Adherence to ethical principles in clinical research and practice is becoming topical issue in China, where the prevalence of mental illness is rising, but treatment facilities remain underdeveloped. This paper reports on a study aiming to understand the ethical knowledge and attitudes of Chinese mental health professionals in relation to the process of diagnosis and treatment, informed consent, and privacy protection in clinical trials.

The development of Confucianism has most frequently been divided into three periods: the classical period from Pre‐Qin to Han dynasty, the neo‐Confucian period in (Tang) Song, Yuan, Ming, and Qing dynasties, and contemporary new Confucianism in the 20th and 21st centuries. This chapter is devoted to the third period. If neo‐Confucianism can be seen as a Confucian response to challenges posed by Buddhism, contemporary new Confucianism is a Confucian response to the challenge posed by modern Western ideology. If what is (...) unique about the neo‐Confucian response is to provide a metaphysical foundation for or explanation of classical Confucian values, what is unique about the contemporary Confucian response is its attempt to show that traditional Confucian values and such modern Western values as rationality, modernity, science, and democracy, among others are not only compatible but can also significantly enrich each other. (shrink)

Juri Lotman’s well-known distinction of primary modeling system versus secondary modeling system is a lasting legacy of his that has been adhered to, modified, and refuted by semioticians of culture and nature. Adherence aside, modifications and refutations have focused on the issue whether or not language is a primary modeling system, and, if not, what alternatives can be made available to replace it. As Sebeok would concur, for both biosemiosis and anthroposemiosis, language can only be a secondary modeling system on (...) top of the biological experience of Umwelt or human sensory system. This paper proposes to explore the possibility of a “preverbal” modeling system suggested by Lotman’s spatial concept of semiosphere, and discuss its implications in cross-cultural dialogue. (shrink)

Like other sciences, biosemiotics also has its time-honoured archive, consisting, among other things, of writings by those who have been invented and revered as ancestors of the discipline. One such example is Jakob von Uexküll who has been hailed as a precursor of semiotics, developing his theory of “sign” and “meaning” independently of Saussure and Peirce. The juxtaposition of “sign” and “meaning” is revelatory because one can equally legitimately claim Uexküll as a hermeneutician in the same way as others having (...) claimed him as a semiotician. Such a novel temptation can be justified by Uexküll’s prolonged obsession with Sinn and Bedeutung since his first book in 1909. This paper attempts to reconstruct the immediate intellectual horizon of Uexküll’s historicity, a discursive space traversed by his contemporaries Frege and Husserl, in order to see how Uexküll’s discussions of Zeichen and Gegenstand, Sinn and Bedeutung, were informedby other philosophers of language, and to establish Uexküll as a phenomenological hermeneutician in the tradition of Husserl, Heidegger and Gadamer. To forestall and counter possible criticism that hermeneutics is primarily concerned with textual interpretation, while Uexküll is at most an interpreter of animal life, the paper will discuss his unfinished parody of the Platonic dialogue Meno, which is entitled Die ewige Frage: Biologische Variationen über einen platonischen Dialog (1943). It is through such textual practice that one witnesses the emergence of an Uexküll who embodies at once the addressee exercising his understanding of ancient texts as well as the second addresser recoding his explanation to another group of targeted addressees. This textual practice already goes beyond the confines of biology and in fact involves the linguistic pragmatics of rhetoric and speech act. (shrink)

The study of natural disaster and its discursive dimensions from a semiotic perspective can provide a theoretical frame for the scientific communication of global catastrophes. In this paper I will suggest two models; one is a semiotic model on the natural catastrophic events and the other is a hexagon model composed of semiotic dimensions of natural disaster discourse. The six main modules include narration, description, explication, visualization, prevention, and recovery action.

