Wilhelm Ostwald, Ernst Mach y Pierre Duhem se encuentran entre los más relevantes críticos del atomismo de finales del siglo XIX. Repasamos y analizamos los argumentos que aducen dichos autores para oponerse a la concepción atomista de la materia. Mostramos cómo esos argumentos surgen de posiciones filosóficas de fondo sobre el fundamento de la naturaleza, el objeto de la ciencia y el papel de la metafísica. Comparamos dichas posiciones filosóficas. Y enmarcamos la crítica del atomismo en el problema epistemológico más (...) general de la explicación para mostrar la tensión entre explicación y experiencia, y su relación con la metafísica. (shrink)

El surgimiento de la teoría de la relatividad de Einstein a principios del siglo XX suscitó el debate sobre la vigencia de la filosofía kantiana. El positivista Schlick sostenía que esta quedaba refutada, pues estaba indisolublemente ligada a la física de Newton y a los conceptos de espacio y tiempo absolutos. Los neokantianos Natorp y Sellien defendían la vigencia de Kant basándose en la diferencia entre filosofía y ciencia. Cassirer y Reichenbach abogaban por un neokantismo modificado basado en principios constitutivos. (...) Y Einstein y Carnap rechazaban tanto kantismo como positivismo puros abrazando el holismo epistemológico. (shrink)

Chromosome segregation requires the ordered separation of the newly replicated chromosomes between the two daughter cells. In most cells, this requires nuclear envelope (NE) disassembly during mitotic entry and its reformation at mitotic exit. Nuclear envelope breakdown (NEB) results in the mixture of two cellular compartments. This process is controlled through phosphorylation of multiple targets by cyclin‐dependent kinase 1 (Cdk1)‐cyclin B complexes as well as other mitotic enzymes. Experimental evidence also suggests that nucleo‐cytoplasmic transport of critical cell cycle regulators such (...) as Cdk1‐cyclin B complexes or Greatwall, a kinase responsible for the inactivation of PP2A phosphatases, plays a major role in maintaining the boost of mitotic phosphorylation thus preventing the potential mitotic collapse derived from NEB. These data suggest the relevance of nucleo‐cytoplasmic transport not only to communicate cytoplasmic and nuclear compartments during interphase, but also to prepare cells for the mixture of these two compartments during mitosis. (shrink)

La introducción al ensayo relaciona la escritura y la supervivencia en Unamuno y en Lledó -en el primero como voluntad multidimensional y en el segundo como memoria viva colectiva- y después compendia la vida y la obra de Emilio Lledó El ensayo comenta varios textos de la obra de Lledó Memoria de la ética acerca de la muerte y de la existencia extendida en la época clásica de la cultura y la filosofía griegas. Como conclusión, y a partir del epicureísmo (...) de Lledó, se reafirma una cierta distinción entre las propuestas de una teoría de la vida post-mortem basada en la pervivencia por la memoria y otra que apunta a la vida perdurable por el impulso del ánimo o thymós. (shrink)

La filosofía de la tecnología es una rama reciente de la filosofía en general. Puede aportar herramientas para problemas derivados de aplicaciones tecnológicas recientes, como la telemedicina. Un problema señalado reiteradamente por la bioética lo constituye la privacidad en general, y las modificaciones que pueden introducirse por el cada vez mayor uso de las tecnologías. Comentando propuestas desde la Asociación Médica Mundial y datos contemporáneo derivados de la pandemia de COVID-19, puede reconocerse que la privacidad es una exigencia ética que (...) requiere regularse a través de su implementación política para su adecuada protección legal. (shrink)

