The origin of the genetic code has been attributed in part to an accidental assignment of codons to amino acids. Although several lines of evidence indicate the subsequent expansion and improvement of the genetic code, the hypothesis of Francis Crick concerning a frozen accident occurring at the early stage of genetic code evolution is still widely accepted. Considering Crick’s hypothesis, mathematical descriptions of hypothetical scenarios involving a huge number of possible coexisting random genetic codes could be very important to explain (...) the origin and evolution of a selected genetic code. This work aims to contribute in this regard, that is, it provides a theoretical framework in which statistical parameters of error functions are calculated. Given a genetic code and an amino acid property, the functional code robustness is estimated by means of a known error function. In this work, using analytical calculations, general expressions for the average and standard deviation of the error function distributions of completely random codes with standard stop codons were obtained. As a possible biological application of these results, any set of amino acids and any pure or mixed amino acid properties can be used in the calculations, such that, in case of having to select a set of amino acids to create a genetic code, possible advantages of natural selection of the genetic codes could be discussed. (shrink)

The increasing availability of personal data of a sequential nature, such as time-stamped transaction or location data, enables increasingly sophisticated sequential pattern mining techniques. However, privacy is at risk if it is possible to reconstruct the identity of individuals from sequential data. Therefore, it is important to develop privacy-preserving techniques that support publishing of really anonymous data, without altering the analysis results significantly. In this paper we propose to apply the Privacy-by-design paradigm for designing a technological framework to counter the (...) threats of undesirable, unlawful effects of privacy violation on sequence data, without obstructing the knowledge discovery opportunities of data mining technologies. First, we introduce a k-anonymity framework for sequence data, by defining the sequence linking attack model and its associated countermeasure, a k-anonymity notion for sequence datasets, which provides a formal protection against the attack. Second, we instantiate this framework and provide a specific method for constructing the k-anonymous version of a sequence dataset, which preserves the results of sequential pattern mining, together with several basic statistics and other analytical properties of the original data, including the clustering structure. A comprehensive experimental study on realistic datasets of process-logs, web-logs and GPS tracks is carried out, which empirically shows how, in our proposed method, the protection of privacy meets analytical utility. (shrink)

The new wave of ‘foundation models’—general-purpose generative AI models, for production of text (e.g., ChatGPT) or images (e.g., MidJourney)—represent a dramatic advance in the state of the art for AI. But their use also introduces a range of new risks, which has prompted an ongoing conversation about possible regulatory mechanisms. Here we propose a specific principle that should be incorporated into legislation: that any organization developing a foundation model intended for public use must demonstrate a reliable detection mechanism for the (...) content it generates, as a condition of its public release. The detection mechanism should be made publicly available in a tool that allows users to query, for an arbitrary item of content, whether the item was generated (wholly or partly) by the model. In this paper, we argue that this requirement is technically feasible and would play an important role in reducing certain risks from new AI models in many domains. We also outline a number of options for the tool’s design, and summarize a number of points where further input from policymakers and researchers would be required. (shrink)

Now in its Third Edition, Philosophy of Language: A Contemporary Introduction introduces students to the main issues and theories in twentieth-century philosophy of language, focusing specifically on linguistic phenomena. Author William G. Lycan structures the book into four general parts. Part I, Reference and Referring, includes topics such as Russell's theory of descriptions (and its objections), Donnellan's distinction, problems of anaphora, the description theory of proper names, Searle's cluster theory, and the causal-historical theory. Part II, Theories of Meaning, surveys the (...) competing theories of linguistic meaning and compares their various advantages and liabilities. Part III, Pragmatics and Speech Acts, introduces the basic concepts of linguistic pragmatics and includes a detailed discussion of the problem of indirect force. Part IV, The Expressive and the Figurative, examines various forms of expressive language and what "metaphorical meaning" is and how most listeners readily grasp it. (shrink)

