Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Recently, psychologists have explored moral concepts including obligation, blame, and ability. While little empirical work has studied the relationships among these concepts, philosophers have widely assumed such a relationship in the principle that “ought” implies “can,” which states that if someone ought to do something, then they must be able to do it. The cognitive underpinnings of these concepts are tested in the three experiments reported here. In Experiment 1, most participants judge that an agent ought to keep a promise (...) that he is unable to keep, but only when he is to blame for the inability. Experiment 2 shows that such “ought” judgments correlate with judgments of blame, rather than with judgments of the agent’s ability. Experiment 3 replicates these findings for moral “ought” judgments and finds that they do not hold for nonmoral “ought” judgments, such as what someone ought to do to fulfill their desires. These results together show that folk moral judgments do not conform to a widely assumed philosophical principle that “ought” implies “can.” Instead, judgments of blame play a modulatory role in some judgments of obligation. (shrink)

ABSTRACTThe psychological and philosophical literature exploring the role of social influence in moral judgments suggests that conformity in moral judgments is common and, in many cases, seems to b...

This article seeks to show how several rhetorical tools were used and, in fact, played a central role in the argumentation advanced by Niles Eldredge and Stephen Jay Gould in their 1972 seminal article on the theory of Punctuated Equilibria. It is analyzed how Eldredge and Gould proceeded through three steps that, sequentially integrated, made their argument compelling. It is shown how they made use of analogies, metaphors and other rhetorical tools. It is sustained that they began by priming the (...) reader to distrust the current interpretation of the fossil record offered by most paleontologists and then, in a second step, they used specific visual representations in order to suggest that the competitor theory was committed to the idea of an even and slow evolution at a constant rate, an image utilized by them as straw man. Finally, it is analyzed how, in their third step, Eldredge and Gould made use of several rhetorical arguments to present their theory as new for paleontology while, at the same time, placing it well inside the frame of the modern synthesis, and how they also managed to present their theory as more promising and capable of making predictions for future researches than the competitor theory. (shrink)

The problem of commensurability/incommensurability of different cultural codes is a key problem of modern civilizational development. This is the problem of the search for communicative unity in the world of cultural and biological diversity, which has to be protected, and the search for the cohesion of different Umwelten, of semiotically-defined artificial and natural environments, of ecological and cognitive niches, taking into account that each of them has their own identity and uniqueness. The purpose of the article is to draw attention (...) to the fact that the question of the so-called incommensurability of different conceptual schemes, paradigms, language consciousnesses is widely discussed not only in cross-cultural studies and philosophical problems of translation but also in connection with the problems of incommensurability between the language of classical physics and the language of relativistic quantum physics. Attention is drawn to the problem of the incommensurability and correlation of different languages that are used in debates about the foundations of quantum mechanics, its interpretation, comprehension and ontology. Two approaches stand out in this debate. The first approach is based on the language of the formed being, on the language of things localized in time and on the logic of Aristotle. The second approach is based on the language of the becoming, process and nonlocality, on the search for various processual-oriented temporal logics. In this regard, we discuss the processual approach to understanding quantum mechanics, proposed in the philosophical and physical works of D. Bohm. The authors argue that the experience of constructive understanding of the metaproblems of the interpretation of quantum mechanics, the critical reception of the legacy of such philosophers of the process as Peirce, Bergson and Whitehead, the deep reflection on the problems of commensurability/ incommensurability of linguistic consciousnesses of different cultures – will eventually create a common synergetic-interdisciplinary space of cooperation for the solutions of the above-mentioned issues. (shrink)

Appearing here in English for the first time, Vladimir Jankélévitch's _Henri Bergson_ is one of the two great commentaries written on Henri Bergson. Gilles Deleuze's _Bergsonism_ renewed interest in the great French philosopher but failed to consider Bergson's experiential and religious perspectives. Here Jankélévitch covers all aspects of Bergson's thought, emphasizing the concepts of time and duration, memory, evolution, simplicity, love, and joy. A friend of Bergson's, Jankélévitch first published this book in 1931 and revised it in 1959 to (...) treat Bergson's later works. This unabridged translation of the 1959 edition includes an editor's introduction, which contextualizes and outlines Jankélévitch's reading of Bergson, additional essays on Bergson by Jankélévitch, and Bergson's letters to Jankélévitch. (shrink)