El artículo plantea condiciones clínico-epidemiológicas peculiares cuando la humanidad se enfrente a una zoonosis emergente. El ejemplo que groseramente ha golpeado a la humanidad es la pandemia de Covid-19, enfermedad causada por el coronavirus SARS-CoV-2. Si bien la historia de la humanidad da cuenta de múltiples pandemias ocasionadas por varios agentes infectocontagiosos, es cierto que en el primer momento de afrontar una problemática global de esta naturaleza lo que prima es la incertidumbre. Ante ella, existe la obligación moral de proveer (...) los mejores servicios de salud que sea posible; a la par, debe realizarse una investigación para encontrar medidas farmacéuticas específicas que contengan y mitiguen el daño poblacional (medicamentos específicos y/o vacunas). Mientras tanto, sabiendo que en el caso de la actual pandemia de Covid-19 la principal y más eficiente vía de transmisión es la propagación por gotas de saliva, el distanciamiento físico es crucial. Una consulta médica involucra hablar en el interrogatorio y una proximidad física durante la exploración. Existen datos que indican que la telemedicina tiene un alto grado de recomendación para la protección de la salud, tanto de profesionales como de pacientes. Se recuerda que una declaración de la Asociación Médica Mundial ha tratado el tema de la telemedicina; con su exposición, se indican alcances, limitaciones y proyecciones en el futuro. (shrink)

Localization Wireless Sensor Networks (WSN) represent a research topic with increasing interest due to their numerous applications. However, the viability of these systems is compromised by the attained localization uncertainties once implemented, since the network performance is highly dependent on the sensors location. The Node Location Problem (NLP) aims to obtain the optimal distribution of sensors for a particular environment, a problem already categorized as NP-Hard. Furthermore, localization WSN usually perform a sensor selection for determining which nodes are to be (...) utilized for maximizing the achieved accuracy. This problem, defined as the Sensor Selection Problem (SSP), has also been categorized as NP-Hard. While different metaheuristics have been proposed for attaining a near optimal solution in both problems, no approach has considered the two problems simultaneously, thus resulting in suboptimal solutions since the SSP is biased by the actual node distribution once deployed. In this paper, a combined approach of both problems simultaneously is proposed, thus considering the SSP within the NLP. Furthermore, a novel metaheuristic combining the Black Widow Optimization (BWO) algorithm and the Variable Neighbourhood Descent Chains (VND-Chains) local search, denominated as BWO-VND-Chains, is particularly devised for the first time in the author’s best knowledge for the NLP, resulting in a more efficient and robust optimization technique. Finally, a comparison of different metaheuristic algorithms is proposed over an actual urban scenario, considering different sensor selection criteria in order to attain the best methodology and selection technique. Results show that the newly devised algorithm with the SSP criteria optimization achieves mean localization uncertainties up to 19.66 % lower than traditional methodologies. (shrink)

According to the broaden-and-build theory of positive emotions, the frequency of positive emotions is associated with the development of positive attitudes, cognitions, and behaviors in organizational contexts. However, positive and negative attitudes at work might also be influenced by different personal and job resources. While emotional intelligence has been significantly associated with positive job attitudes and personal well-being, no studies have yet examined the joint role of teacher happiness and emotional intelligence in key teacher job attitudes. The present study assesses (...) whether emotional intelligence interacts with levels of teacher happiness to jointly explain important teacher job attitudes. A total sample of 685 teaching professionals filled out a battery of scales including subjective happiness, emotional intelligence, job satisfaction, and turnover intention. Our results revealed that subjective happiness was significantly associated with both higher job satisfaction and lower turnover intention. Likewise, emotional intelligence was positively related to happiness and job satisfaction, and negatively related to turnover intention. Finally, interaction analysis showed the main effects of happiness and emotional intelligence in explaining teacher job attitudes. Beyond the main effects, the interaction effects of happiness and emotional intelligence were significant in predicting all teachers' job attitude indicators, even controlling for the effects of their sociodemographic variables. This work expands our knowledge about the role of teachers' positive emotions in the development of positive work attitudes, and also supports the inclusion of emotional skills in future teacher preparation programs as resources to facilitate work-related well-being. (shrink)

