Summary This article compares the discoveries of the planets Neptune and Pluto and the unsuccessful search of intra-Mercurial planets. Its conclusion is, that the search of intra-Mercurial planets was started on the basis of reasonable assumptions and competently pursued, that the success in the search of Neptune and Pluto and the failure in the search of intra-Mercurial planets was not due to greater competence of the successful planet searchers, but to good luck of the successful researchers and bad luck of (...) the unsuccessful researchers. (shrink)

Der Streit darüber, ob es objektive Wahrheitskriterien gibt, wird oft mit der Frage vermengt, ob Wissenschaft immer fortschreite. Vor allem Popper in "Objective Knowledge" unterstellt in starkem Maße einen allgemeinen Trend der Wissenschaft zum Fortschritt. In diesem Beitrag wird gezeigt, daß Wissen verloren gehen kann: 1. Weil es nicht aufgezeichnet wird; 2. weil die Dokumente, in denen es niedergelegt wurde, verloren gehen; 3. weil das Wissen um die Sprache der Dokumente, in denen es niedergelegt wurde, verloren gegangen (...) ist, 4. weil die spätere Wissenschaftlergemeinschaft die Dokumente nicht genügend beachtet, in denen es niedergelegt wurde. Der Verlust nichtaufgezeichneten Wissens ist äußerst üblich. Der Verlust veröffentlichter Dokumente war besonders vor der Erfindung der Drucktechnik häufig und hat besonders in manchen Zweigen der Geisteswissenschaften einen Rückschritt bedeutet, weil entweder Dokumente, die das Objekt dieser Wissenschaften ausmachen , oder Aufzeichnungen historischer Ereignisse verloren gingen. Der Verlust veröffentlichter Dokumente nach der Erfindung der Drucktechnik war etwas weniger bedeutend, aber er kam dennoch vor. Der Verlust unveröffentlichter Dokumente geschah häufig, und zwar sowohl vor wie nach der Erfindung der Drucktechnik. Ob in unentzifferten Dokumenten definitiv Wissensverlust vorliegt, ist einigermaßen zweifelhaft. Einige unentzifferte Sprachen mögen eines Tages entziffert werden, aber einige unentzifferte Sprachen mögen auch für immer unentziffert bleiben. Der Verlust von Wissen wegen unzureichender Aufmerksamkeit gegenüber dem Werk eines früheren Wissenschaftlers kann behoben werden, wenn man seine Behauptungen nochmals untersucht. Wissensverlust kommt hauptsächlich in den Geisteswissenschaften vor. In der Mathematik und einigen Naturwissenschaften gibt es fast nur Zunahme an Wissen wegen der Wiederholbarkeit der Experimente. (shrink)

Summary This article compares the discoveries of the planets Neptune and Pluto and the unsuccessful search of intra-Mercurial planets. Its conclusion is, that the search of intra-Mercurial planets was started on the basis of reasonable assumptions and competently pursued, that the success in the search of Neptune and Pluto and the failure in the search of intra-Mercurial planets was not due to greater competence of the successful planet searchers, but to good luck of the successful researchers and bad luck of (...) the unsuccessful researchers. (shrink)

Name der Zeitschrift: Zeitschrift für Religionswissenschaft Jahrgang: 21 Heft: 2 Seiten: i-ii.

Der Beweis des Vierfarbensatzes mit Hilfe eines Computers, der so viel Zeit erforderte, daß ein Mensch die Berechnungen niemals überprüfen könnte, hat Zweifel erregt an vier philosophischen Annahmen über Mathematik. Die Mathematik ist die Lehre der Klassifikation, insoweit als sie vollständig abstrahiert von der Art der zu klassifizierenden Dinge. Diese Auffassung wird vom Beweis des Vierfarbensatzes nicht erschüttert. Wahrscheinlich kann mathematisches Denken nicht vor sich gehen ohne sinnliche Vorstellungen, aber die Eigenschaften mathematischer Gegenstände sind unabhängig von ihrer Weise sinnlicher Vorstellung.

