Alternative cleavage and polyadenylation (APA) can diversify coding and non‐coding regions, but has particular impact on increasing 3′ UTR diversity. Through the gain or loss of regulatory elements such as RNA binding protein and microRNA sites, APA can influence transcript stability, localization, and translational efficiency. Strikingly, the central nervous systems of invertebrate and vertebrate species express a broad range of transcript isoforms bearing extended 3′ UTRs. The molecular mechanism that permits proximal 3′ end bypass in neurons is mysterious, and only (...) beginning to be elucidated. This landscape of neural 3′ UTR extensions, many reaching unprecedented lengths, may help service the unique post‐transcriptional regulatory needs of neurons. A combination of approaches, including transcriptome‐wide profiling, genetic screening to identify APA factors, biochemical dissection of alternative 3′ end formation, and manipulation of individual neural APA targets, will be necessary to gain fuller perspectives on the mechanism and biology of neural‐specific 3′ UTR lengthening. (shrink)

El presente trabajo hace un análisis de la corta narración “decisión ante el trapecio”, escrita por el autor con motivo de la vida y obra del novelista Franz Kafka. Con ello se invita al lector ha reconocer en la aplicación del método (o enfoque) fenomenológico del “Análisis reflexivo”, una herramienta conceptual importante para lograr una mejor comprensión de las relaciones entre el arte y la filosofía. La soledad, el solipsismo y obviamente “las relaciones con el Otro”, son temas recurrentes tanto (...) a la literatura como a la fenomenología de Husserl, y por este motivo se propone el análisis partiendo de la narración literaria. (shrink)

La Orientación Educativa en la Enseñanza Reglada.

Purpose The purpose of this paper is to propose an e-business assessment framework for organizations that aim to enhance the effectiveness of their online presence and maximize the benefits that result from it. The framework is based on three main pillars derived from the academic literature research: e-marketing strategies, customer relationship management strategies and business model strategies. Design/methodology/approach This paper reviews the literature from e-Marketing, CRM and business model strategies, leading to the generation of an e-Business assessment framework. Second, it (...) takes 19 case studies and analyzes them using ATLAS.ti, through qualitative content analysis, to validate that framework. Findings Pragmatic advice for practitioners derives from research results considering that this framework enables managers to characterize the company in terms of its e-business approach, making it possible to determine the level of depth of competitive online strategies. Lessons for an improved e-business approach can be derived from this paper. Originality/value This study proposes a novel e-business framework to assist organizations that want to have an online presence. This framework is comprised of the factors identified in the literature review that contribute to define and scope that online presence. The framework is then validated through the collection of 19 case studies of companies that have this online presence, validating the theoretical findings. (shrink)

En este artículo, trato de mostrar la pertinencia de Fenomenología de la percepción para responder a los desafíos de la filosofía en un mundo, a la vez, desgarrado y globalizador. Si dejamos de lado la dimensión teorética del mundo, recuperamos el fondo oscuro de la existencia, fondo de todos los espacios. Se trataría de un espacio primigenio en el que se encuentra el vínculo afectivo que es el propio de la experiencia de los niños y los primitivos. Lo vivido de (...) estos espacios implica empero una pérdida del espacio de juego gracias al cual «hay mundo», como apertura y posibilidad de intersubjetividad. Pero la respuesta ante el psicologismo de Merleau-Ponty supone un giro respecto a la filosofía tradicional al conseguir mantener cercana a su conciencia las conciencias otras del esquizofrénico o del niño. (shrink)

El artista chileno José Miguel Blanco tuvo un rol protagónico en la escena cultural del país durante la segunda mitad del siglo XIX. Aparte de su labor escultórica, traducida en una cantidad importante de obras, una buena parte de su quehacer estuvo vinculado con la escritura de arte, lo que se materializó, principalmente, en el periódico El Taller Ilustrado, el primer medio informativo en el país dedicado exclusivamente a temas de arte, que este escultor creó y dirigió por casi cinco (...) años. Desde esa tribuna Blanco promovió información, debates e iniciativas que favorecieron el desarrollo cultural del país. Este escultor es, sin lugar a dudas, el autor más prolífico en la escritura artística chilena de su tiempo. The Chilean artist José Miguel Blanco had a protagonic role in the culture scene in the country during the second half of the 19th century. Besides his works of sculpture, reflected in an important quantity of pieces of art, a great part of his work was related to the Artistic Writing, which was materialized, mainly in the newspapers called El Taller Ilustrado, the first informative media in the country dedicated exclusively to the topics of Art, that this sculptor created and managed for almost five years. From this tribune, Blanco promoted information, debates and initiatives that contributed to the development of culture in Chile. The sculptor is, without any doubt, the most prolific author in Chilean Artistic Writing in his time. (shrink)

