Cognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. The (...) investigation of neurodegenerative processes in an early stage, especially in older patients, is probably warranted. (shrink)

Resumen: El propósito del texto es analizar la relación entre cuidado de sí e innovación educativa, considerando que el diálogo y la ironía, son prácticas que posibilitan que el cuidado de sí surja como novedad en la vida del sujeto. Para alcanzar dicho propósito, el texto está dividido en dos apartados, en el primero se revisan las nociones de cuidado de sí e innovación educativa, en el segundo se analizan el diálogo y la ironía. Se acepta que la innovación educativa (...) es esa posibilidad de mantener en novedad el cuidado de sí como transformación de sí. Se asume que diálogo e ironía son experiencia radical en una continua exigencia de reflexión como una manera de habitar la extrañeza y, simultáneamente, bajo el ejercicio pedagógico del ser y hacer de las prácticas educativas. Finalmente se considera al cuidado de sí e innovación educativa como: reflexión y vida en ejercicio. Asumimos que en el diálogo y en la ironía hay un doblez y giro de la atención, la inquietud y el cuidado de sí que lo hacen emerger como innovación educativa. Palabras clave: Cuidado de sí; Innovación educativa; Diálogo; Ironía; Reflexión. Autocuidado e inovação educacional: Diálogo e ironia Resumo: O objetivo do texto é analisar a relação entre o autocuidado e a inovação educativa, considerando que o diálogo e a ironia são práticas que permitem que o autocuidado surja como novidade na vida do sujeito. Para atingir esse objetivo, o texto está dividido em duas seções, na primeira são revisadas as noções de autocuidado e inovação educacional, na segunda analisam-se o diálogo e a ironia. Admite-se que a inovação educacional é a possibilidade de manter o cuidado de si como uma transformação de si como novidade. Assume-se que o diálogo e a ironia são uma experiência radical em uma demanda contínua de reflexão como forma de habitar a estranheza e, simultaneamente, sob o exercício pedagógico do ser e do fazer nas práticas educativas. Por fim, considera-se o autocuidado e a inovação educacional como: reflexão e vida em exercício. Partimos do pressuposto de que no diálogo e na ironia há uma reviravolta de atenção, inquietação e autocuidado que a fazem emergir como inovação educativa. Palavras-chave: Autocuidado; Inovação educacional; Diálogo; Ironia; Reflexão. Self-care and educational innovation: Dialogue and irony Summary: The purpose of the text is to analyze the relationship between self-care and educational innovation, considering that dialogue and irony are practices that allow self-care to emerge as a novelty in the subject's life. To achieve this purpose, the text is divided into two sections, in the first the notions of self-care and educational innovation are reviewed, in the second the dialogue and irony are analyzed. It is accepted that educational innovation is the possibility of keeping care of oneself as a transformation of oneself as novel. It is assumed that dialogue and irony are a radical experience in a continuous demand for reflection as a way of inhabiting strangeness and, simultaneously, under the pedagogical exercise of being and doing in educational practices. Finally, self-care and educational innovation are considered as: reflection and life in practice. We assume that in the dialogue and in the irony there is a twist and turn of attention, restlessness and self-care that make it emerge as an educational innovation. Keywords: Self-care; Educational innovation; Dialogue; Irony; Reflection. Data de registro: 04/07/2022 Data de aceite: 26/10/2022. (shrink)

Regularization may be used as an alternative to dimensionality reduction when the number of variables in a model is much larger than the number of available observations. In a recent study from our group regularized regression was employed to quantify brain functional connectivity in a sample of healthy controls using a brain parcellation and resting state fMRI images. Here regularization is applied to evaluate resting state connectivity abnormalities at the voxel level in a sample of patients with schizophrenia. Specifically, ridge (...) regression is implemented with different degrees of regularization. Results are compared to those delivered by the weighted global brain connectivity method, which is based on averaged bivariate correlations and from the non-redundant connectivity method, a dimensionality reduction approach that applies supervised principal component regressions. Ridge regression is able to detect a larger set of abnormally connected regions than both GBC and NRC methods, including schizophrenia related connectivity reductions in fronto-medial, somatosensory and occipital structures. Due to its multivariate nature, the proposed method is much more sensitive to group abnormalities than the GBC, but it also outperforms the NRC, which is multivariate too. Voxel based regularized regression is a simple and sensitive alternative for quantifying brain functional connectivity. (shrink)

