‘Gender ’ is a troublesome loanword in Japan. While this term has been prevalent in feminist and scholarly circles, it has evoked confusion in the government and stimulated a backlash from the ultra-conservatives against gender equality. Japanese reactionaries have attacked the concept of gender because of their anxiety about cultural destruction – I thus call them the ‘old guard’. Focusing on a dispute over the term ‘gender’ between feminists and the old guard, this paper examines the changes in the term's (...) usage and meanings in the Japanese political context. I first shed light on Japan's reaction to the newly arrived term ‘gender’, outlining different attitudes towards gender between the feminist/scholarly circles and the government. Secondly, I discuss the old guard's condemnation of the concept of gender, in which they distort its significance in order to diminish its positive impact on society. I then scrutinize the old guard's reasons behind their attack on the concept of gender. My findings reveal that the old guard, whose political cause is to protect traditional Japanese culture, asserts that gender equality damages this culture. Moreover, I refute their emphasis on Japan's uniqueness, demonstrating that Japanese women's traditional virtues under the patriarchal family system are not peculiar to Japan. To gauge how the concept of gender has been interpreted politically, I highlight legislative debates about the term ‘gender’. In doing so, I elucidate the extent to which the concept of gender has infiltrated Japanese society through the dispute.Export citation Request permission. (shrink)

AbstractThe Belmont Report continues to be held in high regard, and most bioethical analyses conducted in recent years have presumed that it affects United States federal regulations. However, the assessments of the report’s creators are sharply divided. Understanding the historic reputation of this monumental report is thus crucial. We first recount the historical context surrounding the creation of this report. Subsequently, we review the process involved in developing ethical guidelines and describe the report’s features. Additionally, we analyze the effect of (...) unfolding events on the subsequent creation of federal regulations, especially on gene therapy clinical trials. Moreover, throughout this paper we evaluate the ethical principles outlined in this report and describe how they overlap with the issue of protecting socially vulnerable groups. Based on the analysis, we conclude that the features of the Belmont Report cannot be considered as having affected the basic sections of the federal regulations for ethical reviews that were made uniform in 1981. Nevertheless, regarding the regulations on gene therapy clinical trials—which were at first expected to be applicable to research involving children—in addition to implementing policies regarding the public review of protocols that passed ethical review, this report’s principles are clearly reflected in the key notes that should have been referred to when the report was created. (shrink)

The state of the body is central to guiding motivational behaviours. Here we discuss how afferent information from face and viscera influence the processing and communication of emotional states. We highlight (a) the fine-grained impact that facial muscular and patterned visceral responses exert on emotional appraisal and communicative signals; (b) short-term changes in visceral state that bias brain responses to emotive stimuli; (c) the commonality of brain pathways and substrates mediating short- and long-term bodily effects on emotional processes; (d) how (...) topographically distinct representations of different bodily states are coupled to reported feelings associated with subtypes of disgust; and (e) how pupil signals contribute to affective exchange. Integrating these observations enriches our understanding of emotional processes and psychopathology. (shrink)

The PIWI-interacting RNA pathway, one of the major eukaryotic small RNA silencing pathways, is a genome surveillance system that silences selfish genes in animal gonads. piRNAs guide PIWI protein to target genes through Watson–Crick RNA–RNA base-parings. Loss of piRNA function causes genome instability, inducing failure in gametogenesis and infertility. Studies using fruit flies and mice as key experimental models have resulted in tremendous progress in understanding the mechanism underlying the piRNA pathway. Recent work using cultured silkworm germline cells has also (...) expanded our knowledge of piRNA biogenesis in particular, since these silkworm cells are the only cells of germline origin that can be cultured. In this review, we describe elucidation of the piRNA pathway using cultured silkworm cells as an experimental model by focusing on recent work in biochemistry and structural biology. Earlier studies that made important contributions to the field are also described. PIWI-interacting RNAs are germline-enriched small RNAs that silence transposons to maintain genome integrity. Recently, cultured silkworm germline cells such as BmN4 made great contributions to understand the mechanism underlying piRNA biogenesis in particular. In this review, we highlight the recent progress in biochemical and structural biology. (shrink)

Vertebrate haemoglobin (Hb), the oxygen‐carrying protein of the blood, consists of two α‐ and two β‐subunits, each containing one haem, and shows cooperative oxygen binding known as the haem–haem interaction. The amino‐acid sequences of Hbs found in different species have diverged considerably and the homology in the most distantly related ones is only 40%. How can such varied amino‐acid sequences give rise to similar three‐dimensional structures and functional properties? To what extent do amino‐acid replacements affect the structure of haemoglobin? Which (...) mutations are responsible for the functional differences between haemoglobins from different species? Expression of α‐ and β‐globins in Escherichia coli has enabled us to introduce any mutations in the haemoglobin molecule at will. By X‐ray crystallographic and functional studies of the engineered mutants, we are trying to answer these questions. (shrink)

