La filosofía desde la teoría general del derecho, por H. Cairns.--Teoría jurídica integralista, por J. Hall.--Más allá del pragmatismo jurídico, por T.A. Cowan.--La tecla para una ciencia jurídica estimativa, por A.H. Pekelis.--Palabras y música, por J. Frank.--Teoría de los intereses sociales de Pound, por E.W. Patterson.--La metamorfosis de la idea de justicia, por H. Kelsen.--Sobre la naturaleza del derecho natural, por A.-H. Chroust.

It is the contemporary belief, in American legal circles at all events, that law or jurisprudence, whatever it may have been in the past, has now the status of a social science. This is an assumption easier to make than to substantiate, and in view of the increasing insistence upon this point, it is now appropriate to inquire whether or not it possesses a tangible foundation. This requires a consideration of the distinctive characteristics of social science, the determination whether or (...) not jurisprudence exhibits these characteristics, and, if not, if it is possible for it to assume them. It will be convenient to begin, briefly and concisely, with an examination of the characteristics of modern legal thought. (shrink)

Here the techniques customarily employed in the interpretation of legal phenomena are critically analyzed from the position of rigorous scientific method. Cairns's book is a brilliant statement for the possibilities of the scientific approach in regard to social institutions in general and to the sociology of law in particular. Originally published in 1941. A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously (...) out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value. (shrink)

In "reason and conduct" henry david aiken maintains that there is an antinomy of moral objectivity and freedom. Freedom requires that we each choose our own moral principles while objectivity requires that there be universally binding principles. He resolves the antinomy by proposing a principle of objectivity consistent with a diversity of moral codes, Thus forsaking universalizability in ethics. However, His notion of freedom is too stringent and his objectivity inadequate in not encompassing universalizability. Still, Aiken's concept of objectivity is (...) important in pointing to the defeasibility of all our moral positions. (staff). (shrink)

The Effect: An Introduction to Research Design and Causality is about research design, specifically concerning research that uses observational data to make a causal inference. It is separated into two halves, each with different approaches to that subject. The first half goes through the concepts of causality, with very little in the way of estimation. It introduces the concept of identification thoroughly and clearly and discusses it as a process of trying to isolate variation that has a causal interpretation. Subjects (...) include heavy emphasis on data-generating processes and causal diagrams. Concepts are demonstrated with a heavy emphasis on graphical intuition and the question of what we do to data. When we "add a control variable" what does that actually do? (shrink)

Structural Causal Modeling (SCM) is an approach to causal inference closely associated with Judea Pearl and given an accessible instroduction in [Pearl, J., & Mackenzie, D. (2018). The book of why: The new science of cause and effect. Basic Books]. It is highly popular outside of economics, but has seen relatively little application within it. This paper briefly introduces the main concepts of SCM through the lens of whether applied economists are likely to find marginal benefit in these methods beyond (...) standard economic approaches to causal inference. The most promising areas are those where SCM's causal diagrams alone offer significant value: covariate selection, the development of placebo tests, causal discovery, and identification in complex models. (shrink)

In Instrumental Variables (IV) estimation, the effect of an instrument on an endogenous variable may vary across the sample. In this case, IV produces a local average treatment effect (LATE), and if monotonicity does not hold, then no effect of interest is identified. In this paper, I calculate the weighted average of treatment effects that is identified under general first-stage effect heterogeneity, which is generally not the average treatment effect among those affected by the instrument. I then describe a simple (...) set of data-driven approaches to modeling variation in the effect of the instrument. These approaches identify a Super-Local Average Treatment Effect (SLATE) that weights treatment effects by the corresponding instrument effect more heavily than LATE. Even when first-stage heterogeneity is poorly modeled, these approaches considerably reduce the impact of small-sample bias compared to standard IV and unbiased weak-instrument IV methods, and can also make results more robust to violations of monotonicity. In application to a published study with a strong instrument, the preferred approach reduces error by about 19% in small (N ≈ 1, 000) subsamples, and by about 13% in larger (N ≈ 33, 000) subsamples. (shrink)

Samuel Phillips Huntington was an influential American political scientist. He was also a consultant to various America government agencies. He upholds the idea of conservative realism in politics. His research covers several areas of political science, such as civil-military relations, modernization and political development, comparative politics, and international relations. Regarding the role of military, he argues for autonomous military professionalism. In discussing about modernization of developing countries, he emphasizes the priority of political order over democracy. In the case of (...) America, as well as other democratizing countries, he worries that the excess of political participation would diminish the authority and effectiveness of state governance, enhancing political instability, and, at worst, leading to the reverse of democratization. After the end of the Cold War, Huntington characterizes the international order as multicivilizational, in which the clash of civilizations will direct the development of global politics. In such a multicultural situation, Huntington urges Americans to affirm their unique national identity by revitalizing Anglo-Protestant culture and its religiosity which has defined America since its founding. (shrink)

This article presents a set of moral arguments regarding the selective abortion of fetuses on the basis of prenatal screening for late onset genetic diseases only, and for Huntington's Disease* in particular. After discussion of human suffering, human perfection and the distinctive features of the lives of people confronting late onset genetic disease, the author concludes that selective abortion is difficult to justify ethically, although it must remain a matter of personal choice.