This chapter aims to illuminate ways in which hope was significant in the philosophy of classical Greece. Although ancient Greek philosophies contain few dedicated and systematic expositions on the nature of hope, they nevertheless include important remarks relating hope to the good life, to reason and deliberation, and to psychological phenomena such as memory, imagination, fear, motivation, and pleasure. After an introductory discussion of Hesiod and Heraclitus, the chapter focuses on Plato and Aristotle. Consideration is given both to Plato’s direct (...) comments on hope and to the narrative contexts of his dialogues, with analysis of Plato’s positive and negative representations of hope, hope’s relationship to reason, and Plato’s more psychological approach in the Philebus, where hope finds a place among memory, recollection, pleasure, and pain. The chapter then reviews Aristotle’s discussions of confidence, hope, and courage, observing that although Aristotle does not mention hope as a virtue, he does note its importance to human agency and deliberation and as a foundation for the further development of virtue. The chapter concludes that discussions surrounding hope in ancient Greek philosophy are rich and challenging and can serve as a lively stimulus to further exploration of the concept of hope. (shrink)

COVID-19 has stolen millions of lives and devastated livelihoods around the world and led to the exacerbation of existing inequities within and between countries. This part of a tragic pattern in catastrophes, where the most vulnerable populations are typically the ones to bear the greatest burdens. Jecker and Au1 offer a keen observation of how one particular COVID-19 response—Zero COVID—appears particularly problematic from a health equity perspective. Under Zero COVID, countries enact stringent lockdowns and movement restrictions in order to keep (...) cases as low as possible. Yet such restrictive policies hurt disadvantaged populations the most, by severely curtailing their ability to earn a living and forcing them to remain in cramped living spaces for potentially extended periods of time. However, the link between Zero COVID and health inequity is more complex than it might at first appear. This is because Zero COVID is itself compatible with meaningful efforts to mitigate inequities, including those caused by Zero COVID policies themselves. Conversely, certain inequities seemingly characterised by Zero COVID may persist even when Zero COVID is abandoned, indicating their ultimate root and …. (shrink)

_Winner of the Fabian Dorsch ESA Essay Prize._ Julian Dodd defends the view that, in musical work-performance practice, interpretive authenticity is a more fundamental value than score compliance authenticity. According to him, compliance with a work’s score can be sacrificed in cases where it conflicts with interpretative authenticity. Stephen Davies and Andrew Kania reject this view, arguing that, if a performer intentionally departs from a work’s score, she is not properly instantiating that work and hence not producing an authentic performance (...) of it. I argue that this objection fails. A detailed analysis of work-performance practice reveals, first, that the normative scope of interpretive authenticity encompasses the practice of composing musical versions and that, second, when performers sacrifice score compliance to maximize interpretive authenticity, they are performing the target work by means of performing a version of it. By means of the nested types theory, I then show how performances produced in this way can be properly formed instances, and hence authentic performances, of their target work. (shrink)

Furthermore, adults with decision-making capacity, including pregnant women, can currently accept interventions with moderate net risks for themselves in other settings (e.g., open f...

Erik Wielenberg recently invoked the parent-child analogy in an argument against Christian theism. The argument relies on the claim that a loving parent would never allow her child to feel abandoned in the midst of what feels like gratuitous suffering. In this paper, I offer three clear counterexamples to Wielenberg’s central premise. At the same time, a successful counterexample does not a robust theology of suffering make. To that end, and with a careful eye towards anti-theodical concerns, I defend the (...) need for a more proactive Christian philosophical examination of the role of suffering in a meaningful life. (shrink)

We prove an effective version of the Lopez-Escobar theorem for continuous domains. Let $Mod(\tau )$ be the set of countable structures with universe $\omega $ in vocabulary $\tau $ topologized by the Scott topology. We show that an invariant set $X\subseteq Mod(\tau )$ is $\Pi ^0_\alpha $ in the Borel hierarchy of this topology if and only if it is definable by a $\Pi ^p_\alpha $ -formula, a positive $\Pi ^0_\alpha $ formula in the infinitary logic $L_{\omega _1\omega }$. As (...) a corollary of this result we obtain a new pullback theorem for positive computable embeddings: Let $\mathcal {K}$ be positively computably embeddable in $\mathcal {K}'$ by $\Phi $, then for every $\Pi ^p_\alpha $ formula $\xi $ in the vocabulary of $\mathcal {K}'$ there is a $\Pi ^p_\alpha $ formula $\xi ^{*}$ in the vocabulary of $\mathcal {K}$ such that for all $\mathcal {A}\in \mathcal {K}$, $\mathcal {A}\models \xi ^{*}$ if and only if $\Phi (\mathcal {A})\models \xi $. We use this to obtain new results on the possibility of positive computable embeddings into the class of linear orderings. (shrink)