Social-bots-mediated information manipulation is influencing the public opinion environment, and their role and behavior patterns in news proliferation are worth exploring. Based on the analysis of bots' posting frequency, influence, and retweeting relationship, we take the diffusion of The New York Times' coverage of Xinjiang issue on the overseas social platform Twitter as an example and employ the two-step flow model. It is found that in the role of second-step diffusion, unlike posting news indiscriminately in first-step diffusion, social bots are (...) more inclined to postcontroversial information in second-step diffusion; in terms of diffusion patterns, although social bots are more engaged in first-step diffusion than in second-step diffusion and can trigger human users to retweet, they are still inferior to humans in terms of influence. (shrink)

When ancient Chinese philosophy culminated in the sixth to third centuries BCE, “hundreds of flowers [intellectual schools] were blooming”, yet not many theoreticians were particularly interested in questions regarding the relationship between animal and human life — despite their profuse discussion of, and heated debates about, both “nature” and “human nature” in their writings. This indifferent attitude towards creatures lower than humans is best illustrated by Confucius (551–479 BCE), who observed: “It is impossible to associate with birds and beasts, as (...) if they were the same as us.” Later, however, this condescending attitude of the Sage would be challenged by the Daoist philosopher Zhuangzi (370 to 301 BCE), who untiringly advocates the equity of all creatures in the universe — a place where both living and fabulous organisms cohabit and co-evolve with one another, as well as with their environments. Morever, even Confucius’s descendent Mencius (c.372–289 BCE) did not endorse his mentor’s position, for the latter’s own writings are likewise inhabited by all kinds of creatures which not only serve the passive role of poetic figuration, but actually also construct their respective Umwelten, paralleled by the umwelt-construction of human beings. Recent advances in biosemiotics and ecosemiotics have enabled us to reread some of these philosophical texts, and to shed new light on this obscure aspect of Chinese thinking. This paper will draw upon the sign reflections of C. S. Peirce (1839–1914) and Jakob von Uexküll (1864–1944), and make use of a composite analytical method of text semiotics and dialogue studies, to examine a number of political and ethical allegories by Zhuangzi and Mencius. Acknowledging the necessarycircularity of interpretation and the homogeneity of observer and observed, the essay explores the ways in which ancient philosophical texts can be made compatible with contemporary biological and semiotic thinking. (shrink)

For all his profound interest in Secondness and its manifestation in various kinds of indices, including deictics, Peirce rarely addresses the inter-pronominalrelationships. Whilst the American founder of semiotics would designate language as a whole to Thirdness, only within the larger framework of which deictics can work, the German philosopher Cassirer observes that “what characterizes the very first spatial terms that we find in language is their embracing of a defi nite ‘deictic’ function”. For Cassirer the significance of pronominals, especially the (...) I-Thou relationship, lies in its impact on the development of spatial concept that lays the foundation of symbolic forms. It may look strange why the “designatives” of I, Thou, He, in Peirce’s own terms, so obvious in their categorial and empirical differentiation, should fail to be reduceable to the triad of Firstness, Secondness, and Thirdness. It is interesting, however, that in his 1906 correspondence with Lady Welby, Peirce should refer to the strange “Communicational Interpretant”, or “the Cominterpretant, which is a determination of that mind into which the minds of utterer and interpreter have to be fused in order that any communication should take place”. Peirce asserts that this communication of a Form, say, being in love, is made possible by sign. This paper discusses Peirce’s and Cassirer’s references to deictics or indexical sign, in particular, inter-personal relationships, in light of Benveniste’s concept of discourse, and probes into a possible subtext underlying the Peirce-Welby correspondence. (shrink)