En el marco de la reflexión sobre las relaciones entre ética y política como dimensiones de la experiencia humana y de la vida en común, se presenta una aproximación comparativa a la noción de democracia del filósofo estadounidense John Dewey y la del neozapatismo mexicano. Se señalan algunos puntos de encuentro entre estas nociones, principalmente, la consideración de la democracia como forma de vida comunitaria, como ethos, no sólo como forma de gobierno, y la afirmación de la coexistencia entre lo (...) diverso, en distintas escalas, como condición de la democracia —el pluralismo en Dewey y el pluriversalismo en el neozapatismo—. Se indican también importantes diferencias como el énfasis en el desarrollo de las potencialidades humanas individuales presente sólo en Dewey, y la historicidad y las relaciones de poder que contempla la noción de democracia de los neozapatistas, a diferencia de la de Dewey. El texto afirma la posible fecundidad del diálogo entre distintas tradiciones de pensamiento para la comprensión de la democracia en un sentido más radical, en el que se imbriquen ética y política. (shrink)

El uso prolongado de la voz es un factor de riesgo para el desarrollo de patologías vocales en docentes. Actualmente, estos profesionales se ven obligados a usar mascarilla para dictar sus clases, lo que puede resultar en alteraciones vocales. Durante la virtualización de las clases los docentes debieron adaptar algún espacio doméstico para desempeñar sus funciones frente a un computador, disminuyendo la actividad física y fomentando un estilo de vida sedentario, lo que pudo ocasionar algún trastorno músculo-esquelético. Con este panorama, (...) el propósito del estudio es identificar efectos en la voz por la mascarilla y lesiones músculo-esqueléticas en docentes. (shrink)

This article presents the stance taken by José Ortega y Gasset in the debate that took place in early-twentieth-century Spain regarding the convenience of reading Don Quixote in schools. To this end, we start by describing, albeit briefly, the state of Ortega y Gasset’s thought in 1920, when he writes Biología y pedagogía, the essay with which we shall concern ourselves. According to Ortega y Gasset, Don Quixote must not be read in the classroom because it does not contribute to (...) the development of the students’ spontaneous life, or natura naturans. In order to foster this development, Ortega y Gasset suggests leaving Don Quixote aside and resort to myths such as Odysseus or Heracles because their exploits would excite the students’ vital pulse. However, we suggest several reasons why the aim stated by Ortega y Gasset —and several other highly valuable educational benefits— could be reached resorting to the reading of selected passages of Don Quixote instead of the feats of Odysseus and Heracles. (shrink)

En este artículo se muestra que la locura, dentro del contexto de la obra tardía de Wittgenstein, no ha de ser confundida con el hueco gramatical que se abre cuando tiene lugar una reacción que no tiene cabida dentro del juego de lenguaje que se esté jugando en cierto momento. Además, y teniendo en cuenta que en muchas ocasiones no se puede apreciar y valorar algo en su justa medida hasta que se carece de ello, se señala que es precisamente (...) en el loco, entendiendo por tal el sujeto que se halla gramaticalmente aislado, en quien más claramente podemos apreciar el acuerdo en la forma de vida sobre el que se cimenta la obra tardía de Wittgenstein. In this paper I show that madness, in the context of Wittgenstein's later work, should not be mistaken for the grammatical gap which is opened when a reaction takes place, which has no place in the language-game played in that very moment. Besides, and bearing in mind that we often do not place worth on something until we miss it, it is emphasized that it is in the madman, taken as a grammatically isolated individual, with whom, we are best able to appreciate agreement in form of life on which Wittgenstein's later work is based. (shrink)

