Fused, elongated mitochondria are more efficient in generating ATP than fragmented mitochondria. In diverse C. elegans longevity pathways, increased levels of fused mitochondria are associated with lifespan extension. Blocking mitochondrial fusion in these animals abolishes their extended longevity. The long‐lived C. elegans vhl‐1 mutant is an exception that does not have increased fused mitochondria, and is not dependent on fusion for longevity. Loss of mammalian VHL upregulates alternate energy generating pathways. This suggests that mitochondrial fusion facilitates longevity in C. elegans (...) by increasing energy metabolism. In diverse animals, ATP levels broadly decreases with age. Substantial evidence supports the theory that increasing or maintaining energy metabolism promotes the survival of older animals. Increased ATP levels in older animals allow energy‐intensive repair and homeostatic mechanisms such as proteostasis that act to prevent cellular aging. These observations support the emerging paradigm that maintaining energy metabolism promotes the survival of older animals. (shrink)

The clinical application of the concept of patient autonomy has centered on the ability to deliberate and make treatment decisions (decisional autonomy) to the virtual exclusion of the capacity to execute the treatment plan (executive autonomy). However, the one-component concept of autonomy is problematic in the context of multiple chronic conditions. Adherence to complex treatments commonly breaks down when patients have functional, educational, and cognitive barriers that impair their capacity to plan, sequence, and carry out tasks associated with chronic care. (...) The purpose of this article is to call for a two-component re-conceptualization of autonomy and to argue that the clinical assessment of capacity for patients with chronic conditions should be expanded to include both autonomous decision-making and autonomous execution of the agreed-upon treatment plan. We explain how the concept of autonomy should be expanded to include both decisional and executive autonomy, describe the biopsychosocial correlates of the two-component concept of autonomy, and recommend diagnostic and treatment strategies to support patients with deficits in executive autonomy. (shrink)

The rise of surrogacy in India over the last decade has helped individuals across the world to realize their parenting aspirations. In the macro-context of poverty in India and the hierarchical and patriarchal family set-up, concerns are expressed about coercion of women to participate in surrogacy. While the ethical issues engulfing surrogacy are widely discussed, not much is known about the role women play in the decision-making to participate in surrogacy. The paper aims to addresses this gap and is based (...) on a part of a larger ethnographic study conducted at a surrogacy clinic in Anand, Gujarat, India. We explored experiences of forty-one surrogate mothers using in-depth interviews and analysed the narratives to identify women’s own perceived role in the decision-making to participate in surrogacy. Narratives describing the decision-making process were identified and treated as a preliminary unit of analysis. We examined the use of singular and plural pronouns like “I,” “me,” and “mine” versus “we,” “us,” and “our,” along with the use of active and passive voice to determine whether women assumed responsibility for the decision to participate in surrogacy or they attributed the decision to others. Findings unravelled the complexities of the decision-making process and indicated that eighty-five percent of the women played an active role in the decision-making to participate in surrogacy, albeit with new avenues of exploitation in the commercial market space and raised serious bioethical concerns. (shrink)

This study aimed to determine the factors influencing the use of spacing contraceptive methods in India, particularly from men’s perspective. Data were obtained through a semi-structured interview schedule from 2687 married men aged between 18 and 40 years from central Mumbai City, India, during 1999. Chi-squared tests and binary logistic regression analysis was carried out to determine the relationship between various variables and the likelihood of a couple using spacing contraceptive methods. Of the 2687 couples, 1395 (51·9%) were using one (...) or other method of spacing contraceptives and 1292 (48·1%) were not using any method at the time of survey. Male participation in contraceptive use was 23% (condom and withdrawal). The results indicate that the use of spacing contraceptive methods was significantly higher among those couples where the men desired one or two children (OR=4·3), had knowledge of five or more contraceptive methods (OR=1·9) and discussed with their wives obtaining family planning information (OR=3·2), spacing (OR=2·7) and permanent (OR=2) contraceptive methods. Age, income, desired number of children, knowledge of a greater number of contraceptive methods, inter-spouse communication regarding obtaining family planning information, spacing and permanent methods were found to be strong predictors of the use of spacing contraceptive methods. The study underlines the importance of intervention programmes aimed at promoting a small family norm, increasing the number of contraceptive choices available and encouraging inter-spouse communication. Hence, policymakers and programme managers should encourage interventions in this direction, targeting couples to enhance the use of spacing contraceptive methods. (shrink)

