Although initiation of DNA replication is considered to be highly coordinated through multiple protein–DNA and protein–protein interactions, it is poorly understood how particular locations within the eukaryotic chromosome are selected as origins of DNA replication. Here, we discuss recent reports that present structural information on the interaction characteristics of the archaeal orthologues of the eukaryotic origin recognition complex with their cognate binding sequences.1,2 Since the archaeal replication system is postulated as a simplified version of the one in eukaryotes, by analogy, (...) these works provide insights into the functions of the eukaryotic initiator proteins. BioEssays 30:208–211, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

武士の切腹は宣教師の殉教に通じる。「義」は「愛」に呼応する―武士道とキリスト教の根幹には、驚くべき共通点があった。牧師である著者は、日本屈指の剣術家というもうひとつの顔を持つ。礼拝が終わると教会は武道 場に早変わり、将軍家指南役を務めた小野派一刀流・第十七代宗家の稽古が始まる。「格好だけ良いのは本物でない」「魂とは私という人格である」...人の生死を問う二つの「道」を究めて得た、いま日本人に必要な智 恵。.

School leaders are constantly challenged by diverse students and conflicting interests between faculty and staff. They are often called upon to make sense of ethical quagmires, where rules might conflict with desired outcomes or personal values clash with professional obligations. Negotiating these dilemmas can be challenging, but democratic ethics can offer an effective process to work through them. Drawing from the writings of John Dewey, Leading Through the Quagmire advocates his notion that democracy is an appropriate response to the multitude (...) of conflicting interests, needs, and values in educational settings. Moreover, Enomoto and Kramer propose an inquiry method to harness democratic ethics for engaging in fair deliberation and conflict resolution. This book provides the foundation for understanding tensions, as well as the methods and applications to navigate through them. Stories and examples are provided to enable readers to understand such terms as utilitarianism, ethical tensions, religious attitudes, and eco-feminism in meaningful ways. (shrink)

「和歌」「声」「文字」という表現メディアに着目し宣長思想と教育との関わりを検証。幼児教育への応用についても検討する。.

Funded by the U.S. Department of Education, the Baltimore Learning Community (BLC) project established a networked electronic learning community through the use of high-quality digital science and social studies resources and high-speed networking. The project will enable science and social studies teachers to access images, text, Web sites, and full motion video via high-speed connections to the Internet. Extending such multimedia configurations into urban schools has facilitated a rethinking of teaching and learning in content classes as well as a reconsideration (...) of how media and method are integrated. It facilitates teacher engagement in designing authentic classroom instruction framed by performance assessments and links project teachers and school site coordinators through a client server, thus promoting a network of teachers and students engaged in learning across schools. However, such a project is not without its challenges—human as well as technological. This article discusses the BLC project identifying technology possibilities, current situational constraints, and implications of creating networked learning communities across disciplines and beyond school walls. (shrink)