Han sido numerosas las ocasiones en que se ha tratado de condensar en una definición la concepción que Wittgenstein tenía de los problemas filosóficos. En este artículo pretendo demostrar que semejante pretensión va en contra del talante mismo de la obra de Wittgenstein por basarse aquella en una orientación esencialista totalmente opuesta a la actitud preconizada por el pensador austriaco, actitud que no era otra que la de atender a los usos del lenguaje para aclarar meras confusiones en las que (...) incurrimos al utilizar un concepto: el término "problema" invita a pensar en la correspondiente "solución", pero Wittgenstein no pretende ofrecer soluciones o explicaciones sino mostrar un modus operandi filosófico comparable a una labor tan simple como la de desatar nudos. (shrink)

Tras describir a grandes rasgos los sistemas de creencias propuestos por Quine y Wittgenstein, en este artículo hago referencia a las similitudes y diferencias que Pieranna Garavaso y Danièle Moyal Sharrock advierten entre ambos sistemas. Partiendo de la crítica de estas interpretaciones, llamaré la atención sobre un aspecto del sistema wittgensteiniano de creencias que, desde mi punto de vista, es de la mayor importancia. Concretamente, me refiero a la posibilidad de revisar incluso las creencias más básicas de este sistema. El (...) análisis de este problema me llevará a tratar otra cuestión no menos importante: ¿supondría la revisión de nuestras creencias más fundamentales que el concepto mismo de humanidad dejara de tener sentido? After describing the main lines of the systems of beliefs Quine and Wittgenstein expounded, I make reference in this paper to the similarities and differences Pieranna Garavaso and Danièle Moyal-Sharrock find between both systems. Through the critique of these interpretations, I will place emphasis on one aspect of the Wittgensteinian system of beliefs which, from my point of view, is of highest importance. I am referring specifically to the possibility of revising even the most basic beliefs of this system. The analysis of this problem will lead me to approach another very important question, i. e.: would the revision of our most fundamental beliefs mean that the concept of humanity itself lose all sense? (shrink)

En un contexto nacional e internacional de emergencia sanitaria que generó una situación atípica de cierre simultáneo de todas las instituciones educativas, atravesamos una experiencia del ejercicio de la docencia extremadamente particular: una migración forzada hacia la virtualidad cargada de incertidumbre. En este escenario, se reactualiza la pregunta por las desigualdades y su presencia en las trayectorias educativas, en este caso, de estudiantes universitarias/os de la universidad pública. Aquí presentamos algunas reflexiones, preguntas y algunos pasos en el camino de la (...) interpretación, para que, en toda la vorágine del teletrabajo en pandemia, lo que pasa a quienes están a ambos lados de la pantalla no nos pase desapercibido. (shrink)

Informed consent forms have been useful in clinical practice and they constitute a part of the shared decision making in the informed consent process. They provide information to patients about clinical procedures and techniques. They also act as a remainder of the information discussed after the medical interview. Sometimes these documents are not readable to everybody. Belgian law specifies that all information that patients receive has to be proportionate verbally, but written information is also handled. The present research analyzes the (...) readability of the Flemish informed consent forms located in the webs of all General Hospitals using a simple random sample of 75 informed consent forms. By using the Douma tool, which bases its analysis in the length of words and sentences, the readability mean of the sample was 46, level “Difficult”. The 59% of them had a difficult level. The 11% were normal. It is a fact, then, that the 59% of the informed consent forms evaluated in this study are not suitable for everybody in Flanders, especially those people with low literacy. There were some researches made in other countries that agreed with these results. Written clinical information was poorly written so the informed consent forms were not working helping patients to recall information nor helping patients to become a part in the shared decision making about their health. The use of readability formulas represented a simple way to discriminate those informed consent forms that had normal readability scores from those that should be adapted. (shrink)

