Cas9/guide RNA (gRNA)‐based gene drive systems are expected to play a transformative role in malaria elimination efforts., whether through population modification, in which the drive system contains parasite‐refractory genes, or population suppression, in which the drive system induces a severe fitness load resulting in population decline or extinction. DNA sequence polymorphisms representing alternate alleles at gRNA target sites may confer a drive‐resistant phenotype in individuals carrying them. Modeling predicts that, for observed levels of SGV at potential target sites and observed (...) rates of de novo DRA formation, population modification strategies are uniquely resilient to DRAs. We conclude that gene drives can succeed when fitness costs incurred by drive‐carrying mosquitoes are low enough to prevent strong positive selection for DRAs produced de novo or as part of the SGV and that population modification strategies are less prone to failure due to drive resistance. (shrink)

A modified flanker task was used to assess the effects of spatial attention during conscious and nonconscious processing. In line with prior findings, we demonstrated that increasing spatial separation between flankers and probes diminished the differences between reaction times to the incongruent and congruent probe–flanker pairs. This trend occurred even when the identity of flankers was suppressed from awareness by a metacontrast mask, indicating that spatial attention can be allocated to information processed at the nonconscious, in addition to the conscious, (...) levels, that effects of spatial attention at these two levels can be equivalent, and that attention deployed at the nonconscious level of processing can be characterized by a spatial gradient that is nearly identical to that found at the conscious level of processing. (shrink)

This article analyzes ‘commemorative’ images of Diana Spencer for how they invoke tropes of charity and sympathy to produce racialized mediations of history, memory, motherhood and US national identity. Drawing from cultural theory that establishes technologies of memory and forgetting as material forces, this discussion illumines how images of Diana appearing in such popular US magazines as People and Life incorporate visual scripts of race and sentiment that have historically demarcated the relative social value(s) of maternity and reproduction. Understanding visual (...) culture as a force that is both structured by and structuring of hierarchies of power enables us to see how the posthumous circulation of images of ‘Our Princess’ are indeed not ideologically innocent memorializations. Rather, these images are the physical, embodied material of a national monument that provides faithful ‘visitors’ an affective connection to historically idealized notions of whiteness, motherhood, and the family. (shrink)

Since there are so few controls over detecting and preventing faculty misconduct, one of the most common ways in which it is discovered is through student reports. Given the importance of student reports in bringing to light faculty’s ethical lapses, this paper seeks to understand what factors influence students’ likelihood to report faculty misconduct. We develop an empirical model that integrates the decision process of the Prosocial Organizational Behavior Model with insights from the emotional perspective on whistleblowing. Specifically, we use (...) an experimental survey to examine how students’ perceived unfairness of the faculty misconduct, feelings of anger, and the students’ self-interest in the situation in conjunction with situational “cues for inaction” lead to the intention to blow the whistle. Overall, the results from our structural model partially support our theoretical model. Interestingly, these findings demonstrate that, in the case of faculty member misconduct, anger and perceptions of unfairness play a greater role than the more rational cost-benefit process of the POB model. These results could aid in development of ethics education for students and could also inform the development of university policies that encourage students to come forward when faced with faculty misconduct. (shrink)

Parental burnout is a unique and context-specific syndrome resulting from a chronic imbalance of risks over resources in the parenting domain. The current research aims to evaluate the psychometric properties of the Spanish version of the Parental Burnout Assessment across Spanish-speaking countries with two consecutive studies. In Study 1, we analyzed the data through a bifactor model within an Exploratory Structural Equation Modeling on the pooled sample of participants obtaining good fit indices. We then attained measurement invariance across both gender (...) and countries in a set of nested models with gradually increasing parameter constraints. Latent means comparisons across countries showed that among the participants’ countries, Chile had the highest parental burnout score, likewise, comparisons across gender evidenced that mothers displayed higher scores than fathers, as shown in previous studies. Reliability coefficients were high. In Study 2, we tested the relations between parental burnout and three specific consequences, i.e., escape and suicidal ideations, parental neglect, and parental violence toward one’s children. The medium to large associations found provided support for the PBA’s predictive validity. Overall, we concluded that the Spanish version of the PBA has good psychometric properties. The results support its relevance for the assessment of parental burnout among Spanish-speaking parents, offering new opportunities for cross-cultural research in the parenting domain. (shrink)

