In the Netherlands fertility doctors increasingly formulate protocols, which oblige patients to quit their unhealthy lifestyle before they are admitted to IVF procedures. We argue that moral arguments could justify parenting protocols that concern all future parents. In the first part we argue that want-to-be parents have moral responsibilities towards their future children to prevent them from harm by diminishing or eliminating risk factors before as well as during the pregnancy. This is because of the future children's potential to become (...) of a certain type, more specifically: a person that will be the want-to-be parents' child. Want-to-be parents intend to become pregnant and therefore have an additional moral reason to diminish the risks. Also, people who become pregnant unintentionally have the responsibility to prevent their children from harm, unless they become pregnant due to contraception failure. All people not wanting to become pregnant should use contraception methods carefully.In the second part of this paper we translate the want-to-be parents' responsibilities into practice. We distinguish four determinants of risk factors: modifiability, chance, severity and effort. We examine some evidence-based risk factors based on these variables and deduce levels of responsibility.In conclusion, formulating informal requirements for want-to-be parents is morally required and therefore also for want-to-be parents in need of medical assistance. The protocols developed by fertility doctors in the Netherlands could be seen as the precursor for a general, informal Parenting Protocol that could be developed on the basis of an extended and thoroughly debated risk-responsibility analysis. (shrink)

Ras proteins function as critical relay switches that regulate diverse signaling pathways between cell surface receptors and the nucleus. Over the past 2‐3 years researchers have identified many components of these pathways that mediate Ras activation and effector function. Among these proteins are several guanine nucleotide exchange factors (GEFs), which are responsible for directly interacting with and activating Ras in response to extracellular stimuli. Analogous GEFs regulate Ras‐related proteins that serve other diverse cellular functions. In particular, a growing family of (...) proteins (Dbl homology proteins) has recently been identified, which may function as GEFs for the Rho family of Ras‐related proteins. This review summarizes our current knowledge of the structure, biochemistry and biology of Ras and Rho family GEFs. Additionally, we describe mechanisms of GEF activation of Ras in signal transduction and address the potential that deregulated GEFs might contribute to malignant transformation through chronic Ras protein activation. (shrink)

Entanglement theory posits that the interrelationship of humans and objects is a delimiting characteristic of human history and culture. This edited volume of original studies by leading archaeological theorists applies this concept to a broad range of topics, including archaeological science, heritage, and theory itself. In the theoretical explications and ten case studies, the editors and contributing authors: build on the intersections between science, humanities and ecology to provide a more fine-grained, multi-scalar treatment emanating from the long-term perspective that characterizes (...) archaeological research; bring to light the subtle and unacknowledged paths that configure historical circumstances and bind human intentionality; examine the constructions of personhood, the rigidity of path dependencies, the unpredictable connections between humans and objects and the intricate paths of past events in varied geographic and historical contexts that channel future actions. This broad focus is inclusive of early complex developments in Asia and Europe, imperial and state strategies in the Andes and Mesoamerica, continuities of postcolonialism in North America, and the unforeseen and complex consequences that derive from archaeological practices. This volume will appeal to archaeologists and their advanced students. (shrink)