This article defends the view that liars need not intend to deceive. I present common objections to this view in detail and then propose a case of a liar who can lie but who cannot deceive in any relevant sense. I then modify this case to get a situation in which this person lies intending to tell his hearer the truth and he does this by way of getting the hearer to recognize his intention to tell the truth by lying. (...) This case, and further cases that I develop from it, demonstrate that lying without the intention to deceive is possible. (shrink)

The article draws a conceptual distinction the (French) structuralism of the 50’s–60’s and the post-structuralism of the 70’s, which are discussed as overlapping in their intellectual paths; their mutual dynamics is defined as a reaction of the intelligence to the pressure of depersonalized unified schemes within the logic of structuralism against free improvisation and loose interpretation instead of total explanations in the post-structuralism interpretation. The article establishes a conceptual identity of the paradoxical nature between post-structuralism (and deconstructionism, which is homogeneous (...) and identical thereto in a number of aspects), on the one hand, and constructionism with its specific process of language dismantling – social/ideological languages, social group dialects, on the other hand, which naturally leads the authors to the analysis of the paradoxicality principles, defined by post-structuralism (five principles of paradoxicality of Gilles Deleuze – paradox of regress, paradox of sterile reiteration, paradox of neutrality, paradox of absurd, paradox of Levi-Strauss); poststructuralists’ paralogisms are examined through paradoxical denotation; the late Roland Barthes’ phenomenon of paradoxicality, becoming a plot-forming principle of narration, is analyzed. Poststructuralism is conceptualized in the article as the first decisive step of post-modernism; the affinity of post-structuralist and postmodernist commitment to parody, game and irony is stated; the theory of language games in post-modern interpretation is explored; one of those games – a game of carnival – is explored within the diachronic retrospective; the affinity of parody and carnival tradition of post-structuralism and post-modernism to the romantic irony of the XIXth century and its inconsistency with the popular culture of laugh is established. The genesis of poststructuralism and post-modernism is connected with the ideological restart of the Western society before the “very end” of the Resistance ideas and the disappointment of the left European intellectuals in the “great legends” and illusions of Marxism. The blurred concepts of relativism are connected with the mutual disproportion of different layers of historical experience. (shrink)

We conducted two experiments to determine whether common folk think that so-called _tell-tale sign_ bald-faced lies are intended to deceive—since they have not been tested before. These lies involve tell-tale signs (e.g. blushing) that show that the speaker is lying. Our study was designed to avoid problems earlier studies raise (these studies focus on a kind of bald-faced lie in which supposedly everyone knows that what the speaker says is false). Our main hypothesis was that the participants will think that (...) the protagonists from our examples lied without intending to deceive, and the results of our surveys confirmed this hypothesis: most of our participants rated tell-tale sign lies as lies not intended to deceive. Therefore, our analysis suggests that common folk think that some lies are not intended to deceive. (shrink)

This paper refines the received analysis of deceptive lies. This is done by assessing some cases of lies that are supposedly not intended to deceive and by arguing that they actually involve sophisticated strategies of intentional deception. These lies, that is, merely seem not to be intended to deceive and this is because our received analysis of deceptive lies is insufficiently sophisticated. We need to add these strategies to our analysis of deceptive lying. The argument ends by presenting this refined (...) analysis. (shrink)

