANNO A unique collection of photographs by WRA photographer Hikaru Iwasaki focuses on resettlement using photos of Japanese Americans following their release from WRA camps from 1943 to 1945. Author Lane Hirabayashi explores the use of photography in the WRA mission to encourage “loyal” Japanese Americans to return to society at large, and convince Euro-Americans this was safe. Hirabayashi also assesses the success of the WRA project, and the multiple uses of the photographs over time.

Poor sleep quality negatively affects memory performance, and working memory in particular. We investigated sleep habits related to sleep quality including sleep duration, daytime nap duration, nap frequency, and dream content recall frequency (DCRF). Declarative working memory can be subdivided into verbal working memory (VWM) and visuospatial working memory (VSWM). We hypothesized that sleep habits would have different effects on VWM and VSWM. To our knowledge, our study is the first to investigate differences between VWM and VSWM related to daytime (...) nap duration, nap frequency, and DCRF. Furthermore, we tested the hypothesis that the effects of duration and frequency of daytime naps and DCRF on VWM and VSWM differed according to sex. We assessed 779 healthy right-handed individuals (434 males and 345 females; mean age: 20.7 ± 1.8 years) using a digit span forward and backward VWM task, a forward and backward VSWM task, and sleep habits scales. A correlation analysis was used to test the relationships between VWM capacity (VWMC) and VSWM capacity (VSWMC) scores and sleep duration, nap duration, nap frequency, and DCRF. Furthermore, multiple regression analyses were conducted to identify factors associated with VWMC and VSWMC scores and to identify sex-related differences. We found significant positive correlations between VSWMC and nap duration and DCRF, and between VWMC and sleep duration in all subjects. Furthermore, we found that working memory capacity (WMC) was positively correlated with nap duration in males and with sleep duration in females, and DCRF was positively correlated with VSWMC in females. Our finding of sex-related differences in the effects of sleep habits on WMC has not been reported previously. The associations between WMC and sleep habits differed according to sex because of differences in the underlying neural correlates of VWM and VSWM, and effectiveness of the sleep habits in males and females. (shrink)

In this article we assess the general claim that Durkheimian sociology has reactionary, fascist, or totalitarian affinities, and the specific claim that Marcel Déat’s Durkheimian background was a significant factor in his becoming a Nazi sympathizer. We do so by comparing the different trajectories of the interwar generation of young Durkheimians and find that only one, i.e. Déat, can be said to have become fascist. Indeed, what characterizes this generation of Durkheimians is the variety of the ways in which they (...) responded to the crises of the interwar years, both politically and scientifically. Nonetheless, most remained on the political left, and during the war many younger members of the Durkheimian group either fled the country or were involved in the French Resistance. As the only personal link between the Durkheimian group and fascism, Déat’s career is of particular interest. Instead of Déat’s being an orthodox Durkheimian, his successive engagements embody the intellectual fragmentation and heterodoxy characteristic of the interwar generation. We outline Déat’s career by foregrounding the conjunctural and dispositional factors that we believe point toward a more plausible explanation of Déat’s transformation than does an internalist history-of-ideas approach according to which his political evolution can be explained by reference to an underlying intellectual continuity. Déat’s fascism is better explained by the repeated frustration of his political and intellectual ambitions that ultimately led to a fateful accommodation with Nazi power than by any tendency inherent to Durkheimian sociology. (shrink)

The recent declaration of the largest municipal bankruptcy in US history has propelled Detroit’s plight into the international spotlight. Though a victim of the general decline of US manufacturing, drawing on Thomas Sugrue’s pioneering work I argue that Detroit’s crisis is better understood as a specifically urban crisis. The city’s concentrated poverty and desolation and its fiscal straits are not reducible to broader economic trends, nor are they exclusively the product of political mismanagement. Rather, they are the outcome of a (...) long history of economic decentralization and racial segregation, made worse by a politico-administrative arrangement that distributes wealth and services unequally across the metropolitan area. By imposing municipal austerity, Detroit’s bankruptcy is unlikely to do much to address these fundamental inequalities. Any plan to revitalize the city must move beyond boosterism and tackle head on the problems of racial and economic segregation that continue to affect Detroit’s 700,000 residents. (shrink)

