We re-examine the relationship between coordination, legal sanctions, and free-riding in light of the recent controversy regarding the applicability of the coordination problem paradigm of law-making. We argue that legal sanctions can help solve coordination problems by eliminating socially suboptimal equilibrium outcomes. Once coordination has taken place, however, free-riding can not lead to the breakdown of coordination outcomes, even if sanctions may still be effective at increasing the equity of such outcomes. Finally, we argue that it is the choice of (...) a legal or constitutional system rather than the choice of law that is paradigmatic of the coordination problem. This view requires a re-assessment of the normative status of sanctions attached to individual laws. (shrink)
Time discounting is the phenomenon that a desired result in the future is perceived as less valuable than the same result now. Economic theories can take this psychological fact into account in several ways. In the economic literature the most widely used type of additive time discounting is exponential discounting. In exponential discounting, the fall of valuation depends by a constant factor on the length of the delay period. It is well known, however, that exponential time discounting often does not (...) describe well how people actually behave. Most people are averse to short delays in gratification now, while their future selves may not mind a bit of extra waiting. This behaviour can be described well by non-exponential discounting functions such as hyperbolic discounting. In hyperbolic discounting, valuations fall rapidly for small delay periods, but the fall gets slower for longer delay periods. Hyperbolic discounting captures phenomena such as procrastination, addiction and in general inconsistency over time. This chapter investigates whether forms of non-exponential discounting, in particular close to the so called Quasi-Hyperbolic model, could also be characterized in terms of dynamically consistent choices when individuals discount the welfare of future selves as well as their payoffs. (shrink)
The paper presents a variation of the EMAIL Game, originally proposed byRubinstein (American Economic Review, 1989), in which coordination ofthe more rewarding-risky joint course of actions is shown to obtain, evenwhen the relevant game is, at most, ``mutual knowledge.'' In the exampleproposed, a mediator is introduced in such a way that two individualsare symmetrically informed, rather than asymmetrically as in Rubinstein,about the game chosen by nature. As long as the message failure probabilityis sufficiently low, with the upper bound being a (...) function of the gamepayoffs, conditional beliefs in the opponent's actions can allow playersto choose a more rewarding-risky action. The result suggests that, forefficient coordination to obtain, the length of interactive knowledge onthe game, possibly up to ``almost common knowledge,'' does not seem to bea major conceptual issue and that emphasis should be focused instead onthe communication protocol and an appropriate relationship between thereliability of communication channels and the payoffs at stake. (shrink)
Should democracts value the freedom to choose? Do people value facing distinct choices when they make collective decisions? ‘Autonomy’ – the ability to participate in the making of collective decisions – is a paltry notion of freedom. True, democrats must be prepared that their preferences may not be realized as the outcome of the collective choice. Yet democracy is impoverished when many people cannot even vote for what they most want. ‘The point is not to be free, but to act (...) freely.’ Rosa Luxemburg Footnotes I am grateful to Jess Benhabib and Bernard Manin for several heated discussions and to Joanne Fox-Przeworski, DimitriLanda, Avishai Margalit, and Ignacio Sanchez-Cuenca for comments. Special thanks are due to the editor of this journal, Geoffrey Brennan, for pushing me further than I was prepared to go. (shrink)
This collection of essays covers the classical heritage and Islamic culture, classical Arabic science and philosophy, and Muslim religious sciences, showing continuation of Greek and Persian thought as well as original Muslim contributions ...