For all his profound interest in Secondness and its manifestation in various kinds of indices, including deictics, Peirce rarely addresses the inter-pronominalrelationships. Whilst the American founder of semiotics would designate language as a whole to Thirdness, only within the larger framework of which deictics can work, the German philosopher Cassirer observes that “what characterizes the very first spatial terms that we find in language is their embracing of a defi nite ‘deictic’ function”. For Cassirer the significance of pronominals, especially the (...) I-Thou relationship, lies in its impact on the development of spatial concept that lays the foundation of symbolic forms. It may look strange why the “designatives” of I, Thou, He, in Peirce’s own terms, so obvious in their categorial and empirical differentiation, should fail to be reduceable to the triad of Firstness, Secondness, and Thirdness. It is interesting, however, that in his 1906 correspondence with Lady Welby, Peirce should refer to the strange “Communicational Interpretant”, or “the Cominterpretant, which is a determination of that mind into which the minds of utterer and interpreter have to be fused in order that any communication should take place”. Peirce asserts that this communication of a Form, say, being in love, is made possible by sign. This paper discusses Peirce’s and Cassirer’s references to deictics or indexical sign, in particular, inter-personal relationships, in light of Benveniste’s concept of discourse, and probes into a possible subtext underlying the Peirce-Welby correspondence. (shrink)

The study of natural disaster and its discursive dimensions from a semiotic perspective can provide a theoretical frame for the scientific communication of global catastrophes. In this paper I will suggest two models; one is a semiotic model on the natural catastrophic events and the other is a hexagon model composed of semiotic dimensions of natural disaster discourse. The six main modules include narration, description, explication, visualization, prevention, and recovery action.

Juri Lotman’s well-known distinction of primary modeling system versus secondary modeling system is a lasting legacy of his that has been adhered to, modified, and refuted by semioticians of culture and nature. Adherence aside, modifications and refutations have focused on the issue whether or not language is a primary modeling system, and, if not, what alternatives can be made available to replace it. As Sebeok would concur, for both biosemiosis and anthroposemiosis, language can only be a secondary modeling system on (...) top of the biological experience of Umwelt or human sensory system. This paper proposes to explore the possibility of a “preverbal” modeling system suggested by Lotman’s spatial concept of semiosphere, and discuss its implications in cross-cultural dialogue. (shrink)

Naming, according to Sebeok, constihttes the first stage of zoosemiotics. This special but common use of language acrually inaugurates more complicated procedures of human discourse on non-human kingdom, including classification of its members. Because of language's double articulation in sound and sense, as well as the grapheme's pleremic (meaning-full) rather than cenemic (meaning-empty) characteristic (according to Hjelmslev). Chinese script is capable of naming and grouping animals randomly but effectively. This paper attempts to describe the said scriptorial "necessity of naming" (Kripke) (...) in classical Chinese by citing all the creatures, real or fabulous, with a /ma/ (horse) radical. (shrink)

In traditional Chinese literary criticism, textual strategies comparable to intertextuality have governed Chinese critics’ and poets’ reading and writing aboutliterature throughout the dynasties. Drawing on the intertextual theories of Kristeva and Riffaterre, the paper probes into the phenomenon of sign system-mutations in two highly influential ancient texts: the Confucian Classic of Changes of the fifth century B.C.E. and Liu Xie’s The Literary Mind and the Carving of Dragons, an ars poetica in the third century. The transformation of sign systems from (...) nonverbal to verbal, in the case of the Changes, and from literate to literary or “creative” to “theoretical”, in the case of the Dragons, bears witness to the Hjelmslevian reciprocity of object-semiotic and meta-semiotic. (shrink)

The metaphor of parasites or parasitism has dominated literary critical discourse since the 1970s, prominent examples being Michel Serres in France and J. Hillis Miller in America. In their writings the relationship between text and paratext, literature and criticism, is often likened to that between host and parasite, and can be therefore deconstructed. Their writings, along with those by Derrida, Barthes, and Thom, seem to be suggesting the possibility of a semiotics of parasitism. Unfortunately, none of these writers has drawn (...) enough on the biological foundation of parasitism. Curiously, even in biology, parasitism is already a metaphor through which the signified of an ecological phenomenon involving two organisms is expressed by the signifier of “[eating] food at another’s [side] table”. This paper will make some preliminary remarks on semiotics of parasitism, based on the notions of Umwelt (Jakob von Uexküll) and structural coupling (Maturana and Varela). It will look into the phenomenon of co-evolutionary process in community ecology. With reference to empirical history, the project will briefly surveythe literary and medical praxis of the 17th century England where large number of creative writings referred to the phenomenon of parasitism, which was deeply embedded in religious practice (e.g., the Eucharist) and political life (e.g., the courtier ecology in monarchy) of the times. Finally, it will touch upon the possible ‘parasitic’ relationship between language and biology. (shrink)