Este trabajo se centra en la gestión de los bienes naturales comunes, y desarrolla brevemente dos enfoques sobre el ambiente y su cuidado; destaca las ventajas de un enfoque interdisciplinario en la gestión comunal de los bienes naturales y en la consiguiente elaboración de políticas ambientales. Se analiza la gestión comunal de estos bienes comunes partiendo de la noción de responsabilidad fuerte, que cuestiona la concepción de las personas como agentes autointeresados, y se identifican requisitos ineludibles: adecuación a las condiciones (...) sociales y ecológicas de cada lugar, información completa y relevante, procesos democráticos de decisión y reconocimiento por parte de los gobiernos de la capacidad y el derecho de los usuarios de elaborar sus propias normas y monitorear su cumplimiento. (shrink)

In the text we approach the trajectory of the Peruvian thinker Aníbal Quijano and how he came to the formulation by which he is known, the explanatory pair modernity / coloniality. We propose a problematizing reading of his intellectual itinerary, recovering a recurrent and highly suggestive metaphor in his approach, the explanatory allegory of the knot. We consider that this figure has multiple potentialities, both in the epistemic-philosophical and political-cultural dimension.

La legislación ambiental en Argentina tuvo un impulso después de la Cumbre de la Tierra en 1992, que conllevó un incremento de la conciencia ciudadana y una creciente preocupación académica desde varias perspectivas filosóficas. Las líneas de investigación de los principales grupos de trabajo en la actualidad incluyen: (a) el trabajo interdisciplinario sobre ética ambiental y justicia ambiental global centrada en los recursos naturales y los ecosistemas, (b) las raíces ecológicamente apropiadas del patrimonio cultural de la civilización occidental en la (...) Antigüedad, y (c) la ontología gestáltica, la ecología profunda y la ecosofía. La emergencia de la ecofilosofía ha demandado que la educación ambiental vaya más allá de la mera formación ecológica para incluir una comprensión de las implicaciones filosóficas del manejo ambiental y de una vida con preocupación ambiental. La investigación interdisciplinaria se ha constituido en un campo promisorio en continuo crecimiento que ha reunido a especialistas de las ciencias naturales, económicas, antropológicas, filosóficas y sociales. (shrink)

La legislación ambiental en Argentina tuvo un impulso después de la Cumbre de la Tierra en 1992, que conllevó un incremento de la conciencia ciudadana y una creciente preocupación académica desde varias perspectivas filosóficas. Las líneas de investigación de los principales grupos de trabajo en la actualidad incluyen: (a) el trabajo interdisciplinario sobre ética ambiental y justicia ambiental global centrada en los recursos naturales y los ecosistemas, (b) las raíces ecológicamente apropiadas del patrimonio cultural de la civilización occidental en la (...) Antigüedad, y (c) la ontología gestáltica, la ecología profunda y la ecosofía. La emergencia de la ecofilosofía ha demandado que la educación ambiental vaya más allá de la mera formación ecológica para incluir una comprensión de las implicaciones filosóficas del manejo ambiental y de una vida con preocupación ambiental. La investigación interdisciplinaria se ha constituido en un campo promisorio en continuo crecimiento que ha reunido a especialistas de las ciencias naturales, económicas, antropológicas, filosóficas y sociales. (shrink)

The versatile clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has emerged as a promising technology for therapy and molecular diagnosis. It is especially suited for overcoming viral infections outbreaks, since their effective control relies on an efficient treatment, but also on a fast diagnosis to prevent disease dissemination. The CRISPR toolbox offers DNA‐ and RNA‐targeting nucleases that constitute dual weapons against viruses. They allow both the manipulation of viral and host genomes for therapeutic purposes and the detection of viral (...) nucleic acids in “Point of Care” sensor devices. Here, we thoroughly review recent advances in the use of the CRISPR/Cas system for the treatment and diagnosis of viral deleterious infections such as HIV or SARS‐CoV‐2, examining their strengths and limitations. We describe the main points to consider when designing CRISPR antiviral strategies and the scientific efforts to develop more sensitive CRISPR‐based viral detectors. Finally, we discuss future prospects to improve both applications. Also see the video abstract here: https://www.youtube.com/watch?v=C0z1dLpJWl4. (shrink)