Es wird die Frage untersucht, ob die Annahme der Existenz von universellen Normen für die Annäherung der Wissenschaft an die Wahrheit nicht in praxi lediglich Gegenwartszentrismus und Ethnozentrismus heißt. Die griechisch-römische Zivilisation förderte die Wissenschaft durch ihre Demokratie, aber andere Zivilisationen haben sehr wertvolle Datensammlungen geliefert. Die Universalität der Wissenschaft impliziert u. a. daß, wo verschiedene Zivilisationen mit ihren Wissenschaften einander begegnen, sie von einander lernen können.

Der Streit darüber, ob es objektive Wahrheitskriterien gibt, wird oft mit der Frage vermengt, ob Wissenschaft immer fortschreite. Vor allem Popper in "Objective Knowledge" unterstellt in starkem Maße einen allgemeinen Trend der Wissenschaft zum Fortschritt. In diesem Beitrag wird gezeigt, daß Wissen verloren gehen kann: 1. Weil es nicht aufgezeichnet wird; 2. weil die Dokumente, in denen es niedergelegt wurde, verloren gehen; 3. weil das Wissen um die Sprache der Dokumente, in denen es niedergelegt wurde, verloren gegangen (...) ist, 4. weil die spätere Wissenschaftlergemeinschaft die Dokumente nicht genügend beachtet, in denen es niedergelegt wurde. Der Verlust nichtaufgezeichneten Wissens ist äußerst üblich. Der Verlust veröffentlichter Dokumente war besonders vor der Erfindung der Drucktechnik häufig und hat besonders in manchen Zweigen der Geisteswissenschaften einen Rückschritt bedeutet, weil entweder Dokumente, die das Objekt dieser Wissenschaften ausmachen, oder Aufzeichnungen historischer Ereignisse verloren gingen. Der Verlust veröffentlichter Dokumente nach der Erfindung der Drucktechnik war etwas weniger bedeutend, aber er kam dennoch vor. Der Verlust unveröffentlichter Dokumente geschah häufig, und zwar sowohl vor wie nach der Erfindung der Drucktechnik. Ob in unentzifferten Dokumenten definitiv Wissensverlust vorliegt, ist einigermaßen zweifelhaft. Einige unentzifferte Sprachen mögen eines Tages entziffert werden, aber einige unentzifferte Sprachen mögen auch für immer unentziffert bleiben. Der Verlust von Wissen wegen unzureichender Aufmerksamkeit gegenüber dem Werk eines früheren Wissenschaftlers kann behoben werden, wenn man seine Behauptungen nochmals untersucht. Wissensverlust kommt hauptsächlich in den Geisteswissenschaften vor. In der Mathematik und einigen Naturwissenschaften gibt es fast nur Zunahme an Wissen wegen der Wiederholbarkeit der Experimente. (shrink)

Grenzen van dialoog -/- De universalismegedachte van de Verlichting heeft een -postmodernistische maatschappij van slachtoffers geschapen. Het geloofsverlies in de grote verhalen en de universalisering van het individu zorgen ervoor, dat zijn schreeuw naar verontwaardiging geen toehoorders meer vindt. Zijn roep in de woestijn gaat verloren in het chaotisch geschreeuw van de anderen. Tegenover dit koude, steriele postmodernisme stellen wij het eco-communautarisme. Vanuit de vaststelling dat het individu denkt, spreekt en handelt in de context van zijn taal en cultuur, (...) dus vanuit zijn gemeenschap, voegen wij aan Kants transcendentale ideeën 'Ik', 'Wereld' en 'God', een vierde idee toe: het 'Wij' of het principe van inclusiviteit. De Kantiaanse burgermoraal is Copernicaans geïnspireerd en steunt op de Newtoniaanse ruimte-tijdstructuur. Door middel van Hackings sociaal constructivisme, het Leibniziaanse meer-werelden-beeld en het biologische paradigma als nieuw denkkader, structureren wij de -gemeenschap volgens een cyclisch en een lineair tijdsverloop. Het cyclische waarborgt de traditie van een gemeenschap, het lineaire doet de gemeenschap evolueren naar een moreel betere toekomst. Het eco-communautarisme biedt het kader voor een kwalitatieve evolutie van individuen en gemeenschappen. Het normerend aspect hiervan is de pluriforme en multi-culturele dialoog. Een dialoog met grenzen. (shrink)

Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so by proposing four hallmark processes of the germline: meiosis, epigenetic plasticity, migration, and metabolic plasticity. Together, these hallmarks enable replicative immortality of germ cells as well as cancer cells. Especially meiotic genes are frequently expressed in cancer, implying that genes unique to meiosis may play a (...) role in oncogenesis. Because GC genes are not expressed in healthy somatic tissues, they form an appealing source of specific treatment targets with limited side effects besides infertility. Although it is still unclear why germ cell specific genes are so abundantly expressed in cancer, from our hypothesis it follows that the germline's reproductive program is intrinsic to cancer development. (shrink)

Patient-reported outcomes are frequently used for medical decision making, at the levels of both individual patient care and healthcare policy. Evidence increasingly shows that PROs may be influenced by patients’ response shifts and dispositions. We identify how response shifts and dispositions may influence medical decisions on both the levels of individual patient care and health policy. We provide examples of these influences and analyse the consequences from the perspectives of ethical principles and theories of just distribution. If influences of response (...) shift and disposition on PROs and consequently medical decision making are not considered, patients may not receive optimal treatment and health insurance packages may include treatments that are not the most effective or cost-effective. We call on healthcare practitioners, researchers, policy makers, health insurers, and other stakeholders to critically reflect on why and how such patient reports are used. (shrink)

Parameters of a Bertalanffy type of temperature dependent growth model are fitted using data from a population of stone loach ( Barbatula barbatula ). Over two periods respectively in 1990 and 2010 length data of this population has been collected at a lowland stream in the central part of the Netherlands. The estimation of the maximum length of a fully grown individual is given special attention because it is in fact found as the result of an extrapolation over a large (...) interval of the entire lifetime. It is concluded that this parameter should not at forehand be set at one fixed value for the population at that location due to varying conditions over the years. (shrink)

This paper is on the update semantics for might of Veltman. Threeconsequence relations are introduced and studied in an abstract setting.Next we present sequent-style systems for each of the consequence relations.We show the logics to be complete and decidable. The paper ends with asyntactic cut elimination result.

The frequent occurrence of comorbidity has brought about an extensive theoretical debate in psychiatry. Why are the rates of psychiatric comorbidity so high and what are their implications for the ontological and epistemological status of comorbid psychiatric diseases? Current explanations focus either on classification choices or on causal ties between disorders. Based on empirical and philosophical arguments, we propose a conventionalist interpretation of psychiatric comorbidity instead. We argue that a conventionalist approach fits well with research and clinical practice and resolves (...) two problems for psychiatric diseases: experimenter’s regress and arbitrariness. (shrink)

We model three examples of beliefs that agents may have about other agents’ beliefs, and provide motivation for this conceptualization from the theory of mind literature. We assume a modal logical framework for modelling degrees of belief by partially ordered preference relations. In this setting, we describe that agents believe that other agents do not distinguish among their beliefs (‘no preferences’), that agents believe that the beliefs of other agents are in part as their own (‘my preferences’), and the special (...) case that agents believe that the beliefs of other agents are exactly as their own (‘preference refinement’). This multi-agent belief interaction is frame characterizable. We provide examples for introspective agents. We investigate which of these forms of belief interaction are preserved under three common forms of belief revision. (shrink)

People cannot understand intentions behind observed actions by direct simulation, because goal inference is highly context dependent. Context dependency is a major source of computational intractability in traditional information-processing models. An embodied embedded view of cognition may be able to overcome this problem, but then the problem needs recognition and explication within the context of the new, layered cognitive architecture.