In the last few decades, the emergence of mid-scale, intermediated marketing channels that fall between commodity and direct markets has attracted growing interest from scholars for their potential to preserve small and mid-sized farms while scaling up alternative agrifood sourcing. When such mid-scale supply chains are formed among multiple business partners with shared ethics or values related to the qualities of the food and the business relationships along the supply chain, they may be termed “values-based supply chains (VBSCs).” Most of (...) the research on VBSCs to date has relied primarily on a case study approach that investigates the performance of VBSCs from the perspective of VBSC founders or leaders. In contrast, this research seeks out the perspectives of farmers who participate in VBSCs. A nationwide farmer survey conducted in 2017 offers original insights on farmer motivations for participating in VBSCs and how they are being used by farmers relative to other marketing channels. We find that VBSCs serve farms of all sizes. Overall, smaller farms were more likely to market a higher percentage of overall sales through their VBSC and more likely to rank their VBSC as one of the top three marketing channels in their portfolio. But it was the larger farms that were more likely to perceive VBSC-specific benefits. Our findings confirm that while there is a limited volume of product that such regional supply chains can currently handle, farmers view VBSCs as a valuable marketing option that aligns with their own values and preserves their product’s identity. (shrink)

Background Previous reports have described that simple cognitive training using reading aloud and solving simple arithmetic calculations, so-called “learning therapy”, can improve executive functions and processing speed in the older adults. Nevertheless, it is not well-known whether learning therapy improve a wide range of cognitive functions or not. We investigated the beneficial effects of learning therapy on various cognitive functions in healthy older adults. Methods We used a single-blinded intervention with two groups (learning therapy group: LT and waiting list control (...) group: WL). Sixty-four elderly were randomly assigned to LT or WL. In LT, participants performed reading Japanese aloud and solving simple calculations training tasks for 6 months. WL did not participate in the intervention. We measured several cognitive functions before and after 6 months intervention periods. Results Compared to WL, results revealed that LT improved inhibition performance in executive functions (Stroop: LT (Mean = 3.88) vs. WL (Mean = 1.22), adjusted p =.013 and reverse Stroop LT (Mean = 3.22) vs. WL (Mean = 1.59), adjusted p =.015), verbal episodic memory (logical memory: LT (Mean = 4.59) vs. WL (Mean = 2.47), adjusted p =.015), focus attention(D-CAT: LT (Mean = 2.09) vs. WL (Mean = -0.59), adjusted p =.010) and processing speed compared to the waiting list control group (digit symbol coding: LT (Mean = 5.00) vs. WL (Mean = 1.13), adjusted p =.015 and symbol search: LT (Mean = 3.47) vs. WL (Mean = 1.81), adjusted p =.014). Discussion This RCT can showed the benefit of learning therapy on inhibition of executive functions, verbal episodic memory, focus attention, and processing speed in healthy elderly people. Our results were discussed under overlapping hypothesis. Trial registration “This trial was registered in The University Hospital Medical Information Network Clinical Trials Registry (UMIN000006998).”. (shrink)

Functional electrical stimulation (FES), a method for inducing muscle contraction, has been successfully used in gait rehabilitation for patients with deficits after neurological disorders and several clinical studies have found that it can improve gait function after stroke and spinal cord injury. However, FES gait training is not suitable for patients with walking difficulty, such as those with severe motor paralysis of the lower limbs. We have previously shown that action observation combined with motor imagery (AO + MI) of walking (...) induces walking-related cortical activity. Therefore, we combined FES, which alternately generates dorsiflexion and plantar flexion, with AO + MI as an alternative to gait training. The present study investigates the transient effects of 20-min of FES simultaneously with and without AO + MI of walking on corticospinal and spinal reflex excitability in able-bodied participants. We measured motor evoked potentials and Hoffmann-reflexes to assess corticospinal and spinal reflex excitability at rest before and after the 20-min FES with and without the AO + MI. Our results show that FES without AO + MI did not change excitability (p > 0.05), while FES with AO + MI facilitated corticospinal excitability (p < 0.05). This facilitation likely occurred due to the synchronization of sensory inputs from FES and cortical activity during AO + MI. Facilitation was observed only in the dorsiflexor but not the plantar flexor muscle (p < 0.05), suggesting muscle specificity of the facilitation. These results demonstrate the effectiveness of combining FES with AO + MI and pave the way for novel neurorehabilitation strategies for patients with neurological gait deficits. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

Something should be done for a better global environment as soon as possible. This paper investigates the direction of management of the global environment and proposes new, concrete ideas for it.

