Recent advances in genomic and imaging techniques have revealed the complex manner of organizing billions of base pairs of DNA necessary for maintaining their functionality and ensuring the proper expression of genetic information. The SMC proteins and cohesin complex primarily contribute to forming higher‐order chromatin structures, such as chromosomal territories, compartments, topologically associating domains (TADs) and chromatin loops anchored by CCCTC‐binding factor (CTCF) protein or other genome organizers. Cohesin plays a fundamental role in chromatin organization, gene expression and regulation. This (...) review aims to describe the current understanding of the dynamic nature of the cohesin‐DNA complex and its dependence on cohesin for genome maintenance. We discuss the current 3C technique and numerous bioinformatics pipelines used to comprehend structural genomics and epigenetics focusing on the analysis of Cohesin‐centred interactions. We also incorporate our present comprehension of Loop Extrusion (LE) and insights from stochastic modelling. (shrink)

The article reviews the book The Problem of Evil, by Peter van Inwagen.

The article employs music to describe the dynamics of Central European identity at the turn of the 20th century. Conceptually, the analysis is based on the notion of cultural resonance and the distinction between political territories, which isolate identity, and cultural landscapes which let it escape. This theoretical understanding is derived from the acoustic philosophy and musical practice of two Central European composers, Leoš Janáček and Béla Bartók. Exemplified here is artistic ‘extra-territorial’ identity, which is indeed how Theodor Adorno at (...) one point referred to the ‘peripheral’ sound coming from the region. This process of identity construction amplifies paradoxical middle spaces, which Jean Luc Nancy describes evocatively as a cultural mêlée. The vitality of cultural resonance is fuelled by this primary contact with mundane reality and the ‘navigational hesitation’ underpinning identity and its many trajectories. (shrink)

Psychiatrists' accounts of clinical significance in depression Clinical significance is a crucial element in the diagnosis of mental illness, yet, it is practically untheorised and significantly under-researched. This article takes up the question of how the criterion of clinical significance is translated into psychiatric practice. More particularly, it examines how psychiatrists account for the threshold between health and depression. The paper is anchored in the constructionist view of discourse underpinned by the assumptions of critically oriented discourse analysis. It is based (...) upon a convenience sample of 39 semi-structured interviews with specialist-psychiatrists in south-western Poland. There is no discursive space for clinical significance in psychiatrists' accounts. There is no boundary, no decision to be taken as to whether the symptoms are clinically significant. Depression, invariably constructed in terms of diagnostic criteria, is always represented as fully developed, appearing out of thin air, with no period of falling ill. The article raises the issue of the validity and usefulness of psychiatric diagnosis. (shrink)

In Germany the positivistic tendencies in sciences in the second half of the 19th century gave rise to attempts of establishing metaphysics on the empirical ground. In his philosophy Hermann Lotze takes the laws of nature as a starting point and considers them from the point of the fundamental teleological principle. The sense of beauty, being an important element of this teleology, consists in the feeling of compatibility of the cognitive faculties and the material of cognition, the latter reaching beyond (...) the content of purely intellectual cognition. Following Kant Lotze describes it as a vital feeling which enables him to postulate the existence of spiritual principle governing the mechanism of the material world. (shrink)

This article considers the main methodological objections against the theory of intelligent design. In general, they claim that it lacks a scientific character and they emphasize that design cannot be detected using scientific tools. The critics focus on showing that intelligent design violates various methodological criteria. In response to these objections, this article examines the methodological claim made by its proponents that the characteristic effects of the designer’s activity do provide a sufficient basis for inferring design. This paper also argues (...) that the procedure of inferring that a certain feature has been designed by a supernatural being does not differ in principle from design-detection procedures in other spheres of research. (shrink)

In this paper, we study natural language constructions which were first examined by Barwise: The richer the country, the more powerful some of its officials. Guided by Barwise’s observations, we suggest that conceivable interpretations of such constructions express the existence of various similarities between partial orders such as homomorphism or embedding. Semantically, we interpret the constructions as polyadic generalized quantifiers restricted to finite models. We extend the results obtained by Barwise by showing that similarity quantifiers are not expressible in elementary (...) logic over finite models. We also investigate whether the proposed readings are sound from the cognitive perspective. We prove that almost all similarity quantifiers are intractable. This leads us to first-order variants, which only approximate the strong readings, but are cognitively more plausible. Driven by the question of ambiguity, we recall Barwise’s argumentation in favour of strong readings, enriching it with some arguments of our own. Given that Barwise-like sentences are indeed ambiguous, we use a generalized Strong Meaning Hypothesis to derive predictions for their verification. Finally, we propose a hypothesis according to which conflicting pressures of communication and cognition might give rise to an ambiguous construction, provided that different semantic variants of the construction withstand different pressures involved in its usage. (shrink)

Name der Zeitschrift: Millennium Jahrgang: 10 Heft: 1 Seiten: 13-38.

