The activation of leukocytes by bacterial cell wall lipopolysaccharide (LPS) contributes to the pathogenesis of septic shock. It is well established that, in the presence of plasma LPS‐binding protein (LBP), LPS binds with high affinity to CD14. The binding of LPS to CD14 has been associated with the activation of cells, although available evidence indicates that CD14 itself does not transduce intracellular signalling. The physiological function of this interaction is to promote host defense mechanisms of cells to combat the infection (...) and clear LPS from the circulation. At higher concentrations of LPS, however, the activation of cells can take place in the absence of LBP and CD14, presumably through a distinct low‐affinity signalling LPS receptor. On the evidence published by us and others, we propose that in neutrophils, and possibly other leukocytes, L‐selectin can act as a low‐affinity LPS receptor. (shrink)

The East has been for centuries the holy, the sacred, the source of life. Not only does the sun rise in the East, so does a Gautam Buddha. This book offers a compilation of Osho's discourses on some of the enlightened Masters who were born in the East: Atisha, Baul mystics, Boddhidharma, the Buddha, Chuang Tze, Kabir, and others. The East has been for centuries, or perhaps forever, the holy, the sacred, the source of life. Not only does the sun (...) rise in the East, so does a Gautam Buddha. The East has produced thousands of mystics. Just as the West has produced great. (shrink)

ACHAKYA RAJNEESH Acharya Rajneesh is an Enlightened One, who has become one with the infinity, the totality. He is NOT, but the infinity breathes through him. He is not a person but the divinity personified. Transcendental Truth shines...

A series of dialogues with the most exciting and controversial German philosopher writing today. Peter Sloterdijk first became known in this country for his late 1980s Critique of Cynical Reason, which confronted headlong the “enlightened false consciousness” of Habermasian critical theory. Two decades later, after spending seven years in India studying Eastern philosophy, he is now attracting renewed interest for his writings on politics and globalization and for his magnum opus Spheres, a three-volume archaeology of the human attempt to dwell (...) within spaces, from womb to globe: Bubbles, 1998; Globes, 1999; Foam, 2004, all forthcoming from Semiotext. In Neither Sun nor Death, Sloterdijk answers questions posed by German writer Hans-Jürgen Heinrichs, commenting on such issues as technological mutation, development media, communication technologies, and his own intellectual itinerary. Iconoclastic and provocative, alternatively sparkling and bombastic, a child of '68 and a libertarian, Sloterdijk is the most exciting and controversial German philosopher to appear on the world scene since Nietzsche and Heidegger. Like Nietzsche, Sloterdijk remains convinced that contemporary philosophers have to think dangerously and let themselves be “kidnapped” by contemporary “hypercomplexities”; they must forsake our present humanist and nationalist world for a wider horizon at once ecological and global. Neither Sun nor Death is the best introduction available to Sloterdijk's philosophical theory of globalization. It reveals a philosophe extraordinaire, encyclopedic and provocative, as much at ease with current French Theory as with Heidegger and Indian mystic Osho Rajneesh. (shrink)

Peter Sloterdijk first became known in this country for his late 1980s Critique of Cynical Reason, which confronted headlong the "enlightened false consciousness" of Habermasian critical theory. Two decades later, after spending seven years in India studying Eastern philosophy, he is now attracting renewed interest for his writings on politics and globalization and for his magnum opus Spheres, a three-volume archaeology of the human attempt to dwell within spaces, from womb to globe: Bubbles, 1998; Globes, 1999; Foam, 2004, all forthcoming (...) from Semiotext. In Neither Sun nor Death, Sloterdijk answers questions posed by German writer Hans-Jürgen Heinrichs, commenting on such issues as technological mutation, development media, communication technologies, and his own intellectual itinerary.Iconoclastic and provocative, alternatively sparkling and bombastic, a child of '68 and a libertarian, Sloterdijk is the most exciting and controversial German philosopher to appear on the world scene since Nietzsche and Heidegger. Like Nietzsche, Sloterdijk remains convinced that contemporary philosophers have to think dangerously and let themselves be "kidnapped" by contemporary "hypercomplexities"; they must forsake our present humanist and nationalist world for a wider horizon at once ecological and global.Neither Sun nor Death is the best introduction available to Sloterdijk's philosophical theory of globalization. It reveals a philosophe extraordinaire, encyclopedic and provocative, as much at ease with current French Theory as with Heidegger and Indian mystic Osho Rajneesh. (shrink)