Review: Valentin A. Bazhanov, Brain — Culture — Society: Kantian Programme in Cognitive Science. Moscow: Kanon+ ROOI “Reabilitatsiya”, 2019, 288 pp.

The discussing subject supposes that in a globalized society communication and information resources (the term of authors) not only provide for the needs of the subjects of relationships, but also become virtually uncontested basis of the progress of the human community. When creating information products, the main means of production of these intangible resources is the human intellect. Thus, the characteristic feature of the process of communication and information production is its subjectivity and lack of direct correlation between material costs (...) and estimate the final cost of production of new information and intangible resources. This approach suggests a new paradigm of the global information space research. (shrink)

Present time the term ‘knowledge economy‘ is widely used to determine the type of economy in which the decisive role is played by knowledge and the generation of new knowledge becomes a source of socio-economic development. The emergence of the knowledge economy was predetermined by the rapid development of information and communication technologies. Therefore, different approaches to the of knowledge economy measurement define the level of the information-communication technologies development as one of the most important indicators. The state programs of (...) infotelecommunication development support are an important tool to affect global rating of the country according to the level of development of the knowledge economy. (shrink)

Some RNases possess preferential cytotoxicity against malignant cells. The best known of these RNases, onconase, was isolated from frog oocytes and is in clinical trials as anticancer therapy. Here we propose an alternative platform for anticancer therapy based on T1 RNases of microbial origin, in particular binase from Bacillus intermedius and RNase Sa from Streptomyces aureofaciens. We discuss their advantages and the most promising directions of research for their potential clinical applications. BioEssays 30:781–790, 2008. © 2008 Wiley Periodicals, Inc.

The article deals with finding finite total equivalence systems for formulas based on an arbitrary closed class of functions of several variables defined on the set {0, 1, 2} and taking values in the set {0,1} with the property that the restrictions of its functions to the set {0, 1} constitutes a closed class of Boolean functions. We consider all classes whose restriction closure is either the set of all functions of two-valued logic or the set T a of functions (...) preserving \. In each of these cases, we find a finite total equivalence system, construct a canonical type for formulas, and present a complete algorithm for determining whether any two formulas are equivalent. (shrink)

Genesis of the scientific ideas and views on intellectual capital is characterized by various approaches highlighting the role of knowledge, skill and professional employees as a form of productive capital. This tendency is mostly revealed at the present stage of economic science development in transiting to an information society. In these conditions the holistic study of intellectual capital requires an expansion of the methodological research base using the evolutionary theory of economic development of the world community, general theory of complex (...) systems, theory of informational economics and other disciplines. Moreover, in Russia there are a number of problems associated with creating a necessary institutional and regulatory environment for protecting the intellectual property. According to the authors, the study of the intellectual capital is necessary from the institutional analysis perspective, as it allows to more accurately determine the current state of the legal status of intellectual assets in the economic activity of an enterprise. (shrink)

Three experiments investigated the role of target-target perceptual similarity within the attentional blink. Various geometric shapes were presented in a rapid serial visual presentation task. Targets could have 2, 1, or 0 shared features. Features included shape and size. The second target was presented after five or six different lags after the first target. The task was to detect both targets on each trial. Second-target report accuracy was increased by target-target similarity. This modulation was observed more for mixed-trial design as (...) compared with blocked design. Results are discussed in terms of increased stability of working memory representations and reduced interference for second-target processing. (shrink)

Ad Serapionem I, 20 by Athanasius was of paramount importance for theology of Nicephorus Blemmydes, John XI Beccus and Gregory of Cyprus. Blemmydes seems to have produced several changes of words in the passage making Athanasius say of the Spirit as of the Life and Energy of the Son. In such a form Ad Serapionem I, 20 gave Blemmydes an excellent opportunity for substantiating his own doctrine on the Spirit's eternal illumination through the Son. In his teaching no strict demarkation (...) line had been drawn between the Person and energy of the Spirit. Nicephorus might have tried to approach to a more "essentialist" discourse in triadology, e.g., like that which is found in Symeon the New Theologian. By his sometimes ambiguous, but generally fresh and suggestive pneumatology Nicephorus has paved the way for Gregory of Cyprus, Gregory Palamas and the Palamites. While taken at face value, Nicephorus' teaching seemed to open a path for early Scholastics, with John Beccus at their head, as well as for subsequent anti-Palamites, whereas the Palamites took pains to interpret Blemmydes along the lines of traditional Cappadocian, Maximian and Photian triadology. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection (...) of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc. (shrink)