A paramount, yet unresolved issue in personalised medicine is that of automated reasoning with clinical guidelines in multimorbidity settings. This entails enabling machines to use computerised generic clinical guideline recommendations and patient-specific information to yield patient-tailored recommendations where interactions arising due to multimorbidities are resolved. This problem is further complicated by patient management desiderata, in particular the need to account for patient-centric goals as well as preferences of various parties involved. We propose to solve this problem of automated reasoning with (...) interacting guideline recommendations in the context of a given patient by means of computational argumentation. In particular, we advance a structured argumentation formalism ABA+G (short for Assumption-Based Argumentation with Preferences (ABA+) and Goals) for integrating and reasoning with information about recommendations, interactions, patient’s state, preferences and prioritised goals. ABA+G combines assumption-based reasoning with preferences and goal-driven selection among reasoning outcomes. Specifically, we assume defeasible applicability of guideline recommendations with the general goal of patient well-being, resolve interactions (conflicts and otherwise undesirable situations) among recommendations based on the state and preferences of the patient, and employ patient-centered goals to suggest interaction-resolving, goal-importance maximising and preference-adhering recommendations. We use a well-established Transition-based Medical Recommendation model for representing guideline recommendations and identifying interactions thereof, and map the components in question, together with the given patient’s state, prioritised goals, and preferences over actions, to ABA+G for automated reasoning. In this, we follow principles of patient management and establish corresponding theoretical properties as well as illustrate our approach in realistic personalised clinical reasoning scenaria. (shrink)

We revisit the notion of initial sets by Xu and Cayrol 2016), i. e., non-empty minimal admissible sets in abstract argumentation frameworks. Initial sets are a simple concept for analysing conflicts in an abstract argumentation framework and to explain why certain arguments can be accepted. We contribute with new insights on the structure of initial sets and devise a simple non-deterministic construction principle for any admissible set, based on iterative selection of initial sets of the original framework and its induced (...) reducts. In particular, we characterise many existing admissibility-based semantics via this construction principle, thus providing a constructive explanation on the structure of extensions. We also investigate certain problems related to initial sets with respect to their computational complexity. (shrink)

When we say “I know why he was late”, we know not only the fact that he was late, but also an explanation of this fact. We propose a logical framework of “knowing why” inspired by the existing formal studies on why-questions, scientific explanation, and justification logic. We introduce the Kyi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{\mathcal {K}}{}\textit{y}}_i$$\end{document} operator into the language of epistemic logic to express “agent i knows why φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} (...) \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}” and propose a Kripke-style semantics of such expressions in terms of knowing an explanation of φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}. We obtain two sound and complete axiomatizations w.r.t. two different model classes depending on different assumptions about introspection. Finally we connect our logic with justification logic technically by providing an alternative semantics and an in-depth comparison on various design choices. (shrink)

ABSTRACTThis paper studies abduction in abstract argumentation frameworks. Given an argument, an agent verifies whether the argument is justified or not in its argumentation framework. If the argument is not justified in the argumentation framework, the agent seeks conditions to explain the justification state by hypothesising arguments in the universal argumentation framework. We formulate such abductive reasoning in argumentation semantics and provide its computation in logic programming. We also apply abduction to enforcement and simple dialogue games in argumentation frameworks.

Cases or examples can be often explained by the interplay of arguments in favour or against their outcomes. This paper addresses the problem of finding explanations for a collection of cases where an explanation is a labelled argumentation graph consistent with the cases, and a case is represented as a statement labelling. The focus is on semi-abstract argumentation graphs specifying attack and subargument relations between arguments, along with particular complete argument labellings taken from probabilistic argumentation where arguments can be excluded. (...) The framework and computational considerations lead to an iterated local iterative deepening depth-first search to collect ‘interesting’ semi-abstract argumentation graphs consistent with a collection of statement labellings. Finally, the framework is illustrated and evaluated with a proof-of-concept implementation. (shrink)

In this essay, Weinstein wants to address the issue of argument strength, of how strongly the premises of an argument support a conclusion. Using the framework of the Toulmin model, arguments have warrants which indicate some general connection between the premises and the conclusion of the argument. We may ask for the backing of the warrant, evidence for it. If the connection is an empirical generalization, the backing includes data supporting the generalization. But the backing may include theoretical generalizations, which (...) may explain the warrant. Furthermore, theories may be reduced by more comprehensive theories. A warrant then may ultimately be backed by some deep and very comprehensive theoretical explanation.Weinstein seeks to explicate the relation between the depth of backing for the warrant and the strength of the connection between premises and conclusion which the warrant indicates through the Model of Emerging Truth . Data relevant to confirming the theory have empir .. (shrink)