Health‐related data uses and data sharing have been in the spotlight for a while. Since the beginning of the big data era, massive data mining and its inherent possibilities have only increased the debate about what the limits are. Data governance is a relevant aspect addressed in ethics guidelines. In this context, the European project BRIDGE Health (BRidging Information and Data Generation for Evidence‐based Health policy and research) strove to achieve a comprehensive, integrated and sustainable EU health‐information system. One of (...) the aims of the project was to evaluate the requirements to construct a data‐linkage infrastructure for the secure management of health information. In a blueprint provided for this infrastructure, the topics ethics and the intimately related governance occupied a whole section, where the recent ethics guidelines by the Council for International Organizations of Medical Sciences (CIOMS) and the World Medical Association (WMA) were referenced. We explore what has changed in the latest versions of the ethics documents adopted by CIOMS and WMA regarding the management of health data and human tissues, the appropriateness of their application in new forms of research and infrastructures as the proposed in the BRIDGE Health project, and whether society should be so concerned about this topic, in the digital era of social exchange. (shrink)

Running marathons is an increasingly popular activity with an ever-increasing number of events and participants. Many participants declare that they pursue a variety of goals by running, namely, the maintenance of good health, the development of strength and improvement of fitness, the management of emotions, and the achievement of resilience and psychological wellbeing. The research has examined marathon running, like many other sports, and has studied various factors that reduce athletic performance, such as the experience of anxiety, and that enhance (...) such performance, such as an increase in general wellbeing. This article reports the results of a study on the experience of competitive anxiety among 238 male marathon runners who participated in Seville’s 26th Marathon race on February 23, 2020, and investigates the relationship between anxiety and key dimensions of wellbeing as measured by the Spanish-adapted 20-item PWB Scale. We hypothesized that participating athletes who rated high on the dimensions of PWB would experience lower levels of competitive anxiety with respect to this race. We also proposed that PWB would function as a mediating factor with respect to the experience of anxiety. The results show, as hypothesized, that marathon running enhances wellbeing and reduces anxiety. The data showed significant negative correlations between four of five wellbeing dimensions and the three types of anxiety measured, namely, somatic anxiety, worry, and concentration-impairing anxiety. Other findings supported our hypothesis that wellbeing, as measured, functions as a mediating factor for the moderation of competitive anxiety. Generalization of these findings is limited by the fact that the low number of female participants recruited did not permit valid statistical analyses in this respect. It is known that both anxiety and wellbeing are subjects to variation by gender. The future inclusion of male and female subjects in equivalent studies will undoubtedly add valuable information concerning the dynamics of anxiety and wellbeing. The implications of these findings and the limitations of the study will be discussed. (shrink)

Este artículo busca delinear el papel activo que tuvo la Iglesia católica y sus directrices sobre la cinematografía, en la renovación del documental chileno en las décadas del 50 y el 60. En particular, el trabajo de asimilación y divulgación de este ideario, que realiza un grupo de sacerdotes jesuitas responsables de la redacción de revista Mensaje y su gravitación en la producción documental universitaria, impulsada por Rafael Sánchez en el Instituto Fílmico de la Universidad Católica de Chile, a partir (...) de 1955. El presente trabajo examina estas directrices, y sus eventuales efectos en dos ámbitos específicos de interés: la reflexión y divulgación de las posturas de la Iglesia católica sobre el cine en la revista Mensaje, y en el ámbito de la práctica cinematográfica, específicamente en la producción de documentales de Rafael Sánchez. (shrink)