This article characterizes Florence Nightingale's nursing reform as the cleaning of the Victorian home which she found unheimlich. She laid strong emphasis on an improvement in the hygiene of the house as a significant part of nursing, and, by establishing the nurse as a new occupation, gave the surplus of unmarried women a decent means of escape from the stifling domesticity in which they had been helplessly trapped. Her nursing at once reformed and reinforced the traditional role of woman as (...) a domestic figure, for she created the nurse as a mother figure in charge of the home space. In the Crimean War, Nightingale successfully nursed the idea of England as Home by attending to the dying soldiers at the front. Her crusade to nurse the unhomely space into a home, however, dismissed one uncanny place inside the imperial Home that needed urgent nursing, that is, Ireland, which had been suffering from the Great Famine and its aftermath. Nightingale confronted Irish Sisters of Mercy, who came to the Crimea to save the lives and souls of the Irish soldiers. These Irish nuns not only embodied the memories of the Famine which they had recently relieved, but also threatened Nightingale's single female authority by representing Ireland as a nation through their equally motherly presence. The service of the Irish nuns in the Crimean War was erased from the myth of the Lady with the Lamp. Nightingale could establish herself as an authoritative female subject and assumed the voice of England only by suppressing another female voice which challenged England's competence in Home management. (shrink)

The situation-dependent lateralization of sympathetic electrodermal arousal during real-life stress may challenge a unitary notion of arousal, and call into question the practice of unilateral electrodermal recording, but there are broader implications. Here we consider a potential relationship between stress-induced lateralized shifts in electrodermal activity, and a theory concerning lateralized emotion-induced cardiac arrhythmia.

Graphical AbstractEnvironmental oxygen might have been the key for the evolution of novel developmental mechanisms, such as the interdigital cell death of amniotes. Increased amount of oxygen can also induce cell death in interdigital regions of an amphibian that typically lacks it. To learn more about the role of environmental oxygen in the evolution of new traits, see the article number 2000025 by Ingrid Rosenburg Cordeiro and Mikiko Tanaka. Cover image by Itoko Tanaka and Mikiko Tanaka.

Oxygen is a key regulator of both development and homeostasis and a promising candidate to bridge the influence of the environment and the evolution of new traits. To clarify the various ways in which oxygen may modulate embryogenesis, its effects are reviewed at distinct organizational levels. First, the role of pathways that sense dioxygen levels and reactive oxygen species are reviewed. Then, the effects of microenvironmental oxygen on metabolism, stemness, and differentiation throughout embryogenesis are discussed. Last, the interplay between ecology (...) and development are reexamined with a focus on the evolution of tetrapods, including during the emergence of a novel mechanism that shapes amniote limbs—interdigital cell death. Both genetic and environmental components work together during the formation of organisms, highlighting the importance of a multidisciplinary approach for understanding the evolution of new traits. (shrink)

L’acte de la philosophie japonaise est celui d’un évidement de soi: acte d’accueil des traditions philosophiques du monde, acte en résonance, créateur d’une terminologie, d’une logique, d’une conceptualité originales, s’alimentant aux sources d’une pensée mythique jamais tarie. Les textes présentés ici en feront sentir l’inclassable nouveauté: cette philosophie n’est ni purement shintoïste, bouddhique, chrétienne, néoconfucianiste ; elle n’est ni « orientale » ni « occidentale », mais proprement japonaise.

現代の哲学界にあって、全く独自のアプローチを積み上げてきた永井均。永井哲学の最重要キーワードでもある「“私”」について、永井自身と森岡正博が哲学する。“私”、すなわち、「いまここに現にひとりだけ特殊な 形で存在している、私の特別なあり方」は決して普遍化できないはずだが、ひとたびそれを語ってしまうと、他者にも適用できる単なる「私」の話となり、本当に言いたかった特別さは消えてしまう。どうすれば私たちは私 だけがもつその特別さに近づくことができるだろうか?―独在性の解釈をめぐって、永井と森岡は徐々にすれ違いを見せていく。2人の議論の「噛み合わなさ」から浮かび上がってくる“私”の真相とは?この世の最大の謎 、“私”をめぐって繰り広げられるオリジナルでスリリングな知的冒険。.

Summary In Japan, the demand for the philosophy of science has recently increased, and in the last decade many changes have been brought about, among which the most remarkable is the rise of analytic philosophy.

2014年から2021年のツイートから哲学を主題とするものを厳選。あらゆる人を哲学に誘う刺激とやさしさに満ちた一冊。.