At the end of his book Configurations d’Hermès, Dominique Jaillard mentions Hermes’ connection with the political sphere and, as an ideal continuation of his work, proposes the study of the roles and prerogatives of the god “dans les cités, entre marges et centres”, “dans les structures et le fonctionnement même de la pόlis, communauté des citoyens, territoire, institutions”. Hermes und die Bürger by Antje Kuhle carries out this project. By abandoning the image of Hermes as an inferior divini...

Chi è quel soggetto che nell’autobiografia dice “io”? Raccontarsi non è già diventare altro? L’autobiografia è un esercizio filosofico in cui l’identità si scopre tramata da altre vite e l’io emerge soltanto perché dislocato nei suoi segni. Sono forse proprio le condizioni di impossibilità di un’autopresentazione trasparente e definitiva che rendono possibile una soggettività autobiografica. Scrivere di sé infatti è già trascendenza: insinua il sospetto di un’alterità, di un’alterazione e turba la rigida identità, che si presume autonoma e precedente alle (...) sue iscrizioni. L’intreccio tra autós, bíos e graphein non è dunque una neutra auto-espressione, ma uno specchio in cui il proprio volto è riflesso e capovolto, il sé si racconta e si ascolta, recita e osserva. In che modo quindi l’autobiografia è un luogo di verità? «La verità può essere il cuore dell’autobiografia», afferma John M. Coetzee, «ma ciò non vuol dire che l’autobiografia abbia a cuore la verità». Ogni lettera scritta traccia l’aderenza di sé a sé e alle cose, nell’istante stesso in cui marca una separazione e una distanza. In questo paradosso si infrange ogni pretesa di obiettività o di adeguazione. Qui la trasparenza dell’io viene disdetta, come anche la sua sovranità del discorso. L’autobiografia è, allora, la scrittura impossibile come unica iscrizione possibile: il tentativo estremo di restituire il senso di una vita incompiuta, di dare una verità senza verità, di raccontare di sé da sé. È una messa in scena dell’identità e della propria distanza, un’autosospensione e una torsione tropica dell’io, che si racconta e si espone. Dietro ogni scrittura autobiografica c’è infatti un nome proprio, che sigilla l’autore, il narratore, il personaggio. Ma proprio in questa firma si custodisce, più che il diritto a una proprietà, la promessa di verità per sé e per gli altri: un corpo a corpo con la lingua e con la propria storia. (shrink)

Against the opinion that DNA as program is not sufficiently explanatory, we maintain that the cellular machinery is entirely computational, and we identify the crucial notion of the interpreter that expresses the gene with the minimal gene set. Epigenetics research does not so much need paradigm shifts as the unraveling of an exceedingly complex computational machine.

This book presents a historical and scientific analysis as historical epistemology of the science of weights and mechanics in the sixteenth century, particularly as developed by Tartaglia in his Quesiti et inventioni diverse, Book VII and Book VIII (1546; 1554). -/- In the early 16th century mechanics was concerned mainly with what is now called statics and was referred to as the Scientia de ponderibus, generally pursued by two very different approaches. The first was usually referred to as Aristotelian, where (...) the equilibrium of bodies was set as a balance of opposite tendencies to motion. The second, usually referred to as Archimedean, identified statics with centrobarica, the theory of centres of gravity based on symmetry considerations. In between the two traditions the Italian scholar Niccolò Fontana, better known as Tartaglia (1500?–1557), wrote the treatise Quesiti et inventioni diverse (1546). -/- This volume consists of three main parts. In the first, a historical excursus regarding Tartaglia’s lifetime, his scientific production and the Scientia de ponderibus in the Arabic-Islamic culture, and from the Middle Ages to the Renaissance, is presented. Secondly, all the propositions of Books VII and VIII, by relating them with the Problemata mechanica by the Aristotelian school and Iordani opvsculvm de ponderositate by Jordanus de Nemore are examined within the history and historical epistemology of science. The last part is relative to the original texts and critical transcriptions into Italian and Latin and an English translation. -/- This work gathers and re-evaluates the current thinking on this subject. It brings together contributions from two distinguished experts in the history and historical epistemology of science, within the fields of physics, mathematics and engineering. It also gives much-needed insight into the subject from historical and scientific points of view. The volume composition makes for absorbing reading for historians, epistemologists, philosophers and scientists. (shrink)

This chapter contains sections titled: Hunting: A Rite of American Secular Religion Rights and the Burden of Ownership Off the Grid: Civilization's Joyous Discontent Big Green: The New Nonsense of the Eco‐Gentry Notes.

