Offers a comprehensive nonmathematical treatment regarding the design and analysis of experiments, focusing on basic concepts rather than calculation of technical details. Much of the discussion is in terms of examples drawn from numerous fields of applications. Subjects include the justification and practical difficulties of randomization, various factors occurring in factorial experiments, selecting the size of an experiments, different purposes for which observations may be made and much more.

Oxidative damage to DNA has been associated with neurodegenerative diseases. Developmental exposure to lead has been shown to elevate the Alzheimer's disease related beta-amyloid peptide , which is known to generate reactive oxygen species in the aging brain. This study measures the lifetime cerebral 8-hydroxy-2'-deoxyguanosine levels and the activity of the DNA repair enzyme 8-oxoguanine DNA glycosylase in rats developmentally exposed to Pb. Oxo8dG was transiently modulated early in life , but was later elevated 20 months after exposure to Pb (...) had ceased, while Ogg1 activity was not altered. Furthermore, an age-dependent loss in the inverse correlation between Ogg1 activity and oxo8dG accumulation was observed. The effect of Pb on oxo8dG levels did not occur if animals were exposed to Pb in old age. These increases in DNA damage occurred in the absence of any Pb-induced changes in copper/zinc-superoxide dismutase , manganese-SOD , and reduced-form glutathion . These data suggest that oxidative damage and neurodegeneration in the aging brain could be impacted by the developmental disturbances. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

"By combining recent advances in the physical sciences with some of the novel ideas, techniques, and data of modern biology, this book attempts to achieve a new and different kind of evolutionary synthesis. I found it to be challenging, fascinating, infuriating, and provocative, but certainly not dull."--James H, Brown, University of New Mexico "This book is unquestionably mandatory reading not only for every living biologist but for generations of biologists to come."--Jack P. Hailman, Animal Behaviour , review of the first (...) edition "An important contribution to modern evolutionary thinking. It fortifies the place of Evolutionary Theory among the other well-established natural laws."--R.Gessink, TAXON. (shrink)

I would refer to the introductory paragraphs of J. Diggle's ‘Notes on Ovid's Tristia, Books I-II’ , 401–19). His list of modern editions does not include F. Della Corte, I Tristia , which I too have not seen. For Book IV we have an edition by T. J. de Jonge.

People who trust modern indexes will suppose that the name of Sex. Clodius, the disreputable henchman of Publius, comes twice in the Ad Atticum letters, 14. 13. 6 and 14. 13 A. 2. The manuscripts give it as follows.

R. Renehan's ingenious solutions to the problems of Symphosius 42. 1 and Anth. Lat. 207 in this journal, 471 f.) are much to be welcomed. On the other hand, I do not think that his defence of the manuscript reading in Anth. Lat. 24. 3 marcent post rorem violae, rosa perdit odorem holds water. Taking rorem as = rorem marinum he explains that ‘the poet is not presenting us with a piece of botanical information about the relative seasons of the (...) violet and rosemary; he means rather that all flowers wither and fade’. Actually, however, the poet on this showing does present information; and whether the information is botanically correct or not, that is an odd way to make his point. Stranger still is his choice of rosemary out of all the fading flowers of field and garden. It was bound to be I misunderstood. As Renehan indicates, ros = ros marinus is supported only by Virg. Georg. 2. 212–13, where the identity has been doubted, and Plin. HN 24. 100, where ex rore supra dicto refers back to ros marinum in 99. Renehan may well be the first reader not to take rorem as dew. And an evergeen shrub makes a singularly unfortunate illustration of floral decay, even though the shrub does produce a flower. Pliny classes it with herbs. (shrink)

The text of Quintus Curtius benefited greatly from Conrad Müller's edition of 1954 . In particular, his thorough investigation of Curtius' rhythms enabled him to settle many hitherto doubtful points. Problems remain, unsolved or undetected. In Curtius, as in other prose texts, scribal omissions are a prolific source of corruption, sometimes productive of interpolation. Most of the following notes postulate corruptions of this type.

The text of Quintus Curtius benefited greatly from Conrad Müller's edition of 1954. In particular, his thorough investigation of Curtius' rhythms enabled him to settle many hitherto doubtful points. Problems remain, unsolved or undetected. In Curtius, as in other prose texts, scribal omissions are a prolific source of corruption, sometimes productive of interpolation. Most of the following notes postulate corruptions of this type.