In his well-known essay, ‘What Is a Sign?’ (CP 2.281, 285) Peirce uses ‘likeness’ and ‘resemblance’ interchangeably in his definition of icon. The synonymity of the two words has rarely, if ever, been questioned. Curiously, a locus classicus of the pair, at least in F. M. Cornford’s English translation, can be found in a late dialogue of Plato, namely, the Sophist. In this dialogue on the myth and truth of the sophists’ profession, the mysterious ‘stranger’, who is most likely Socrates’ (...) persona, makes the famous distinction between eikon (likeness) and phantasma (semblance) (236a,b). For all his broad knowledge in ancient philosophy, Peirce never mentioned this parallel; nor has any Peircean scholar identified it. There seems to be little problem with eikon as likeness, but phantasma may give rise to a puzzle which this paper will attempt to solve. Plato uses two pairs of words: what eikon is to phantasma is eikastikén (the making of likeness [235d]) to phantastikén (semblance making [236c]). In other words, icons come into being because of the act of icon-making, which is none other than indexicality. Witness what Peirce says about the relationship between photographs and the objects they represent: “But this resemblance is due to the photographs having been produced under such circumstances that they were physically forced to correspond point by point to nature.” (Ibid.) Thus the iconicity which links the representamen (sign) and its object is made possible not only by an interpretant, but also by idexisation. Their possible etymological and epistemological links aside, the Peircean example of photographing and the Platonic discussion of painting and sculpturing in the Sophist, clearly show the physio-pragmatic aspect of iconicity. The paper will therefore reread the Peircean iconicity by closely analysing this relatively obscure Platonic text, and by so doing restore to the text its hidden semiotic dimension. (shrink)

Like other sciences, biosemiotics also has its time-honoured archive, consisting of writings by those who have been invented and revered as ancestors of the discipline. One such example is Jakob von Uexküll. As to the people who ‘invented’ him, they are either, to paraphrase a French cliché, ‘agents du cosmopolitisme sémiotique’ like Thomas Sebeok, or de jure and de facto progenitor like Thure von Uexküll. In the archive is the special issue of Semiotica 42. 1 (1982) edited by the late (...) Sebeok and introduced by Thure von Uexküll. It is in the opening essay that Thure von UexküIl tries to restore Jakob von Uexküll’s role as a precursor of semiotics by negotiating the Elder with Saussure and the linguistics-oriented ‘semiology’ in his wake. However, semiotic mapping, in the strictly ‘disciplinary’ sense, of Jakob von Uexküll is no easy task because he ‘knew neither Peirce nor Saussure and did not use their terminology’ (Thure von Uexküll 1982,2). Because Thure prefers to call the Elder’s science ‘general semiotics’ (Thure von Uexküll 1982), this paper begins by assessing Thure von Uexküll’s semiotic configuration of Jakob, probe into the force and limits of the linguistic analogy, revisit the already time-honoured debate on the primary and secondary modelling systems, which was made famous by the Moscow-Tartu semioticians in the early 1970s, but severely criticized by Sebeok and his followers. The paper engages Sebeok from several fronts, directed first at his relegation of the Saussurian linguistic model, then at his critique of the Primary Modelling System, and finally at his reservation about evolutionism in light of the current debate on gene/meme co-evolution. (shrink)

