Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis which has infected one third of the mankind and causes 2–3 million deaths worldwide each year. The persistence of the infection ensues from the ability of M. tuberculosis to subvert host immune responses in favor of survival and growth of mycobacteria in macrophages. The mechanisms by which M. tuberculosis manipulates the host immune system have only recently come to light. These activities are attributed to lipoarabinomannans (LAM) and their precursors lipomannans (LM), (...) two predominant glycolipids of M. tuberculosis cell wall. LM are able to skew anti‐mycobacterial immune responses into un‐protective ones, while LAM evoke immunosupression upon binding to macrophage and dendritic cell receptors specialized in binding to “self” host components. A newly emerging idea implicates plasma membrane rafts in LM and LAM signaling. Depending on acylation patterns, the glycolipids may either directly incorporate into the raft membrane via mannosylphosphatidylinositol anchors or interact with raft‐associated proteins to affect the assembly of receptor signaling complexes. BioEssays 30:943–954, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In this article, we analyse the relation of philosophy and theology in the work of Jean‑Luc Marion in order to be able to see not only how the phenomenology of givenness can serve as a “new apologetics” for theology, but also how Marion’s phenomenology itself, in its historical development and in its core principle and method, is influenced and changed by theological phenomena. We present three ways of describing the relation, tension, mutual influence and separation of philosophy and theology: firstly, (...) in line with Pascal’s distinction between the orders of reason and of the heart; secondly, in phenomenology, in terms of indications to the effect that there can be a phenomenon of revelation in the mode of possibility that is distinguished from the phenomenon of Revelation in theology in the mode of historicity; and thirdly, by analogy with Christian apologetics. In particular, we analyse this third dimension, putting forward the thesis that Marion’s phenomenology itself has some characteristics of the Christian apologetics he describes. We try to demonstrate this interpretation of his phenomenology in its key dimensions, such as the counter-method and descriptions of the phenomena of love and revelation, which constitute the culmination of the phenomenology of givenness, although at the same time, as it were, its limit, crossing over into the theological order. (shrink)

Research on the media representations of nanotechnology have flourished during the last decennium. However, most of the projects were focused on Western Europe and North America, especially the English speaking countries. This paper aims to move the focus towards Poland - a Central European country that has not been studied in this context before. This study looks at the frames, themes and tone used in the Polish coverage of nanotechnology between 2004 and 2009. Other issues, such as main actors in (...) the debate or articles’ geographical focus have also been considered. (shrink)