10. 2. lugentem timentemque custodire solemus, ne solitudine male utatur. Reynolds does not mention Haupt's conjecture amentemque, which is certainly on the right lines. Bereaved persons may need watching because in the violence of their grief they may do themselves an injury , and the same applies to madmen or to anyone suspected of suicidal inclinations custodio). It does not apply to persons afraid; they may sometimes be glad of company, but do not require surveillance. My only doubt is whether (...) amentem, seldom used of actual insanity, is the right word. Perhaps dementem or furentem, which makes a better match with the participle lugentem. (shrink)

Seneca ‘Rhetor’ was last critically edited by H. J. Müller in 1887; the editions of H. Bornecque and W. A. Edward lack an apparatus criticus, though the latter's notes give some attention to textual points. Whoever next addresses himself to the task can take heart from Eduard Norden : ‘der Text ist schwer korrupt, für Konjekturalkritik noch viel zu tun.’ It may be added that he will do a service by jettisoning a large proportion of what Konjekturalkritik has already produced-too (...) much of this nature in Müller's text and apparatus, to say nothing of later contributions, is merely depressing. (shrink)

Seneca ‘Rhetor’ was last critically edited by H. J. Müller in 1887; the editions of H. Bornecque and W. A. Edward lack an apparatus criticus, though the latter's notes give some attention to textual points. Whoever next addresses himself to the task can take heart from Eduard Norden : ‘der Text ist schwer korrupt, für Konjekturalkritik noch viel zu tun.’ It may be added that he will do a service by jettisoning a large proportion of what Konjekturalkritik has already produced-too (...) much of this nature in Müller's text and apparatus, to say nothing of later contributions, is merely depressing. (shrink)

10. 2. lugentem timentemque custodire solemus, ne solitudine male utatur. Reynolds does not mention Haupt's conjecture amentemque, which is certainly on the right lines. Bereaved persons may need watching because in the violence of their grief they may do themselves an injury, and the same applies to madmen or to anyone suspected of suicidal inclinations custodio). It does not apply to persons afraid; they may sometimes be glad of company, but do not require surveillance. My only doubt is whether amentem, (...) seldom used of actual insanity, is the right word. Perhaps dementem or furentem, which makes a better match with the participle lugentem. (shrink)

Few authors, I should suppose, get less expert treatment in this lexicon than Cicero, so far at least as his letters are concerned. That is largely because the editors chose to trust Tyrrell and Purser, to whom Cicero's Greek was no less full of pitfalls than his Latin. The following notes may be of help in the preparation of a tenth edition.

Cicero's use of the term is hardly a joke, and has to do with medicine, not logic. He says that his predecessor as governor of Cilicia, App. Claudius Pulcher, is like a doctor whose patient has been transferred to another practitioner, and who takes offence when the new man alters the treatment.

Few authors, I should suppose, get less expert treatment in this lexicon than Cicero, so far at least as his letters are concerned. That is largely because the editors chose to trust Tyrrell and Purser, to whom Cicero's Greek was no less full of pitfalls than his Latin. The following notes may be of help in the preparation of a tenth edition.

Cicero's use of the term is hardly a joke, and has to do with medicine, not logic. He says that his predecessor as governor of Cilicia, App. Claudius Pulcher, is like a doctor whose patient has been transferred to another practitioner, and who takes offence when the new man alters the treatment.

Few authors, I should suppose, get less expert treatment in this lexicon than Cicero, so far at least as his letters are concerned. That is largely because the editors chose to trust Tyrrell and Purser, to whom Cicero's Greek was no less full of pitfalls than his Latin. The following notes may be of help in the preparation of a tenth edition.

Critics, once so busy with Manilius, have left him alone since Housman's edition was completed a quarter of a century ago. Perhaps I shall seem rash to break the silence by challenging a few of his verdicts. I do so in no spirit of iconoclasm, but rather believing that Housman wrote for readers who will occasionally call him wrong—at their peril, and on their knees.

‘He was of Rutulian blood, born of a Saguntine mother; but he had Greek blood too, and by his two parents he combined the seed of Italy with that of Dulichium’. So Duff, and Ruperti's ‘Murrus matre Graia et patre Romano progenitus’ is not the whole story. To Silius Saguntine = Greek because, as Duff says, ‘men of Zacynthos had taken part in founding Saguntum’. prole = ‘with his children’—van Veen's Itala may well be right.

‘He was of Rutulian blood, born of a Saguntine mother; but he had Greek blood too, and by his two parents he combined the seed of Italy with that of Dulichium’. So Duff, and Ruperti's ‘Murrus matre Graia et patre Romano progenitus’ is not the whole story. To Silius Saguntine = Greek because, as Duff says, ‘men of Zacynthos had taken part in founding Saguntum’. prole = ‘with his children’—van Veen's Itala may well be right.