Discussion of epistemic responsibility typically focuses on belief formation and actions leading to it. Similarly, accounts of collective epistemic responsibility have addressed the issue of collective belief formation and associated actions. However, there has been little discussion of collective responsibility for preventing epistemic harms, particularly those preventable only by the collective action of an unorganized group. We propose an account of collective epistemic responsibility which fills this gap. Building on Hindriks' (2019) account of collective moral responsibility, we introduce the Epistemic (...) Duty to Join Forces. Our theory provides an account of the responsibilities of scientists to prevent epistemic harms during inquiry. (shrink)

This paper examines lessons obtained by means of simulations in the form of agent-based models about the norms that are to guide disagreeing scientists. I focus on two types of epistemic and methodological norms: norms that guide one’s attitude towards one’s own theory, and norms that guide one’s attitude towards the opponent’s theory. Concerning I look into ABMs that have been designed to examine the context of peer disagreement. Here I challenge the conclusion that the given ABMs provide a support (...) for the so-called Steadfast Norm, according to which one is epistemically justified in remaining steadfast in their beliefs in face of disagreeing peers. I argue that the proposed models at best provide evidence for a weaker norm, which concerns methodological steadfastness. Concerning I look into ABMs aimed at examining epistemic effects of scientific interaction. Here I argue that the models provide diverging suggestions and that the link between each ABM and the type of represented inquiry is still missing. Moreover, I examine alternative strategies of arguing in favor of the benefits of scientific interaction, relevant for contemporary discussions on scientific pluralism. (shrink)

In this paper I examine the epistemic function of agent-based models of scientific inquiry, proposed in the recent philosophical literature. In view of Boero and Squazzoni’s classification of ABMs into case-based models, typifications and theoretical abstractions, I argue that proposed ABMs of scientific inquiry largely belong to the last category. While this means that their function is primarily exploratory, I suggest that they are epistemically valuable not only as a temporary stage in the development of ABMs of science, but by (...) providing insights into theoretical aspects of scientific rationality. I illustrate my point with two examples of highly idealized ABMs of science, which perform two exploratory functions: Zollman’s ABM which provides a proof-of-possibility in the realm of theoretical discussions on scientific rationality, and an argumentation-based ABM, which provides insights into potential mechanisms underlying the efficiency of scientific inquiry. (shrink)

Formal models of scientific inquiry, aimed at capturing socio-epistemic aspects underlying the process of scientific research, have become an important method in formal social epistemology and philosophy of science. In this introduction to the special issue we provide a historical overview of the development of formal models of this kind and analyze their methodological contributions to discussions in philosophy of science. In particular, we show that their significance consists in different forms of ‘methodological iteration’ whereby the models initiate new lines (...) of inquiry, isolate and clarify problems with existing knowledge claims, and stimulate further research. (shrink)

Scientific research in the formal sciences comes in multiple degrees of formality: fully formal work; rigorous proofs that practitioners know to be formalizable in principle; and informal work like rough proof sketches and considerations about the advantages and disadvantages of various formal systems. This informal work includes informal and semi-formal debates between formal scientists, e.g. about the acceptability of foundational principles and proposed axiomatizations. In this paper, we propose to use the methodology of structured argumentation theory to produce a formal (...) model of such informal and semi-formal debates in the formal sciences. For this purpose, we propose ASPIC-END, an adaptation of the structured argumentation framework ASPIC+ which can incorporate natural deduction style arguments and explanations. We illustrate the applicability of the framework to debates in the formal sciences by presenting a simple model of some arguments about proposed solutions to the Liar paradox, and by discussing a more extensive—but still preliminary—model of parts of the debate that mathematicians had about the Axiom of Choice in the early twentieth century. (shrink)

Recent studies of scientific interaction based on agent-based models suggest that a crucial factor conducive to efficient inquiry is what Zollman has dubbed ‘transient diversity’. It signifies a process in which a community engages in parallel exploration of rivaling theories lasting sufficiently long for the community to identify the best theory and to converge on it. But what exactly generates transient diversity? And is transient diversity a decisive factor when it comes to the efficiency of inquiry? In this paper we (...) examine the impact of different conditions on the efficiency of inquiry, as well as the relation between diversity and efficiency. This includes certain diversity-generating mechanisms previously proposed in the literature, as well as some factors that have so far been neglected. This study is obtained via an argumentation-based ABM. Our results suggest that cautious decision-making does not always have a significant impact on the efficiency of inquiry while different evaluations underlying theory-choice and different social networks do. Moreover, we find a correlation between diversity and a successful performance of agents only under specific conditions, which indicates that transient diversity is sometimes not the primary factor responsible for efficiency. Altogether, when comparing our results to those obtained by structurally different ABMs based on Zollman’s work, the impact of specific factors on efficiency of inquiry, as well as the role of transient diversity in achieving efficiency, appear to be highly dependent on the underlying model. (shrink)