The complexity of current social and environmental grand challenges generates many conflicts and tensions at the individual, organization and/or systems levels. Paradox theory has emerged as a promising way to approach such a complexity of corporate sustainability going beyond the instrumental business-case perspective and achieving superior sustainability performance. However, the fuzziness in the empirical use of the concept of “paradox” and the absence of a systems perspective limits its potential. In this paper, we perform a systematic review and content analysis (...) of the empirical literature related to paradox and sustainability, offering a useful guide for researchers who intend to adopt the concept of “paradox” empirically. Our analysis provides a comprehensive account of the uses of the construct - which allows the categorization of the literature into three distinct research streams: 1) paradoxical tensions, 2) paradoxical frame/thinking, and 3) paradoxical actions/strategies - and a comprehensive overview of the findings that emerge in each of the three. Further, by adopting a system perspective, we propose a theoretical framework that considers possible interconnections across the identified paradoxical meanings and different levels of analysis (individual, organizational, systems) and discuss key research gaps emerging. Finally, we reflect on the role a clear notion of paradox can have in supporting business ethics scholars in developing a more “immanent” evaluation of corporate sustainability, overcoming the current instrumental view. (shrink)

Name der Zeitschrift: Klio Jahrgang: 98 Heft: 2 Seiten: 746-750.

Pierre de Fermat is known as the inventor of modern number theory. He invented–improved many methods useful in this discipline. Fermat often claimed to have proved his most difficult theorems thanks to a method of his own invention: the infinite descent. He wrote of numerous applications of this procedure. Unfortunately, he left only one almost complete demonstration and an outline of another demonstration. The outline concerns the theorem that every prime number of the form 4n + 1 is the sum (...) of two squares. In this paper, we analyse a recent proof of this theorem. It is interesting because: it follows all the elements of which Fermat wrote in his outline; it represents a good introduction to all logical nuances and mathematical variants concerning this method of which Fermat spoke. The assertions by Fermat will also be framed inside their historical context. Therefore, the aims of this paper are related to the history of mathematics and to the logic of proof-methods. (shrink)

Lazare Carnot was the unique example in the history of science of someone who inadvertently owed the scientific recognition he eventually achieved to earlier political prominence. He and his son Sadi produced work that derived from their training as engineers and went largely unnoticed by physicists for a generation or more, even though their respective work introduced concepts that proved fundamental when taken up later by other hands. There was, moreover, a filial as well as substantive relation between the work (...) of father and son. Sadi applied to the functioning of heat engines the analysis that his father had developed in his study of the operation of ordinary machines. Specifically, Sadi's idea of a reversible process originated in the use his father made of geometric motions in the analysis of machines in general. (shrink)

El texto trata de abordar la noción de «significante» lacaniano desde una hermenéutica filosófica. Para ello se recorrerán algunos momentos clave de la elaboración de Lacan sin dar por supuesto ningún uso o definición que se promueve del término en cuestión, todo ello con la intención de subrayar aspectos como el del sentido y la vedad que desde un análisis hermenéutico-filosófico pueden ser captados en toda su profundidad.

Forums, I extensively analysed Tartaglia’s corpus: science of weights, geometry, arithmetic, mathematics and physics–trajectories of the projectiles, fortifications, included its intelligibility science in the military architecture. The latter is exposed in Book VI of the Quesiti et invention diverse. In Quesiti there is La Gionta del sesto libro—a kind of appendix to the Book VI containing drawings of the geometric shape of the Italian fortifications. It is based on Euclidean geometry and other figures where a scale is displayed. The interest—included (...) intellectual history and cultural foundations of science—is: what is the role–played by La Gionta del sesto libro in the Quesiti? Is it independent booklet/speeches? If yes, when Tartaglia did write it? In this paper, I present an historical–philological–foundational hypothesis on the Tartaglia’s fortifications corpus, as exposed in the Book VI and La Gionta del sesto libro; with respect to dates of editions of Quesiti. This goal is important to make historically clear both the editorial role–played by Curzio Troiano Navò in the Tartaglia’s corpus before—after Tartaglia’s death and the particular interest and development of subject of fortifications by Tartaglia between 1537–1546 and 1554. (shrink)

