Vertebrates respond to light with more than just their eyes. In this article, we speculate on the intriguing possibility that a link remains between non‐visual opsins and neurohormonal systems that control neuronal circuit formation and activity in mammals. Historically, the retina and pineal gland were considered the only significant light‐sensing tissues in vertebrates. However over the last century, evidence has accumulated arguing that extra‐ocular tissues in vertebrates influence behavior through non‐image‐forming photoreception. One such class of extra‐ocular light detectors are the (...) long mysterious deep brain photoreceptors. Here, we review recent findings on the cellular identity and the function of deep brain photoreceptors controlling behavior and physiology in zebrafish, and discuss their implications. (shrink)

Recently a number of complex electrophysiological responses to neurotransmitters have been observed that cannot be described as simple excitation or inhibition. These responses are often characterized as modulatory, although there is no consensus on what defines modulation. Morphological studies reveal certain neurotransmitters stored in what might be release sites without synaptic contact. There is no direct evidence for nonsynaptic release from CNS sites, although such release does occur in the periphery and in invertebrates. Nonsynaptic release might provide a basis for (...) diffuse one-cell-to-many communication, but it might also simply be a means of sending the transmitter to a broader area of a single neuron than occurs in typical synapses. Several kinds of macromolecules have been found to be transported in a retrograde direction – and in some cases transsynaptically. There have been suggestions that some neurons may release more than one type of transmitter. Particularly intriguing is the possibility of release of substances that modulate actions of a primary transmitter. Taken together this range of evidence suggests that neurons may use a variety of forms of molecular communication in addition to traditionally described synaptic transmission.Several authors have suggested modes of communication distinct from classical synaptic transmission and have classified released substances using terms such as neurohumor, neurohormone, neuroregulator, and modulator. These suggestions have the heuristic value of drawing together diverse kinds of data, but it remains to be established that the pieces fit together in that fashion – for example, that complex electrophysiological effects are associated with substances released nonsynaptically. In order to reduce confusion, a flexible, generic approach to nomenclature for substances released from neurons and for hypothetical modes of communication is recommended. Some behavioral implications of nonconventional transmission are considered. (shrink)

Vertebrates respond to light with more than just their eyes. In this article, we speculate on the intriguing possibility that a link remains between non‐visual opsins and neurohormonal systems that control neuronal circuit formation and activity in mammals. Historically, the retina and pineal gland were considered the only significant light‐sensing tissues in vertebrates. However over the last century, evidence has accumulated arguing that extra‐ocular tissues in vertebrates influence behavior through non‐image‐forming photoreception. One such class of extra‐ocular light detectors are the (...) long mysterious deep brain photoreceptors. Here, we review recent findings on the cellular identity and the function of deep brain photoreceptors controlling behavior and physiology in zebrafish, and discuss their implications. (shrink)

Human skin produces numerous neurohormones and neuropeptides. Recent evidence has shown that the neuroendocrine regulation of human skin biology also extends to keratins, the major structural components of epithelial cells. For example, thyrotropin‐releasing hormone, thyrotropin, opioids, prolactin, and cannabinoid receptor 1‐ligands profoundly modulate human keratin gene and protein expression in human epidermis and/or hair follicle epithelium in situ. Since selected keratins are now understood to exert important regulatory functions beyond mechanical stability, we argue that neuroendocrine pathways of keratin regulation (...) are important for maintaining skin and hair follicle homeostasis. This invites innovative neuroendocrine therapeutic interventions for skin disorders characterized by abnormal keratin expression, ranging from psoriasis to genodermatoses, and for promoting skin wound healing and hair growth. This strategy can be probed in simple, but instructive and readily available human skin and hair follicle organ culture assays as ideal models for exploring this new neuroendocrine frontier in translational epithelial biology. (shrink)

An evolutionary theory of socialization suggests that children from father-absent families will mature earlier, and form less-stable pair bonds, compared with those from father-present families. Using a sample of about 1,000 persons the recent study focuses on elements of father-absent children’s behavior that could be better explained by a Darwinian approach than by rival social science theories. As a result of their enhanced interest in male competition, father-absent boys were found to engage in rule-breaking behavior more intensively than father-present boys. (...) Compared with father-present children, adolescents from widowed households (both boys and girls) showed a higher intensity of various kinds of noncompliant behavior, which can be linked to their earlier maturation. School attendance, age at marriage, and marital success proved to be influenced by the children’s early family experiences, governed by adapted evolutionary strategies. Father-absent daughters conceived more children than those whose fathers were present during their childhood. As evolutionary theory predicts, reproductive behavior of individuals from divorced households differed from that of individuals who grew up in widowed households. Finally, the strong correlation found between spontaneous abortion/stillbirths and family arrangement indicates that father absence has certain direct impacts on the neurohormonal processes of child development. (shrink)

It is well established that neural grafts can exert functional effects on the host animal by a multiplicity of different mechanisms – by diffuse release of trophic molecules, neurohormones, and deficient neurotransmitters, as well as by growth and reformation of neural circuits. Our challenge is to understand how these different mechanisms complement each other.