The rise of surrogacy in India over the last decade has helped individuals across the world to realize their parenting aspirations. In the macro-context of poverty in India and the hierarchical and patriarchal family set-up, concerns are expressed about coercion of women to participate in surrogacy. While the ethical issues engulfing surrogacy are widely discussed, not much is known about the role women play in the decision-making to participate in surrogacy. The paper aims to addresses this gap and is based (...) on a part of a larger ethnographic study conducted at a surrogacy clinic in Anand, Gujarat, India. We explored experiences of forty-one surrogate mothers using in-depth interviews and analysed the narratives to identify women’s own perceived role in the decision-making to participate in surrogacy. Narratives describing the decision-making process were identified and treated as a preliminary unit of analysis. We examined the use of singular and plural pronouns like “I,” “me,” and “mine” versus “we,” “us,” and “our,” along with the use of active and passive voice to determine whether women assumed responsibility for the decision to participate in surrogacy or they attributed the decision to others. Findings unravelled the complexities of the decision-making process and indicated that eighty-five percent of the women played an active role in the decision-making to participate in surrogacy, albeit with new avenues of exploitation in the commercial market space and raised serious bioethical concerns. (shrink)

In natural language processing (NLP), named entity recognition (NER) and semantic classification are essential tasks. NER is a fundamental task, that identify named entities in text such as people, organizations, and locations. In Legal domain, NER is particularly important due to the variety of named entities that appear in legal documents and are important for legal analysis whereas Semantic classification is the process of giving each sentence in a text a semantic label, such as ”fact,””arguments,” or”judgement”. Both NER and Semantic (...) classi- fication are critical component of many NLP applications such as Knowledge base construction and semantic search. Semantic searching of legal documents is a powerful technique that can be used to quickly find the information that you need. By combining NER and semantic classification, one can identify the key elements of a legal document and search for documents that are related to a particular topic or contain a particular type of information. This paper proposes a novel approach to NER and Semantic classification in legal domain using Long short-term memory (LSTM) model. The proposed approach is evaluated on a corpus of legal text and the result of this study suggest that LSTM models are a promising approach for NER and Semantic classification in legal domain and can be used to improve the performance of semantic searching of legal documents. (shrink)

The book analyses the Indian Supreme Court's jurisprudence on homosexuality, its current approach and how its position has evolved in the past ten years. It critically analyses the Court's landmark judgments and its perception of equality, family, marriage and human rights from an international perspective. With the help of European Court of Human Rights' judgments and international conventions, it compares the legal and social discrimination meted out to the Indian LGBTI community with that in the international arena. From a social (...) anthropological perspective, it demonstrates how gay masculinity, although marginalized, serves as a challenge to patriarchy and hegemonic masculinity. This unique book addresses the lack of in-depth literature on gay masculinity, elaborately narrating and analysing contemporary gay masculinity and emerging gay lifestyles in India and highlighting the latest research on the subject of homosexuality in general and in particular with respect to India. It also discusses several new issues concerning the gay men in India supported by the living law approach put forth by Eugen Ehrlich. (shrink)

This biography is a short yet comprehensive overview of the life of Meghnad Saha, the mastermind behind the frequently used Saha equations and a strong contributor to the foundation of science in India. The author explores the lesser known details behind the man who played a major role in building scientific institutions in India, developed the breakthrough theory of thermal ionization, and whose fervor about India's rapid progress in science and technology, along with concern for uplifting his countrymen and optimizing (...) resources, led him to eventually enter politics and identify the mismanagement of many programs of national importance to Parliament. This book is free of most academic technicalities, so that the reader with general scientific knowledge can read and understand it easily. One interested only in Saha's contribution to physics can pick up just that part and read it. Conversely, the average reader may skip the technical chapters, and read the book without loss of continuity or generality to still get a coherent picture. This work touches on all aspects of Saha's multidimensional personality, which overflows in the pages of his periodical, Science and Culture,as well as his many speeches, debates and discussions in Parliament, all of which is appropriately conveyed in this book. (shrink)

The clinical application of the concept of patient autonomy has centered on the ability to deliberate and make treatment decisions to the virtual exclusion of the capacity to execute the treatment plan. However, the one-component concept of autonomy is problematic in the context of multiple chronic conditions. Adherence to complex treatments commonly breaks down when patients have functional, educational, and cognitive barriers that impair their capacity to plan, sequence, and carry out tasks associated with chronic care. The purpose of this (...) article is to call for a two-component re-conceptualization of autonomy and to argue that the clinical assessment of capacity for patients with chronic conditions should be expanded to include both autonomous decision-making and autonomous execution of the agreed-upon treatment plan. We explain how the concept of autonomy should be expanded to include both decisional and executive autonomy, describe the biopsychosocial correlates of the two-component concept of autonomy, and recommend diagnostic and treatment strategies to support patients with deficits in executive autonomy. (shrink)

Vol 1. Substance truth and person -- vol 2. Perfecting reality -- vol 3. Practical implication -- vol 4. The idealist theory of truth.

