Problems and Paradigms is a feature series devoted to discussions of major problems in biology. Past contributions have dealt with the selector gene hypothesis, problems of pattern formation, the phenomenon of paramutation, theories of aging, and the origins of life. In this article, Brian C. Goodwin discusses the problem of morphogenesis, in terms of the idea of the genetic program and in the light of recent findings.

Brian Goodwin, author of How the Leopard Changed Its Spots, argues for a view of nature as complex, interrelated networks of relationships. He proposes that, in order for us to once again work with nature to achieve true sustainability on our planet, we need to adopt a new science, new art, new design, new economies and new patterns of responsibility. We must be willing to pay nature its due: to recognize what we owe to the natural world and resist exploiting (...) it solely for our own ends. (shrink)

Homology continues to be a concept of central importance in the study of phylogenetic relations, but its relation to ontogenetic processes remains problematical. A definition of homology in terms of equivalent morphogenetic processes is defined and applied to the comparative study of tetrapod limbs. This allows for a consistent treatment of relations of similarity and difference of appendage structure in vertebrates, and the distinction between fishes fins and tetrapod limbs in terms of the concept of equivalence is described. The role (...) of genes can also be clarified in this context, in particular the influence of the Hox 4 complex in determining digit character and the homeotic transformations that arise from changes in their expression patterns. It is argued that these observations are not compatible with the notion of homology between individual digits (I, II, III, etc.) across the tetrapods, and that homology cannot be consistently identified with gene action. The relations between homology and the properties of the morphogenetic limb field are discussed. (shrink)

Consciousness in the biological sciences.

The argument that I shall pursue here will take the following form. Organisms are wholes that are centres of agency. To live is to act intentionally, to discriminate and to experience. To accommodate within science an understanding of the life with which we as organisms are familiar, it is necessary to acknowledge the reality of qualitative experience. This leads to an expanded conception of science that preserves all that is of value in our tradition of exploring reality but avoids the (...) unfortunate conclusion that some of our deepest experiences are in some sense unreal. (shrink)

Professor Brian Goodwin (1931-2007) was a visionary biologist, mathematician and philosopher. Understanding organisms as dynamics wholes, he worked to develop an alternate view to extreme Darwinism based solely on genetic factors. He was a pioneer in the field of theoretical biology.