In the twentieth century, many contemporary epistemologists in the analytic tradition have entered into debate regarding the right to belief with new tools: Richard Swinburne, Anthony Kenny, Alvin Plantinga, Nicholas Wolterstorff, Peter van Inwagen defend or contest the requirement of evidence for any justified belief. The best things we can do, it seems, is to examine more attentively the true notion of "right to believe," especially about religious matters. This is exactly what the contributors in this book do.

Główną część artykułu stanowi przykładowa analiza ilustrowanego ogłoszenia reklamowego, której celem jest zaprezentowanie sposobów perswazji, jakimi posługują się twórcy takich komunikatów. Na poziomie słowa przedstawiona została przede wszystkim strategia wykorzystywania faktu, że poszczególne wyrazy posiadają określone konotacje. W następnym etapie, analizie składni jednej z części tekstu reklamy, wyjaśniono, jak poprzez odpowiednie konstruowanie zdań udaje się stworzyć wrażenie rzeczowej argumentacji. Kolejny krok stanowi - podobnie jak na poziomie słowa - semantyczna analiza dłuższego fragmentu tekstu, jak również części wizualnej reklamy. Analiza ta (...) ma na celu pokazanie, jak m. in. poprzez budowę tzw. płaszczyzn izotopii semantycznej można przedstawić nic tylko obraz reklamowanego produktu, lecz także obraz adresata komunikatu. Ostatnia część analizy zawiera szczegółową prezentację werbalno-wizualnych figur retorycznych występujących w całym ogłoszeniu. Część właściwą artykułu poprzedzają rozdziały zawierające podstawy' teoretyczne do analizy o naszkicowanych ramach. I tak w pierwszej części publikacji przedstawione zostało rozszerzone pojęcie języka reklamy, cechy odróżniające go od języka standardowego, jak również jego aspekty semiotyczne. Następny rozdział poświęcony jest charakterystyce takich lingwistycznych aspektów reklamy jak leksyka, składnia i stylistyka W kolejnym rozdziale omówione zostały problemy semiotycznej analizy komunikatów wizualnych, ze szczególnym uwzględnieniem analizy tych treści obrazu, które nie są wyrażone bezpośrednio, lecz tworzą tzw. implikaty. Ostatnia z części teoretycznych dotyczy werbalno-wizualnych figur retorycznych, których istota została tu krótko wyjaśniona na przykładach wybranych z analizowanego w artykule ogłoszenia reklamowego. (shrink)

Many contemporary writers misunderstand early Christian views on philosophy because they identify the critical stances of the ante-Nicene fathers toward specific pagan philosophical schools with a general negative stance toward reason itself. Dariusz Karlowicz's Socrates and Other Saints demonstrates why this identification is false. The question of the extent of humanity's natural knowledge cannot be reduced to the question of faith's relationship to the historical manifestations of philosophy among the Ancients. Karlowicz closely reads the writings of Justin Martyr, Tertullian, (...) Clement of Alexandria, and others to demonstrate this point. He also builds upon Pierre Hadot's thesis that ancient philosophy is not primarily theory but a "way of life" taught by sages, which aimed at happiness through participation in the divine. The fact that pagan philosophers falsely described humanity's telos did not mean that the spiritual practices they developed could not be helpful in the Christian pilgrimage. As it turns out, the ancient Christian writers traditionally considered to be enemies of philosophy actually borrowed from her much more than we think-and perhaps more than they admitted. -- back cover. (shrink)

Opatrzność Boża a przypadek w świecie Celem artykułu jest obrona dwóch tez: pierwszej, że istnienie zdarzeń przypadkowych jest do pogodzenia z istnieniem Boga oraz tezy drugiej, że przypadek może być częścią Bożej opatrzności. Koniunkcja obu powyższych tez nazwana jest w artykule tezą kompatybilizmu. Argumentacja w obronie kompatybilizmu opiera się na danych współczesnej nauki oraz na idei wszechmocnego Boga Stwórcy. Porządek argumentacji w artykule jest następujący. W części drugiej przedstawiony jest historyczny kontekst oraz podstawy doktrynalne pojęcia opatrzności. W części trzeciej omówiony (...) jest argument za nieistnieniem Boga oparty na założeniu głoszącym istnienie zdarzeń przypadkowych w świecie oraz przedstawiona jest krytyka tego argumentu. W części czwartej prezentowane są możliwe modele działania Boga w świecie, w ramach których przyjmuje się istnienie zdarzeń przypadkowych. W części piątej i ostatniej rozważana jest idea Bożej doskonałości obejmującej takie atrybuty jak wszechmoc, wszechwiedzę, doskonałą dobroć i suwerenną wolę Bożą. (shrink)