Criticises G. E. Moore’s highly influential proposal that ascriptions of agent ability implying freedom of choice or action, what the agent could do, are analyzable as conditional statements regarding what the agent would do under certain circumstances. Austin objects against Moore that some uses of ‘if’ are non-conditional and goes on to examine the uses of these non-conditional cases. Moore’s proposal also lies at the heart of some compatibilist theories of free will and determinism. Austin argues determinism to be a (...) pseudo-problem, so long as it remains a notion that is not itself clear cut. (shrink)

“Perfect Day” by Lou Reed and “Village Ghetto Land” by Stevie Wonder are prime examples of “melic” irony in song—cases in which expressive irony is achieved through the interplay and tension between a song’s lyrics and its musical accompaniment. But how exactly can a song achieve this ironic effect, especially if, as formalists maintain, music on its own is incapable of meaning, much less communicative irony? In this paper, I illuminate this type of irony by applying a Gricean account of (...) verbal irony to song. I explore the complexities of this application, and suggest that, through ironic interplay with lyrics, the music of a song can acquire semantic capacities of its own. (shrink)

Monitored Emergency Use of Unregistered and Experimental Interventions (MEURI) is an ethical framework developed by the WHO for using unproven interventions in public health emergencies outside the context of medical research. It is mainly intended for use when medical research would be impracticable, but there is still a need to systematically gather data about unproven interventions. As such, it is designed as something of a middle ground between clinical and research ethical frameworks.However, I argue that MEURI does not truly lie (...) at the intersection of clinical care and research. Due to its intent, structure and oversight requirements, it takes on most of the crucial features of research, to the point that it is best understood as a form of research. As a result, cases where MEURI could practicably be applied should instead make use of existing research frameworks. For those circumstances where research is truly impracticable, a more straightforward oversight system than MEURI is needed. While existing practices of compassionate use have some applicability, proposals to make use of clinical ethics committees to oversee unproven interventions may help achieve the right balance in acting in a patient’s best interests when the relevant evidence base is weak. (shrink)

This chapter explains that most of the standard objections to substance dualism (SD) count as effectively against property dualism (PD), and that PD is hardly more plausible, or less implausible, than SD. Dualism competes, not with neuroscience (a science), but with materialism, an opposing philosophical theory. The chapter shows that although Cartesian dualism faces some serious objections, that does not distinguish it from other philosophical theories, and the objections are not an order of magnitude worse than those confronting materialism in (...) particular. There remain the implausibilities required by the Cartesian view; but bare claim of implausibility is not argument. The dialectical upshot is that, on points, and going just by actual arguments as opposed to appeals to decency and what good guys believe, materialism is not significantly better supported than dualism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Introduction to the Special SectionFranklin G. MillerHappy is a female elephant who has been confined at the Bronx Zoo for over 40 years. In 2018 the Nonhuman Rights Project sued the Wildlife Conservation Society, which manages the zoo, seeking habeas corpus for Happy in order to release her to an elephant sanctuary. Numerous amicus curiae briefs were filed in favor and against the petition on behalf of Happy. The (...) case reached the highest court in New York State, which denied the petition of the plaintiff in June 2022.This special section includes views on the case of Happy by David DeGrazia, Martha Nussbaum, and Christine Korsgaard, three distinguished moral philosophers who have made significant contributions to animal ethics. The essays by Martha Nussbaum and Christine Korsgaard are drawn from the amicus briefs that they filed in the legal proceedings, which they agreed could be published here.Professor Nussbaum applies her "capabilities approach" as a foundation for promoting wellbeing and recognizing rights to Happy and to elephants in general. She argues that Happy is a being with a meaningful life and is entitled to be treated with respect and dignity, which is incompatible with her conditions of confinement at the zoo. Professor Korsgaard applies her understanding of the moral philosophy of Immanuel Kant to the case of Happy—a "cognitively sophisticated [End Page 1] animal" which, like human beings, should be treated as an end in herself and not merely as a means to the purposes of human beings. Professor DeGrazia, in an invited essay, analyzes the meanings of "person" and examines the pertinent characteristics of elephants that make them at least "borderline persons," with the moral status of possessing basic rights.While Happy remains confined at the Bronx Zoo, these three incisive contributions challenge readers to reflect on the ethical treatment of nonhuman animals, especially those with complex and rich capacities of intelligence and emotion. [End Page 2]Franklin G. MillerWeill Cornell Medical College, New YorkCopyright © 2023 Johns Hopkins University Press... (shrink)