At stake in the classical realism-debate is the clash between realist and anti-realist positions. In recent years, the classical form of this debate has undergone a double transformation. On the one hand, the champions of realism began to pay more attention to the interpretative dimensions of scientific research. On the other hand, anti-realists of various sorts realized that the rejection of the hypostatization of a “reality out there” does not imply the denial of working out a philosophically adequate concept of (...) reality. Against the background of this double transformation, new arguments in the realism-debate emerged. The present Introduction is an attempt at systematizing these arguments within the spectrum of doctrines between the poles of scientific realism (exposed and defended by Howard Sankey) and hermeneutic realism (advocated by Dimitri Ginev). The authors try also to demonstrate that after the classical debates the issue of scientism has to be addressed in new ways. (shrink)
Dimitris Vardoulakis, The Doppelgänger: Literature's Philosophy Content Type Journal Article Category Book Review Pages 418-422 Authors Carlo Salzani, Monash University, Australia Journal Critical Horizons: A Journal of Philosophy & Social Theory Online ISSN 1568-5160 Print ISSN 1440-9917 Journal Volume Volume 12 Journal Issue Volume 12, Number 3 / 2011.
Many standard philosophical accounts of scientific practice fail to distinguish between modeling and other types of theory construction. This failure is unfortunate because there are important contrasts among the goals, procedures, and representations employed by modelers and other kinds of theorists. We can see some of these differences intuitively when we reflect on the methods of theorists such as Vito Volterra and Linus Pauling on the one hand, and Charles Darwin and Dimitri Mendeleev on the other. Much of Volterra's (...) and Pauling's work involved modeling; much of Darwin's and Mendeleev's did not. In order to capture this distinction, I consider two examples of theory construction in detail: Volterra's treatment of post-WWI fishery dynamics and Mendeleev's construction of the periodic system. I argue that modeling can be distinguished from other forms of theorizing by the procedures modelers use to represent and to study real-world phenomena: indirect representation and analysis. This differentiation between modelers and non-modelers is one component of the larger project of understanding the practice of modeling, its distinctive features, and the strategies of abstraction and idealization it employs. (shrink)
Shortly before G. E. Moore wrote down the formative for the early analytic philosophy lectures on Some Main Problems of Philosophy (1910–1911), he had become acquainted with two books which influenced his thought: (1) a book by Husserl's pupil August Messer and (2) a book by the Greifswald objectivist Dimitri Michaltschew. Central to Michaltschew's book was the concept of the given. In Part I, I argue that Moore elaborated his concept of sense-data in the wake of the Greifswald concept. (...) Carnap did the same when he wrote his Aufbau, the only difference being that he spoke not of sense-data but of Erlebnisse. This means, I argue, that both Moore's sense-data and Carnap'sErlebnisse have little to do with either British empiricists or the neo-Kantians. In Part II, I try to ascertain what made early analytic philosophy different from all those philosophical groups and movements that either exercised influence on it, or were closely related to it: phenomenologists, Greifswald objectivists, Brentanists. For this purpose, I identify the sine qua non practices of the early analytic philosophers: exactness; acceptance of the propositional turn; descriptivism; objectivism. If one of these practices was not explored by a given philosophical school or group, in all probability, it was not truly analytic. (shrink)
This paper investigates the regulation of ethical behavior of professionals. Ethical perceptions of South African professionals operating in the business community (specifically accountants, lawyers and engineers) concerning their need for and awareness of professional codes, and the frequency and acceptability of peer contravention of such codes were sought. The existence of conflict between corporate codes and professional codes was also investigated. Results, based on 217 replies, indicated that the professionals believe that codes are necessary and are relatively aware of the (...) contents of such codes. Despite these ethical tendencies, respondents (particularly lawyers) believe that their peers contravene their professional codes relatively often. No significant differences in ethical tendencies between professionals consulting to and those working in business were found. Many respondents were regulated by more than one code of ethics, but few experienced conflict between such codes. In the events of conflict occurring professionals chose to adhere to their professional code above others. (shrink)