Max Weber’s thesis on the decisive influence of Protestant ethic on the formation and development of modern capitalism has become one of the best-known and widely shared canonical claims in social sciences. Since its publication at the beginning of the 20th century, this thesis, supported by subsequent great works by the German classic, has rarely been the subject of major controversy. The work of correcting Weber’s thesis was undertaken in the late 20th century by Michael Novak. Novak’s correction is not (...) confrontational, but complementary. The American thinker abandons the research area of minority Protestant communities, which caught Weber’s attention, and undertakes an analysis of the broader religious tradition, developing both before and after the Reformation. In particular, the achievements of Pope John Paul II, interpreted by Novak in terms of the renewal of a liberty current of Catholic social thought, provide important corrective data. (shrink)

This paper explores the relationship between crisis and experience, concentrating on ‘excentric positionality’ in relation to the shared world, as presented in the work of Helmuth Plessner. A by-product of the 1920s Weimar Germany, Plessner’s philosophical anthropology, it is argued, presents us with a forgotten blueprint for transitive and compositional approaches to the social world. Instead of the familiar ‘crisis of experience’ used to diagnose ‘what has gone wrong’, it allows us to re-learn how to work with ‘the experience of (...) crisis’ itself. The latter holds the key to a different type of approach based on ‘xeno-communication’. This type of communication utilizes the productive potential of crisis in its uncertainty and hesitation before a decision, showing a way to extend and enlarge experience itself. Cultivation of these ‘excentric’ dynamics in turn suggests new ‘excentric methodologies’ based on a more flexible fit between concepts and the worlds they are meant to describe. ‘Excentric methodologies’ constitute a type of experience-based, analytical response to the shared world. They work with phenomena across spaces and problems, analytically utilizing their joint emergence from the fundamental imbalance and discontinuity characteristic of the human environment. (shrink)

The article presents problems of intellectual intuition in metaphysics from a semiotic point of view. There are various types of intuition in philosophy: rational intuition, irrational intuition, and sensual intuition. All of them are immediate ways of cognition. Classical metaphysics uses intellectual intuition as its main method to find out and justify its statements. The main problem of intellectual intuition is an intersubjective approach to the object of metaphysics. The main aim of this paper is the objectivization and rationalization of (...) intellectual intuition in language. The semantic notion of meaning and the pragmatic notion of understanding are the fundamental tools which are used to translate the issue of intuition from the subject-ma$er level into the language level. This operation allows to look at intuition in a non-psychological manner. It enables the objectivization of the method of intellectual intuition in the light of the understanding of meanings. (shrink)

Opatrzność Boża a przypadek w świecie: odpowiedzi W artykule przedstawiam odpowiedzi do zarzutów, zawartych w innych artykułach tego numeru, wobec proponowanej przeze mnie w artykule otwierającym oraz monografii z roku 2014 koncepcji opatrzności i przypadku. Argumentuję, że istnienie różnie rozumianych zdarzeń przypadkowych nie implikuje tezy, że Bóg Stwórca świata nie interesuje się losem indywidualnych bytów stworzonych, w tym istot ludzkich. Staram się w swoich odpowiedziach pokazać, że powodem, dla którego Bóg może dopuszczać występowanie zdarzeń przypadkowych jest Boża wola stworzenia świata (...) względnie autonomicznego, który ma zdolność samodzielnego rozwoju. W świecie takim może występować zło bezcelowe, za które Bóg nie ponosi bezpośredniej odpowiedzialności. (shrink)

Mit seinem Buch Philosophie der Freiheit ist St. Kowalczyk, Professor an der Katholischen Universität Lublin und Priester, der Versuch gelungen, die Entwicklung der Freiheitsideen im Rahmen der allgemeinen Philosophiegeschichte sjnithetisch darzustellen. Zugleich ist es eine grundsätzliche Stellungnahme zu den Fragen: Was ist Freiheit? bzw. Wie kann der Mensch Sklaverei und Selbstversklavung vermeiden? Die Weise, auf welche die Freiheit begriffen wird, entscheidet darüber, ob man sich in Richtung Theismus oder Atheismus bewegt, ob in Richtung Spiritualismus oder Materialismus, Determinismus oder Indeterminismus. Sie (...) hängt ihrerseits zweifellos davon ab, wie man den Menschen, die Geschichte, Gott und die Gesellschaft begreift. So stellt der Verfasser etliche Philosophen einander gegenüber, die nicht nur in ihren Anthropologien, sondern auch in ihren Konzeptionen von Freiheit sehr von einander abweichen und einander widersprechen. (shrink)