Closed-loop administration of propofol for the control of hypnosis in anesthesia has evidenced an outperformance when comparing it with manual administration in terms of drug consumption and post-operative recovery of patients. Unlike other systems, the success of this strategy lies on the availability of a feedback variable capable of quantifying the current hypnotic state of the patient. However, the appearance of anomalies during the anesthetic process may result in inaccurate actions of the automatic controller. These anomalies may come from the (...) monitors, the syringe pumps, the actions of the surgeon or even from alterations in patients. This could produce adverse side effects that can affect the patient postoperative and reduce the safety of the patient in the operating room. Then, the use of anomaly detection techniques plays a significant role to avoid this undesirable situations. This work assesses different one-class intelligent techniques to detect anomalies in patients undergoing general anesthesia. Due to the difficulty of obtaining real data from anomaly situations, artificial outliers are generated to check the performance of each classifier. The final model presents successful performance. (shrink)

IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

The main purpose of this study was to analyze the presence and current situation of the game of skittles throughout the northern route of the Camino de Santiago. Thus, we considered its current practice, modalities, where it is played, and its different manifestations as an informal and formal game, comparing it with other traditional games on this pilgrimage route. To do this, a mixed qualitative-quantitative study was designed with 89 participants, constituting an informant for each municipality through which the Northern (...) Way passes. An ad hoc questionnaire was used for the data collection, which was processed through content analysis by expert judges and by using the IBM-SPSS statistical package. The results of the study show notable skittles activity on the Northern Camino, reflected in the number of skittles alleys, the number of clubs, associations, and peñas participating in federated leagues, and the wide range of varieties of skittles currently active on the Camino. The relationship between skittles and local culture, both symbols of identity in these northern Spanish regions, made it possible to preserve the traditional heritage in these places, keeping it alive today, despite the push toward new and more attractive leisure and sport trends. (shrink)

En este artículo se estudia el papel jugado por diferentes órdenes religiosas con vistas a la instalación de alguna de sus comunidades en el antiguo cenobio agustino de Nuestra Señora de Regla sito en la localidad gaditana de Chipiona en el marco del proceso de restauración de las órdenes religiosas vivido en España tras la supresión de las mismas, sobre todo con la llegada al trono español del rey Alfonso XII en 1875, proceso que se vio complicado por la instalación (...) en nuestro país de las comunidades religiosas expulsadas de Francia a partir de 1880. Se analiza especialmente el papel desempeñado por los franciscanos misioneros españoles y los monjes benedictinos franceses de las abadías de Solesmes y Ligugé. (shrink)

En este artículo se analizan las transformaciones producidas en el patrimonio artístico de la iglesia parroquial de la Purísima Concepción de Gilena entre los años 1874 y 1928 según los datos contenidos en varios inventarios de dicha iglesia realizados en ese tiempo.

Ampliación de un estudio anterior en la que se dan a conocer nuevas aportaciones acerca del devenir histórico de la iglesia parroquial de Gilena desde sus orígenes, en el siglo XVI, hasta el siglo XIX.

Con el presente trabajo nos acercamos a la figura de don Pedro José Baena y Núñez, quien fuera vicario general de Estepa, esto es, titular de una prelacía menor que gobernaba eclesiásticamente una jurisdicción exenta o nullius dioecesis que comprendía el territorio de lo que fue el marquesado de Estepa; especialmente se analiza su comportamiento durante la ocupación francesa de este territorio entre los años 1810 y 1812, del cual hemos tenido conocimiento a través de un proceso judicial que se (...) le incoó, llamado de purificación, al poco tiempo de la marcha de los franceses y que se conserva en el archivo de la vicaría de Estepa, custodiado hoy en el del arzobispado hispalense. (shrink)

En este artículo se analiza un expediente conservado en el Archivo General del Arzobispado de Sevilla que trata acerca del intento de fundar una nueva congregación del Oratorio de San Felipe Neri en la ciudad de Écija el año 1749, fundación que finalmente no se llevó a cabo.

