Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

Branner, H.C. Humanismens krise.--Hansen, Martin A. Eneren og massen.

A novel Protocol Ethics Tool Kit (‘Ethics Tool Kit’) has been developed by a multi-stakeholder group of the Multi-Regional Clinical Trials Center of Brigham and Women9s Hospital and Harvard. The purpose of the Ethics Tool Kit is to facilitate effective recognition, consideration and deliberation of critical ethical issues in clinical trial protocols. The Ethics Tool Kit may be used by investigators and sponsors to develop a dedicated Ethics Section within a protocol to improve the consistency and transparency between clinical trial (...) protocols and research ethics committee reviews. It may also streamline ethics review and may facilitate and expedite the review process by anticipating the concerns of ethics committee reviewers. Specific attention was given to issues arising in multinational settings. With the use of this Tool Kit, researchers have the opportunity to address critical research ethics issues proactively, potentially speeding the time and easing the process to final protocol approval. (shrink)

Self-harm is a potentially lethal symptom of borderline personality disorder (BPD) that often improves with dialectical behavior therapy (DBT). While DBT is effective for reducing self-harm in many patients with BPD, a small but significant number of patients either does not improve in treatment or ends treatment prematurely. Accordingly, it is crucial to identify factors that may prospectively predict which patients are most likely to benefit from and remain in treatment. In the present preliminary study, twenty-nine actively self-harming patients with (...) BPD completed brain-imaging procedures probing activation of the prefrontal cortex during impulse control prior to beginning DBT and after seven months of treatment. Patients that reduced their frequency of self-harm the most over treatment displayed lower levels of neural activation in the bilateral dorsolateral prefrontal cortex prior to beginning treatment, and they showed the greatest increases in activity within this region after seven months of treatment. Prior to starting DBT, treatment non-completers demonstrated greater activation than treatment-completers in the medial prefrontal cortex and right inferior frontal gyrus. Reductions in self-harm over the treatment period were associated with increases in activity in right dorsolateral prefrontal cortex even after accounting for improvements in depression, mania, and BPD symptom severity. These findings suggest that pre-treatment patterns of activation in the prefrontal cortex underlying impulse control may be prospectively associated with improvements in self-harm and treatment attrition for patients with BPD treated with DBT. (shrink)

There are few moments in human history where the forces of religion, culture and politics converge to produce some of the most significant philosophical ideas in the world. India in the early 20thcentury was one of these moments, where we saw the rise of activist-thinkers like Nehru, Jinnah and Gandhi; individuals who not only liberated human lives but their minds as well. One of most influential members of the group was the poet-philosopher Muhammad Iqbal. Commonly known as the "spiritual father (...) of Pakistan", the philosophical and political ideas of Iqbal not only shaped the face of Indian Muslim nationalism but also shaped the direction of modernist reformist Islam around the world. Bringing together a diverse number of prominent and emerging scholars, from backgrounds in political science, philosophy and religious studies, this book offers novel examinations of the philosophical ideas that laid at the heart of Iqbal's own As such, by producing new developments in research on Iqbal's thought from a diversity of prominent and emerging voices within American and European Islamic studies, this text will offer new and novel examinations of the ideas that lies at the heart of Iqbal's own thought: religion, science, metaphysics, nationalism and religious identity. In our text, the reader will (re)discover many new connections between the "Sage of the Ummah" to the greatest thinkers and ideas of European and Islamic philosophies. (shrink)

The fundamental tenet of contemporary sociobiology, namely the assumption of a single process of evolution involving the selection of genes, is critically examined. An alternative multiple-level, multiple-process model of evolution is presented which posits that the primary process that operates via selection upon the genes cannot account for certain kinds of biological phenomena, especially complex, learned, social behaviours. The primary process has evolved subsidiary evolutionary levels and processes that act to bridge the gap between genes and these complex behaviours. The (...) subsidiary levels are development, individual animal learning, and socioculture itself. It is argued that individual learning is pivotal to the derivation and biological analysis of culture. The differences between cultural and noncultural societies are stressed. It is concluded that such a multiple-level model of evolution can form the basis for reconciling opposing sides in the sociobiology debate. (shrink)

In describing the account of the εδη in the Phaedo, Burnet says, ‘they are explained in a peculiar vocabulary which is represented as that of a school. The technical terms are introduced by such formulas as “we say”’. Similarly Taylor has written of the ‘characteristic technical nomenclature’ used in the dialogues, of the ‘technicalities’ of the theory of εδη, of ‘the technical phrases of the Phaedo’ The validity of such language has been taken for granted by both these and many (...) other Platonic scholars. But the assumption which it represents—that Plato employed certain words in a significance peculiar to his use of them—carries such wide implications for the history and interpretation of his philosophy that it can hardly be accepted without further investigation. In this article I shall examine the evidence in fifth- and early fourth-century literature about these words which Plato or Socrates is alleged to have transformed into ‘technicalities’: first, εδος and δσ, which I shall assume to be more or less synonymous; second, the various terms used to describe the relation between εδη and particulars—,μετέχειν, κοινωνεν,παρεναι, νεναι,μιμησις,μοιωαις, and so on. (shrink)

