Der Schrift liegt die Einsicht zugrunde, daß auch die reflektierende Urteilskraft auf einem Prinzip a priori beruht, nämlich dem der Zweckmäßigkeit. Im ersten Hauptteil widmet sich Kant der ästhetischen Beurteilung der Zweckmäßigkeit der Formen der Natur für unsere Erkenntnisvermögen. Im zweiten Hauptteil erörtert er die Frage, inwieweit wir der Natur selbst eine objektive Zweckmäßigkeit ihrer Formen zuschreiben können. Im Zentrum stehen dabei die Begriffe des Naturzwecks und der sich selbst organisierenden Wesen. Auf eine teleologische Beurteilung der Natur kann dort nicht (...) verzichtet werden, wo wir die Form des Gegenstandes durch den Naturmechanismus nicht erklären können. Die Edition dokumentiert den Wortlaut der zweiten Originalausgabe von 1793. Sie verzeichnet alle relevanten Lesarten der ersten und dritten Ausgabe sowie die wichtigsten Konjekturen früherer Herausgeber. Die Einleitung des Herausgebers führt in die Themenstellung der Schrift ein und diskutiert einige in der Literatur kontrovers erörterte Lehrstücke. Die ausführlichen Sachanmerkungen weisen Zitate und verdeckte Anspielungen nach. Dieser 2. Auflage ist als Beilage der Text der von Kant verworfenen ersten Einleitung in die KdU beigegeben, die in der Forschung als ein wichtiges Dokument gilt für die Erschließung des nachgelassenen Opus postumum. (shrink)

4,12f. über Erkenntnismöglichkeiten - Bleistijtzusatz 11 4,15 über eigene Erkenntnismöglichkeit - Bleistijtzusatz 11 4,18ff..... müssen wir zunächst zweifellose Fälle haben von Erkenntnissen oder Erkennt­ nismöglichkeiten, die Erkenntnis wirklich treffen, und daher nicht unbesehen Erkenntnis als Erkenntnis hinnehmen; - der Satz in seiner ursprünglichen Form 114,22f. von sonst hätten wir.... bis volles Ziel Bleistijtzusatz 115,5 und Geisteswissenschaften - Bleistijtzusatz nach 1922 11 5,20f. Dieser Satz ist eine Bleistijtergänzung 11 5,28 voll und ganz adäquat - Bleistiftergänzung 11 5,33 adäquat - Bleistiftzusatz 116,2-16 (...) Der Text von: Was ich will bis sie nicht anzuknüpfen steht in eckiger Bleistiftklammer ; am Rande von Husserl vermerkt: Das ist unklar oder nicht gut passend. Beilage. 11 6,5 der Möglichkeit - Bleistiftzusatz 11 6,23 ihrer Leistung Hinzufügung nach 1922 11 6,32 Zusatz nach 1922: als Prämisse, selbst als Hypothese 11 7,2 ihrer Leistung - Bleistift­ verbesserung für: irgend einer Idee wie es ursprünglich hieß 11 7,3ff. Der letzte Teil dieses Satze8, von es heißt an, bis herleiten steht in eckiger Bleistiftklammer 117,15 Hinzugefügt: der Mensch 117,20 Hinzu­ gefügt: dieser Mensch 11 7,30 Bewußtsein des Menschen - Verbesserung von: Ichbewußtsein wie es ursprünglich hieß 11 7,32ff. Spätere Rand­ bemerkung zum Text: Das Immanente bezweifelt man nicht, aber die Erkenntnis des Immanenten ist genau so problematisch und auch ein schwieriges Problem. 11 9,18f. (shrink)

Background: Frailty is a common syndrome among older adults and patients with several comorbidities. Grip strength is a representative parameter of frailty because it is a valid indicator of current and long-term physical conditions in the general population and patients with severe mental illnesses. Physical and cognitive capacities of people with SMIs are usually impaired; however, their relationship with frailty or social functioning have not been studied to date. The current study aimed to determine if GS is a valid predictor (...) of changes in cognitive performance and social functioning in patients with type-2 diabetes mellitus and SMIs. Methods: Assessments of social functioning, cognitive performance, and GS were conducted in 30 outpatients with type 2 diabetes mellitus, 35 with major depressive disorder, 42 with bipolar disorder, 30 with schizophrenia, and 28 healthy controls, twice during 1-year, follow-up period. Descriptive analyses were conducted using a one-way analysis of variance for continuous variables and the chi-squared test for categorical variables. Differences between groups for the motor, cognitive, and social variables at T1 and T2 were assessed using a one-way analysis of covariance, with sex and age as co-variates. To test the predictive capacity of GS at baseline to explain the variance in cognitive performance and social functioning at T2, a linear regression analysis was performed. Results: Predictive relationships were found among GS when implicated with clinical, cognitive, and social variables. These relationships explained changes in cognitive performance after one year of follow-up; the variability percentage was 67.7%, in patients with type-2 diabetes mellitus and 89.1% in patients with schizophrenia. Baseline GS along with other variables, also predicted changes in social functioning in major depressive disorder, bipolar disorder, and schizophrenia, with variability percentages of 67.3, 36, and 59%, respectively. Conclusion: GS combined with other variables significantly predicted changes in cognitive performance and social functioning in people with SMIs or type-2 diabetes mellitus. Interventions aimed to improve the overall physical conditions of patients who have poor GS could be a therapeutic option that confers positive effects on cognitive performance and social functioning. (shrink)

