Recent experiments have begun to decipher the molecular dialog that mediates differentiation at sites of synaptic between neurons and their targets. It had been hypothesized that the protein agrin is released by axon terminals at embryonic neuromuscular junctions and binds to a receptor on the myofiber surface to trigger postsynaptic differentiation. Now a genetic ‘Knockout’ experiment has confirmed the essential role of agrin in signaling between developing nerve and muscle(1). A second ‘knockout’ has shown that the muscle‐specific receptor tyrosine (...) kinase MuSK is a critical element in the agrin‐induced signaling cascade(2). Additional results suggest that MuSK may comprise a portion of the agrin receptor(3). (shrink)

Systems Theory analyses the world in terms of communications and divides the natural world into environment and systems. Systems are characterised by their high density of communications and tend to become more complex and efficient with time, usually by means of increased specialisation and coordination of functions. Management is an organisational sub-system which models all necessary aspects of organisational activity such that this model may be used for monitoring, prediction and planning of the organisation as a whole. The function of (...) a specific management system depends on its history of selection by interactions with the environment (which includes other systems). The main function of a management system will be a consequence of the most powerful and sustained selection pressure it has experienced. Systems Theory implies a management science which is quantitative and comparative. It is quantitative because it is based upon the measurement and mapping of communications as the basis of analysis; it is comparative because evaluations relate to specific variables measured in a specific spatio-temporal context and subjected to analytic processes of constrained complexity. Selection processes are broadly responsible for the dominance of management in contemporary Western societies. The complexity of management systems will probably continue to increase for as long as the efficiency-enhancing potential of complexity outweighs its increased transaction costs. (shrink)

After decades of deregulation and innovation, contemporary financial markets remain firmly anchored in law and legal institutions. The idea that private financial actors simply want to escape government oversight and regulation is simplistic as private interests find the coercive powers of the state too useful to forgo. Instead, such actors engage law selectively to create a more certain environment for themselves and their profit-seeking activities. Contract law adds certainty to financial transactions; law shapes how financial actors use information and exploit (...) information technology; law constitutes financial values; and law allows financial institutions to be turned into assets. Law’s application is shaped by changing conceptions of risk, as well as by new business models for financial institutions. (shrink)

This paper elaborates three approaches to the issue of state autonomy, and uses two empirical cases (British and American treasury policy during the 1930s) to illustrate them. The three approaches are the group affiliations approach, which considers the social characteristics of the individuals who work in an organization; the structural dependance approach, which considers the structural position of the organization within a network of resource flows; and a cultural approach, which considers the role of ideology in the determination of organizational (...) autonomy. The application of these three approaches to the two cases gives some support to all three, but the cultural approach proves especially useful in conjunction with the other two. (shrink)

Steven Rose regards oversimplification of biology as the supreme sin, inevitably leading to evil consequences, and requiring an unique distortion of scientific practice to avoid it. To avoid this, he proposes a short-cut to scientific knowledge by defining certain areas of biology that are intrinsically flawed. But this achieves only a subordination of science to politics. There are no general-purpose shortcuts for evaluating the validity of theories, and no substitutes for testing specific theories using relevant evidence.

The same aggressive act will – all else being equal – have a different behavioral significance according to whether it is performed by a man or a woman. Such a perspective should have profound implications for legal and psychiatric practice, and for social policy in general.

The “somatic marker mechanism” (SMM; Damasio 1994) is proposed as the cognitive and neural basis of the theory of mind mechanism. The SMM evolved for evaluating the intentions, dispositions, and relationships of conspecifics; hence, it is adaptive in the social domain. It is predicted that chimpanzees will indeed have theory of mind (ToM) ability, but that this will be socially domain-specific. Domain-general ToM will be found only in primates with abstract, symbolic language (adult humans). Putative ToM tests require revision in (...) the light of these distinctions. (shrink)

Money undergirds market exchange, but the social significance of money goes well beyond the obvious importance of its highly uneven distribution in modern market economies. In addition, modern money imposes an ostensibly precise and unidimensional valuation on social products, processes and relations that often conflicts with other modes of social valuation. In this regard, monetarization is a particular instance of quantification. Money’s status as an official economic metric is the result of a long, contingent, and uneven historical process. Given alternative (...) forms of valuation, people manage and constrain the commensurability of money through a variety of individual, institutional and organizational practices. The social reception of money is active, not passive. A variety of examples are discussed to illustrate and develop these points. (shrink)

Recent work in artificial intelligence, or AI, has produced programs capable of serious intellectual work in science. Results from AI are used to show that there exist mechanized procedures for discovering hypotheses and that these methods often lead to plausible hypotheses. The question to be answered is: By what methods can a computer program find plausible explanations of empirical data? To answer this, the common metaphor of search for describing several AI programs is examined followed by a look at examples (...) of programs actually constructed. Five types of search considered are: random, exhaustive, selective, heuristic, and opportunistic search. From there, the paper generalizes to some conclusions about mechanizing hypothesis formation. (shrink)

This paper elaborates three approaches to the issue of state autonomy, and uses two empirical cases (British and American treasury policy during the 1930s) to illustrate them. The three approaches are the group affiliations approach, which considers the social characteristics of the individuals who work in an organization; the structural dependence approach, which considers the structural position of the organization within a network of resource flows; and a cultural approach, which considers the role of ideology in the determination of organizational (...) autonomy. The application of these three approaches to the two cases gives some support to all three, but the cultural approach proves especially useful in conjunction with the other two. (shrink)