Humans are a part of the complex system including both natural and cultural-technological environment. Evolution of this system included self-amplifying feedbacks that lead to the appearance of human conscious mind. We describe the current state of the understanding of human brain evolution that stresses neurohormonal and biochemical changes rather than simple increase of anatomical substrate for the mind. It follows that human brain is strongly influenced by the state of the body and may operate at various levels of consciousness depending (...) on its biochemical environment created by ingestion of various substances and by specific physical activities. Through the study of the widespread phenomenon of shamanism that uses mind-altering practices we argue that altered states of consciousness and non-local minds are not only real phenomena, but that they are products of natural evolution, valuable for human survival and development. Consideration of altered states of consciousness and broadening of the framework for understanding brain function beyond mechanistic interpretations is necessary to further develop human adaptations and provide a better way of fitting humans as parts of the interconnected system into the global and universal patterns. (shrink)

ZusammenfassungIn massenmedialen Darstellungen wird das Hormon Oxytocin gegenwärtig als biochemische Basis von Sozialität und wirkmächtiger neuropharmakologischer Lösungsansatz für die (Wieder‑)Herstellung der gesellschaftlichen Kohäsion verhandelt. Mit Blick auf die ursprüngliche Bedeutung des Hormons als „Körperhormon“ zu Beginn des 20. Jahrhunderts soll im vorliegenden Artikel die außergewöhnliche Karriere von Oxytocin vom Regulator des Geburtsvorgangs hin zum Regulator der Gesellschaft nachgezeichnet werden. Woraus bezieht eine solch voraussetzungsvolle Behauptung ihre Intelligibilität und Akzeptabilität? Unsere Analyse des wissenschaftlichen Diskurses um Oxytocin (1906–1990), des massenmedialen Diskurses seit (...) den 1990er Jahren sowie dessen Rückwirkungen auf den wissenschaftlichen Diskurs im gleichen Zeitraum verweist auf eine Serie von Re-Konfigurationen von wissenschaftlichen Theorien und Praktiken, sowie der Konzeption der Substanz an sich. Nachdem es sich in der ersten Hälfte des 20. Jahrhunderts etabliert, wird Oxytocin bereits in den 1950er Jahren zum Neurohormon, findet in den folgenden Jahrzehnten jedoch kaum wissenschaftliche Aufmerksamkeit. Erst im Zuge des massenmedialen Interesses für die postulierten Wirkungen des Hormons in Zusammenhang mit Liebe und Bindung gerät die Substanz zunehmend in den Fokus empirischer Forschung. Die Rezeption von Oxytocin als neurohormonelle Basis der individuellen Soziabilität speist sich zum einen aus dem massenmedialen Diskurs, zum anderen aus bereits in der ersten Hälfte des 20. Jahrhunderts gemachten biopolitischen Verknüpfungen, die auf die Regulierung des Lebendigen abzielen, sowie aus einem technowissenschaftlichen Modus der Oxytocinforschung: an ihrem Schnittpunkt avanciert Oxytocin zum Sozialhormon, so unsere These. (shrink)

Parental mental disorders increase the risk for insecure attachment in children. However, the quality of caregiver–infant interaction plays a key role in the development of infant attachment. Dyadic interaction is frequently investigated via global scales which are too rough to uncover micro-temporal mechanisms. Prior research found that the latency to reparation of uncoordinated dyadic states is associated with infant behavioral and neuroendocrine regulation. We investigated the hypothesis that this interactive mechanism is critical in predicting secure vs. insecure attachment quality in (...) infancy. We also assessed the predictive quality of infant attachment regarding neuroendocrine reactivity later in childhood. A subsample of N = 58 dyads from a larger study were analyzed. At 3–8 months postpartum, maternal anxiety disorders were diagnosed via a structured clinical interview as well as dyadic interaction during the Face-to-Face-Still-Face was observed and coded on a micro-temporal scale. Infant attachment quality was assessed with the strange situation paradigm at 12–24 months of age. In an overlapping subsample of N = 39, we assessed child cortisol reactivity at 5 to 6 years of age. Generalized linear modeling revealed that longer latencies to interactive reparation during the reunion episode of the FFSF as well as maternal diagnosis at 3–8 months of age predict insecure attachment in children aged 12–24 months. Cox regressions demonstrated that dyads with infants who developed insecure attachment at 12–24 months of age were 48% less likely to achieve an interactive reparation at 3–8 months of age. Mixed models revealed that compared to securely attached children, children who had developed an insecure attachment at 12–24 months of age had an increased cortisol reactivity at 5 to 6 years of age during free play. The results confirm the hypothesis that the development of attachment is affected by experienced micro-temporal interactive patterns besides diagnostic categories. They also showed that infants of mothers with postpartum anxiety disorders have a more than fivefold increased risk of developing an insecure attachment than the infants of the control group. Moreover, results imply that these patterns may influence neurohormonal regulation even in preschool aged children. (shrink)