Antoni Andreu fue un pensador clave en la formación y difusión del pensamiento escotista. El objetivo del presente número monográfico consiste en arrojar un poco de luz sobre estos dos aspectos fundamentales de la obra de Antoni Andreu: el pensamiento filosófico de Andreu y las diferencias que presenta respecto al de Escoto, y su influencia posterior, fundamentalmente en autores de la modernidad.

In daily academic life, students are exposed to a wide range of potentially stressful situations which could negatively affect their academic achievement and their health. Among the factors that could be weakened by academic stress, attention has been paid to expectations of self-efficacy, which are considered one of the most important determinants for student engagement, persistence, and academic success. From a proactive perspective, research on academic stress has emphasized the importance of coping strategies in preventing harmful consequences. In recent years, (...) there has been a growing interest in discovering the extent to which individuals are able to combine different coping strategies and the adaptive consequences this flexibility entails. However, studies using this person-centered approach are still scarce in the academic context. On that basis, this current study had two objectives: (a) to examine the existence of different profiles of university students based on how they combined different approach coping strategies (positive reappraisal, support seeking, and planning); and (b) to determine the existence of differences in general expectations of self-efficacy between those coping profiles. 1072 university students participated in the study. The coping profiles were determined by Latent Profile Analysis (LPA). The differences in the self-efficacy variable were determined using ANCOVA, with gender, university year, and degree type as covariates. Four approach coping profiles were identified: (a) low generalized use of approach coping strategies; (b) predominance of social approach coping approaches; (c) predominance of cognitive approach coping approaches; (d) high generalized use of approach coping strategies. The profile that showed that a greater combination of the three strategies was related to higher general self-efficacy expectations, and vice versa. These results suggest that encouraging flexibility in coping strategies would help to improve university students’ self-efficacy. (shrink)

La adaptación a la vida universitaria representa un gran desafío para los jóvenes. Dadas las nuevas dificultades que se añaden a este reto como consecuencia del COVID-19, el objetivo de este estudio es analizar la producción científica sobre esta cuestión de las últimas tres décadas (1991-2021). Para ello, se ha combinado el estudio bibliométrico con técnicas de análisis de redes sociales a través de los softwares Rstudio y Vosviewer. Se han analizado 291 artículos procedentes de la base de datos Scopus. (...) Los resultados permiten obtener una visión holística de este campo y de su evolución a lo largo del tiempo. (shrink)

Credit unions are one of the most widely established corporate entities in the financial systems of most of the world’s nations. Their historical support to the financing needs of small savers, as well as their assimilation into the framework of contemporary microfinance, gives them an important specific weight in the economic-financial literature of our time. In this sense, our research has carried out a systematic review of the main contributions focused on the area of credit unions over the period 1936–2020, (...) using Scopus and WoS as bibliographic databases. In summary, the main countries, journals, authors, articles, and the main collaborative research networks at the level of authors or countries have been analyzed. In the same way, the implementation of strategic diagrams based on Callon’s procedure has facilitated the classification of the most important terms linked to financial cooperativism, which has served to detect future lines of research related to the terms : asymmetric-information, capital-provision, cooperative-principles, customer-reduction, gender-issues, neoinstitutionalism, poverty, and urban-economy. (shrink)