Based on an analysis of double hermeneutics in the human sciences, a distinction between a weak and a strong rhetorical analysis of human-scientific research is introduced, taking account of the self-reflective character of hermeneutic interpretation. The paper argues that there are three hermeneutic topics in the research process for human-scientific experience, which are associated with applying specific rhetorical tools. The three topics are described under the following rubrics: (a) bridging the gap between experience-near and experience-distant concepts; (b) achieving integrity of (...) the cultural objects dispersed in different interpretive strategies; and (c) taking into consideration that an important task of hermeneutic interpretation in human-scientific research is to give an account of the object's immanent narrative coherence. The paper is written in the conviction that a kind of re-methodologization of philosophical hermeneutics which does not rehabilitate epistemological foundationalism can provide a new philosophical identity to the human sciences. (shrink)
The paper examines the sense in which Gianni Vattimo’s story of a long goodbye of modernity along with an interminable weakening of Being inaugurates a leftist philosophico-political project. The hermeneutics of “weak thought” is criticized for (a) its ambiguous concept of interpretation; (b) its way of integrating proceduralism in post-metaphysical philosophizing; and (c) the unhappy marriage it promotes between nihilism and emancipation. Finally, a philosophico-political version of hermeneutic ontology based on the idea of situated transcendence is suggested as an alternative (...) to Vattimo’s nihilistic socialism. (shrink)
This is a sequel to my paper, "Searching for a (Post)Foundational Approach to Philosophy of Science", which appeared in an earlier issue of this Journal [Ginev 2001, Journal for General Philosophy of science 32, 27-37]. In the present paper I continue to scrutinize the possibility of a strong hermeneutics of scientific research. My aim is to defend the position of cognitive existentialism that combines the advocacy of science's cognitive specificity and the rejection of any form of essentialism. A special attention (...) will be paid to the notion of the thematizing project of scientific research. (shrink)
The paper provides an overview of the hermeneutic and phenomenological context from which the idea of a “constitutional analysis” of science originated. It analyzes why the approach to “hermeneutic fore-structure of scientific research” requires to transcend the distinction between the context of justification and the context of discovery. By incorporating this approach into an integral “postmetaphysical philosophy of science”, I argue that one can avoid the radical empiricism of recent science studies, while also preventing the analysis of science's discursive practices (...) from collapsing into the frames of radical anti-epistemological critique mandated by some hermeneutic philosophers. (shrink)
This paper is an assessment of the key debates on Heidegger’s existential conception of science. It relates the topics to contemporary problems in the philosophy of the natural sciences, providing the reader with a framework to evaluate various versions of hermeneutic phenomenology of scientific research as alternatives to both, naturalistic and normativeepistemological conceptions of scientific research. The paper delineates a context of constitution that is irreducible to the context-distinction between discovery and justification. In this context, the tenets of the doctrine (...) of cognitive existentialism are formulated. (shrink)
This paper discusses the tenets of the politics of postmodern philosophy of science. At issue are Rouse's version of naturalism and his reading of Quine's distinction between the indeterminacy of translation and the underdetermination of theories by empirical evidence. I argue that the postmodern approach to science's research practices as patterns of interaction within the world is not in line with the naturalistic account Rouse aims at. I focus also on Rouse's readings of Heidegger's existential conception of science and Kuhn's (...) concept of normal science. Finally, a strategy of defending science's cognitive distinctiveness in terms of hermeneutic philosophy is suggested as an alternative to the postmodern philosophy of science. (shrink)
This paper represents an attempt to articulate the basic principles of a hermeneutic philosophy of science. Throughout, the author is at pains to show that both (i) overcoming epistemological foundationalism and (ii) insisting on the multiplicity, patchiness, and heterogeneity of the discursive practices of scientific research do not imply a farewell to an analysis of the constitution of science's autonomous cognitive structure. Such an analysis operates in two directions: “continuous weakening” of epistemological foundationalism and “hermeneutic grounding” of a cognitive structure. (...) Carrying out the analysis in both directions leads to a (post) foundational picture of science. The main thrust of the first part of the paper is to outline the tenets of a constitutional analysis of scientific research. This part focuses especially on the notion of “unified narrativestructures” which refers to the “effective histories” of the main epistemic types of science. (shrink)
Intensive Science and Virtual Philosophy cuts to the heart of the philosophy of Gilles Deleuze and of today's science wars.At the start of the 21st Century, ...