Recent studies of scientific interaction based on agent-based models suggest that a crucial factor conducive to efficient inquiry is what Zollman has dubbed ‘transient diversity’. It signifies a process in which a community engages in parallel exploration of rivaling theories lasting sufficiently long for the community to identify the best theory and to converge on it. But what exactly generates transient diversity? And is transient diversity a decisive factor when it comes to the efficiency of inquiry? In this paper we (...) examine the impact of different conditions on the efficiency of inquiry, as well as the relation between diversity and efficiency. This includes certain diversity-generating mechanisms previously proposed in the literature, as well as some factors that have so far been neglected. This study is obtained via an argumentation-based ABM. Our results suggest that cautious decision-making does not always have a significant impact on the efficiency of inquiry while different evaluations underlying theory-choice and different social networks do. Moreover, we find a correlation between diversity and a successful performance of agents only under specific conditions, which indicates that transient diversity is sometimes not the primary factor responsible for efficiency. Altogether, when comparing our results to those obtained by structurally different ABMs based on Zollman’s work, the impact of specific factors on efficiency of inquiry, as well as the role of transient diversity in achieving efficiency, appear to be highly dependent on the underlying model. (shrink)

Science advances by means of argument and debate. Based on a formal model of complex argumentation, this article assesses the interplay between evidential and inferential drivers in scientific controversy, and explains, in particular, why both evidence accumulation and argumentation are veritistically valuable. By improving the conditions for applying veritistic indicators , novel evidence and arguments allow us to distinguish true from false hypotheses more reliably. Because such veritistic indicators also underpin inductive reasoning, evidence accumulation and argumentation enhance the reliability of (...) inductive inference, for example, inference to the best explanation. 1 Introduction2 Theory of Dialectical Structures3 Debate Simulations4 From Evidence and Arguments to Truth: The First Route5 From Evidence to Truth: The Second Route6 Conclusion. (shrink)

Scientific reasoning represents complex argumentation patterns that eventually lead to scientific discoveries. Social epistemology of science provides a perspective on the scientific community as a whole and on its collective knowledge acquisition. Different techniques have been employed with the goal of maximization of scientific knowledge on the group level. These techniques include formal models and computer simulations of scientific reasoning and interaction. Still, these models have tested mainly abstract hypothetical scenarios. The present thesis instead presents data-driven approaches in social epistemology (...) of science. A data-driven approach requires data collection and curation for its further usage, which can include creating empirically calibrated models and simulations of scientific inquiry, performing statistical analyses, or employing data- mining techniques and other procedures. -/- We present and analyze in detail three co-authored research projects on which the thesis’ author was engaged during her PhD. The first project sought to identify optimal team composition in high energy physics laboratories using data-mining techniques. The results of this project are published in (Perović et al. 2016), and indicate that projects with smaller numbers of teams and team members outperform bigger ones. In the second project, we attempted to determine whether there is an epistemic saturation point in experimentation in high energy physics. The initial results from this project are published in (Sikimić et al. 2018). In the thesis, we expand on this topic by using computer simulations to test for biases that could induce scientists to invest in projects beyond their epistemic saturation point. Finally, in previous examples of data-driven analyses, citations are used as a measure of epistemic efficiency of projects in high energy physics. In order to additionally justify and analyze the usage of this parameter in their data-driven research, in the third project Perović & Sikimić (2019) analyzed and compared inductive patterns in experimental physics and biology with the reliability of citation records in these fields. They conclude that while citations are a relatively reliable measure of efficiency in high energy physics research, the same does not hold for the majority of research in experimental biology. -/- Additionally, contributions of the author that are for the first time published in this theses are: (a) an empirically calibrated model of scientific interaction of research groups in biology, (b) a case study of irregular argumentation patterns in some pathogen discoveries, and (c) an introductory discussion of the benefits and limitations of data- driven approaches to the social epistemology of science. Using computer simulations of an empirically calibrated model, we demonstrate that having several levels of hierarchy and division into smaller research sub-teams is epistemically beneficial for researchers in experimental biology. We also show that argumentation analysis in biology represents a good starting point for further data-driven analyses in the field. Finally, we conclude that a data-driven approach is informative and useful for science policy, but requires careful considerations about data collection, curation, and interpretation. (shrink)