To commemorate the 50th anniversary of his passing, this special book features studies on Alexandre Koyré, one of the most influential historians of science of the 20th century, who re-evaluated prevalent thinking on the history and philosophy of science. In particular, it explores Koyré’s intellectual matrix and heritage within interdisciplinary fields of historical, epistemological and philosophical scientific thought. Koyré is rightly noted as both a versatile historian on the birth and development of modern science and for his interest in philosophical (...) questions on the nature of scientific knowledge. In the 1940s and 1950s his activities in the United States established a crucial bridge between the European historical tradition of science studies and the American academic environments, and an entire generation of historians of science grew up under his direct influence. The book brings together contributions from leading experts in the field, and offers much-needed insights into the subject from historical, nature of science, and philosophical perspectives. It provides an absorbing and revealing read for historians, philosophers and scientists alike. (shrink)

I now intend to return to Husserl’s argument against psychologism in logic, aiming to frame it within the broader antinaturalistic controversy and see how recent proposals of a natural (or naturalized) epistemology could affect it.

A key question in comparative law is why different legal systems provide different legal solutions for the same problem. To answer this question, we use novel comparative evidence on how the conflict between the dispossessed original owner and the bona fide purchaser of a stolen good is resolved in different countries. This is the most primitive manifestation of a fundamental legal choice: the balance between the protection of the owner’s property rights and the enhancement of the buyer’s reliance on contracts. (...) We test four prominent theories: functional equivalence, legal origins, political economics and cultural economics. We find that a culture of self-reliance is the key determinant of comparative variation in this area of law. (shrink)

A partir de algunos motivos presentes en Poesie in forma di rosa, La Divina Mimesis y, sobre todo, Petrolio, atenderemos algunos motivos de la propuesta estética de Pasolini en relación con la crítica de lo político. Lo que inicialmente parece una crítica o semiología de la sociedad y lo político se revela, con el tiempo, como un problema artístico en el cual el arte es en sí político y lo político es en sí artístico. Este asunto no es más que (...) el de la forma tal y como aparece en las mencionadas obras del poeta. (shrink)

This paper is divided into two parts, this being the first one. The second is entitled ‘Historical and Epistemological Reflections on the Culture of Machines around Renaissance: Machines, Machineries and Perpetual Motion’ and will be published in Acta Baltica Historiae et Philosophiae Scientiarum in 2015. Based on our recent studies, we provide here a historical and epistemological feature on the role played by machines and machineries. Ours is an epistemological thesis based on a series of historical examples to show that (...) the relations between theoretical science and the construction of machines cannot be taken for granted, a priori. Our analysis is mainly based on the culture of machines around 15th and 17th centuries, namely the epoch of Late Renaissance and Early Modern Age. For this is the period of scientific revolution and this age offers abundant interesting material for researches into the relations of theoretical science/construction of machines as well. However, to prove our epistemological thesis, we will also exploit examples of machines built in other historical periods. Particularly, a discussion concerning the relationship between science theory and the development of science art crafts produced by non-recognized scientists in a certain historical time is presented. The main questions are: when and why did the tension between science give rise to a new scientific approach to applied discipline such as studies on machines and machineries? What kind of science was used for projecting machines and machineries? Was science at the time a necessary precondition to build a machine? In the first part we will focus on the difference between Aristotelian-Euclidean and Archimedean approaches and we will outline the heritage of these two different approaches in late medieval and Renaissance science. In the second part, we will apply our reconstructions to some historical and epistemological problems concerning the relations of science/technology/constructions of machines. The problem of perpetual motion will play an important role in this context. (shrink)

In recent decades, the development of sciences and technologies had a significant impact in society. This impact has been object of analysis from several standpoints, i.e., scientific, communication, historical and anthropological. Consequently, serious changes were required by the society. One of these has been the emerging relationship science in society and its foundations of applied sciences. A related foundational challenging is the educational process, which was and still is an unlimited challenge for teachers and professors: i.e., levels of understanding, curricula, (...) activing critical engagement, transfer knowledge—and—skills, management, classroom and subsequently pre-service teachers need special teacher education. Taking into account Joule’s bicentenary commemoration in physics and Nature of Science teaching this paper introduces to a level of inquiring within historical and NoS approaches in the pre-service teachers, typically science, technology, engineering and mathematics. In particular, history and historiography of Joule’s physics are dealt with. (shrink)