In 2022, at an interdisciplinary conference on Creation and the Imago Dei, Biola psychologist Liz Hall posed a powerful challenge to the philosophers and theologians in the room. In the face of the “already and not yet” nature of Christian theology, she put forth the need for a “theology of tension.” Over and over again, while reading Biblical Philosophy, I was reminded of this challenge. The features Johnson puts forth as emblematic of Hebraic Philosophy can help in this respect, in (...) two clear ways: First, retrospectively, Johnson’s categories are useful for diagnosing both the philosophical missteps targeted by critiques of theodicy and the features held in common by some of the more successful accounts. Second, going forward, the convictions and modes of argument central to Hebraic philosophy may help guide future philosophical responses to suffering. In general, I believe that the philosophical problems related to suffering are especially well-suited to responses that are pixelated, networked, mysterianist, creationist, transdemographic, and ritualist. Perhaps Hebraic philosophy can succeed where Hellenist philosophy has struggled: in addressing the tension that arises from the experience of suffering in a world governed by a loving, providential, sovereign God. While I am largely in favor of Johnson’s Hebraic philosophy, I will conclude by breaking from his view in one important respect. Johnson presents the Biblical view as substantially contrasting with the correspondence theory affirmed by many contemporary philosophers. I will end by pushing back on this claim. On Johnson’s own account, the Hebraic notion of truth is determined with reference to the divinely designed order. I propose that we understand the Hebraic notion of truth as degrees of correspondence to this divinely ordered, absolute reality. (shrink)

We study the algorithmic complexity of embeddings between bi-embeddable equivalence structures. We define the notions of computable bi-embeddable categoricity, \ bi-embeddable categoricity, and degrees of bi-embeddable categoricity. These notions mirror the classical notions used to study the complexity of isomorphisms between structures. We show that the notions of \ bi-embeddable categoricity and relative \ bi-embeddable categoricity coincide for equivalence structures for \. We also prove that computable equivalence structures have degree of bi-embeddable categoricity \, or \. We furthermore obtain results (...) on the index set complexity of computable equivalence structure with respect to bi-embeddability. (shrink)

This contribution focuses on three aspects of Nietzsche’s art of living that have become relevant today especially in the United States (but not only here): first, regarding some facets of the economic-political conditions of any contemporary art of living; second, the widespread adoption of Nietzsche’s notion of self-overcoming and artistic self-design in entrepreneurship and individual’s lives; and third, how his notion of ‘incorporation’ has been further developed in current approaches to habit design. Eventually I will show via the example of (...) Anthony Robbins that some notions of Nietzsche’s art of living have become most popular outside of academia, namely in the commercial industries of what has been called ‘self-growth’ or ‘self-development.’. (shrink)

Consider three widely shared claims that have not been discussed vis-à-vis one another. In his Proslogion, Saint Anselm argued that the claim “God exists” is true. If an intuition that a claim c is a useful a-priori justificatory resource, this can only be because such an intuition is a justification that c is true. And if an intuition that c is a justification that c is true, c can stand, not only for mathematical or logical claims, but also for controversial (...) philosophical ones, e.g., “God exists”. This essay addresses to while dialoguing with the literature on Anselm and intuition and articulating an alternative reading of the Proslogion. The alternative reading is that regardless of whether the Proslogion backs up or aims to back up the claim that “God exists” is true, it implicitly articulates the Meaning Argument whose conclusion is that all persons of faith are able to understand that the claim “God exists” is meaningful. This argument, it is argued, is evidence that an intuition that c may be a useful a-priori justificatory resource even if such intuition does not track truth, but merely meaning in being a justification for taking c to be meaningful. It is also supported that an intuition that “God exists” is not a justification that this claim is true. This is an indication that there may be reasons for thinking that the same applies to other controversial philosophical claims. (shrink)

Sun Yat-Sen was a Chinese philosopher and politician, who served as the provisional first president of the Republic of China, and first leader of the Kuomintang. He argued that common blood, language, customs, religion and livelihood were the five essential elements that constituted a nation. Sun was influenced by social Darwinism in his understanding that socio-cultural forces could override the innate characteristics of race. Thus, he employed racially defined nationalism by invoking anti-Manchuism. Although China’s modernisation in the first decades of (...) the 20th century was attributed to Sen, this paper shows that his insistence on the consanguine Han race produced inconsistencies, as his racially defined nationalism and republicanism were mutually exclusive, the latter being based on the inclusion of all citizens regardless of their ethnic background. Indeed, modern nations are constituted by both naturally inherited and culturally acquired qualities of the people. Since China consists of many ethnic groups, Sen’s emphasis on consanguine Chinese race has produced a racially exclusionary nation and has caused racial conflict. (shrink)