The concept of meaningful work is used to evaluate the quality of work. Typical cases of meaningless work that have been used to clarify this concept are assembly line work, and work involving other types of mindless tasks, but also David Graeber's ‘bullshit jobs’. I argue that there are at least two fundamental reasons to care about meaningful work: reasons from the wellbeing of the worker and reasons pertaining to meaningfulness of the worker's life. I first argue that a concept (...) of meaningful work needs to reflect these two values, but that these two values may come apart. Because of this, accounts that provide a single answer to the question to what extent a particular work context is meaningful work for a particular worker are unable to reflect these two values. I then survey three promising accounts of meaningful work: perfectionism, which captures the self-interested aspect of meaningful work well but fails to capture the meaningfulness aspect appropriately; consequentialism, which captures the meaningfulness aspect well but fails to capture the self-interested aspect; and Wolf's Fitting Fulfilment View of meaningful projects, which can be read as addressing both concerns but leads to implausible judgments about meaningful work. I then argue that we should conceive of the concerns that fall under the notion of meaningful work as two separate concepts and values. The best work incorporates both these dimensions but falling short on either dimension is problematic for different reasons. (shrink)

In three experiments, picture quality between test items was manipulated to examine whether subjects’ expectations about the fluency normally associated with these different stimuli might influence the effects of fluency on preference or familiarity-based recognition responses. The results showed that fluency due to pre-exposure influenced responses less when objects were presented with high picture quality, suggesting that attributions of fluency to preference and familiarity are adjusted according to expectations about the different test pictures. However, this expectations influence depended on subjects’ (...) awareness of these different quality levels. Indeed, imperceptible differences seemed not to induce expectations about the test item fluency. In this context, fluency due to both picture quality and pre-exposure influenced direct responses. Conversely, obvious, and noticed, differences in test picture quality did no affect responses, suggesting that expectations moderated attributions of fluency only when fluency normally associated with these different stimuli was perceptible but difficult to assess. (shrink)

Background Since the enactment of the euthanasia law in the Netherlands, there has been a lively public debate on assisted dying that may influence the way patients talk about euthanasia and physician-assisted suicide with their physicians and the way physicians experience the practice of EAS. Aim To show what developments physicians see in practice and how they perceive the influence of the public debate on the practice of EAS. Methods We conducted a secondary analysis of in-depth interviews with 28 Dutch (...) physicians who had experience with a complex case of EAS. Respondents were recruited both by the network of physicians working for SCEN as well as via a national questionnaire, wherein participating physicians could indicate their willingness to be interviewed. Results Three themes came up in analysing the interviews. First, the interviewed physicians experienced a change in what patients would expect from them: from a role as an involved caregiver to being the mere performer of EAS. Second, interviewees said that requests for EAS based on non-medical reasons came up more frequently and wondered if EAS was the right solution for these requests. Last, respondents had the impression that the standards of EAS are shifting and that the boundaries of the EAS regulation were stretched. Conclusions The perceived developments could make physicians less willing to consider a request for EAS. Our results also raise questions about the role of physicians and of EAS in society. (shrink)

This paper examines the increasingly popular view that new insights from the science of subjective well-being (SSWB) should play a prominent role in the determination of public policy. Though there are instrumental reasons for caring about societal happiness too, these political aspirations of the SSWB appear to be mostly intrinsically motivated. As the intrinsic value of happiness is endorsed across the political happiness as a fitting response to the state of the world, authenticity, and merit – it is shown that (...) different views of the conditionality of the intrinsic value of happiness have widely diverging policy implications, which greatly undermines the political aspirations of the SSWB. (shrink)

Until late in the nineteenth century, madder was the most popular natural red dye. Holland was the largest and best-known supplier. As early as the fourteenth and fifteenth centuries, the province of Zeeland and adjoining parts of the provinces of South Holland and Brabant developed into important producers. In the course of the seventeenth century these areas even succeeded in acquiring a monopoly position. Early in the nineteenth century, however, this position came under attack because France had gone over to (...) industrial production methods from around 1800, whereas Holland continued to produce with craft technologies. After 1820, as a result, a period of stagnation and decay set in. The fate of the Dutch madder industry would have been completely sealed if the production capacity of the French factories had been sufficiently large to satisfy the great increase in demand. Consequently, in Holland, after 1845, a process of revival based upon the French manufacturing methods began slowly and hesitatingly. This process started too late and was not persevered with sufficiently to regain lost markets. The Dutch producers remained strongly attached to their own out-dated, craft methods of production. (shrink)