Body ownership concerns what it is like to feel a body part or a full body as mine, and has become a prominent area of study. We propose that there is a closely related type of bodily self-consciousness largely neglected by researchers—experiential ownership. It refers to the sense that I am the one who is having a conscious experience. Are body ownership and experiential ownership actually the same phenomenon or are they genuinely different? In our experiments, the participant watched a (...) rubber hand or someone else’s body from the first-person perspective and was touched either synchronously or asynchronously. The main findings: (1) The sense of body ownership was hindered in the asynchronous conditions of both the body-part and the full-body experiments. However, a strong sense of experiential ownership was observed in those conditions. (2) We found the opposite when the participants’ responses were measured after tactile stimulations had ceased for 5 s. In the synchronous conditions of another set of body-part and full-body experiments, only experiential ownership was blocked but not body ownership. These results demonstrate for the first time the double dissociation between body ownership and experiential ownership. Experiential ownership is indeed a distinct type of bodily self-consciousness. (shrink)

Facial muscle activities are essential for the appearance and communication of human beings. Therefore, exploring the activation patterns of facial muscles can help understand facial neuromuscular disorders such as Bell’s palsy. Given the irregular shape of the facial muscles as well as their different locations, it should be difficult to detect the activities of whole facial muscles with a few electrodes. In this study, a high-density surface electromyogram system with 90 electrodes was used to record EMG signals of facial muscles (...) in both healthy and Bell’s palsy subjects when they did different facial movements. The electrodes were arranged in rectangular arrays covering the forehead and cheek regions of the face. The muscle activation patterns were shown on maps, which were constructed from the Root Mean Square values of all the 90-channel EMG recordings. The experimental results showed that the activation patterns of facial muscles were distinct during doing different facial movements and the activated muscle regions could be clearly observed. Moreover, two features of the activation patterns, 2D correlation coefficient and Centre of Gravity were extracted to quantify the spatial symmetry and the location of activated muscle regions respectively. Furthermore, the deviation of activated muscle regions on the paralyzed side of a face compared to the healthy side was quantified by calculating the distance between two sides of CGs. The results revealed that corr2 of the activated facial muscle region in Bell’s palsy subjects was significantly lower than that in healthy subjects, while CG distance of activated facial region in Bell’s palsy subjects was significantly higher than that in healthy subjects. The correlation between corr2 of these regions and Bell’s palsy [assessed by the Facial Nerve Grading Scale 2.0] was also significant in Bell’s palsy subjects. The spatial information on activated muscle regions may be useful in the diagnosis and treatment of Bell’s palsy in the future. (shrink)

Physicians play a substantial role in facilitating communication regarding life-supporting treatment decision-making including do-not-resuscitate in the intensive care units. Physician-related fact...

Timely detection and efficient recognition of fault are challenging for the bogie of high-speed train, owing to the fact that different types of fault signals have similar characteristics in the same frequency range. Notice that convolutional neural networks are powerful in extracting high-level local features and that recurrent neural networks are capable of learning long-term context dependencies in vibration signals. In this paper, by combining CNN and RNN, a so-called convolutional recurrent neural network is proposed to diagnose various faults of (...) the HST bogie, where the capabilities of CNN and RNN are inherited simultaneously. Within the novel architecture, the proposed CRNN first filters out the features from the original data through convolutional layers. Then, four recurrent layers with simple recurrent cell are used to model the context information in the extracted features. By comparing the performance of the presented CRNN with CNN, RNN, and ensemble learning, experimental results show that CRNN achieves not only the best performance with accuracy of 97.8% but also the least time spent in training model. (shrink)