El vídeo fue considerado por Gene Youngblood (1979) como un nuevo medio de creación artística, cuyos códigos abrirán nuevas perspectivas a la imagen en movimiento dándole entidad estética propia. Se analiza diversas teorías relacionadas con la comunicación y el arte de autores como Wiener, Benjamin, Brecht, McLuhan, Burris. Así mismo estudia obras pioneras y el uso del feedback loop como elemento de retroalimentación entre emisor receptor. Wipe Cycle (1969) de Frank Gillette e Ira Schneider y Time Delay Room (1974) de (...) Dan Graham nos mostrarán las claves para entender el funcionamiento interno de un nuevo medio que acababa de nacer. (shrink)

En la literatura árabe islámica pueden rastrearse diversos textos en torno a personajes de la Historia de Salvación que pleitean o discuten con la divinidad, como Adán y Eva, Moisés, ʿUzayr / Ezra y hasta el mismo profeta Muhammad. Dichos textos, dispersos en diversas fuentes árabes medievales, representan la recepción fragmentaria y discontinua que la rica literatura de debate medioriental tuvo en el imaginario religioso islámico, desde los textos sumerios y acadios hasta el género literario hebreo de la disputa o (...) rīb, así como la apocalíptica apócrifa judeocristiana. (shrink)

We give an account of stable reasoning, a recent and novel approach to problem solving from a formal, logical point of view. We describe the underlying logic of stable reasoning and illustrate how it is used to model different domains and solve practical reasoning problems. We discuss some of the main differences with respect to reasoning in classical logic and we examine an ongoing research programme for the rational reconstruction of human knowledge that may be considered a successor to the (...) logical empiricists’ programme of the mid-twentieth century. (shrink)

En este artículo retomo la discusión con Pérez Otero sobre la interpretación de Wittgenstein. Defiendo la tesis de que el análisis gramatical de Wittgenstein implica que las atribuciones de comprensión y seguimiento de reglas poseen un carácter retrospectivo, en línea con el análisis de la gramática de “capacidad”, que atribuye “estados” a los objetos a partir de sus efectos. Indico que esta tesis no desemboca en una concepción antirrealista incoherente, ya que es parte integral del factualismo deflacionario que caracteriza a (...) la “solución escéptica” propuesta por Kripke en su interpretación de Wittgenstein. En contraste, destaco la inconsistencia de las posiciones que intentan limitar su momento antirrealista a la crítica a las condiciones de verdad mentalistas subjetivistas. Analizo las dificultades de esta concepción para elucidar el concepto de criterio y muestro cómo una elucidación escéptica de este concepto evita estas dificultades. (shrink)

Postulating that Pope Francis continues the unfinished agenda of the Second Vatican Council, the authors propose, through bibliographical analysis, a re-reading of three important texts, showing their relationship with the pontificate of Francis, from the perspective of the conciliar reception: the document still little considered of the Pact of the Catacombs is rescued but inseparable from the council and its reception, especially in our continent, revealing a path of conversion and commitment of the Church of the poor and for the (...) poor; next, some aspects of the two dogmatic constitutions of the council are analyzed, Dei Verbum and Lumen Gentium, important matrices for the current pontificate, in its dynamics of reform, aggiornamento, and renewal. In the end, concrete resins in Francis' words, gestures and attitudes can be seen in the texts thematic axes: the principle of pastorality, the centrality of the Gospel, and the displacement of a Church in the process of exit from itself, aspects required that documents end up revealing are agendas still open in the 21st century. (shrink)

In this paper, I examine phenomenologically the structure of the normative noema, which I call the “nomothetic noema.” I distinguish the meaning content, its normative characters, which I call “ductive forces”, and its modes of givenness. Next, I introduce the traditional difference between modalities de re and de dicto. I argue that the current tendency, in deontic logic, to treat deontic expressions as operators over sentences induces, at least on the syntactic surface, a de dicto reading. I then discuss some (...) of the theoretical decisions that underlie deontic logic, starting from two basic asymmetries between modal alethic logic and deontic logic. The decisive point is to recover a strong sense of permission that I equate with the factor of free agency, which is difficult to formalize. Finally, I return to the analysis of the nomothetic noema and try to show how a de re reading is better suited to account for normative intentionality. I simultaneously introduce the concept of status-imposing norms, which must be formulated with a normative use of the copulas “is” and “has.” I conclude that the treatment of normative expressions is more appropriate when they are understood as complex copulas, irreducible to assertive sentences, rather than as operators over whole sentences. I emphasize on this occasion that, from a phenomenological point of view and within the framework of genetic analysis, the primitive basic datum is the freedom of agency, on which the normative domain of assigning statuses to agents, obligations, and prohibitions is built. (shrink)

In this paper I discuss Berkeley’s theories about vision, perception of distance, and the foundations of Geometry. I start with Locke’s answer to Molineaux’s problem and the criticisms Berkeley addressed to it. I explain the fundamentais of Berkeley’s theory about our cognitive shaping of the visual field and the type of connections that visual data establishes with data from the haptic field. I show how interesting are Berkeley’s conceptions for a phenomenology of perception, and, eventually, I carried some phenomenological evidence (...) against Berkeley’s too much strict location of the idea of distance in the haptic field alone. (shrink)