Variants of Critical Philosophy of Science. It is the purpose of this paper to represent an analysis of four variants of critical philosophy of science: the constructivistic methodology, the reflexion upon science from the viewpoint of the critical theory of society, the 'social natural science' as a further development of the finalization conception, and the projective philosophy of science. Special attention is paid to the comparison of these variants. Some points of convergence as well as of divergence among them are (...) revealed. A common shortcoming is indicated. (shrink)
Starting from a distinction between global and globalised and a definition of the concept of global threat for future generations, this paper aims to identify cognitive, moral and emotional phenomena that hinder to the adoption of effective policies against global warming. The main thesis of this paper is that it is difficult to reduce emissions of greenhouse gases mainly because the unlimited economic growth is the imperative of our company and the continuous increase of material goods and personal consumption is (...) what is closest to our idea of happiness and wellbeing. (shrink)
The paper attempts to elucidate and evaluate Oskar Becker’s search for a complementarity between the paradigm of constitutional analysis put forward by Heidegger’s hermeneutic phenomenology and constructivism as a meta-mathematical position suggesting criteria for existence of the mathematical objects. At stake is the issue of the possibility of an existential analytic of “the mathematical”. In this regard, a special attention is paid to the temporality of “mathematical existence”. Th e paper invites new forms of a dialogue between phenomenology and philosophy (...) of mathematics. (shrink)
In der Wissenschaft spielen Visualisierungen eine immer wichtigere Rolle. Sie sind zum einen Gegenstand der Forschung und zum anderen unverzichtbares Hilfsmittel bei der Präsentation und Distribution von Forschungsergebnissen. Beides stellt neue Anforderungen an den Wissenschaftler und seine praktische wie auch theoretische Arbeit und lässt nach einer kritischen Reflexion dieses Bildhandelns fragen. Was zeigen uns MRT-Bilder in der Medizin wirklich? Wie hat die Weiterentwicklung der Mikroskopie-Technologie unsere Vorstellung von der menschlichen Zelle verändert? Welche Rolle können Bilder bei der Vermittlung von Wissen (...) im didaktischen Kontext spielen? Zeigen uns Visualisierungen die Wirklichkeit? Oder sind sie bloß ein weiterer Anhaltspunkt für die soziale Konstruktion wissenschaftlicher Erkenntnis? Kann es eine Logik der Bilder geben? In welchen Begriffen reden wir über Bilder? Ziel des Sammelbandes Visualisierung und Erkenntnis. Bildverstehen und Bildverwenden in Natur- und Geisteswissenschaften ist es, die Forschung mit und an Visualisierungen in den Einzelwissenschaften auf eine reflektierte Basis zu stellen. Zu diesem Zweck werden nicht nur die wissenschafts- und erkenntnistheoretischen Grundlagen und Herausforderungen beleuchtet, die die Verwendung von Visualisierungen mit sich bringt, sondern auch die Rolle der Visualisierungen im konkreten Anwendungsfall betrachtet. Der Band lässt dabei Geistes- und Naturwissenschaftler, Theoretiker und Praktiker in einen Dialog über den gemeinsamen Forschungsgegenstand treten. (shrink)
This paper considers the relevance of a class of hermeneutic concepts to the philosophical reading of normal scientific research. The author opposes the view that the notion of "normal science" can only be read in socio-psychological, sociological or ethnomethodological terms. By drawing parallels between Kuhn's original reading of puzzle-solving enterprise and Gadamer's philosophical hermeneutics, a context of "Continental theories" for interpreting the dynamics of research practices is delineated. The rereading of normal science provides the opportunity for developing a hermeneutic alternative (...) to the analytic philosophy of science. /// Este trabajo examina la relevancia de cierta clase de conceptos hermenéuticos para la lectura filosófica de la investigación cientifica normal. El autor se opone a la idea de que la noción de "ciencia normal" sólo se puede entender en términos socio-psicológicos, sociológicos o etnometodológicos. Trazando paralelos entre la lectura original kuhniana de la empresa de solutión de enigmas y la hermenéutica filosófica de Gadamer, se delinea un contexto de "teorias de Europa continental" para interpreter la dinámica de las prácticas de investigación. La relectura de la ciencia normal da la oportunidad de desarrollar una alternativa hermenéutica a la filosofia analitica de la ciencia. (shrink)
In agreement with Behrendt & Young (B&Y), we considered the role of perception disturbances in schizophrenia in our first clinical approaches, using the Bender test with schizophrenic patients. Following this, we reproduced nuclear symptoms of schizophrenia in animal models, showing that perceptual disturbances, acquisition disturbances, and decrease in affective levels can be induced by glutamatergic blockade within the nucleus accumbens septi. Our results link the proposed corticostriatal dysfunction with the thalamocortical disturbances underlying perceptual problems reviewed by B&Y.
