The COVID-19 pandemic has exacerbated the drug poisoning epidemic in a number of ways: individuals use alone more often, there is decreased access to harm reduction services and there has been an increase in the toxicity of the unregulated drug supply. In response to the crisis, clinicians, policy makers and people who use drugs have been seeking ways to prevent the worst harms of unregulated opioid use. One prominent idea is safe supply. One form of safe supply enlists clinicians to (...) prescribe opioids so that people have access to drugs of known composition and strength. In this paper, we assess the ethical case for clinicians providing this service. As we describe, there is much that is unknown about safe supply. However, given the seriousness of the overdose death epidemic and the current limited evidence for safe supply’s efficacy, we argue that it is ethically permissible for clinicians to begin prescribing opioids for some select patients. (shrink)

Este texto pretende apresentar algumas posições sobre o problema do gênero, na modernidade. Partindo do diagnóstico de Foucault de que os processos de constituição e de produção do sujeito implicariam ter um modelo de autodeterminação de si, buscamos pensar o problema do gênero por duas vertentes: por um lado, uma proposta de Butler, em que a sexualidade não poderia ser determinada, pois ela sempre resistiria a qualquer forma de normatização; por outro, uma luta por reconhecimento da individualidade que procura incluir (...) todas as possibilidades de autorrealização de si, na esfera jurídica. Nossa proposta é avaliar esses dois modelos e questionar o que poderia estar mais próximo das demandas sociais em relação ao problema do gênero e, de um modo mais amplo, do problema da identidade individual. This paper aims to present certain positions regarding the question of gender in modernity. Starting from Foucault’s diagnosis that the processes of the constitution and production of the subject involve having a model of self-determination, we have attempted to reexamine the question of gender from two different perspectives: on the one hand, Butler’s proposal that sexuality cannot be determined, since it always resists any form of normatization; on the other, the struggle for recognition of individuality which seeks the inclusion into the legal sphere of all possibilities for self-fulfillment. Our aim is to evaluate these two models and to question which of the two might be closer to social demands connected to the issue of gender and, more broadly, the issue of individual identity. (shrink)

Prefrontal cortex is dysregulated in women with restricting anorexia nervosa . It is not known whether appetitive non-conscious stimuli bias cognitive responses in those with RAN. Thirteen women with RAN and 20 healthy controls completed a dorsolateral PFC working memory task and an anterior cingulate cortex conflict task, while masked subliminal food, aversive and neutral images were presented. During the DLPFC task, accuracy was higher in the RAN compared to the HC group, but superior performance was compromised when subliminal food (...) stimuli were presented: errors positively correlated with self-reported trait anxiety in the RAN group. These effects were not observed in the ACC task. Appetitive activation is intact and anxiogenic in women with RAN, and non-consciously interacts with working memory processes associated with the DLPFC. This interaction mechanism may underlie cognitive inhibition of appetitive processes that are anxiety inducing, in people with AN. (shrink)