Depletion of mitochondrial endo/exonuclease G‐like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS). Here, we show that neurohormonal stress triggers cell death in endo/exonuclease G‐like‐depleted cells, and this is marked by a decrease in mitochondrial reserve capacity. Neurohormonal stimulation with phenylephrine (PE) did not have an additive effect on the hypertrophic response induced by endo/exonuclease G‐like depletion. Interestingly, PE‐induced atrial natriuretic peptide (ANP) gene expression was completely abolished in endo/exonuclease (...) G‐like‐depleted cells, suggesting a reverse signaling function of endo/exonuclease G‐like. Endo/exonuclease G‐like depletion initially resulted in increased mitochondrial OCR, but this declined upon PE stimulation. In particular, the reserve capacity of the mitochondrial respiratory chain and maximal respiration were the first indicators of perturbations in mitochondrial respiration, and these marked the subsequent decline in mitochondrial function. Although pathological stimulation accelerated these processes, prolonged EXOG depletion also resulted in a decline in mitochondrial function. At early stages of endo/exonuclease G‐like depletion, mitochondrial ROS production was increased, but this did not affect mitochondrial DNA (mtDNA) integrity. After prolonged depletion, ROS levels returned to control values, despite hyperpolarization of the mitochondrial membrane. The mitochondrial dysfunction finally resulted in cell death, which appears to be mainly a form of necrosis. In conclusion, endo/exonuclease G‐like plays an essential role in cardiomyocyte physiology. Loss of endo/exonuclease G‐like results in diminished adaptation to pathological stress. The decline in maximal respiration and reserve capacity is the first sign of mitochondrial dysfunction that determines subsequent cell death. (shrink)

ZusammenfassungIn massenmedialen Darstellungen wird das Hormon Oxytocin gegenwärtig als biochemische Basis von Sozialität und wirkmächtiger neuropharmakologischer Lösungsansatz für die (Wieder‑)Herstellung der gesellschaftlichen Kohäsion verhandelt. Mit Blick auf die ursprüngliche Bedeutung des Hormons als „Körperhormon“ zu Beginn des 20. Jahrhunderts soll im vorliegenden Artikel die außergewöhnliche Karriere von Oxytocin vom Regulator des Geburtsvorgangs hin zum Regulator der Gesellschaft nachgezeichnet werden. Woraus bezieht eine solch voraussetzungsvolle Behauptung ihre Intelligibilität und Akzeptabilität? Unsere Analyse des wissenschaftlichen Diskurses um Oxytocin (1906–1990), des massenmedialen Diskurses seit (...) den 1990er Jahren sowie dessen Rückwirkungen auf den wissenschaftlichen Diskurs im gleichen Zeitraum verweist auf eine Serie von Re-Konfigurationen von wissenschaftlichen Theorien und Praktiken, sowie der Konzeption der Substanz an sich. Nachdem es sich in der ersten Hälfte des 20. Jahrhunderts etabliert, wird Oxytocin bereits in den 1950er Jahren zum Neurohormon, findet in den folgenden Jahrzehnten jedoch kaum wissenschaftliche Aufmerksamkeit. Erst im Zuge des massenmedialen Interesses für die postulierten Wirkungen des Hormons in Zusammenhang mit Liebe und Bindung gerät die Substanz zunehmend in den Fokus empirischer Forschung. Die Rezeption von Oxytocin als neurohormonelle Basis der individuellen Soziabilität speist sich zum einen aus dem massenmedialen Diskurs, zum anderen aus bereits in der ersten Hälfte des 20. Jahrhunderts gemachten biopolitischen Verknüpfungen, die auf die Regulierung des Lebendigen abzielen, sowie aus einem technowissenschaftlichen Modus der Oxytocinforschung: an ihrem Schnittpunkt avanciert Oxytocin zum Sozialhormon, so unsere These. (shrink)