Rather than attempting to combine the two meta-methodological programmes for justifying the epistemological study of science, which is the case of Laudan's normative naturalism, this paper aims at presenting a third alternative to the controversy between the traditional normativism and the reductionistic naturalism. The paper is a preliminary move in developing a theory of the autopoietic cognitive organization of science. The underlying assumption of this project calls that science is a self-constructing, self-specifying and homeostatic system. The scrutinizing of these three (...) predicates leads to the view that the epistemological propositions about science cognitive organization are neither normative, nor descriptive, but transcendental ones. The final discussion shows the connection between this project and the theory of group rationality. (shrink)
What I hope to do in this paper is to see whether Laudan’s normative naturalism may suggest a third alternative to normativism-naturalism dilemma in the analytical philosophy of science. In criticizing the view that all methodological rules are to be specified in the form of hypothetical imperatives, I offer the idea that a theory of scientific rationality (including its normative dimension) must go beyond the usual analytical format of “rational reconstruction”. It is precisely this idea that opens the door for (...) a hermeneutic alternative to normative naturalism. On this alternative, one has to pay attention to the contextual normativity of doing scientific research, if one wants to give an account of the articulation of methodological rules and norms. (shrink)
The paper presents a comparative analysis between hermeneutics and ethnomethodology of science. A careful examination of the approaches suggested by the two programs not only demonstrates that a non-essentialist inquiry of scientific practices is possible, it also reveals how the significant methodological differences between these (post-phenomenological) programs inform divergent pictures of science’s practical rationality. The role these programs play in the debates on science’s cognitive autonomy is illuminated by spelling out the idea of the internal criticism of scientific research they (...) advance. In contrast to the external criticism of social epistemologists, the internal one does not aim at a deconstruction of science’s cognitive autonomy. Its task is to promote the epistemic emancipation of scientific communities by stressing the reflexive dimension of scientific research. (shrink)
http://dx.doi.org/10.5007/1808-1711.2012v16n2p209 This article explores and attempts to resolve some issues that arise when at stake is the incommensurability between the concepts of reality developed by philosophical hermeneutics, on the one hand, and realist branches of analytical philosophy, on the other. The view of hermeneutic realism is suggested not as a remedy against this incommensurability, but as a vehicle for revising those aspects of both hermeneutics and ontological realism which impede the dialogue between them. It is a view that opposes epistemological (...) foundationalism, Cartesian dualism, essentialism about theoretical objects, and cognitive relativism. The role of reading/textualizing in science’s spaces of representation is specified. (shrink)
Table at Dimitri's Taverna : on seeking a philosophy of old age -- Old Greek's olive trees : on Epicurus's philosophy of fulfillment -- Deserted terrace : on time and worry beads -- Tasso's rain-spattered photographs : on solitary reflection -- Sirocco of youth's beauty : on existential authenticity -- Tintinnabulation of sheep bells : on mellowing to metaphysics -- Iphigenia's guest : on stoicism and old old age -- Burning boat in Kamini Harbor : on the timeliness of (...) spirituality -- Returning home : on a mindful old age. (shrink)
Here's the article which was a 1964 Stanford AI Memo. After the original memo, several people offered different proofs of the theorem including Shmuel Winograd, Marvin Minsky and Dimitri Stefanyuk - none published, to my knowledge. Winograd claimed that his proof was non-creative, because it didn't use an extraneous idea like the colors of the squares. This set off a contest to see who could produce the most non-creative proof. Minsky's idea was to start with the diagonal next to (...) an excluded corner ssquare, note that 2 dominoes had to project from it to the diagonal with three squares, and from there 1 domino to the four square diagonal, etc. Coming from the other end also leaves only six of the eight squares in the long diagonal covered. Minsky's proof gets high points for non-creativity, because it is specific to the 8 by 8 board. (Using the colors it is easy to show that a Minsky style proof will work for any even sized board.). (shrink)