This book offers insights relevant to modern history and epistemology of physics, mathematics and, indeed, to all the sciences and engineering disciplines emerging of 19th century. This research volume is the first of a set of three Springer books on Lazare Nicolas Marguérite Carnot’s (1753–1823) remarkable work: Essay on Machines in General (Essai sur les machines en général [1783] 1786). The other two forthcoming volumes are: Principes fondamentaux de l’équilibre et du mouvement (1803) and Géométrie de position (1803). Lazare Carnot (...) – l'organisateur de la victoire – in Essai sur le machine en général (1786) assumed that the generalization of machines was a necessity for society and its economic development. Subsequently, his new coming science applied to machines attracted considerable interest for technician, as well, already in the 1780’s. With no lack in rigour, Carnot used geometric and trigonometric rather than algebraic arguments, and usually went on to explain in words what the formulae contained. His main physical– mathematical concepts were the Geometric motion and Moment of activity–concept of Work . In particular, he found the invariants of the transmission of motion (by stating the principle of the moment of the quantity of motion) and theorized the condition of the maximum efficiency of mechanical machines (i.e., principle of continuity in the transmission of power). While the core theme remains the theories and historical studies of the text, the book contains an extensive Introduction and an accurate critical English Translation – including the parallel text edition and substantive critical/explicative notes – of Essai sur les machines en général (1786). The authors offer much-needed insight into the relation between mechanics, mathematics and engineering from a conceptual, empirical and methodological, and universalis point of view. As a cutting–edge writing by leading authorities on the history of physics and mathematics, and epistemological aspects, it appeals to historians, epistemologist–philosophers and scientists (physicists, mathematicians and applied sciences and technology). (shrink)

The violent death of Landauer in May 1919 at the end of the Räterepublik of Munich left several of his best friends with a terrible feeling: a sense of tension between the unique hopes incarnated by Landauer and the spiritual and political void his passing left behind. This article is an attempt to capture the tragic shift from a living revolutionary who projected his unique anarchist views onto the failed Munich Revolution to the efforts of a group of close friends (...) who searched to save their dear Landauer from the infamy of failure, making of his months in Munich and his death an important amendment to his spiritual and political legacy. (shrink)

One century after Gustav Landauer’s death, in a time marked by a deep doubt concerning modern politics, the volume proposes a fascinating overview of the articulation between _skepsis_ and _antipolitics_ in his multifaceted unconventional anarchism.

In this paper, we present an interdisciplinary discussion on the relations between Science–Technology Education and Culture both historical standpoint and nowadays. The idea that a human mind can produce an intellectual revolution within science and its approaches strongly crossed like a paradigm both in the history of sciences and disciplines–literatures : but what about its social impact and science mission, as well? To describe the impact of the disseminated knowledge is a consequent aim. A case study on energy conceptualization and (...) its exhibitions in Society in Context is discussed; their correlations with education, science–techniques, industry and social impacts are discussed, as well. (shrink)

James Prescott Joule’s (1818–1889) bicentenary took place in 2018 and commemorated by the IDTC with a Symposium—‘James Joule’s Bicentenary: Scientific and Pedagogical Issues Concerning Energy Conservation’—at the European Society for the History of Science (ESHS & BSHS), 14th–17th September, 2018, in London. This symposium had three main objectives: It aimed specifically to celebrate James Joule’s achievements considering the most recent historiographical works with a particular focus on the principle of conservation of energy; It served the purpose of discussing the scientific (...) and pedagogical issues related to heat, energy and work and how they are presented in textbooks and worked out in classrooms; It also provided discussions on the present situation of teaching and learning science through the use of History of Science, both in K-12 and college level with an emphasis on energy and related concepts. In the following, the Introduction of this Special Issue on Joule is presented. (shrink)

Pharmacists, physicians, and other health care personnel practice within an integrated system of laws and regulations that influence many treatment modalities. Capitation, managed care, and other controls strain these relationships by mandating greater oversight of how health care is delivered. From a pharmacists’s perspective, any use of medication requites knowledge of three omnipresent factors: regulatory control, formularies, and economic decision making. My objective is to raise awareness of these issues as they relate to the prescription of pain medication and to (...) pain management generally.All practice-oriented drug law and regulation is based on the federal Controlled Substances Act of 1970. The Act, also known as Title II, is part of a much larger piece of legislation, the Comprehensive Drug Abuse Prevention and Control Act of 1970. CSA was enacted to regulate the manufacturing, distribution, dispensing, and delivery of drugs or substances that are subject to, or have the potential for, abuse or physical or psychological dependence. (shrink)