Membership in voluntary organizations is associated with individual and social benefits. Due to the negative consequences of the global pandemic on older people, and the governmental challenges posed by population aging, voluntary membership is of great importance to society. To effectively promote volunteering among older people, it is necessary to understand the determinants of voluntary membership. This study analyses the influence of individual values—secular/traditional and survival/self-expression–on voluntary membership among European adults. Specifically, it examines which values orient two age groups, as (...) well as men and women toward a certain type of association. The sample of 31,985 comprises 60% of adults aged 50–64 and 40% aged 65–79; of which 56% are women and 44% men. The empirical estimation considers different levels of data aggregation: individual, national and welfare system, therefore multilevel analysis is used as an analytical strategy. Individual-level variables from the Integrated Values Survey and national-level variables from the World Bank and Eurostat are used. The results indicate that traditional and self-expression values promote membership in voluntary organizations in general more than secular and survival values. However, there are differences according to the type of organization. Furthermore, values are found to moderate the effect of age and gender on voluntary membership. (shrink)

Este artículo realiza un análisis léxico-semántico de la terminología irreligiosa en la literatura griega. Se ha seleccionado un término clave y un autor relevante a fin de ilustrar la importancia del fenómeno irreligioso en la sociedad de Época Clásica. El adjetivo ὅσιος describe el respeto religioso en acciones y actitudes hacia las divinidades y también hacia otros seres humanos. Sófocles usa la forma privativa ἀνόσιος en contextos donde falta ese respeto religioso, con consecuencias negativas para la polis.

© The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved.Cell walls of grasses, including cereal crops and biofuel grasses, comprise the majority of plant biomass and intimately influence plant growth, development and physiology. However, the functions of many cell wall synthesis genes, and the relationships among and the functions of cell wall components remain obscure. To better understand the patterns of cell wall accumulation and identify genes that act in grass (...) cell wall biosynthesis, we characterized 30 samples from aerial organs of rice at 10 developmental time points, 3-100 d post-germination. Within these samples, we measured 15 cell wall chemical components, enzymatic digestibility and 18 cell wall polysaccharide epitopes/ligands. We also used quantitative reverse transcription-PCR to measure expression of 50 glycosyltransferases, 15 acyltransferases and eight phenylpropanoid genes, many of which had previously been identified as being highly expressed in rice. Most cell wall components vary significantly during development, and correlations among them support current understanding of cell walls. We identified 92 significant correlations between cell wall components and gene expression and establish nine strong hypotheses for genes that synthesize xylans, mixed linkage glucan and pectin components. This work provides an extensive analysis of cell wall composition throughout rice development, identifies genes likely to synthesize grass cell walls, and provides a framework for development of genetically improved grasses for use in lignocellulosic biofuel production and agriculture. (shrink)

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.

Este artículo busca delinear el papel activo que tuvo la Iglesia católica y sus directrices sobre la cinematografía, en la renovación del documental chileno en las décadas del 50 y el 60. En particular, el trabajo de asimilación y divulgación de este ideario, que realiza un grupo de sacerdotes jesuitas responsables de la redacción de revista Mensaje y su gravitación en la producción documental universitaria, impulsada por Rafael Sánchez en el Instituto Fílmico de la Universidad Católica de Chile, a partir (...) de 1955. El presente trabajo examina estas directrices, y sus eventuales efectos en dos ámbitos específicos de interés: la reflexión y divulgación de las posturas de la Iglesia católica sobre el cine en la revista Mensaje, y en el ámbito de la práctica cinematográfica, específicamente en la producción de documentales de Rafael Sánchez. (shrink)