Machine generated contents note: Part I -- Doctors -- Dr. Joseph Messer -- Dr. Sharon Sandell -- ER -- Dr. John Barrett -- Marc and Noreen Levison, a paramedic and a nurse -- Lloyd (Pete) Haywood, a former gangbanger -- Claire Hellstern, a nurse -- Ed Reardon, a paramedic -- Law and Order -- Robert Soreghan, a homicide detective -- Delbert Lee Tibbs, a former death-row inmate -- War -- Dr. Frank Raila -- Haskell Wexler, a cinematographer -- Tammy Snider, (...) a Hiroshima survivor (hibakusha) -- Mothers and Sons -- V.I.M. (Victor Israel Marquez), a Vietnam vet -- Angelina Rossi, his mother -- Guadalupe Reyes, a mother -- God's Shepherds -- Rev. Willie T. Barrow -- Father Leonard Dubi -- Rabbi Robert Marx -- Pastor Tom Kok -- Rev. Ed Townley -- The Stranger -- Rick Rundle, a city sanitation worker -- Part II -- Seeing Things -- Randy Buescher, an associate architect -- Chaz Ebert, a lawyer -- Antoinette Korotko-Hatch, a church worker -- Karen Thompson, a student -- Dimitri Mihalas, an astronomer and physicist -- A View from the Bridge -- Hank Oettinger, a retired printer -- Ira Glass, a radio journalist -- Kid Pharaoh, a retired "collector" -- Quinn Brisben, a retired teacher -- Kurt Vonnegut, a writer -- The Boomer -- Bruce Bendinger, an advertising executive and writer -- Part III -- Fathers and Sons -- Doc Watson, a folksinger -- Vernon Jarrett, a journalist -- Country Women -- Peggy Terry, a retired mountain woman -- Bessie Jones, a Georgia Sea Island Singer (1972) -- Rosalie Sorrels, a traveling folksinger -- The Plague I -- Tico Valle, a young man -- Lori Cannon, "curator" of the Open Hand Society -- Brian Matthews, an ex-bartender, writer for a gay weekly -- Jewell Jenkins, a hospital aide -- Justin Hayford, a journalist, musician -- Matta Kelly, a case manager -- The Old Guy -- Jim Hapgood -- The Plague II -- Nancy Lanoue -- Out There -- Dr. Gary Slutkin -- Day of the Dead -- Carlos Cortez, a painter and poet -- Vine Deloria, a writer and teacher -- Helen Sclair, a cemetery familiar -- The Other Son -- Steve Young, a father -- Maurine Young, a mother -- The Job -- William Herdegen, an undertaker -- Rory Moina, a hospice nurse -- The End and the Beginning -- Mamie Mobley, a mother -- Dr. Marvin Jackson, a son -- Epilogue -- Kathy Fagan and Linda Gagnon, mothers. (shrink)
According to some representationalists (M. Tye, Ten problems of consciousness, MIT Press, Massachusetts, USA, 1995; W.G. Lycan, Consciousness and experience, MIT Press, Cambridge, Massachusetts, USA, 1996; F. Dretske, Naturalising the mind, MIT Press, Massachusetts, USA 1995), qualia are identical to external environmental states or features. When one perceives a red rose for instance, one is visually representing the actual redness of the rose. The represented redness of the rose is the actual redness of the rose itself. Thus redness is not (...) a property of one’s experience but an externally constituted property of the perceived physical object. In this sense, qualia are out there, in the external world. Here, I argue that the main representationalist arguments to this effect, if successful, establish no more than a symmetrical supervenience relation between representational content and qualia, and that a supervenience relation alone (albeit symmetrical) doesn’t suffice for identity. This supervenience thesis between qualia and representational content leaves open the question as to the essential nature of qualia. (shrink)
This paper explores a form of activism that operates with and within matter. For more than 150 years materialism has informed activist practice through materialist conceptions of history and modes of production. The paper discusses the ambivalences of these previous configurations of activism and materialism and explores possibilities for enacting activist interventions in conditions where politics is not only performed as a politics of history but as the fundamental capacity to remake and transform processes of matter and life. What is (...) activism when politics is increasingly performed as a politics of matter? What is activism when it comes to a materialist understanding of matter itself? (shrink)