Objective: Cognitive impairment is a common neurological complication in patients with end-stage renal disease undergoing maintenance hemodialysis. Brain network analysis based on graph theory is a promising tool for studying CI. Therefore, the purpose of this study was to analyze the changes of functional brain networks in patients on MHD with and without CI by using graph theory and further explore the underlying neuropathological mechanism of CI in these patients.Methods: A total of 39 patients on MHD and 25 healthy controls (...) matched for age, sex, and years of education were enrolled in the study. Resting-state functional magnetic resonance imaging and T1-weighted high-resolution anatomical data were obtained, and functional brain networks for each subject were constructed. The brain network parameters at the global and regional levels were calculated, and a one-way analysis of covariance was used to compare the differences across the three groups. The associations between the changed graph-theory parameters and cognitive function scores in patients on MHD were evaluated using Spearman correlation analysis.Results: Compared with HCs, the global parameters [sigma, gamma, and local efficiency ] in both patient groups decreased significantly. The clustering coefficient in patients with CI was significantly lower than that in the other two groups. The regional parameters were significantly lower in the right superior frontal gyrus, dorsolateral and gyrus rectus of patients with CI than those of patients without CI; however the nodal local efficiency in the left amygdala was significantly increased. The global Cp and regional parameters in the three brain regions were significantly correlated with the cognitive function scores.Conclusion: This study confirmed that the topology of the functional brain network was disrupted in patients on MHD with and without CI and the disruption of brain network was more severe in patients with CI. The abnormal brain network parameters are closely related to cognitive function in patients on MHD. (shrink)

BackgroundAt present, adherence to antipsychotic treatment is often poor, leading to the recurrence of symptoms. This increases the likelihood of the patient experiencing disability and thus increases the disease burden for the patient, their family, and society as a whole. However, to date, there is no clear evidence regarding the effect of medication adherence interventions on outcomes for patients with schizophrenia. Moreover, the traditional intervention methods are limited by manpower and resources in low- and middle-income countries. Recent studies have demonstrated (...) that increasing a patient’s level of self-compassion may improve their treatment adherence. Online mental health care interventions have advantages in terms of feasibility and acceptability for patients with schizophrenia. In this regard, a WeChat-based self-compassion training protocol to improve patient treatment adherence was designed in this study and will be evaluated in the future to determine its impact on patients with schizophrenia.MethodsThe protocol for the randomized controlled trial is based on the SPIRIT 2013 statement. This parallel RCT will aim to recruit 392 patients with schizophrenia who will be randomized at a 1:1 ratio into a 3-week intervention or control group. Both groups will receive routine care. The intervention group will also receive WeChat-based self-compassion training, which requires participants to complete three tasks every day, including a reading task, a meditation task, and a self-compassion journal task. The control group will receive WeChat-based psychological health education, which will only require participants to read positive articles about psychological health every day. Medication adherence, self-compassion, stigma, and social support will be measured at baseline, immediately after the intervention, and 3 weeks after the intervention. Program feasibility will be evaluated throughout the course of the study, and acceptability will be measured immediately after the intervention.Expected results:The intervention described here will address the barriers to accessing mental health care for people with schizophrenia, including patients’ desire for independent management, difficulty accessing providers, and concerns about privacy and stigma. The current study provides guidance for clinical nurses to carry out psychological intervention, with the ultimate aim of addressing the problems associated with a shortage of psychological professionals in low- and middle-income countries. (shrink)

La revolución darwiniana, lejos de ser algo ya superado, como a veces se pretende, aún no ha concluido del todo. Y no ha concluido porque todavía nos falta una adecuada explicación darwinista de uno de los aspectos fundamentales de los seres vivos. Tenemos explicaciones darwinistas de cientos, quizás de miles de rasgos adaptativos, pero aún no contamos con una explicación bien establecida del origen y desarrollo evolutivo de las capacidades cognitivas en aquellos seres vivos que las poseen, y muy en (...) particular del origen y desarrollo evolutivo de la mente humana. Este libro analiza las principales hipótesis que han elaborado los científicos al respecto e intenta obtener algunas conclusiones filosóficas relevantes a partir ellas y de los datos sobre las que se sustentan. Antonio Diéguez es catedrático de Lógica y Filosofía de la Ciencia en la Universidad de Málaga. Sus líneas principales de investigación son la epistemología evolucionista y el realismo científico. Entre sus publicaciones destacan los siguientes libros: la teoría de las ciencias morales en John Stuart Mill (1988), Realismo científico (1998) y Filosofía de la Ciencia (2005), publicado este último por Biblioteca Nueva. (shrink)

A positive connection has been established between personality traits and suicidal ideation. However, the possible mediation of resilience within this association has never been thoroughly discussed. In this study, we aimed to investigate this topic by using population-based cross-sectional survey data of 4,489 Chinese children and adolescents. A self-administered questionnaire was used to collect information from the participants. Univariate and multivariate logistic regression models were adopted to measure the crude and adjusted associations between personality traits, SI, and resilience. Path analysis (...) was performed to evaluate the mediation of resilience in the association between personality traits and SI. For 4,489 study subjects, the mean age was 13.4 years, ethnic minorities accounted for 71.8%, and over a half were middle school students. The reported prevalence rates for 1-week, 1-year, and lifetime SI were 27.6%, 35.5%, and 56.7%, respectively. Girls reported a significantly higher prevalence of SI than boys. Path analysis results revealed a prominent mediation of resilience; moreover, for different dimensions of personality traits, the proportion of mediation by resilience varied. Our major findings suggest that resilience-based intervention measures could be considered in preventing personality traits related to suicidal risk among youngsters. For children and adolescents, the measuring of personality dimensions may also be helpful in targeting key subpopulations of intervention priority. (shrink)