We investigate two issues about the subjective experience of one's body: first, is the experience of owning a full-body fundamentally different from the experience of owning a body-part?Second, when I experience a bodily sensation, does it guarantee that I cannot be wrong about whether it is me who feels it? To address these issues, we conducted a series of experiments that combined the rubber hand illusion (RHI) and the “body swap illusion.” The subject wore a head mounted display (HMD) connected (...) with a stereo camera set on the experimenter's head. Sitting face to face, they used their right hand holding a paintbrush to brush each other's left hand. Through the HMD, the subject adopted the experimenter's first-person perspective (1PP) as if it was his/her own 1PP: the subject watched either the experimenter's hand from the adopted 1PP, and/or the subject's own hand from the adopted third-person perspective (3PP) in the opposite direction (180°), or the subject's full body from the adopted 3PP (180°, with or without face). The synchronous full-body conditions generate a “self-touching illusion”: many participants felt that “I was brushing my own hand!” We found that (1) the sense of body-part ownership and the sense of full-body ownership are not fundamentally different from each other; and (2) our data present a strong case against the mainstream philosophical view called the immunity principle (IEM). We argue that it is possible for misrepresentation to occur in the subject's sense of “experiential ownership” (the sense that I am the one who is having this bodily experience). We discuss these findings and conclude that not only the sense of body ownership but also the sense of experiential ownership call for further interdisciplinary studies. (shrink)

Ecological innovation is an inevitable trend for firms to enhance competitiveness and sustainably operate in the context of green economy. The previous literature has rarely discussed the influence of ambidextrous learning on the eco-innovation performance of startups and ignored the moderating effect of top management’s environmental awareness from the perspective of microscopic psychology. We have conducted a questionnaire survey on 212 firms established within 4 years in the Pearl River Delta of China, using the structure mode and the PROCESS by (...) Hayes (2013) to analyze the influence of ambidextrous learning, such as exploratory learning and exploitative learning, by startups on eco-innovation performance and verify the moderating effect of top management’s environmental awareness. The results show that: exploratory learning and exploitative learning have a positive and significant influence on eco-innovation performance, indicating that the organizational learning of startups is conducive to improving eco-innovation performance; under the moderating effect of top management’s environmental awareness, the influence of exploratory learning and exploitative learning on eco-innovation performance may differ. The results also show that in the process of organizing ambidextrous learning, startups should help raise the environmental awareness of top management to improve the eco-innovation performance, thus providing guidance for startups to carry out eco-innovation activities and for local governments to make decisions on green economy. (shrink)

Drawing on ancient and modern sources, "a lucid discussion of Taoism and the Chinese language [that's] profound, reflective, and enlightening." —Boston Globe According to Deepak Chopra, "Watts was a spiritual polymatch, the first and possibly greatest." Watts treats the Chinese philosophy of Tao in much the same way as he did Zen Buddhism in his classic The Way of Zen. Critics agree that this last work stands as a perfect monument to the life and literature of Alan Watts. "Perhaps the (...) foremost interpreter of Eastern disciplines for the contemporary West,... Watts begins with scholarship and intellect and proceeds with art and eloquence to the frontiers of the spirit."—Los Angeles Times. (shrink)

In a recent study (Chen et al., 2018), we conducted a series of experiments that induced the “four-hand illusion”: using a head-mounted display (HMD), the participant adopted the experimenter’s first-person perspective (1PP) as if it was his/her own 1PP. The participant saw four hands via the HMD: the experimenter’s two hands from the adopted 1PP and the subject’s own two hands from the adopted third-person perspective (3PP). In the active four-hand condition, the participant tapped his/her index fingers, imitated by the (...) experimenter. Once all four hands acted synchronously and received synchronous tactile stimulations at the same time, many participants felt as if they owned two more hands. In this paper, we argue that there is a philosophical implication of this novel illusion. According to Merleau-Ponty (1945/1962) and Legrand (2010), one can experience one’s own body or body-part either as-object or as-subject but cannot experience it as both simultaneously, i.e., these two experiences are mutually exclusive. Call this view the Experiential Exclusion Thesis. We contend that a key component of the four-hand illusion—the subjective experience of the 1PP-hands that involved both “kinesthetic sense of movement” and “visual sense of movement” (the movement that the participant sees via the HMD)—provides an important counter-example against this thesis. We argue that it is possible for a healthy subject to experience the same body-part both as-subject and as-object simultaneously. Our goal is not to annihilate the distinction between body-as-object and body-as-subject, but to show that it is not as rigid as suggested by the phenomenologists. (shrink)

Business Ethics, the Environment &Responsibility, Volume 31, Issue 4, Page 999-1013, October 2022.