Mit seinem Buch Philosophie der Freiheit ist St. Kowalczyk, Professor an der Katholischen Universität Lublin und Priester, der Versuch gelungen, die Entwicklung der Freiheitsideen im Rahmen der allgemeinen Philosophiegeschichte sjnithetisch darzustellen. Zugleich ist es eine grundsätzliche Stellungnahme zu den Fragen: Was ist Freiheit? bzw. Wie kann der Mensch Sklaverei und Selbstversklavung vermeiden? Die Weise, auf welche die Freiheit begriffen wird, entscheidet darüber, ob man sich in Richtung Theismus oder Atheismus bewegt, ob in Richtung Spiritualismus oder Materialismus, Determinismus oder Indeterminismus. Sie (...) hängt ihrerseits zweifellos davon ab, wie man den Menschen, die Geschichte, Gott und die Gesellschaft begreift. So stellt der Verfasser etliche Philosophen einander gegenüber, die nicht nur in ihren Anthropologien, sondern auch in ihren Konzeptionen von Freiheit sehr von einander abweichen und einander widersprechen. (shrink)

This article examines Immanuel Kant’s criticism from the perspective of the preceding tradition of critical thought, with particular emphasis on Greek philosophy. Kant himself views criticism as a way to go beyond dogmatism and scepticism. On the other hand – as many researchers point out – Kant’s philosophy develops certain themes present in ancient scepticism. In the literature, there are numerous studies demonstrating Kant’s debt to the Pyrrhonian scepticism characteristic of Sextus Empiricus (ephecticism and epechism). In this article, I try (...) to show that two different interpretations of scepticism can be formed on the basis of Sextus’ writings: zetetic scepticism and ephectic scepticism. Theinterpretation considers ἐποχή and ἰσοσθένεια as key ideas for scepticism and it is this latter option that is recognized in Kant’s thought by scholars, especially by Michael Forster. In my opinion, however, it is the first interpretation, not yet sufficiently recognized, that constitutes at least an equally strong complement to the first and may even be regarded as the proper source of Kant’s critical philosophy. (shrink)

In the article two key chapters of Thomas Mann’s “The Magic Mountain”, namely “Walpurgis Night” and “Snow” are interpreted in the categories of aesthetic experience. In both of them Hans Castorp is lead into a dream, which could be treated as a hermeneutical symbol. Castorp experiences the feeling of the sublime which is a source of the spiritual metamorphosis. Seen from this angle Castorp turns out to be a literary expression of a new anthropological conception of man, and “The Magic (...) Mountain” – a critique of the attempts to realize such a conception by the help of a solely intellectual argumentation. (shrink)

The article is an attempt to treat Thomas Mann’s The Magic Mountain as a novel about Germany. According to its author the spiritual condition of Germany personified by Hans Castorp was established during the history through the collision of the elements of Western and Eastern cultures. The first protest against the West was raised by Martin Luter in his critique that led to the internalization of German life. As a consequence, the culture of the nation was dominated by music. This (...) domination mirrored the process in which both elements characteristic for both antagonistic spheres, namely arbitrariness and order, were united as in music counterpoint. Thomas Mann’s idea of humanism, being the continuation of Goethe’s and Nietzsche’s postulates, is a project of their synthesis. (shrink)

Genocide as a part of nation or ethnic group extermination process is not a well-defined concept. Its meaning is understood intuitively. When law intervenes, the issue of defining the term comes back. Nevertheless, the Polish nation has been recognized as subjected to genocide activities during the Second World War by the Nazi Germany and Soviet Union. The paper focuses on the genocide against mainly one group of Poles that is to say foresters. The martyrologic evidence proves that foresters were an (...) occupation group which for a variety of reasons suffered most. The research carried out in this respect by the National Forests in Poland has revealed that over 20% of pre-war staff of the institution actually lost their lives. They were killed by the German and Soviet occupiers, as well as the Ukrainian Insurgent Army. In the eastern parts of Poland foresters and their families were deported and sent to various labour and extermination camps e.g. in Siberia. The aim of the paper is to present the scale of genocide with the main emphasis on genocide against foresters. The definition of genocide provided by Lemkin, who coined the term, is a starting point for the analysis. The main research methods included the analysis of pertinent literature and source materials as well as the semiotic analysis of genocide circumstances. The thesis put forward by the authors is that foresters due to their education, practical skills, professional experience and insight knowledge turned out to be the group especially vulnerable and subjected to extermination on purpose. (shrink)

