Hilden and Gammelgaard's comments on the evaluation and application of statistical trials and on informed consent lead to the same conclusion that there are special circumstances when clinical trials are performed in emergency situations.The decision to comment on the work that H&G responded to was motivated by the wish to manifest the need to reach a consensus on modifying the conditions in which clinical trials should be performed in special circumstances.One unquestionable fact must first be addressed: clinical trials are necessary (...) for acquiring new knowledge and consequent improvements in health care services. At the same time, patient participation should be encouraged under conditions that respect patients' decision making capability.Are these conditions being met at present? An answer to this is given below. (shrink)

The problem of non-compliance with treatment and its repercussions on the clinical evolution of different conditions has been widely investigated.1–4 Non-compliance has also been shown to have significant economic implications, not only as a result of product loss but also indirectly through the complication of disease management and its subsequent healthcare and social costs.5–7Non-compliance as a health problemThe term “non-compliance” might be taken to refer both to the failure to follow a drug regimen and to the failure to adopt other (...) measures that contribute to improvement in health—for example, changes in lifestyle or diet. This letter focuses on the former.Non-compliance with a drug regimen can be the result of a number of different factors9–11 and a variety of techniques have been developed in an attempt to control it.12,13 Of these, the few techniques that have been shown to be effective have only managed to solve the problem in specific situations over short periods of time. The use of such techniques to control non-compliance, particularly where these are effective, raises interesting ethical questions about the extent to which their application constitutes an infringement of the patient’s right to decide on how to manage their own health.8 Here we suggest that in some cases one factor that leads to non-compliance is the tendency to provide extensive and exhaustive information on side effects in …. (shrink)

Advances in medicine are closely linked to clinical research, but certain study procedures may be in conflict with the fundamental principles of ethics and codes of conduct in medicine. Following an analysis of two studies involving treatments for acute myocardial infarction (AMI), the admissibility of continuing a study was questioned after the initial results for two types of treatment showed that one was significantly better than the other. Also considered doubtful was the information provided to patients with the object of (...) obtaining their informed consent. (shrink)

This paper studies, with techniques ofAlgebraic Logic, the effects of putting a bound on the cardinality of the set of side formulas in the Deduction Theorem, viewed as a Gentzen-style rule, and of adding additional assumptions inside the formulas present in Modus Ponens, viewed as a Hilbert-style rule. As a result, a denumerable collection of new Gentzen systems and two new sentential logics have been isolated. These logics are weaker than the positive implicative logic. We have determined their algebraic models (...) and the relationships between them, and have classified them according to several standard criteria of Abstract Algebraic Logic. One of the logics is protoalgebraic but neither equivalential nor weakly algebraizable, a rare situation where very few natural examples were hitherto known. In passing we have found new, alternative presentations of positive implicative logic, both in Hilbert style and in Gentzen style, and have characterized it in terms of the restricted Deduction Theorem: it is the weakest logic satisfying Modus Ponens and the Deduction Theorem restricted to at most 2 side formulas. The algebraic part of the work has lead to the class of quasi-Hilbert algebras, a quasi-variety of implicative algebras introduced by Pla and Verdú in 1980, which is larger than the variety of Hilbert algebras. Its algebraic properties reflect those of the corresponding logics and Gentzen systems. (shrink)

Appearing in English for the first time, Schelling’s 1842 lectures develop the idea that many philosophical concepts are born of religious-mythological notions.

In this paper we prove the equivalence between the Gentzen system G LJ*\c , obtained by deleting the contraction rule from the sequent calculus LJ* (which is a redundant version of LJ), the deductive system IPC*\c and the equational system associated with the variety RL of residuated lattices. This means that the variety RL is the equivalent algebraic semantics for both systems G LJ*\c in the sense of [18] and [4], respectively. The equivalence between G LJ*\c and IPC*\c is a (...) strengthening of a result obtained by H. Ono and Y. Komori [14, Corollary 2.8.1] and the equivalence between G LJ*\c and the equational system associated with the variety RL of residuated lattices is a strengthening of a result obtained by P.M. Idziak [13, Theorem 1].An axiomatization of the restriction of IPC*\c to the formulas whose main connective is the implication connective is obtained by using an interpretation of G LJ*\c in IPC*\c. (shrink)

In this paper we obtain a finite Hilbert-style axiomatization of the implicationless fragment of the intuitionistic propositional calculus. As a consequence we obtain finite axiomatizations of all structural closure operators on the algebra of {–}-formulas containing this fragment.