The aim of this book is to present the fundamental theoretical results concerning inference rules in deductive formal systems. Primary attention is focused on: admissible or permissible inference rules the derivability of the admissible inference rules the structural completeness of logics the bases for admissible and valid inference rules. There is particular emphasis on propositional non-standard logics (primary, superintuitionistic and modal logics) but general logical consequence relations and classical first-order theories are also considered. The book is basically self-contained and special (...) attention has been made to present the material in a convenient manner for the reader. Proofs of results, many of which are not readily available elsewhere, are also included. The book is written at a level appropriate for first-year graduate students in mathematics or computer science. Although some knowledge of elementary logic and universal algebra are necessary, the first chapter includes all the results from universal algebra and logic that the reader needs. For graduate students in mathematics and computer science the book is an excellent textbook. (shrink)

Cílem studie je zodpovědět otázku, co znamená v interpretujících humanitních či sociálních vědách zkoumat narativně. Interpretace je pojata jako explikace utváření významu. V návaznosti na toto pojetí je identifikována řada interpretačních dilemat. V tomto kontextu je uveden narativní přístup jako řešení těchto dilemat. Je pojednáno o povaze narativní perspektivy, o vztahu narativity a zkušenosti a o povaze narativních dat. Narativní výzkum je chápán jako rekonstrukce způsobů, jakými je utvářen význam narativními prostředky. Narativní interpretace umožňuje pohybovat se pružně a efektivně: 1) (...) mezi explicitními daty a exemplifikačními schématy, 2) mezi jedincem a kulturou, 3) mezi hermeneutikou podezření a hermeneutikou důvěry, 4) mezi částmi a celkem, 5) mezi obsahem a formou, 6) mezi strukturou a funkcí. (shrink)

Arguably, the existence of bald-faced (i.e. knowingly undisguised) lies entails that not all lies are intended to deceive. Two kinds of bald-faced lies exist in the literature: those based on some common knowledge that implies that you are lying and those that involve tell-tale signs (e.g. blushing) that show that you are lying. I designed the tell-tale sign bald-faced lies to avoid objections raised against the common knowledge bald-faced lies but I now see that they are more problematic than what (...) I initially thought. Therefore, I will discuss these lies in more detail, refine the existing cases, and resolve some anticipated objections. I conclude that tell-tale sign bald-faced lies are genuine lies not intended to deceive. (shrink)

The research analyzes the process of formation of the ethics committee as a new institution in the system of regulation of genetic research. The external factors of this process are the increasing digitalization of medical and research practices, as well as the special situation that is developing in the field of genomic research and the use of genetic technologies, where issues of philosophy, jurisprudence and administration have generated many fundamentally new, and sometimes unexpected contexts. The author shows the similarity and (...) difference of approaches to the inclusion of the ethics committee in the national regulatory systems of different countries and determines the prospects for further integration of the new institution into normative and administrative-regulatory and law enforcement practices. The research applies all the main methods of system analysis and structural and functional analysis, as well as the comparative legal method. At the stage of generalization of empirical material, the author turns to the means and methods of philosophical phenomenology and phenomenological sociology. The study revealed that the ethics committee may have different institutional and regulatory functions in a variety of management and legal systems. Being hybrid in nature, the ethics committee performs various functions, and in various state legal systems and traditions it can combine elements of legislative, executive and judicial power. At times, the ethics committee may go beyond the scope of both a purely administrative and exclusively legal regulator. All this indicates that the integration of this institution into the legal system and into a variety of social practices is far from being completed. (shrink)

A satisfactory analysis of human deception must rule out cases where it is a mistake or an accident that person B was misled by person A's behavior. Therefore, most scholars think that deceivers must intend to deceive. This article argues that there is a better solution: rather than appealing to the deceiver's intentions, we should appeal to the function of their behavior. After all, animals and plants engage in deception, and most of them are not capable of forming intentions. Accordingly, (...) certain human behavior is deceptive if and only if its function is to mislead. This solves our problem because if the function of A's behavior was to mislead, B's ending up misled was not an accident or a mere mistake even if A did not intend to deceive B. (shrink)