Przedmiotem artykułu są teorie pierwszych ontologów greckich: Ksenofanesa, Parmenidesa i Melissosa na temat bytu, jego jedności i tożsamości, z uwzględnieniem niektórych poglądów Zenona. Naczelnym problemem artykułu jest pytanie o naturę relacji bytu względem świata u filozofów eleackich. Celem jest opis sposobu rozumienia tego powiązania, zaproponowanego przez każdego z nich. W rezultacie analiz porównawczych, opierając się na badaniu zachowanych fragmentów tekstów starożytnych, okazało się, że Ksenofanes jest autorem koncepcji Jedno-Boga tożsamego ze światem, zaś Parmenides sformułował oryginalną teorię bytu transcendującego świat cielesny, (...) ale stanowiącego jego rację tożsamości jako całości. Przedstawiona w artykule interpretacja poglądów Parmenidesa stanowi ujęcie odmienne od powszechnie przyjmowanego. Melissos natomiast wykorzystując Parmenidejski sposób rozumienia bytu jako czegoś jednego umieszcza go w świecie. Zbliża to poglądy Melissosa do poglądów Ksenofanesa. Każda z tych teorii nastręcza jednak wielu problemów interpretacyjnych, wynikających przede wszystkim z niewielkiej ilości tekstów źródłowych. ------------------------- Zgłoszono: 06/11/2022. Zrecenzowano: 13/12/2022. Zaakceptowano do publikacji: 20/12/2022. (shrink)

This article examines the evolution of Zygmunt Bauman’s theory of culture during his over-sixty-year-long scholarly activity. Bauman wrote his first books on the theory of culture (Culture and Society; Sketches in the Theory of Culture) when he was a Professor at Warsaw University. The ideas put forward at that time were later developed in his writings. This applies in particular to the critical nature of his thought, the combination of synchronic and diachronic perspectives, the inclusion of the context of the (...) social structure as well as his references to the structural dimension and to agency. Later years – starting with the publication of the book, Culture as Praxis – saw Bauman’s growing emphasis on the transcendence of the existing reality and the creative role of an individual in the transformation of cultural reality. This article shows how other theorists of culture inspired Bauman and how he critically referred to them. The article offers a holistic look at Zygmunt Bauman’s oeuvre. It also creates an opportunity for English-speaking readers to become familiar with Bauman’s writings in his mother tongue. (shrink)

Przedmiotem artykułu jest paradoks Zenona z Elei Korzec prosa. Wszystkie zachowane argumenty Zenona znane są z przekazów filozofów późniejszych. Korzec prosa jest zdawkowo przedstawiony przez Arystotelesa w Fizyce oraz znajduje się w Komentarzu do „Fizyki” Arystotelesa autorstwa Simplikiosa. Obydwa fragmenty, które stanowią przedmiot rozważań, zawierają częściowo odmienną terminologię oraz występują w nich rozumowania, oparte na innych schematach wnioskowania. Celem analiz zawartych w tekście jest uzasadnienie, że fragment z Fizyki Arystotelesa może sytuować omawiany paradoks jako argument przeciw ruchowi, a nie jako (...) argument przeciw wielości, jak przedstawia się go zazwyczaj w świetle przekazu Simplikiosa. W artykule zostały przedstawione obydwa fragmenty w języku greckim wraz z autorskimi tłumaczeniami oraz szczegółową analizą ich treści. -------------- Zgłoszono: 28/09/2020. Zrecenzowano: 30/10/2020. Zaakceptowano do publikacji: 18/11/2020. (shrink)

Plato did not express any single and uniform theory of meaning. The paper presents different conceptions of meaning that can be attributed to Plato. The first presents meaning of names as imitating reality. Primary names are phonetic imitations of things, secondary names are built-up with the former ones. The second presents meaning as a representation in mind. There are two kinds of representations: individual and abstract. Individual representation is an imagination of empirical thing and the abstract representation is a picture (...) of idea - a property. The third conception describes the notion of meaning as a denotation. Denotations of general names are ideas. Plato treats names in an extensional manner. If two names about different forms refer to the same thing, they are the same name. The fourth is the association conception of meaning. It is connected with the theory of anamnesis. This theory says that humans remember ideas, which they observed in the time between death and birth. In the last conception the meaning is interpreted as connotation: the meaning of a name is the feature of the object that is referred to by this name. (shrink)