Pharmacists, physicians, and other health care personnel practice within an integrated system of laws and regulations that influence many treatment modalities. Capitation, managed care, and other controls strain these relationships by mandating greater oversight of how health care is delivered. From a pharmacists’s perspective, any use of medication requites knowledge of three omnipresent factors: regulatory control, formularies, and economic decision making. My objective is to raise awareness of these issues as they relate to the prescription of pain medication and to (...) pain management generally.All practice-oriented drug law and regulation is based on the federal Controlled Substances Act of 1970. The Act, also known as Title II, is part of a much larger piece of legislation, the Comprehensive Drug Abuse Prevention and Control Act of 1970. CSA was enacted to regulate the manufacturing, distribution, dispensing, and delivery of drugs or substances that are subject to, or have the potential for, abuse or physical or psychological dependence. (shrink)

Based on our research regarding the relationship between physics and mathematics in HPS, and recently on Geneva Edition of Newton's Philosophiae Naturalis Principia Mathematica (1739–42) by Thomas Le Seur (1703–70) and François Jacquier (1711–88), in this paper we present some aspects of such Edition: a combination of editorial features and scientific aims. The proof of Proposition XLIII is presented and commented as a case study.

After the birth of thermodynamics’ second principle—outlined in Carnot's Réflexions sur la puissance motrice du feu —several studies provided new arguments in the field. Mainly, they concerned the thermodynamics’ first principle—including energy conceptualisation—, the analytical aspects of the heat propagation, the statistical aspects of the mechanical theory of heat. In other words, the second half of nineteenth century was marked by an intense interdisciplinary research activity between physics and chemistry: new disciplines applied to the heat developed in the form of (...) analytical, mechanical and statistical theories. Inside all these theories, entropy—the brand-new function that Clausius coined in his Mechanical theory of heat—started to play a central epistemic role. In the present paper, we analyse some steps of the historical process of conceptualisation of such function from 1850 to 1902. Particularly, we retrace the historical–foundational path that—starting from Clausius’ Second Law—lead Boltzmann and Gibbs to their distinguished formulations of statistical entropy. As usual, our research has been unrolled through the analyses of primary sources and by leaning on critical readings of the secondary literature. As for the methodological approach, text analysis of historical documents constituted our privileged modus operandi. This paper is the expression of a collaborative historical research program focused on the thermodynamic foundations of physics–chemistry relationship; early results have already been published by the same authors upon the concepts of reversibility––and––thermal equilibrium. (shrink)

One may discuss the role played by mechanical science in the history of scientific ideas, particularly in physics, focusing on the significance of the relationship between physics and mathematics in describing mathematical laws in the context of a scientific theory. In the second Newtonian law of motion, space and time are crucial physical magnitudes in mechanics, but they are also mathematical magnitudes as involved in derivative operations. Above all, if we fail to acknowledge their mathematical meaning, we fail to comprehend (...) the whole Newtonian mechanical apparatus. For instance, let us think about velocity and acceleration. In this case, the approach to conceive and define foundational mechanical objects and their mathematical interpretations changes. Generally speaking, one could prioritize mathematical solutions for Lagrange’s equations, rather than the crucial role played by collisions and geometric motion in Lazare Carnot’s operative mechanics, or Faraday’s experimental science with respect to Ampère’s mechanical approach in the electric current domain, or physico-mathematical choices in Maxwell’s electromagnetic theory. In this paper, we will focus on the historical emergence of mechanical science from a physico-mathematical standpoint and emphasize significant similarities and/or differences in mathematical approaches by some key authors of the 18th century. Attention is paid to the role of mathematical interpretation for physical objects. (shrink)