In their paper published in 2017 in Philosophical Psychology, Ronja Rutschmann and Alex Wiegmann introduce a novel kind of lies, the indifferent lies. According to them, these lies are not intended to deceive simply because the liars do not care whether their audience is going to believe them or not. It seems as if indifferent lies avoid the objections raised against other kinds of lies supposedly not intended to deceive. I argue that this is not correct. Indifferent lies, too, are (...) either intended to deceive or are not lies at all, since they do not involve genuine assertions. (shrink)

According to one influential argument put forward by, e.g. Chisholm and Feehan, Pfister, Meibauer, Dynel, Keiser, and Harris, asserting requires intending to give your hearer a reason to believe what you say (first premise) and, because liars must assert what they believe is false (second premise), liars necessarily intend to cause their hearer to believe as true what the liars believe is false (conclusion). According to this argument, that is, all genuine lies are intended to deceive. ‘Lies’ not intended to (...) deceive are not genuine lies because they do not involve assertions and you need to assert in order to lie. In this paper, I reject this argument by arguing that the first premise is false: intending to give your hearer a reason to believe what you say is not necessary for asserting. (shrink)

In this paper we prove the following theorem: Any one-dimensional definably connected group G over an o-minimal structure is, as an abstract group, isomorphic to either pPp∞δ or δ.

kn. 1. Predystorii͡a, zasedanii͡a -- kn. 2. Khronika, portrety.

People are remarkably smart: They use language, possess complex motor skills, make nontrivial inferences, develop and use scientific theories, make laws, and adapt to complex dynamic environments. Much of this knowledge requires concepts and this study focuses on how people acquire concepts. It is argued that conceptual development progresses from simple perceptual grouping to highly abstract scientific concepts. This proposal of conceptual development has four parts. First, it is argued that categories in the world have different structure. Second, there might (...) be different learning systems that evolved to learn categories of differing structures. Third, these systems exhibit differential maturational course, which affects how categories of different structures are learned in the course of development. And finally, an interaction of these components may result in the developmental transition from perceptual groupings to more abstract concepts. This study reviews a large body of empirical evidence supporting this proposal. (shrink)

In his 2018 AJP paper, Shlomo Cohen hints that deception could be a distinct subset of manipulation. We pursue this thought further, but by arguing that Cohen’s accounts of deception and manipulation are incorrect. Deception under uncertainty need not involve adding false premises to the victim’s reasoning but it must involve manipulating her response, and cases of manipulation that do not interfere with the victim’s reasoning, but rather utilize it, also exist. Therefore, deception under uncertainty must be constituted by covert (...) manipulation. (shrink)

This paper examines the connection between lies, deception, and self-deception. Understanding this connection is important because the consensus is that you cannot deceive yourself by lying since you cannot make yourself believe as true a proposition you already believe is false – and, as a liar, you must assert a proposition you believe is false. My solution involves refining our analysis of lying: people can lie by asserting what they confidently believe is true. Thus, self-deceivers need not replace one belief (...) with another; rather, they may just increase existing credence in a proposition they already believe is true. (shrink)

This paper argues that extant signalling-based analyses cannot explain a range of cases of biological (and psychological) deception, such as those in which the deceiver does not send a signal at all, but that Artiga and Paternotte’s (Philos Stud 175:579–600, 2018) functional and my (Krstić in The analysis of self-deception: rehabilitating the traditionalist account. PhD Dissertation, University of Auckland, 2018: §3; Krstić and Saville in Australas J Philos 97:830–835, 2019) manipulativist analyses can. Therefore, the latter views should be given preference. (...) And because we still do not have a satisfactory definition of manipulation, the functional analysis, according to which a state is deceptive iff its function is to mislead and it misleads, is currently our best theory of deception. This is not to argue that the signalling-based analyses have no value but only that they should not be used in general analyses of biological deception. We need to move on to some other interesting issues. (shrink)

В трактате рассмотрены историко-философские аспекты современных любовных романов в стихах, написанных в русле эниологической поэзии. Для специалистов.