What ethical justification can be found for informing a person that he or she will later develop a lethal disease for which no therapy is available? This question has been discussed during the past twenty years by specialists concerned with the prevention of Huntington's Disease, an incurable late-onset hereditary disorder. Many of them have played an active role in developing experimental testing programmes for at-risk persons. This paper is based on a corpus of 119 articles; it reviews the development (...) of their reflection and includes an outline of the ethical problems identified and the solutions adopted in pre-clinical protocols. Seen in a broader perspective, the experience of presymptomatic testing for Huntington's Disease has given medical geneticists the opportunity to clarify their ethical position in the as yet little explored field of predictive medicine. (shrink)

Activating the ERK pathway (extracellular signal‐regulated kinase pathway) has proven beneficial in several models of Huntington's disease (HD), and drugs that are protective in HD models have recently been found to activate ERK. Thus, the ERK cascade may be a potential target for therapeutic intervention in this currently untreatable disorder. HD is caused by an expanded polyglutamine repeat in the huntingtin (Htt) protein that actuates a diverse set of pathogenic mechanisms. In response to mutant Htt, ERK is activated and (...) directs a protective transcriptional response and inhibits caspase activation. Paradoxically, Htt also interferes with several signaling events of the ERK pathway. Mutant Htt compromises the ERK‐dependent transcriptional response to corticostriatal BDNF signaling. Mutant Htt also hinders glutamate uptake from the synaptic cleft by down‐regulating ERK‐dependent expression of glutamate transporters, leaving cells vulnerable to excitotoxicity. Some of this cellular complexity can be capitalized on to achieve selective activation of ERK, which can be protective. (shrink)

Résumé Le but de l’étude présentée est d’analyser des œuvres de Gumilev et Huntington du point de vue de leurs approches et terminologies. Tous les deux ont essayé de donner une explication globale des phénomènes nouveaux dans l’histoire du monde. Malgré une terminologie différente, leurs thèses sont relativement analogues. Ils proposent une approche synthétique qui envisage la totalité de la société et qui les porte au rang des historiens-civilisationnistes, thèse dont la validité et le statut qu’on leur donne restent (...) très controversés de nos jours. Analogies et différences sont repérables d’abord à travers leur système taxonomique. Ces deux auteurs tentent aussi de répondre à la question posée sur la frontière orientale de la civilisation occidentale. (shrink)

A wide variety of sources, including the Huntington literature and popular mass media, show that Huntington’s “clash of civilizations” idea actually has very little value in understanding the current global political context. The central assumption of Huntington’s view, that cultural kinship ties influence loyalties and agreements on a global scale, has little to do with the daily lives of American citizens and little to do with the decisions made by the current presidential administration. The mass media evidence (...) from the United States shows that the most important “kinship” ties are not religious or cultural, but economic. The argument involves a deeper analysis of the current trend towards religious programs on American television, a timeline of events relating to the Halliburton – Cheney relationship, and views expressed by members of the United States military in Stars and Stripes. (shrink)

The aim of the paper is to analyse works by Gumilev and Huntington from the point of view of their approaches and terminologies. Both of them have attempted to give an overall explanation of new phenomena in world history. Though the terminology differs, their arguments are relatively similar. They propose a synthetic approach that looks at the whole of society and puts them among historians specializing in issues of civilization, a theory whose validity, together with the status they are (...) given, is still very controversial at the present time. Analogies and differences are discernible first through their taxonomic system. Both authors also try to answer the question as to the eastern border of western civilization. (shrink)

Ghosn, Mariam Huntington's disease (HD) is an inherited disorder. Sufferers usually develop symptoms in midlife between the ages of 30 and 50 years. HD causes neurodegeneration resulting in the progressive development of physical, cognitive and emotional symptoms. The impact on sufferers worsens over time with the final stage of the disease resulting in the need for professional assistance in a long-term care facility. More rarely HD develops in children and young adults, with less than 5% of HD sufferers being (...) affected by Juvenile HD. This article considers the ethical aspects of such testing. (shrink)