This paper focuses on the 1986 Amendments to the False Claims Act of 1863, which offers whistle-blowers financial rewards for disclosing fraud committed against the U.S. government. This law provides an opportunity to examine underlying assumptions about the morality of whistle-blowing and to consider the merits of increased reliance on whistle-blowing to protect the public interest. The law seems open to a number of moral objections, most notably that it exerts a morally corrupting influence on whistle-blowers. We answer these objections (...) and argue that the law is not objectionable on these grounds. Since there are no compelling moral objections to the law, it is appropriate and acceptable to judge the law in terms of its economic costs and benefits. We assess the most salient of these and conclude that the benefits outweigh the costs. We suggest that a mechanism similar to the Act should be considered for protecting stockholders’ interests in the private sector. We conclude by making several proposals for improving the existing legislation. (shrink)

This paper starts with one of Chalmers’ basic points: first-hand experience is an irreducible field of phenomena. I claim there is no ‘theoretical fix’ or ‘extra ingredient’ in nature that can possibly bridge this gap. Instead, the field of conscious phenomena requires a rigorous method and an explicit pragmatics for its exploration and analysis. My proposed approach, inspired by the style of inquiry of phenomenology, I have called neurophenomenology. It seeks articulations by mutual constraints between phenomena present in experience and (...) the correlative field of phenomena established by the cognitive sciences. It needs to expand into a widening research community in which the method is cultivated further. (shrink)

This paper focuses on the 1986 Amendments to the False Claims Act of 1863, which offers whistle-blowers financial rewards for disclosing fraud committed against the U.S. government. This law provides an opportunity to examine underlying assumptions about the morality of whistle-blowing and to consider the merits of increased reliance on whistle-blowing to protect the public interest. The law seems open to a number of moral objections, most notably that it exerts a morally corrupting influence on whistle-blowers. We answer these objections (...) and argue that the law is not objectionable on these grounds. Since there are no compelling moral objections to the law, it is appropriate and acceptable to judge the law in terms of its economic costs and benefits. We assess the most salient of these and conclude that the benefits outweigh the costs. We suggest that a mechanism similar to the Act should be considered for protecting stockholders' interests in the private sector. We conclude by making several proposals for improving the existing legislation. (shrink)

With fascinating historical anecdotes and incisive scientific analysis, this important work combines ancient thought with modern theory to reveal a new way of viewing our universe that can expand our awareness, our lives, and may well point the way to a new science for the twenty-first century.

¿Qué importancia tiene para la historia del pensamiento lo hecho durante el s. XIV? Este periodo supone un cambio en el modo de ver el mundo impulsado por Petrarca, Boccaccio, Salutati, Giotto... La ciencia abre una nueva vía de incomparables repercusiones históricas. En teología, junto a la mística del maestro Eckhart, destacan Ockham, Bradwine, Gregorio de Rimini, Wiclif o Hus, figuras ineludibles al estudiar la influencia del s. XIV en la reforma. Sin estudiar el movimiento ockhamista, el desarrollo de la (...) lógica o el resurgir del agustianismo..., No podríamos entender el giro que tanto la filosofía como el pensamiento en general dieron en este siglo. (shrink)

With precision and profundity born of 30 years of devoted study, John Boyle offers an essential introduction to St. Thomas Aquinas on Scripture, shedding helpful light on the goals, methods, and commitments that animate the Angelic Doctor's engagement with the sacred page. Because the genius of St. Thomas's approach to the Bible lies not so much in its novelty but rather in the fidelity and clarity with which he recapitulates the riches of the preceding interpretive Tradition, this initiation into St. (...) Thomas's vision of Scripture is itself an orientation to the Church's vision of Scripture, from the Fathers through and beyond the Middle Ages. St. Thomas's embeddedness within the Church's Tradition and his own historical context is integral to his approach to Scripture, yet it sets him at some distance from modern readers, for whom his interpretive vision may seem perplexing or even impenetrable. In this Primer, Boyle first provides an acclimation to this medieval context through a survey and explanation of pertinent technical terminology used by St. Thomas and characteristic of the scholastic theology of the time. With an eye to the medieval practice of considering Scripture according to the fourfold division of causes, Boyle builds on this initial foundation by exploring in turn St. Thomas's accounts of the end or use of Scripture (final cause), its divine and human authorship (efficient cause), its order and division (material cause), and its literary styles or genres (formal cause). Drawing on writings from across St. Thomas's corpus, but especially his work On the Commendation and Division of Sacred Scripture and the prologues to his biblical commentaries, Boyle masterfully elucidates both the hermeneutical principles and deep wisdom of the Angelic Doctor's approach to Scripture, imparting invaluable guidance not only for reading and understanding St. Thomas and other great masters of the Tradition, but also-and ultimately-for understanding Scripture in light of this Tradition and reading it with greater benefit and joy. (shrink)

