Looking for Trouble: Preventive Genomic Sequencing in the General Population and the Role of Patient Choice

American Journal of Bioethics 15 (7):3-14 (2015)

Authors
Rebecca Walker
University of North Carolina, Chapel Hill
Abstract
Advances in genomics have led to calls for developing population-based preventive genomic sequencing programs with the goal of identifying genetic health risks in adults without known risk factors. One critical issue for minimizing the harms and maximizing the benefits of PGS is determining the kind and degree of control individuals should have over the generation, use, and handling of their genomic information. In this article we examine whether PGS programs should offer individuals the opportunity to selectively opt out of the sequencing or analysis of specific genomic conditions or whether PGS should be implemented using an all-or-nothing panel approach. We conclude that any responsible scale-up of PGS will require a menu approach that may seem impractical to some, but that draws its justification from a rich mix of normative, legal, and practical considerations
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DOI 10.1080/15265161.2015.1039721
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References found in this work BETA

The 'Right' Not to Know.D. E. Ost - 1984 - Journal of Medicine and Philosophy 9 (3):301-312.

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Citations of this work BETA

Looking for Trouble and Finding It.Susan B. Trinidad, Stephanie M. Fullerton & Wylie Burke - 2015 - American Journal of Bioethics 15 (7):15-17.

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