In this paper, using a multilevel approach, we defend the positive role of natural selection in the generation of organismal form. Despite the currently widespread opinion that natural selection only plays a negative role in the evolution of form, we argue, in contrast, that the Darwinian factor is a crucial (but not exclusive) factor in morphological organization. Analyzing some classic arguments, we propose incorporating the notion of ‘downward causation’ into the concept of ‘natural selection.’ In our opinion, this kind of (...) causation is fundamental to the operation of selection as a creative evolutionary process. (shrink)

Prokaryotic genomes of endosymbionts and parasites are examples of naturally evolved minimal cells, the study of which can shed light on life in its minimum form. Their diverse biology, their lack of a large set of orthologous genes and the existence of essential linage (and environmentally) specific genes all illustrate the diversity of genes building up naturally evolved minimal cells. This conclusion is reinforced by the fact that sometimes the same essential function is performed by genes from different evolutionary origins. (...) Nevertheless, all cells perform a set of life‐essential functions however different their cell machinery and environment in which they thrive. An upcoming challenge for biologists will be to discern, by studying differences and similarities in current biodiversity, how cells with reduced genomes have adapted while retaining all basic life‐supporting functions. (shrink)

Gut microbiome plays a significant role in defining the health status of subjects, and recent studies highlight the importance of using time series strategies to analyse microbiome dynamics. In this paper, we develop a Bayesian model for microbiota longitudinal data, based on Dirichlet distribution with time-varying parameters, that take into account the compositional paradigm and consider principal balances. The proposed model can be effective for predicting the future dynamics of a microbial community in the short term and for analysing the (...) microbial interactions using the value of the estimated parameters. The usefulness of the proposed model is illustrated with six different datasets, and a comparison study with four alternative models is provided. (shrink)

En este artículo se defiende la necesidad de que el actor de la ciencia, el científico, disponga de suficiente formación filosófica como para analizar críticamente el alcance de su propia actividad especializada, análisis que debiera empezar por entender qué es eso a lo que llamamos ciencia. Se ejemplifica la necesidad de tal formación recurriendo a la biología sintética. Se muestran los peligros que se corren de la derivación hacia campos no científicos si el científico está imbuido de una ciencia fáustica (...) orientada a la obtención del producto –el ente biológico sintético– disminuyendo veladamente el interés por estudiar el mismo desde la óptica de la ciencia prometeica, aquella que se aproxima progresivamente a la comprensión de los entes vivos. (shrink)

Resumen: Este trabajo pretende exponer la teoría del conocimiento del autor al-Fārābī dentro del marco de su pensamiento como sistema, ahondando en dos asuntos: teoría del conocimiento, profetología y problema entre fe y razón (sección primera); algunas de las fuentes principales de su pensamiento (sección segunda).Palabras clave: al-Fārābī, epistemología, Neo-Platonismo.Abstract: This work is aimed to set out the theory of knowledge of al-Fārābī, seen as part of his own system, and deepen in two aspects: the theory of knowledge itself, the (...) prophecy and the boudaries between reason and faith (first section); some of the main sources of his thought (second section).Key words: al-Fārābī, epistemology, Neo-platonism. (shrink)