Liver transplantation (LT) activities during the COVID-19 pandemic have been curtailed in many countries. The impact of various policies restricting LT on outcomes of potential LT candidates is unclear. We studied all patients on the nationwide LT waitlists in Hong Kong and Singapore between January 2016 and May 2020. We used continuous time Markov chains to model the effects of different scenarios and varying durations of disruption on LT candidates.

Objective: Patients with hypochondriasis hold unexplainable beliefs and a fear of having a lethal disease, with poor compliances and treatment response to psychotropic drugs. Although several studies have demonstrated that patients with hypochondriasis demonstrate abnormalities in brain structure and function, gray matter volume and functional connectivity in hypochondriasis still remain unclear.Methods: The present study collected T1-weighted and resting-state functional magnetic resonance images from 21 hypochondriasis patients and 22 well-matched healthy controls. We first analyzed the difference in the GMV between the (...) two groups. We then used the regions showing a difference in GMV between two groups as seeds to perform functional connectivity analysis. Finally, a support vector machine was applied to the imaging data to distinguish hypochondriasis patients from HCs.Results: Compared with the HCs, the hypochondriasis group showed decreased GMV in the left precuneus, and increased GMV in the left medial frontal gyrus. FC analyses revealed decreased FC between the left medial frontal gyrus and cuneus, and between the left precuneus and cuneus. A combination of both GMV and FC in the left precuneus, medial frontal gyrus, and cuneus was able to discriminate the hypochondriasis patients from HCs with a sensitivity of 0.98, specificity of 0.93, and accuracy of 0.95.Conclusion: Our study suggests that smaller left precuneus volumes and decreased FC between the left precuneus and cuneus seem to play an important role of hypochondriasis. Future studies are needed to confirm whether this finding is generalizable to patients with hypochondriasis. (shrink)

ObjectiveWhen regaining consciousness, patients who emerge from a minimally conscious state (EMCS) present with different levels of functional disability, which pose great challenges for treatment. This study investigated the frontoparietal activity in EMCS patients and its effects on functional disability.Materials and methodsIn this preliminary study, 12 EMCS patients and 12 healthy controls were recruited. We recorded a resting-state scalp electroencephalogram (EEG) for at least 5 min for each participant. Each patient was assessed using the disability rating scale (DRS) to determine (...) the level of functional disability. We analyzed the EEG power spectral density and sensor-level functional connectivity in relation to the patient’s functional disability.ResultsIn the frontoparietal region, EMCS patients demonstrated lower relative beta power (P < 0.01) and higher weighted phase lag index (wPLI) values in the theta (P < 0.01) and gamma (P < 0.01) bands than healthy controls. The frontoparietal theta wPLI values of EMCS patients were positively correlated with the DRS scores (rs = 0.629, P = 0.029). At the whole-brain level, EMCS patients only had higher wPLI values in the theta band (P < 0.01) than healthy controls. The whole-brain theta wPLI values of EMCS patients were also positively correlated with the DRS scores (rs = 0.650, P = 0.022). No significant difference in the power and connectivity between the frontoparietal region and the whole brain in EMCS patients was observed.ConclusionEMCS patients still experience neural dysfunction, especially in the frontoparietal region. However, the theta connectivity in the frontoparietal region did not increase specifically. At the level of the whole brain, the same shift could also be seen. Theta functional connectivity in the whole brain may underlie different levels of functional disability. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