When philosophy of mind goes into every detail in explaining about consciousness and its every aspect, the problem of other minds being its part is not spared. In such context going against the traditional way of giving justification Wittgenstein novel approach to other minds is remarkable and is close to the phenomenological understanding. The analysis of the sensation of pain as one of its important factors in solving the other minds problem is unique and it is this that proves how (...) Wittgenstein dissolves the problem rather than giving a solution. This article focuses Wittgenstein’s two important factors: Private Language Argument and the concept of the sensation of pain in dissolving the issue. And in this I have made an attempt to show how his novelty in approaching this problem gains importance even today. (shrink)

Buku berjudul Franz Magnis Suseno: Sosok dan Pemikirannya, berisi tiga belas artikel yang terdiri dari empat artikel mengenai sosok Franz Magnis-Suseno, lima artikel mengenai pemikiran Magnis, dan empat artikel sebagai catatan, ditulis oleh beliau-beliau yang tidak diragukan lagi profesionalisme mereka. Baiklah kini dimulai dengan mengulas dahulu lima pokok pemikiran yang secara singkat dapat disebut secara tematis: 1) tentang Pancasila, 2) tentang Etika Dialog, 3) tentang sosok agama modern, 4) tentang menalar Tuhan dari dunia, 5) tentang pendekatan ilmiah sesuai teori multijagat (...) dan celah kuantum bagi Tuhan. Ternyata urutan pengulasan tidak sesuai dengan urutan dalam buku, agak mengalami perubahan karena pertimbangan tematik yang runtut.... Komaruddin Hidayat menyebut Magnis sebagai pejuang moral dan pembela hak azasi manusia. Bukankah kekuatan agama menjadi sumber moral dan penggerak masyarakat dalam bidang pendidikan, ekonomi dan lingkungan hidup demi timbulnya kelas menengah yang mandiri? Anjurannya sebaiknya ormas-ormas agama mengambil jarak dari per- mainan politik praktis, dan tidak menjadi bagian birokrasi dan politisi Lele yang sangat menikmati kondisi air keruh yang berlumpur. Kami ingat pepatah memancing di air keruh. Salah satu pemakalah F. Budi Hardiman menyebutkan bahwa Magnis tidak menempuh spiritualitas jalan mistik, meskipun mengawali pengalaman hidup intelektual di Indonesia lewat etika Jawa dan mau tidak mau berurusan dengan wayang, tetapi lebih wayang purwa terkait dengan kejawen atau kebatinan. Pada makalah perihal Etika Dialog pula disebutkan oleh Budi Hardiman bahwa di Indonesia ada jalan lain untuk mengupayakan titik temu agama-agama, yaitu jalan mistik. Memang bila dikembalikan pada bentuk bentuk spiritualitas, spiritualitas mistik yang tidak menjadi pilihan, lebih pada spiritualitas religius, kosmik dan humanistik. Ini merupakan catatan pada ulasan Sudiarja. Kini pemakalah pertama yang disebut terakhir ialah Al. Andang L Binawan yang menarik ulasannya perihal riwayat hidup dan panggilan Magnis, dan penting menyebutkan pada usia 11 tahun sudah berniat menjadi Jesuit, meskipun sempat diuraikan dengan simpatik Magnis kurang suka latihan doa panjang-panjang malah lebih suka latihan musik, dan hobby naik gunung hingga sekarang masih tapi sudah berkurang. Ia juga menguasai dua hal yang perlu baginya ialah Marxisme dan Kromo Inggil. Baginya Tuhan adalah kebenaran, keadilan dan kasih. (Toeti Heraty N. Roosseno, Guru Besar Emeritus Ilmu Filsafat, Universitas Indonesia). (shrink)

In this paper, the tragedy of Hegel's works on索佛克里斯 is interpreted as the object of analysis, to clarify the "Phenomenology of Mind" chapter of the first link: ethical implied the dialectical development of relations. Hegel Antigongnie and Craig Wong as the conflict between the play to express the central theme, the duo behind it as the ethical forces of the two entities split out the two sets of rules of self-symbol, through the wave Li Naike burial period of confrontation with (...) the two sides is not only a Antigongnie ─ ─ Weng personal conflict with Craig, but also family and country, God, law and human law, obligations and civic responsibilities of genetic conflict between, or Sex between women and men conflict. In the ethical stage, the individual and the unity of ethics has a direct relationship between the entities, and directly by its intrinsic norms of behavior, but to achieve out of the ethical nature of the dialectical development of the end point then, replaced by another type. (shrink)