Amphibian metamorphosis is a post‐embryonic process that systematically transforms different tissues in a tadpole. Thyroid hormone plays a causative role in this complex process by inducing a cascade of gene regulation. While natural metamorphosis does not occur until endogenous thyroid hormone has been synthesized, tadpoles are competent to respond to exogenous thyroid hormone shortly after hatching. In addition, even though the metamorphic transitions of individual organs are all controlled by thyroid hormone, each occurs at distinct developmental stages. Recent molecular studies (...) suggest that this competence of premetamorphic tadpoles to respond to the hormone and the developmental stage‐dependent regulation of tissue‐specific transformations are determined in part by the levels of thyroid hormone receptors and the concentrations of cellular free thyroid hormone. In addition, at least two genes, encoding a cytosolic thyroid hormone binding protein and a 5‐deiodinase, respectively, are likely to be critical players in regulating cellular free thyroid hormone concentrations. This review discusses how all of these molecuar components coordinate to induce amphibian metamorphosis in a correct spatial and temporal manner. These studies provde us with general clues as to how and why tissues become competent to respond to hormonal signals. (shrink)

A reanalysis of the eight astronomical images that Johann Adam Schall von Bell incorporated in the first Chinese treatise on the telescope to illustrate the telescopic discoveries made by Galileo Galilei shows that they were borrowed from the works on telescopic astronomy by Galileo Galilei and Johann Georg Locher, a student of Christopher Scheiner. Except minor changes to both Galileo’s illustrations of the telescopic view of the moon and nebulae and Locher’s illustration of sunspots, Locher’s images about the phases of (...) Venus and Jovian satellites were redrawn presumably to convey a clearer commitment to Tycho Brahe’s system of the world and most of the contents in Locher’s image of Saturn was replaced by Schall’s own observation. These changes seem to be the result of two important factors that confined the transcultural transmission of astronomical knowledge from Europe to China through the Jesuits in the seventeenth century, namely the official standpoint of the Catholic Church on the ongoing cosmological issues and the cultural tradition of Chinese astronomy. (shrink)

A reanalysis of the eight astronomical images that Johann Adam Schall von Bell incorporated in the first Chinese treatise on the telescope to illustrate the telescopic discoveries made by Galileo Galilei shows that they were borrowed from the works on telescopic astronomy by Galileo Galilei and Johann Georg Locher, a student of Christopher Scheiner. Except minor changes to both Galileo’s illustrations of the telescopic view of the moon and nebulae and Locher’s illustration of sunspots, Locher’s images about the phases of (...) Venus and Jovian satellites were redrawn presumably to convey a clearer commitment to Tycho Brahe’s system of the world and most of the contents in Locher’s image of Saturn was replaced by Schall’s own observation. These changes seem to be the result of two important factors that confined the transcultural transmission of astronomical knowledge from Europe to China through the Jesuits in the seventeenth century, namely the official standpoint of the Catholic Church on the ongoing cosmological issues and the cultural tradition of Chinese astronomy. (shrink)

Background Supporting physicians in Intensive Care Units s as they face dying patients at unprecedented levels due to the COVID-19 pandemic is critical. Amidst a dearth of such data and guided by evidence that nurses in ICUs experience personal, professional and existential issues in similar conditions, a systematic scoping review is proposed to evaluate prevailing accounts of physicians facing dying patients in ICUs through the lens of Personhood. Such data would enhance understanding and guide the provision of better support for (...) ICU physicians. Methods An SSR adopts the Systematic Evidenced Based Approach to map prevailing accounts of caring for dying patients in ICUs. To enhance the transparency and reproducibility of this process, concurrent and independent use of tabulated summaries, thematic analysis and directed content analysis is adopted. Results Eight thousand three hundred fifty-eight abstracts were reviewed from four databases, 474 full-text articles were evaluated, 58 articles were included, and the Split Approach revealed six categories/themes centered around the Innate, Individual, Relational and Societal Rings of Personhood, conflicts in providing end of life care and coping mechanisms employed. Conclusion This SSR suggests that caring for dying patients in ICU impacts how physicians view their personhood. To resolve conflicts within individual concepts of personhood, physicians use prioritization, reframing and rely on accessible, personalized support from colleagues to steer coping strategies. An adapted form of the Ring Theory of Personhood is proposed to direct timely personalized, appropriate and holistic support. (shrink)

本书内容包括:绪论:思想史的写法及其使命、法律应该是什么、法律的合法性、社会契约理论基本问题、法官与法律的关系等。.

本书共有两篇,第一篇物质矛盾运动概论分为八章,包括矛盾形态和类型、运动形式及类别等。第二篇介绍了关于暗物质等宇宙历史中的若干问题。.

本书系统地阐述了解释学意识与对马克思主义哲学的理解,马克思哲学的自我理解,对马克思主义哲学的“实践唯物主义”理解等内容。.

本书首先对达尔文以群体选择论为主要基础的道德进化论作了细致的考察,接着论述了斯宾塞等人的社会达尔文主义,以及托马斯·赫胥黎和克鲁泡特金等人所提供的早期进化伦理学诸形态,进而考察了进化论在生命哲学伦理学 、精神分析伦理学和实用主义伦理学中所产生的多方面的深刻影响。.

本书分为六章,主要内容包括:混沌的世界、“力”的对峙与“人”的现身、“命”的授受与主体的获得、“道”的歧出与人的可能的绽放、“心”的和合与“人”的解放、“理”的定一与感性的再追求.