Neuroenhancement offers the prospect of improving the cognitive, emotional and motivational functions of healthy individuals. Of all the conceivable interventions, psychopharmacology provides the most readily available ones, such as antidepressants which are thought to make people better than well . However, up until now, whether they possess such an enhancing ability remains controversial and therefore in this systematic review we will evaluate the effect and safety of modern antidepressants in healthy individuals. A search of MEDLINE and EMBASE databases and cross-references (...) was carried out and the pharmaceutical industry was contacted for suitable data. Trials published in any language through the third week of July 2007 were regarded. Included were single or double blind randomised or quasi-randomised controlled trials that compared a placebo to one or more of the following antidepressants: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, moclobemide, paroxetine, reboxetine, sertraline or venlafaxine in any dose or dosing schedule. Eligible studies were those involving healthy people of any age and either sex who showed no evidence of a psychiatric disorder, cognitive decline or other disease. One hundred thirty-five articles met our inclusion criteria reporting single dose trials and trials with repeated drug administration. Sixty-five of these articles were eligible for a statistical analysis. Based on a linear mixed model, a meta-analysis and a fixed effects meta-regression were performed. Pooling of results by meta-analysis was stratified by the outcome measures (a) mood, (b) emotional processing, (c) wakefulness, (d) attention, (e) memory, and (f) executive functions. On a significance level of p < 0.05 the following significant results emerged: After a single dose of an antidepressant, a significant effect was shown in two of the analysed outcomes. Firstly, there was a small yet significant negative effect on wakefulness. On memory, a positive effect after several measurements was found, but this result could be traced to the results of the one study out of all included studies, which had that many assessment points. The analysis of trials with repeated drug administration (mean duration 14 days, standard deviation 9) yielded the following effects: on mood, a non-significant positive effect was detected that was continuously increasing and reached significance at the last assessment point. Regarding attention, a fluctuating effect was found, while for memory, the fact that the two groups started with a group difference confounded the results. For wakefulness there was no significant effect in any particular assessment point, while for emotional processing and executive functions, the small number of studies did not allow for any effect to emerge. In summary, no consistent evidence for enhancing effects of antidepressants could be found. There is little evidence so far to support the popular opinion that antidepressants have a positive effect on the mood of healthy individuals after repeated administration. No evidence of a significant adverse event profile could be found. The studies included in this systematic review not only provide insufficient evidence for or against any effect in healthy people, but they are inapt to be used for answering this question. This may be explained by the fact that most of them were not designed to examine neuroenhancement effects. The growing public interest in neuroenhancement stands in stark contrast to the paucity of data on enhancement effects of available psychopharmacological agents. (shrink)
This paper explores the way that Elizabeth Presa's artworks respond to Jacques Derrida's thought. By examining how the particularity (the beside) and its supplements (the besides) operate in Presa's works, it is shown how this movement between beside and besides is also central to Derrida's thought.
This collection, the first broadly interdisciplinary volume dealing with Spinozan thought, asserts the importance of Spinoza’s philosophy of immanence for contemporary cultural and philosophical debates.