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

The principles that govern the functioning of science and visions of the ethics of scientific research are changing. Many researchers who are examining these changes observe a shift from the academic ethos to the industrial — or “corporate” — ethos. Under the new law on higher education and science, which was passed by the Polish Parliament in 2018, new regulations to the Polish state university system have come into effect. The basic aim of my article has been to examine the (...) scientific ethos in Poland. I based my research on the new statutes adopted by university senates, in which I focused on the value statements and declarations that express the beliefs of university authorities about the most important and desirable model of science. I compared two groups of universities, those which have obtained the status of research universities and colleges from the Upper Silesian Metropolis. My goal was to answer the following questions: 1. What values create the declared ethos of science? 2. What is their hierarchy? 3. To what extent is the ethos of both groups of universities similar? 4. Has the scientific ethos present in the new statutes changed in relation to what was declared earlier? In order to answer these questions, I have applied the technique of document content analysis. My research shows that 1. The ethos of science is changing; 2. The set of declared values in the material under scrutiny is rich and varied. (shrink)

The Tarnowski family was one of the most distinguished families in the history of the Polish Commonwealth. The times of their glory date back to the reign of Ladislaus the Short, when their progenitor, Spycimir, became one of the most important figures in the country. At the beginning of the 16th century, after losing their native Tarnów, they established a new family estate in Dzików, where they resided continuously until 1944. The story of the Tarnowski Family from Dzików is also (...) the account of their service to the motherland. The aim of this article is to present this service over the centuries, with a particular emphasis laid on their contribution to the defence of freedom of the Republic of Poland. This service resulted from the knightly ethos which was being kept alive in the family, the model for which was the figure of Hetman Jan Amor Tarnowski. The attitude of the Tarnowski family, both during the 19th century national uprisings, as well as during the wars of 1920 and 1939–45 are the examples of faithfulness to this ethos and to their own past. The article was based on the published literature about the Tarnowski family and the concept of ethos. The latter was only used as a basis for defining the phenomenon. The archives were also consulted, with a particular stress on the family resources, as they show the most fully and precisely the attitude of the subsequent generations of Tarnowski towards their great ancestor. By means of critical analysis of these sources and the available literature, the author put forward the thesis that the peculiar “cult” of Hetman Jan Tarnowski, cultivated by successive family representatives, was an imperative for subsequent generations of the Tarnowski family to maintain their patriotic attitudes. An important conclusion that emerges from this article is that it shows once again how important the knightly ethos, the faith and other imponderables are in the lives of individuals and communities. (shrink)

Fenomenološki etos, po katerem je povzet naslov knjige, izhaja iz etične prenove v evropski filozofiji, ki se je začela na začetku 20. stoletja. Zasnoval ga je oče fenomenologije Edmund Husserl in se ob tem deloma navezal na Schelerjev koncept materialne etike, etike vrednot. Avtor v knjigi prikaže, kaj to pomeni na eni strani za etiko samo, na drugi strani pa za odnos med etičnostjo in religioznostjo. Celotno problematiko pa konkretizira z analizo in interpretacijo razmerja med kategoričnim imperativom in zlatim pravilom (...) kot najstarejšim moralnim pravilom vseh svetovnih civilizacij, tako da ga danes obravnavamo kot ključni element svetovnega etosa. V tem kontekstu sta prek Assmannovega in Girardovega tematiziranja krščanstva problematizirana tudi monoteistična ekskluzivnost in nasilnost. V sklepnem delu knjige je prikazan razvoj fenomenološkega etosa od Husserl prek Heideggerja in Levinasa do Derridaja in Mariona. Knjiga se sklene s predstavitvijo vloge in pomena fenomenološkega etosa v kontekstu globalne krize sodobnega sveta. (shrink)

Liberalism and marxism are two forms of economism, which separate economic activity from ethics. The social teaching of the Church accepted continued by pope Benedict XVI recognizes the necessity of free market and limited intervention of the state in economy, but first of all postulates creativity of civil society in the field of economic life. The main arguments for observance of moral rules in the economic activity are following: 1. Every conscious and free men’s action is responsible for the effects (...) – economic activity cannot be any exception; 2. The same ethics ought to be applied in the individual-private life and in the public domain – also economy; 3. Ethos of economic activity is connected with three virtues – truth, love and justice (also social justice); 4. Christian-personalistic ethics is based on the principles auxialiarity (personalism) and common good (solidarity). Economic activity completely separated from ethics is inhuman. (shrink)

Academic ethos is a set of norms that are binding for a scholar as such. (1) A scholar should especially take up useful research, do it guardedly (so without infringing higher values), formulating well asked questions, using effective methods of searching for true and sufficiently justified answers to those questions — and expressing the research results in an exact, adjusted to the object of the research, simple, forcible, concise and beautiful language. (2) A scholar should undertake vital, i.e. new, fundamental, (...) creative and difficult research. (3) Conducting research should be accompanied by passion, concentration, reliability, imagination, and self-criticism. 4) A scholar should be a guide,minder and supervisor for his pupils and co-workers. (5) A Catholic scholar should also be expected to behave in a morally impeccable way, and if he does not meet this expectation, at least he should feel ashamed of it. (shrink)