Introduction: Loss of employment is an experience that is lived and interpreted differently depending on a series of individual variables, including the psychological resources available to the affected person, as well as their perception of their degree of employability. Losing one’s job can be one of the most painful and traumatic events a person has to withstand. Following a dismissal, the worker needs to overcome a period of emotional adaptation to the loss. But that period of grieving can also condition (...) the process of job search of the person, and be influenced by different variables, highlighting the age and work experience. The objective of this study is to analyze the relationship between intensity and type of affliction due to the loss of employment in older workers and their level of employability. Method: We carried out a descriptive, analytical, cross-sectional study. The sample consisted of 140 unemployed participants, from 19 to 65 years of age, users of job Orientation in the Public Employment Service of Andalusia (España). Of the total participants, 66 were unemployed and over 45 years of age. They all took the Labour Insertion Potential Assessment Test, and the Texas Inventory revised adapted to job loss Results: Significant differences are shown in the grieving process due to loss of employment between both groups, with the older unemployed living the process more intensely. In relation to the employability potential, differences are found between both groups in terms of availability, perceived difficulties and fears. Interrelationships between total grieving intensity and the importance that older jobseekers give to work are also indicated. Conclusion:Loss of employment and the psychological and health consequences of this situation are identified with those that arise in the grieving process. Older workers present a series of features that determine that their job loss grieving process is more intense and lasts longer than that of other younger workers, regardless of whether the job loss was recent or not. On the other hand, it is shown that the intensity of grieving is related to the decrease of certain variables that are part of the concept of employability. (shrink)

This article explores how historical narratives affect the evaluation of political decisions regarding justice during peace negotiations. Specifically, this study evaluates how different narratives of the Colombian armed conflict relate to the preference for either restorative or retributive justice. Results revealed that a historically accurate narrative that included structural elements correlated with the preference for restorative justice, whereas a schematic narrative that focused on individual greed favoured the preference for retributive justice. These results are explained in terms of the characteristics (...) of expert historical narratives, which include structural elements, such as economic and institutional factors. The presence of these elements in the explanation of conflicts decreases the weight of individual decisions and, in this way, prevent ingroup attributional biases. (shrink)

Introduction and ObjectiveThe early identification of depressive patients having a poor evolution, with frequent relapses and/or recurrences, is one of the priority challenges in this study of high prevalence mental disorders, and specifically in depression. So, this study aims to analyze the factors that may be associated with an increased risk of recurrence of major depression episodes in patients treated in primary care.MethodsA retrospective, descriptive study of cases-controls was proposed. The cases consisted of patients who had been diagnosed with major (...) depression and who had presented recurrences, in comparison with patients who had experienced a single major depression episode with no recurrence. The variables of the study are age at first episode; number of episodes; perception of severity of the depression episode suffered prior to recurrence; number of residual symptoms; physical and psychiatric comorbidity; history of anxiety disorders; family psychiatric history; high incidence of stressful life events ; and experiences of physical, psychological, or sexual abuse in childhood. The differences of the variables were compared between the case subjects and the control subjects, using the Mann–Whitney, chi-square, and Fisher’s U statistics. A multivariate analysis was performed.ResultsThe average age of those suffering more than one depressive episode is significantly older, and a higher percentage of subjects who have experienced more than one depressive episode have a history of anxiety disorders. In the multivariate analysis, the variables that obtained a significant value in the logistic regression analysis were age and having suffered sexual abuse during childhood.ConclusionThese indicators should be considered by primary care physicians when attending patients suffering from major depression. (shrink)

The interest of assigning homework is frequently discussed due to its alleged low impact on student achievement. One of the current lines of research is to emphasize the quality of student homework engagement rather than the amount of time spent on homework. The aim of this study was to determine (a) the extent to which students’ prior achievement affects their homework engagement (i.e., time spent, time management, and amount of teacher-assigned homework done), and (b) how students’ intrinsic motivation towards homework (...) may mediate or moderate the relationship between prior achievement and the homework engagement variables. A large sample of students from the first four years of Secondary Education (N = 1899) completed questionnaires. The results showed that intrinsic motivation partially mediates, but does not moderate, the effect of prior achievement on the three variables related to homework engagement (time spent, time management, and amount of teacher-assigned homework done). These results highlight the importance of considering both students’ current level of achievement and their motivation towards homework engagement when assigning homework. (shrink)