August Weismann proposed that genetic changes in somatic cells cannot pass to germ cells and hence to next generations. Nevertheless, evidence is accumulating that some environmental effects can promote heritable changes in the DNA of germ cells, which implies that some somatic influence on germ line is possible. This influence is mostly detrimental and related to the presence of oxidative stress, which induces mutations and epigenetic changes. This effect should be stronger in males due to the particular characteristics of sperm. (...) Here, we propose the hypothesis that females are able to avoid males with oxidatively damaged DNA in the germ line by using oxidative‐dependent (pre‐ and post‐mating) signals. This new hypothesis may shed light on unsolved questions in evolutionary biology, such as the benefits of polyandry, the lek paradox, or the role of sexual selection on the evolution of aging. BioEssays 30:1212–1219, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The negative impacts of agriculture on the environment and the inequity that limits access to healthy food for the entire population impede sustainable development. This article reflects contributions to food security and alternatives for transitioning to sustainable food systems. It is concluded that food, as a human right, is a complex and transdisciplinary issue, which must be integrated as a transversal axis in the economic, social, environmental, governance, and cultural dimensions to contribute to sustainable development and therefore the convenience of (...) making the transition from the concept of food security to that of food sustainability. (shrink)

El antiguo convento del Carmen calzado de Sevilla fue uno de los edificios religioso más paradigmáticos de su ciudad. No ya sólo por sus dimensiones o por el enorme patrimonio artístico que llegó a albergar (del que hoy nos queda in situ sólo buena parte de su arquitectura), sino también por su amplio significado devocional. En él llegaron a establecerse en el s. XVI y hasta el s. XIX numerosas hermandades y cofradías. En este artículo no se pretende simplemente resumir (...) la historia de dichas corporaciones durante ese periodo carmelitano, sino ahondar en sus relaciones con respecto a los frailes que los acogían, y reflexionar sobre el estrecho paralelismo que hubo entre la evolución y posterior decadencia de esta comunidad religiosa con respecto a esas hermandades. (shrink)

Este artículo de revisión examina la importancia que tienen las comunidades microbianas que colonizan los ambien­tes y equipos de procesado de alimentos formando biopelículas o biofilms en la persistencia microbiana en la industria alimen­taria y consecuentemente, en la seguridad y la calidad de los alimentos. La atención se centra especialmente en biopelículas formadas por microorganismos no deseados, es decir, microor­ganismos alterantes y patógenos. Se presenta información so­bre la variabilidad intraespecífica en la formación, la ecología y la arquitectura de las biopelículas, (...) y los factores que influyen en su formación. Asimismo, se resume la información disponible sobre nuevos agentes o estrategias para el control de la forma­ción o eliminación de biopelículas. (shrink)

This work explores the role that the French anti-colonial left had in active solidarity with Latin American liberation movements and guerrilla groups. To this end, the text reconstructs the process of emergence and development of the Solidarité organization, founded by veterans of the French networks in support of the Algerian FLN, and analyses the relationships established with Latin American revolutionary organizations, particularly in the Dominican Republic since the mid-1960s. The work is built with empirical evidence from the Solidarité archive located (...) in the International Institute of Social History in Amsterdam. Along with this, use has been made of various secondary sources, including biographies of key Solidarité activists, among others. (shrink)

According to a growing body of studies, people’s ability to forecast future emotional experiences is generally biased. Nonetheless, the existing literature has mainly explored affective forecasting in relation to specific events, whereas little is still known about the ability to make general estimations of future emotional states. Based on existing evidence suggesting future-oriented disposition as a key factor for mental health, the aims of the current study were (1) to investigate the relationship between negative (NA) and positive (PA) affective forecasting (...) biases and perceived psychological well-being, and (2) to explore whether positively biased predictions are associated with resilience and foster one’s skills to cope with stressful events. To do so, we asked 85 undergraduate students to forecast PA and NA over two weeks, as well as to report their daily affect through a web-based Ecological Momentary Assessment. According to the results, positively biased PA forecasting (i.e., overestimating positive emotional states) was associated with greater perceived psychological well-being and higher resilience. When high levels of stress were experienced, participants holding an optimistic, yet biased, estimation of future PA were more likely to successfully manage stressors, thus maintaining lower levels of NA and higher levels of positive emotions. We suggest that positively biased PA forecasting is an adaptive cognitive distortion that boosts people’s resilience and mental health, thus opening new avenues for the promotion of psychological well-being. (shrink)