O encontro do herói Odisseu com o ciclope Polifemo na Odisséia de Homero em dado momento saiu do terreno do mito e chegou até o da história. Polifemo tornou-se uma figura do mundo primitivo, em que reina violência, antropofagia, irracionalidade, paixão e música. O problema do valor da vida primitiva na antiguidade clássica conduzia a dois pólos antagônicos de interpretação. De um lado, a perspectiva progressista que via na história a saída de um estado primitivo e selvagem através da técnica. (...) De outro lado, a perspectiva decadentista, segundo a qual os primeiros homens viveram no melhor dos mundos, na idade de ouro. O expediente de síntese dessas concepções opostas resulta num retrato ambíguo do mundo selvagem e primitivo. O presente artigo pretende situar alguns autores dentro dessa problemática. Protágoras, Eurípides e Crítias compartilhariam o quadro da vida ciclópica de Homero. Teócrito, Ovídio e bem mais tarde Góngora, por outro lado, estariam inseridos na tradição da idade de ouro, que vem desde Hesíodo. Por fim, alguns autores preferem destacar as ambigüidades da vida selvagem e primitiva, tal seria o caso de Platão, Montaigne e Vico. (shrink)

As Dag Normann has recently shown, the fully abstract model for PCF of hereditarily-sequential functionals is not ω-complete . This is also applicable to a potentially wider class of models such as the recently constructed by the author fully abstract model for PCF+=PCF+pif . Here we will present an outline of a general approach to this kind of ‘natural’ domains which, although being non-dcpos, allow considering ‘naturally’ continuous functions . There is also an appropriate version of ‘naturally’ algebraic and ‘naturally’ (...) bounded complete ‘natural’ domains which serves as the non-dcpo analogue of the well-known concept of Scott domains, or equivalently, the complete f-spaces of Ershov. It is shown that this special version of ‘natural’ domains, if considered under ‘natural’ Scott topology, exactly corresponds to the class of f-spaces, not necessarily complete. (shrink)

This article seeks to clarify the concept of progress in philosophy. It treats progress as a kind of development. But not every development is a progress. When we talk about progress, what really matters is the direction of development. In some cases it is relatively easy to reach agreement about this direction. But not in the case of philosophy, if we abstract it from the obvious and the trivial, like the number of books on philosophy. As a result, the article (...) concludes that there cannot be progress in philosophy. Instead we see a continual multiplication of interpretations. (shrink)

This article deals with the relations in the triangle state–society–business in modern Russia. It is shown against Russian historical background, that the absolutist state in this country could never be identified with the society and these relations were shaped under its strong domination. The ethics of rule-following characteristic for market economy in general did not develop in Russia. The breakdown of communist Russia and market reforms proceeding since 1992 did not change this situation significantly. The period of political alliance between (...) big business and government was followed by restoration of state dominance in somewhat modified forms. Both periods were characterized by corruption, which contrary to Putin’s slogans, increases in Russia. In the article I show the evolution of Putin administration’s policy which changed from emphasizing and improving legal institutions to selective use of legal norms depending on personal loyalty. Main forms of state exploitation of Russian business are described. The conclusion is that Russian experience of balancing state and market should be called negative. (shrink)

This book contains 86 essays and papers by the Russian sculptor and hermeneutic philosopher Vladimir Zimmerling (1931-2017) addressed the issues in aesthetics, ethics and cultural history. The apparatus includes the introductory article, the commentary, the name and the subject indexes prepared by the book editor, Anton Zimmerling. The appendix contains 70 pictures of Vladimir Zimmerling's sculptures. Vladimir Zimmerling's conception is build on the combination of the empiricism principle with the elements of hermeneutics and metalinguistic criticism. His essays (...) and papers focus on the foundations of aesthetics and ethics. Vladimir Zimmerling was one of the pioneers of the analytic approach to the poetics of Ossip Mandelstam with his paper "Промер" ["The Measurement"], (1974-1975) devoted to 10 difficult Mandelstam's poems including "Грифельная Ода", "Слепая ласточка бросается к ногам", "Я слово позабыл, что я хотел сказать". (shrink)