BackgroundThe coronavirus disease 2019 pandemic has greatly affected people’s mental health resulting in severe psychological consequences. One of the leading causes of long-term disability worldwide is aphasia. The language changes experienced by a person with aphasia often have a sudden and long-lasting negative impact on social interaction, quality of life, and emotional wellbeing. The main aim of this study was to investigate the impact of COVID-19 on the different psychosocial dimensions which affect PWA.MethodsThis retrospective study included 73 PWA and 81 (...) elderly matched controls. All patients were in the chronic phase. They were all discharged from rehabilitation services, which left them with different degrees of language deficits. All participants were administered the hospital anxiety and depression scale through an online survey. PWA also took part in the stroke and aphasia quality of life scale questionnaire.ResultsAlthough the comparison between two different time points [one month before and one month after the lockdown ] led to a significant increase in depression and anxiety symptoms in both groups, lower rates of depression and anxiety were found in PWA compared to the healthy group. Significant deterioration was also present in PWA in the communication and psychosocial scales of the SAQOL-39 test, which correlated with the observed changes in the psychological domains. Interestingly, the results were not significantly influenced by the degree of aphasia severity. Similarly, in both groups, none of the demographic variables significantly affected the scores in the different subscales.ConclusionsThis evidence which, at first glance, seems to suggest that PWA have been partially spared from the impact of COVID-19, actually masks a dramatic situation that has always characterized this population. Indeed, given that PWA already live in a state of social isolation and emotional instability, these conditions might have, paradoxically, limited the effects of the coronavirus. However, as our results showed a deterioration in the emotional state and communication skills of our patients, possible solutions are discussed in order to prevent further decline of their cognitive abilities. (shrink)

James Prescott Joule’s (1818–1889) bicentenary took place in 2018 and commemorated by the IDTC with a Symposium—‘James Joule’s Bicentenary: Scientific and Pedagogical Issues Concerning Energy Conservation’—at the European Society for the History of Science (ESHS & BSHS), 14th–17th September, 2018, in London. This symposium had three main objectives: It aimed specifically to celebrate James Joule’s achievements considering the most recent historiographical works with a particular focus on the principle of conservation of energy; It served the purpose of discussing the scientific (...) and pedagogical issues related to heat, energy and work and how they are presented in textbooks and worked out in classrooms; It also provided discussions on the present situation of teaching and learning science through the use of History of Science, both in K-12 and college level with an emphasis on energy and related concepts. In the following, the Introduction of this Special Issue on Joule is presented. (shrink)

This paper is the second part of our recent paper ‘Historical and Epistemological Reflections on the Culture of Machines around the Renaissance: How Science and Technique Work’. In the first paper—which discussed some aspects of the relations between science and technology from Antiquity to the Renaissance—we highlighted the differences between the Aristotelian/Euclidean tradition and the Archimedean tradition. We also pointed out the way in which the two traditions were perceived around the Renaissance. The Archimedean tradition is connected with machines: its (...) relationship with science and construction of machines should be made clear. It is enough to think that Archimedes mainly dealt with three machines: lever, pulley and screw. As underlined in the first part, our thesis is that many machines were constructed by people who ignored theory, even though, in other cases, the knowledge of the Archimedean tradition was a precious help in order to build machines. Hence, an a priori idea as to the relations between the Archimedean tradition and construction of machines cannot exist. In this second part we offer some examples of functioning machines constructed by people who ignored any physical theory, whereas, in other cases, the ignorance of some principles—such as the impossibility of a perpetuum mobile—induced the attempt to construct impossible machines. What is very interesting is that these machines did not function, of course, as a perpetuum mobile, but anyway had their functioning and were useful for certain aims, although they were constructed on an idea which is completely wrong from a theoretical point of view. We mainly focus on the Renaissance and early modern period, but we also provide examples of machines built before and after this period. We have followed a chronological order in both parts, starting from the analysis of the situation in ancient Greece. Therefore, in the first part, we have examined the relations between the Aristotelian/Euclidean and Archimedean traditions from ancient Greece to the early modern age. In this second part, we analyse the relations of Archimedean tradition/ construction of machines from ancient Greece to the 19th century, focusing on the mentioned period. We remind the reader that our aim is to prove an epistemological thesis, not to provide a complete historical endeavour. As a correlated article, the reader will find three previous paragraphs in the first above-mentioned article. (shrink)

Here we review and discuss the link between regeneration capacity and tumor suppression comparing mammals (embryos versus adults) with highly regenerative vertebrates. Similar to mammal embryo morphogenesis, in amphibians (essentially newts and salamanders) the reparative process relies on a precise molecular and cellular machinery capable of sensing abnormal signals and actively reprograming or eliminating them. As the embryo's evil twin, tumor also retains common functional attributes. The immune system plays a pivotal role in maintaining a physiological balance to provide surveillance (...) against tumor initiation or to support its initiation and progression. We speculate that susceptibility to cancer development in adult mammals may be determined by the loss of an advanced regenerative capability during evolution and believe that gaining mechanistic insights into how regenerative capacity linked to tumor suppression is postnatally lost in mammals might illuminate an as yet unrecognized route to cancer treatment. (shrink)