The island of Ibiza is a western Mediterranean destination known internationally for its nightlife. The aim of this paper is to make a proposal to classify the different types of premises in the Ibiza nightlife offer. This involves making a first definition that allows to delimit which businesses are parts of the sector. The methodology used is based on the case study and specifically, on the review of the promotional actions and activities carried out, completed with the visit to the (...) premises. The classification has been made based on the offer marketed and not only on the legal forms used, as innovation goes ahead of the existing legal classifications. Although it is a particular application, due to the international importance of Ibiza, it is a good starting point to classify the nightlife offer of many other tourist destinations. The resulting typology divides the sector into two large groups: nightclubs and other premises. While nightclubs have musical parties as their main activity declared, the other premises have accommodation or catering as their main activity, with music being an element of differentiation. Nightclubs are divided into several subgroups, depending on their size and relevance. The other premises are subdivided into Beach Clubs, Hotel Clubs, Party Boats, Lounge Clubs, Disco Pubs, among others. (shrink)

Our chapter interrogates the conditions that give rise to the possibility of the Event and proposes a Lacanian-Badiouian perspective to think through conditions for the truth procedures of love and politics. First, we situate the Event, Possibility and Truth in both Badiou and Lacan, which brings forward conceptual tensions between truth and knowledge as presented in the psychoanalytic act. We propose with Badiou and Lacan that the emergence of possibility follows a logic that rupture compulsive repetition and whose effect is (...) precisely the Event which results in knowledge of a savoir faire, of transmissible quality, that grant re-inscription (a new writing of the necessary) and/or a partial inscription of the impossible. The notion of love as beyond narcissism, allows us to discuss how to reimagine politics anew, including approaching it through the problem of ecology. (shrink)

La explicación urbana, definida bajo conceptos psicoanalíticos trascendidos mediante el uso de tópicas complejas en la generación de los problemas urbanos, desarrolla la comprensión de las paradojas de la anti-ciudad en la ciudad, la identidad y la no-identidad, y la marginación y la inclusión. La ciudad es entendida desde el rapport del ámbito urbano, al descubrir su tópica urbana y subordinar su configuración esencial al urbanismo, en relación con la conciencia colectiva, para explicar y comprender los fenómenos que coadyuvan a (...) entender la identidad, la marginación y la violencia como fenómenos urbanos. (shrink)

The aim of this paper is to provide a brief reading of Tractatus 6.421 and its consequences in 6.432 and following, adding to it an sketch of so-lution, which takes hold on the idea, present in his lessons and conver-sations, of "super-mechanism".

El confinamiento 2020 – 21 obligó a la humanidad a adaptarse al nuevo modo de vida y creación de nuevos escenarios con tecnologías que transformaron espacios físicos y tradicionales de enseñanza, abruptamente reemplazados por escenarios virtuales. Este estudio transversal, exploratorio y descriptivo, realizado aplicando formularios y entrevistas semiestructuradas a estudiantes y docentes de Diseño UCTemuco; recogió la percepción e implementación de la docencia a distancia realizada y evaluó el retorno presencial. Levantamos fortalezas, dificultades y oportunidades en esta nueva forma de (...) enseñanza que se nos desafía interpelándonos a raíz de aprendizajes adquiridos, emergentes metodologías, plataformas educativas y políticas de internacionalización institucionales. (shrink)

With the advent of COVID-19, a sudden, unexpected, and forced shift has been produced in the field of psychotherapy. Worldwide, many therapists closed their offices and started to deliver psychotherapy online through a screen. Although different media started to be incorporated, videoconferencing is undoubtedly the most common way in which therapists are doing therapy these days. This is catalyzing a rapid change in the practice of psychotherapy with probable lasting effects and deserves to be carefully reflected upon. Therefore, in this (...) paper our aim is to outline the main challenges for a medium that may have arrived to stay. In that sense, we review the literature to describe the state-of-the-art regarding the main aspects of videoconferencing psychotherapy as well as to suggest possible avenues for future research and practice. (shrink)