Sorensen says that my assertion that p is a knowledge-lie if it is meant to undermine your justification for believing truly that ∼p, not to make you believe that p and that, therefore, knowledge-lies are not intended to deceive. It has been objected that they are meant to deceive because they are intended to make you more confident in a falsehood. In this paper, I propose a novel account according to which an assertion that p is a knowledge-lie if it (...) is intended not to provide evidence that p but to make you stop trusting all testimonies concerning whether p, which is how they undermine your testimonial knowledge. Because they are not intended to provide evidence that bears on the truth of p, they are not intended to make you more confident in a falsehood; therefore, knowledge-lies are not intended to deceive. This makes them a problem for the traditional account, which takes the intention to deceive as necessary for lying, and an interesting example of Kant's idea that allowing lies whenever one feels like it would bring it about that statements in general are not believed. (shrink)

In this paper, I examine a kind of delusion in which the patients judge that their occurrent thoughts are false and try to abandon them precisely because they are false, but fail to do so. I call this delusion transparent, since it is transparent to the sufferer that their thought is false. In explaining this phenomenon, I defend a particular two-factor theory of delusion that takes the proper integration of relevant reasoning processes as vital for thought-evaluation. On this proposal, which (...) is a refinement of Gerrans’s account of delusion as unsupervised by decontextualized processing, I can have all my reasoning processes working reliably and thus judge that my delusion is false but, if I cannot use their outputs when revising the thought itself, the delusion will persist. I also sketch how this framework explains some interesting cases of failed belief-revision in the general population in which people judge that ~p but nonetheless continue to believe that p. (shrink)

In the Renaissance period, being a “humanist” meant graduating from a philosophical faculty and teaching the collection of disciplines necessary to become a university student. In this view, the humanist is the man of the unaccomplished higher education, or, a school teacher. Neither his status, nor the status of the disciplines he taught was high. Over time the situation changed. Studying ancient languages opened a whole world of the disappeared civilization, obvious ancestors to the Renaissance; a conception of humanitarian-historical cognition (...) was founded. The Renaissance was the first to formulate a problem of comprehension—of the historical epochs passed, of the texts based on other experience and different mentality. In the context of unique singularitythe concepts of fate and biography were overestimated. The thesis of micro and macrocosm unity was revived. The humanists have created a new translation of the Holy Writ; as a result, the sense of many rite ceremonies of liturgy became clearer. Historicism and criticism have brought a new type of thinking and a new system of values in the long run. Humanistic values constructed the first system that had no need in religious foundation, and its relation with Christianity was not logical, but historical.All this, though well known, gains quite other sense today. The world becomes more and more complicated and multicultural. A post-secular, polio-confessional socium comes to replace the secular society. The former needs a new experience, as unique as that of Renaissance humanitarians. (shrink)

Self-deception makes best sense as a self-defensive mechanism by which the self protects itself from painful reality. Hence, we typically imagine self-deceivers as people who cause themselves to believe as true what they want to be true. Some self-deceivers, however, end up believing what they do not want to be true. Their behaviour can be explained on the hypothesis that the function of this behaviour is protecting the agent's perceived focal benefit at the cost of inflicting short-term harm, which is (...) a basis for a unified account of the phenomenon. In this paper, I argue that this view is narrow. Cases of altruistic, benevolent, and even self-punishing self-deception also exist. There, the function is not the self-deceiver's benefit. In fact, self-deception may have no function at all. Therefore, I put forward a novel account that analyses the function of self-deception on a case-by-case basis. (shrink)

An algorithm recognizing admissibility of inference rules in generalized form (rules of inference with parameters or metavariables) in the intuitionistic calculus H and, in particular, also in the usual form without parameters, is presented. This algorithm is obtained by means of special intuitionistic Kripke models, which are constructed for a given inference rule. Thus, in particular, the direct solution by intuitionistic techniques of Friedman's problem is found. As a corollary an algorithm for the recognition of the solvability of logical equations (...) in H and for constructing some solutions for solvable equations is obtained. A semantic criterion for admissibility in H is constructed. (shrink)