Self-location—the sense of where I am in space—provides an experiential anchor for one's interaction with the environment. In the studies of full-body illusions, many researchers have defined self-location solely in terms of body-location—the subjective feeling of where my body is. Although this view is useful, there is an issue regarding whether it can fully accommodate the role of 1PP-location—the sense of where my first-person perspective is located in space. In this study, we investigate self-location by comparing body-location and 1PP-location: using (...) a head-mounted display (HMD) and a stereo camera, the subjects watched their own body standing in front of them and received tactile stimulations. We manipulated their senses of body-location and 1PP-location in three different conditions: the participants standing still (Basic condition), asking them to move forward (Walking condition), and swiftly moving the stereo camera away from their body (Visual condition). In the Walking condition, the participants watched their body moving away from their 1PP. In the Visual condition, the scene seen via the HMD was systematically receding. Our data show that, under different manipulations of movement, the spatial unity between 1PP-location and body-location can be temporarily interrupted. Interestingly, we also observed a “double-body effect.” We further suggest that it is better to consider body-location and 1PP-location as interrelated but distinct factors that jointly support the sense of self-location. (shrink)

BackgroundPrevious studies have not investigated the role of resilience and coping style on the association between maladaptive perfectionism and academic procrastination among nursing undergraduates. However, how to mobilize the learning enthusiasm of nursing students and reduce the incidence of academic procrastination is an important factor to reduce nursing loss and improve nursing quality.ObjectivesTo investigate the influence of maladaptive perfectionism, resilience and coping style on academic procrastination among Chinese undergraduate nursing students.MethodsA cross-sectional study was conducted. A convenience sampling method was used (...) to select 665 nursing undergraduates from March to May 2022 in China. Maladaptive perfectionism, coping style, resilience, and academic procrastination were measured using questionnaires. The descriptive analysis, Pearson’s correlation analysis and the Hayes’ PROCESS Macro in SPSS 25.0 were used to test the model.ResultsThe results showed that nursing undergraduates’ maladaptive perfectionism, resilience, positive coping style and academic procrastination were significantly correlated between every two variables, with coefficients ranging between −0.290 and 0.584. In addition, resilience played a partial mediating role in maladaptive perfectionism and academic procrastination, accounting for 15.70% of the total effect; in the meantime, this process was moderated by positive coping style.ConclusionMaladaptive perfectionism positively predicted nursing undergraduates’ academic procrastination; as a mediating mechanism with moderating, resilience and positive coping style further explained how maladaptive perfectionism promoted the academic procrastination of nursing undergraduates. Understanding this mechanism is of great significance for nursing educators to reduce the risk of academic procrastination in nursing undergraduates. (shrink)

BackgroundTinnitus is a common disease, and sound therapy is an effective method to alleviate it. Previous studies have shown that notched sound not only changes levels of cortical blood oxygen, but affects blood oxygen in specific cerebral cortical areas, such as Brodmann area 46, which is associated with emotion. Extensive evidence has confirmed that tinnitus is closely related to emotion. Whether notched sound plays a role in regulating the emotional center is still unclear.MethodsThis study included 29 patients with newly diagnosed (...) chronic tinnitus who were treated with notched sound. Functional near-infrared spectroscopy was conducted before and after treatment to observe bilateral changes in cortical blood oxygen in the cerebral hemispheres. We compared the changes in connectivity between the two regions of interest, as wells as other cortical regions before and after treatment.ResultsThe results showed That global connectivity between the bilateral auditory cortex of the superior temporal sulcus and the ipsilateral cortex did not change significantly between baseline and the completion of treatment, and That the connectivity between channel 14 and the right superior temporal sulcus decreased after treatment. The overall connectivity between the right BA46 region and the right cortex decreased after treatment, and decreases in connectivity after treatment were specifically found for channels 10 and 14 in the right parietal lobe and channels 16, 20, 21, and 22 in the frontal lobe, while there was no significant change on the left side. There were no significant changes in the questionnaire measures of tinnitus, anxiety, or depression before and after treatment.ConclusionThe results of the study indicate that cerebral cortex reorganization occurs in tinnitus patients after submitted to treatment with notched sound for 1 month, and that notched sound decreases the connectivity between the auditory cortex and specific brain regions.SignificanceNotched sound not only regulates the auditory center through lateral inhibition, but also alleviates tinnitus by reorganizing the emotional control center. (shrink)