In this paper we study the relations between the fragment L of classical logic having just conjunction and disjunction and the variety D of distributive lattices, within the context of Algebraic Logic. We prove that these relations cannot be fully expressed either with the tools of Blok and Pigozzi's theory of algebraizable logics or with the use of reduced matrices for L. However, these relations can be naturally formulated when we introduce a new notion of model of a sequent calculus. (...) When applied to a certain natural calculus for L, the resulting models are equivalent to a class of abstract logics (in the sense of Brown and Suszko) which we call distributive. Among other results, we prove that D is exactly the class of the algebraic reducts of the reduced models of L, that there is an embedding of the theories of L into the theories of the equational consequence (in the sense of Blok and Pigozzi) relative to D, and that for any algebra A of type (2,2) there is an isomorphism between the D-congruences of A and the models of L over A. In the second part of this paper (which will be published separately) we will also apply some results to give proofs with a logical flavour for several new or well-known lattice-theoretical properties. (shrink)

This is an English translation of Schelling's Ideas for a Philosophy of Nature (first published in 1797 and revised in 1803), one of the most significant works in the German tradition of philosophy of nature and early nineteenth-century philosophy of science. It stands in opposition to the Newtonian picture of matter as constituted by inert, impenetrable particles, and argues instead for matter as an equilibrium of active forces that engage in dynamic polar opposition to one another. In the revisions of (...) 1803 Schelling incorporated this dialectical view into a neo-Platonic conception of an original unity divided upon itself. The text is of more than simply historical interest: its daring and original vision of nature, philosophy, and empirical science will prove absorbing reading for all philosophers concerned with post-Kantian German idealism, for scholars of German Romanticism, and for historians of science. (shrink)

ABOUT THE BOOK:A new systematization of the main philosophical tenets of Hinayana Buddhism as derived from the Four Noble Truths. The work is divided in three parts: (1) Suffering and the Nature of Existence; (2) Origin of Suffering and the Notion.

I begin by criticizing an elaboration of an argument in this journal due to Hawley , who argued that, where Leibniz’s Principle of the Identity of Indiscernibles faces counterexamples, invoking relations to save PII fails. I argue that insufficient attention has been paid to a particular distinction. I proceed by demonstrating that in most putative counterexamples to PII , the so-called Discerning Defence trumps the Summing Defence of PII. The general kind of objects that do the discerning in all cases (...) form a category that has received little if any attention in metaphysics. This category of objects lies between indiscernibles and individuals and is called relationals: objects that can be discerned by means of relations only and not by properties. Remarkably, relationals turn out to populate the universe. (shrink)

In this paper we study the relations between the fragment L of classical logic having just conjunction and disjunction and the variety D of distributive lattices, within the context of Algebraic Logic. We prove that these relations cannot be fully expressed either with the tools of Blok and Pigozzi's theory of algebraizable logics or with the use of reduced matrices for L. However, these relations can be naturally formulated when we introduce a new notion of model of a sequent calculus. (...) When applied to a certain natural calculus for L, the resulting models are equivalent to a class of abstract logics (in the sense of Brown and Suszko) which we call distributive. Among other results, we prove that D is exactly the class of the algebraic reducts of the reduced models of L, that there is an embedding of the theories of L into the theories of the equational consequence (in the sense of Blok and Pigozzi) relative to D, and that for any algebra A of type (2,2) there is an isomorphism between the D-congruences of A and the models of L over A. In the second part of this paper (which will be published separately) we will also apply some results to give proofs with a logical flavour for several new or well-known lattice-theoretical properties. (shrink)

"Not only one of the best but also the most comprehensive treatment of Stoicism written in this century." --Times Literary Supplement.

Resumen: El presente artículo pretende mostrar que, en el ámbito de la ciencia, la Edad Media no fue un período oscuro y sin avances significativos, y que la modernidad no supuso una ruptura con lo hecho al final del medievo, sino algo muy distinto. Decir lo contrario es mantener un tópico que desfigura la realidad.

La migración internacional es parte de la globalización, todos los países desarrollados han recibido un gran número de inmigrantes. España también ha recibido a alta cantidad de nómadas. La población española era emigrante y ahora ella tiene que hacer frente a este nuevo fenómeno, las sociedades desarrolladas van a tener que adaptarse a las grandes afluencias de extranjeros. La migración ha sido a menudo una fuente de tensiones entre culturas e incluso entre movimientos racistas y xenófobos. Un problema político fundamental (...) en España es la situación que hay en la frontera del sur, por donde mucha gente intenta entrar en la UE desde África, arriesgando su vida y perdiéndola a menudo.International migration is part of globalization, all developed countries have received significant numbers of migrants. Spain have also received a high amount of migrants. Spanish people were traditionally emigrants and now they have to face this new phenomena, developed societies are going to have to face larger inflows of migrants. Migration has often been a source of tensions among cultures and even racist and xenophobic movements. A prominent political problem in Spain is the situation on the Southern border, where many people try to enter the EU from Africa, risking their life and often losing. (shrink)