This chapter is about susceptibility to one type of division within our selves that can occur within self‐conscious experience and is present in certain mental disorders. This is the separation between experiencing oneself as subject and as agent. The chapter considers some disorders of self‐consciousness and examines the role that this particular division may play in those disorders. Companion to consciousness studies is not completed without attention to the philosophical psychopathology of self‐consciousness. The chapter also examines the case of verbal (...) auditory hallucinations. Investigators often say that hallucinations involve “loss of ego boundaries” or “internal/external confusion”. The chapter presents a case of alienated self‐consciousness, and explores the phenomenon of thought insertion. According to the standard or traditional account of thought insertion, the patient is aware of her own thoughts, but denies that they are hers and attributes them to someone else. So, thought insertion certainly seems to constitute alienated awareness of one's own thoughts. (shrink)

We investigate the complexity of embeddings between bi-embeddable structures. In analogy with categoricity spectra, we define the bi-embeddable categoricity spectrum of a structure A as the family of Turing degrees that compute embeddings between any computable bi-embeddable copies of A; the degree of bi-embeddable categoricity of A is the least degree in this spectrum (if it exists). We extend many known results about categoricity spectra to the case of bi-embeddability. In particular, we exhibit structures without degree of bi-embeddable categoricity, and (...) we show that every degree d.c.e above 0(α) for α a computable successor ordinal and 0(λ) for λ a computable limit ordinal is a degree of bi-embeddable categoricity. We also give examples of families of degrees that are not bi-embeddable categoricity spectra. (shrink)

Ernst Cassirer occupies a unique space in Twentieth-century philosophy. A great liberal humanist, his multi-faceted work spans the history of philosophy, the philosophy of science, intellectual history, aesthetics, epistemology, the study of language and myth, and more. The Philosophy of Symbolic Forms is Cassirer's most important work. It was first published in German in 1923, the third and final volume appearing in 1929. In it Cassirer presents a radical new philosophical worldview - at once rich, creative and controversial - of (...) human beings as fundamentally "symbolic animals," placing signs and systems of expression between themselves and the world. This major new translation, the first for over fifty years, brings Cassirer's magnum opus to a new generation of students and scholars. Volume 2: Mythical Thought considers the role of myth in human thought and expression. Cassirer examines the main features of morphology of myth before tackling the relationship between myth and self-consciousness. He argues that human beings' experience of the world around them is charged with affective and emotional significance, as desirable or hateful, comforting or threatening. It is this type of meaning which underlies mythical consciousness and explains its disregard for the distinction between appearance and reality. From mythical thought religion and art develop, Cassirer argues, making the mythical view of the world the earliest form of philosophical expression. Correcting important errors in previous English editions, this translation reflects the contributions of significant advances in Cassirer scholarship over the last twenty to thirty years. Each volume includes a new introduction and translator's notes by S. G. Lofts, a foreword by Peter Gordon, a glossary of key terms, and a thorough index. (shrink)

Florian A.G. Lützen untersucht in dieser Studie den Religionsbegriff ( din) bei Aḥmad Ibn Aǧība (gest. 1224/1809), seine Synthese von Sufitum und Theologie. Den Religionsbegriff beschreibt er insbesondere anhand der im "Gabriel-Hadith" dargestellten Ebenen: islam, iman und i san - Hingabe, Glaube und Vervollkommnung. Dieses Stufengebilde, von vielen Gelehrten in der späten Phase der Islamischen Theologie (etwa 1400-1800) für fundamental erachtet, eignet sich zum einen dazu, die Religion aus der Perspektive der Theologie darzustellen, und zum anderen, um den Weg des (...) Menschen zu Gott zu beschreiben. In seiner Analyse macht der Autor deutlich, wie Ibn Agiba, aufbauend auf seiner Tradition, eine Theologie konzipiert, die das Sufitum ins Zentrum stellt, ohne die anderen Disziplinen der Theologie auszuklammern. (shrink)