One reason to think that names have a predicate-type semantic value is that they naturally occur in count-noun positions: ‘The Michaels in my building both lost their keys’; ‘I know one incredibly sharp Cecil and one that's incredibly dull’. Predicativism is the view that names uniformly occur as predicates. Predicativism flies in the face of the widely accepted view that names in argument position are referential, whether that be Millian Referentialism, direct-reference theories, or even Fregean Descriptivism. But names are predicates (...) in all of their occurrences; they are predicates that are true of their bearers. When a name appears as a bare singular in argument position, it really occupies the predicate position of what in this essay is called a denuded definite description: a definite description with an unpronounced definite article. Sloat provided good evidence for this. The definite article is sometimes pronounced with names in the singular: ‘The Ivan we all love doesn't feel well’. Sloat proposed a disjunctive generalization of when the definite article must be pronounced with a singular name. This essay shows that by slightly revising Sloat's generalization, we arrive at a simple, nondisjunctive, syntactic rule that governs the overt appearance of the definite article with singular names. But Ivan does not necessarily bear the name ‘Ivan’, so one might worry that the sentence “Ivan might not have had ‘Ivan’ as a name” would incorrectly be predicted false. This essay shows that Predicativism does not have this consequence by showing that incomplete definite descriptions in general and incomplete denuded descriptions, such as ‘Øthe Ivan’, in particular are rigid designators. (shrink)

Something could be round even if it were the only thing in the universe, unaccompanied by anything distinct from itself. Jaegwon Kim once suggested that we define an intrinsic property as one that can belong to something unaccompanied. Wrong: unaccompaniment itself is not intrinsic, yet it can belong to something unaccompanied. But there is a better Kim-style definition. Say that P is independent of accompaniment iff four different cases are possible: something accompanied may have P or lack P, something unaccompanied (...) may have P or lack P. P is basic intrinsic iff (1) P and not-P are nondisjunctive and contingent, and (2) P is independent of accompaniment. Two things (actual or possible) are duplicates iff they have exactly the same basic intrinsic properties. P is intrinsic iff no two duplicates differ with respect to P. (shrink)

In this paper, the meanings of sentences containing the word or and a modal verb are used to arrive at a novel account of the meaning of or coordinations. It is proposed that or coordinations denote sets whose members are the denotations of the disjuncts; and that the truth conditions of sentences containing or coordinations require the existence of some set made available by the semantic environment which can be ‘divided up’ in accordance with the disjuncts. The relevant notion of (...) ‘dividing things up’ is made explicit in the paper. Detailed attention is given to the question of how the proposed truth conditions are derived from the syntactic input. The account offered allows for the derivation of both the disjunctive and the nondisjunctive readings of modal/or sentences, including the much-discussed free choice readings of may/or sentences. (shrink)

Most attempts to define culture as used in the cultural evolution literature treat culture as a single phenomenon that can be given a single nondisjunctive definition. In this article I argue that, really, cultural evolutionists employ a variety of distinct but closely related concepts of culture. I show how the main prominent attempts to define a culture concept fail to properly capture all the uses of “culture” employed in cultural evolutionary work. I offer a description of some of the most (...) important culture concepts used by cultural evolutionists. (shrink)

Despite advances in treatments over the last decades, a uniformly reliable and free of side effects therapy of human cancers remains to be achieved. During chromosome replication, a premature halt of two converging DNA replication forks would cause incomplete replication and a cytotoxic chromosome nondisjunction during mitosis. In contrast to normal cells, most cancer cells bear numerous DNA deletions. A homozygous deletion permanently marks a cell and its descendants. Here, we propose an approach to cancer therapy in which a (...) pair of sequence‐specific roadblocks is placed solely at two cancer‐confined deletion sites that are located ahead of two converging replication forks. We describe this method, termed “replication blocks specific for deletions” (RBSD), and another deletions‐based approach as well. RBSD can be expanded by placing pairs of replication roadblocks on several different chromosomes. The resulting simultaneous nondisjunctions of these chromosomes in cancer cells would further increase the cancer‐specific toxicity of RBSD. (shrink)

In multicausal abductive tasks a person must explain some findings by assembling a composite hypothesis that consists of one or more elementary hypotheses. If there are n elementary hypotheses, there can be up to 2n composite hypotheses. To constrain the search for hypotheses to explain a new observation, people sometimes use their current explanation—the previous evidence and their present composite hypothesis of that evidence; however, it is unclear when and how the current explanation is used. In addition, although a person's (...) current explanation can narrow the search for a hypothesis, it can also blind the problem solver to alternative, possibly better, explanations. This paper describes a model of multicausal abductive reasoning that makes two predictions regarding the use of the current explanation. The first prediction is that the current explanation is not used to explain new evidence if there is a simple (i.e., nondisjunctive, concrete) hypothesis to account for that evidence. The second prediction is that the current explanation is used when attempting to discriminate among several alternative hypotheses for new evidence. These hypotheses were tested in three experiments. The results are consistent with the second prediction: the current explanation is used when discriminating among alternative hypotheses. However, the first prediction—that the current explanation is not used when a simple hypothesis can account for new data—received only limited support. Participants used the current explanation to constrain their interpretation of new data in 46.5% of all trials. This suggests that context‐independent strategies compete with context‐dependent ones—an interpretation that is consistent with recent work on strategy selection during problem solving. (shrink)

Chromosome transmission in S. cerevisiae requires the activities of many structural and regulatory proteins required for the replication, repair, recombination and segregation of chromosomal DNA, and co‐ordination of the chromosome cycle with progression through the cell cycle. An important structural domain on each chromosome is the kinetochore (centromere DNA and associated proteins), which provides the site of attachment of chromosomes to the spindle microtubules. Stoler et al.(1) have recently reported the cloning of an essential gene CSE4, mutations in which cause (...) chromosome nondisjunction of a marked chromosome bearing a centromere DNA mutation. The cse4–1 mutation causes cells to arrest in the G2/M phase of the cell cycle with a 2N DNA content in a RAD9 checkpoint‐independent manner. The carboxyl terminus of Cse4p and the human centromere‐localized protein CENP‐A have a high degree of homology to the C‐terminal domain of histone H3. Since both CENP‐A and Cse4p also have biochemical properties similar to histones H3 and H4, it is tempting to speculate that these histone H3‐like proteins are components of specialized nucleosomes, a class of which may be unique to the centromeres. (shrink)

T. H. Morgan, A. H. Sturtevant, H. J. Muller and C. B. Bridges published their comprehensive treatise "The Mechanism of Mendelian Heredity" in 1915. By 1920 Morgan 's "Chromosome Theory of Heredity" was generally accepted by geneticists in the United States, and by British geneticists by 1925. By 1930 it had been incorporated into most general biology, botany, and zoology textbooks as established knowledge. In this paper, I examine the reasons why it was accepted as part of a series of (...) comparative studies of theory-acceptance in the sciences. In this context it is of interest to look at the persuasiveness of confirmed novel predictions, a factor often regarded by philosophers of science as the most important way to justify a theory. Here it turns out to play a role in the decision of some geneticists to accept the theory, but is generally less important than the CTH's ability to explain Mendelian inheritance, sex-linked inheritance, non-disjunction, and the connection between linkage groups and the number of chromosome pairs; in other words, to establish a firm connection between genetics and cytology. It is remarkable that geneticists were willing to accept the CTH as applicable to all organisms at a time when it had been confirmed only for Drosophila. The construction of maps showing the location on the chromosomes of genes for specific characters was especially convincing for non-geneticists. (shrink)