We analyzed the patients’ perception of prenatal diagnosis of fetal cardiac pathology, and the reasons for choosing to continue with pregnancy despite being eligible to receive a medical termination of pregnancy. We also identified the challenges, the motives interfering in decision-making, and the consequences of the decisions on pregnancy, child and mother. This descriptive, prospective and longitudinal study was conducted in France, amongst pregnant women who wished to continue their pregnancy despite an unfavorable medical advice. Socio-demographic data were collected through (...) a questionnaire. Such questionnaire covered information assessing the parents/mother’s perception of prenatal diagnosis, and medical termination of pregnancy, their interpretation of the established diagnosis and their motives for not considering pregnancy termination. 72 eligible patients were analyzed over one year: mean age 33 ± 6.89 years, 47 patients had already given birth to ≥1 healthy child. Mean gestational age at the detection of fetal cardiac pathologies was 30 ± 4.37 weeks of amenorrhea. Patients decided to keep the child after 3 ± 1.25 consultations. 56 patients made their decision with their husbands and 16 made their decision alone. Reasons for declining the medical termination were culpability and responsibility, ideologies and convictions, mistrust and hope. Newborns of 67 patients died with a mean survival duration of 38 days. Patient informed consent should be sought before any decision in neonatology, even if conflicting with the medical team’s knowledge and the pregnant mother’s benefits. Decisions to accept or decline pregnancy termination depend on the patients’ psychological character, ideologies, convictions, and mistrust in the diagnosis/prognosis, or hope in the fetus survival. (shrink)

L’ouvrage intitulé Comment écrit-on l’histoire constitutionnelle ?, réunit les communications d’un colloque qui s’est tenu à Cergy-Pontoise le 17 octobre 2008. Le titre est évidemment emprunté au célèbre ouvrage de Paul Veyne, mais le choix de la forme interrogative signale d’entrée le caractère exploratoire de l’entreprise. Dans leur efficace synthèse introductive, les organisateurs du colloque mettent en valeur un paradoxe : alors que l’histoire constitutionnelle fait l’objet, dans de nombreux pays, d’un engouement remarquable, la question de son domaine, de sa (...) méthode et de ses enjeux n’a suscité en France que peu de réflexions approfondies. L’entreprise a donc pour objet d’ouvrir le débat, mais non bien sûr de le clore. Comme c’est souvent le cas des actes de colloque, le livre trouve une limite dans l’hétérogénéité et la brièveté des interventions. Sur de telles questions, les généralités sont peu éclairantes, car trop évidentes pour ne pas être consensuelles (nécessité de lire et .. (shrink)

Penser une histoire du hasard est se demander comment le hasard est perçu par les sociétés au fil des âges. Toutes n'ont pas la même sensation du phénomène ; l'Orient et l'Occident, les peuples d'Afrique ou d'Amérique du Sud, les différentes religions, entretiennent avec le hasard des relations spécifiques. De plus, le voyageur, dans cet univers étrange, est habité lui-même par ses sentiments et conceptions. Quatre époques scandent les siècles où se déploie cette histoire ; elles sont ossature et fil (...) conducteur, de la préhistoire à nos jours. Homme hasardeux. Impossible de fixer la date originelle mais à un moment de la préhistoire l'être humain découvre le tirage avec un instrument : fruit dissymétrique, écorce, coquillage... Est-ce le signal qui le distingue de l'animalité? Il perçoit le fortuit, l'aléa des jeux, le sort des espérances, les manifestations des divinités en bonheurs et malheurs. Homme de destin. Les religions subliment le hasard et ses manifestations. Le christianisme permet la découverte de la Providence et de la Grâce. La croix fixe est irréductible au cercle mobile. Mes codes et les règles tentent de circonscrire les vertiges des hasards. Homme improbable. Paradoxe étrange qui voit le développement du calcul des probabilités, à partir de la Renaissance, coïncider avec la perte des repères anciens, engendrant incertitudes et troubles contradictoires. Homme téméraire. Né au mois d'août 1945 dans l'explosion des bombes atomiques à Hiroshima et Nagasaki. Age de tous les risques et de tous les excès, nourri de spéculations, de paris, de jeux et de tricheries. Fondé sur une documentation étendue, cet ouvrage propose une vision globale de l'histoire des sociétés occidentales. Vision qui ne manquera pas d'être discutée si l'on sait que l'origine du mot téméraire renvoie à ténèbres. Sommes-nous aujourd'hui dans les ténèbres? L'auteur a publié Bizarre, anthologie, le symbolisme des jeux, la Tarot de Court de Gébélin (Berg International), Histoire des jeux de société (Flammarion). (shrink)

This book, formed as a series of essays in honour of Professor Carl Baudenbacher, addresses the very art of judicial reasoning, and features contributions from many of the foremost current or former national, supranational, or international judges. This unique volume is intended first and foremost for legal scholars, but its approachable style makes it readily accessible for students and for those with a general interest in the application of the law and justice in today's multi-layered world. The collection of essays (...) is rather more philosophical and reflective as opposed to doctrinal. Each contribution focuses on the nature and operation of justice, the independence of the judiciary, and on judicial style primarily from the perspective of the judges themselves. The book provides perspectives on what it means to be accountable and independent as a judge, the role of language and languages in the quest for justice, while other contributions acquaint readers with the some of the structures of courts themselves, or indeed question for whom judgments are written. Each chapter has been written by a presiding judge, or head of an institution and the book is divided into three parts: - Part I Art and Method - Part II Justice and the Judiciary - Part III Reasoning and Language(s). (shrink)

Marcel Beaufils fut un pedagogue exceptionnel qui exerca une influence decisive sur l'evolution de l'esthetique musicale en France, a partir des annees 50. Or, parmi ses ouvrages, Musique du son, musique du verbe est tres certainement celui qui porte le plus fortement la marque de son activite d'enseignant au Conservatoire National Superieur de Musique de Paris ; cette mission, il semblait l'entendre davantage comme celle d'un declencheur d'idees, catalyseur, plutot que du transmetteur d'un savoir fige une fois pour toutes. Bouleversant (...) toute tentative de classification academique, toute certitude acquise, ce livre laisse des pointilles ; un grand souffle traverse son ecriture. N'en deplaise aux musicographes, il s'agit la d'un ouvrage de creation, qui nous rappelle que Marce Beaufils etait egalement un ecrivain qui savait manier le verbe a la fois en tant que dramaturge et en tant que poete. (shrink)

Name der Zeitschrift: Klio Jahrgang: 99 Heft: 2 Seiten: 726-730.

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Modernity is Apocalyptic in essence. This assertion is stated nowhere in The Triumph of Human Empire by Rosalind Williams, nor in l’Apocalypse Joyeuse by Jean-Baptiste Fressoz. But it is everywhere on the pages of these books, which recount the ambivalence with which the project of Modernity and its technological feats has been received in specific times and places, notably nineteenth century Europe. Essence here is not to be understood as transcendental a-historical necessity, but as unfolding historical ontology. Despite contingencies, (...) the project of Modernity has continued to realise a secular ending of the world by continuing to conquer and destroy it.In The Triumph of Human Empire we encounter ambivalence through the biographies and works of three European writers, who employed the genre of romance to express their uneasiness with modern civilisation and progress: Jules Verne, William Morris and Louis Stevenson. Verne is perhaps the writer which we would least expect to have probl .. (shrink)