Since the mid-20th century, the study of Self-Regulated Learning has aimed to identify the distinctive characteristics that enable individuals to acquire new knowledge and skills under their control. The theory of Internal Self-Regulation vs. External-Regulation in Learning has postulated that a large number of self-regulatory variables are mediated by regulated/non-regulated or dysregulated features of the context. After signing their informed consent, a total of 616 university students completed validated instruments of SRL vs. ERL, behavioral regulation, regulatory teaching, and metacognitive study (...) control strategies. Using an ex-post facto design and correlation, regression, structural equation model and mediation analyses, the present research aimed to establish multicausal predictive relationships among the analyzed variables. Results indicated positive predictive effects between the external regulation variables on the self-regulation variables in learning [regulation /non-regulation /dysregulation ]; as well as positive predictive effects between SRL on SRB, RT and metacognitive SRS. Additionally, external regulation not only predicted but mediated numerous relations among the variables studied. Other findings and important considerations for future research in the field of self-regulation are discussed. (shrink)

The theory of separation assumes, with provocation, that an organization cannot reconcile profits and social function. Organizations can reconcile these two, apparently contrasting, missions, by considering emotions, especially moral emotions, to create a genuine motivation for focusing on goals beyond simple economic earnings and protecting organizations or groups of people from dysfunctional attitudes and behaviors, as well as considering the important role of the stakeholder accountability. Using the PRISMA method, we created a review of records using keywords relating to a (...) socio-emotional value within organizations, with a particular focus on the last 20 years. We used the SCOPUS database and, after removing irrelevant records, we used the VOSviewer tool to create a cluster map of different areas in this topic. Some records cite the socio-emotional value that is related to organizational and employee suffering, while other articles consider it a positive factor that improves performance and prevents problems in organizations. (shrink)

El texto propone una nueva interpretación para la descripción que realiza Tácito ( _Ann_. 2.60-61) del viaje por Egipto de Germánico (19 d. C.). El autor establece paralelos de este texto con las _Historias_ de Heródoto para definir una intención teórica en el mismo. Tácito utiliza este episodio egipcio para reflexionar sobre los métodos y las posibilidades de alcanzar certezas por medio del discurso histórico.

Artículos Naturaleza, carácter y violencia: derivas a partir de Schopenhauer. Nature, character and violence: roads from Schopenhauer. Grave, Crescenciano Sobre la posibilidad de un fundamento analógico y simbólico. Ensayo de hermenéutica analógica. About the possibility of an analogical and symbolic fundament. Essay of analogical hermeneutic.Maldonado, Rebeca Consideraciones biojurídicas sobre la vida en el embrión humano. Biojuridical considerations on life of the human embryo. Parra Tapia, Ivonne La Europa unificada según Leibniz: irenismo y política. A unified Europe according to Leibniz: (...) irenism and politics. Rensoli Laliga, Lourdes Repensar el "dilema" comunitarista-liberal en Venezuela. To rethink the communitarism-liberalism "dilemma" in Venezuela. Seoane C., Javier B. Una introducción a la doctrina platónica del alma. An introduction to the platonic doctrine of the soul. Suzzarini, Andrés De vuelta al tribuno. Back to the tribune. Terán Pimentel, Milagros Discusiones en torno a la reparación del daño moral. Discussions about the redress of pain and suffering. Vielma Mendoza, Yoleida Interdisciplinares El giro en la obra de Milan Kundera: un reflejo de la contemporaneidad. The turning on Milan Kundera´s work: a reflex of contemporaneity. Pérez Lo Presti, Alirio Aproximación histórica sobre el consumo de drogas en Venezuela. Historical approach about drug consumption in Venezuela. Salazar, Teresa Informaciones Índice acumulado. (shrink)

A la luz de la propuesta arendtiana de espacio público, en este artículo se analiza uno de los conceptos que más interés está despertando en el contexto de la llamada filosofía política continental: lo común. Desde una revisión comparada con la obra de C. Laval y P. Dardot enfrento los siguientes interrogantes: ¿Qué perspectivas abre la obra arendtiana en la actual reflexión sobre lo común como principio político articulador? ¿Qué nuevas cuestiones suscita la idea de espacio público como comunidad política (...) de Arendt al confrontarla con la propuesta de lo común? (shrink)