This article is a survey of familiar ground—those passages of the Poetics of Aristotle which throw light on the treatment of legend by the tragic poets. Although sweeping generalizations are often made on the use of the traditional stories in drama, our evidence on the subject is slight and inconclusive. We have little knowledge of the form in which most of the legends were known to the Attic playwrights, for the few we find in the Iliad and Odyssey appear there (...) in very different versions from those they take on in the plays, and the fragmentary remains of epic and lyric poetry between Homer and the fifth century B.C. present us with a wide field for speculation, but few certain facts; while vase paintings and other works of art supplement only here and there the scanty information gained from literature.The comments of ancient writers on this aspect of tragedy are surprisingly few, and carry us little farther. The Poetics stands out as the one source from which we can draw any substantial account of the matter. Even Aristotle, of course, is not directly concerned with the history of drama, and deals with it only incidentally in isolated passages; and in considering these it must constantly be borne in mind that he is discussing tragedy as he knew it in the late fourth century, for the benefit of fourth-century readers. But even so, his statements are the main foundation on which our view of the dramatists' use of legend must be built. (shrink)

resumenEl ensayo trata de resaltar diversos aspectos promisorios y progresistas contenidos en el llamado orden premoderno y en la época anterior a la Primera Guerra mundial. Entre estos factores se hallaban la configuración de una estructura familiar sólida, la existencia de individualidades fuertes con concepciones firmes sobre la ética cotidiana y una cultura todavía alejada del relativismo axiológico a ultranza. Esta era del liberalismo clásico se diferenciaba del actual “capitalismo volátil”, caracterizado por su narcisismo autorreferencial y sus tendencias tecnocráticas. A (...) lo positivo del mundo de ayer contribuyó una aristocracia con algunos rasgos premodernos, que reconocía los límites que nos imponen el entorno natural y las carencias humanas.Palabras clave:alta cultura, aristocracia, límites, modernidad, tradicionalidadThe essay tries to detect some promising and progressive aspects which were embodied in the so-called premodern order and in the time previous to the First World War. Among those factors we can mention a solid familiar structure, the existence of strong individualities with firm conceptions about the daily sphere of ethics and a high culture, which was still very distant from the actual and extreme relativism of values. That time of classical liberalism was very different in comparison with the actual “volatile capitalism”, which is characterized by selfrefering narcissism and technocratic tendencies. A contribution to the positive aspects of the world of yesterday was done by an aristocracy, which acknowledged the limits fixed upon us by the natural environment and the human failures.Key words:high culture, aristocracy, limits, modernity, traditionality. (shrink)

ResumenBasado en elementos de la filosofía clásica, el common sense británico y la Escuela de Frankfurt, el autor postula un sentido común guiado críticamente, que serviría para evaluar las tendencias históricas y los modelos de modernización en el Tercer Mundo. Evitando extremos, este teorema rechazaría tanto las pretensiones de verdad de muchos enfoques racionalistas como el relativismo epistemológico y ético. La existencia de leyes y etapas obligatorias de la historia es uno de esos extremos; otro es la opción teórica que (...) afirma que los modelos culturales son incomparables e inconmensurables entre sí. La existencia de un solo paradigma normativo-positivo de desarrollo es insostenible, pero igualmente la posición que decreta la diversidad e incomparabilidad totales de los regímenes civilizatorios. Es conveniente adoptar una línea intermedia entre universalismo y particularismo y alcanzar una síntesis fructífera de ambos.Palabras claveEscuela de Frankfurt, Habermas, Kant, particularismo, sentido común, universalismoAbstractBased on elements of classical philosophy, the British common sense and the Frankfurt School, the author proposes a critically guided common sense, which could be used to evaluate historical tendencies and specially the modernization efforts in the Third World. Avoiding extremes, this theorem rejects the pretensions of truth of rationalist theories and also the epistemic and ethic relativism. The existence of obligatory laws and periods of historical development is one of these extremes; the other one is the position which states that cultural models are incomparable and immeasurable. It is reasonable, for instance, to take a middle way between universalism and particularism and also to reach a fruitful synthesis between both currents.KeywordsCommon sense, Frankfurt School, Habermas, Kant, particularism, universalism. (shrink)

RESUMENUn intento por comprender la realidad sociopolítica podría consistir en situarse entre posiciones que marcan polos opuestos en el espectro de las ideas. Desde la filosofía griega se conocen las bondades y desventajas de colocarse en puntos intermedios que se hallan entre actitudes extremas en lo concerniente a asuntos morales y sociales. Una de las respuestas plausibles es una forma de eclecticismo, que tendría la función de una síntesis fructífera. Este teorema del sentido común guiado críticamente se asienta en concepciones (...) filosóficas clásicas, incluyendo la Escuela de Frankfurt. El ensayo pone como ejemplo principal el tratamiento de las utopías políticas.PLABARAS CLAVEARISTÓTELES, HABERMAS, HEGEL, SENTIDO COMÚN, TEORÍA CRÍTICA, UTOPÍAABSTRACTAn effort to understand the social-political reality could consist in taking a position between opposite poles in the spectrum of ideas. The advantages and disadvantages of placing oneself midway between extreme attitudes concerning moral and social problems have been aknowledged since Greek philosophy. A plausible answer is a form of eclecticism, which could have the function of a fertile synthesis. This theorem of a critically guided common sense is based on classic philosophic conceptions, including the Frankfurt School. This essay sets the analysis of political utopias as a main example.KEY WORDSARISTOTLE, COMMON SENSE, CRITICAL THEORY, UTOPY. (shrink)

Originally published in 1918, this book contains edited English translations of French texts written by the Jansenist inhabitants of Port-Royal during the seventeenth century. Barnard provides an introduction with historical background to the state of education in France at the time, and annotates each translation with pertinent historical and literary references. This book will be of value to anyone with an interest in the history of education and the history of faith schools.

The manuscript traditions of Hesiod’s Theogony and Works and Days are well understood, but for the third poem of the Byzantine triad, the pseudo-Hesiodic Scutum, our knowledge remains imperfect. As a contribution to this subject, two neglected manuscripts of the poem are collated. Their relationship to one another is discussed, and their importance to an editor for the constitution of the text is assessed. In addition, new observations are made about the stemma codicum.