Nuclear bodies contribute to non‐random organization of the human genome and nuclear function. Using a major prototypical nuclear body, the Cajal body, as an example, we suggest that these structures assemble at specific gene loci located across the genome as a result of high transcriptional activity. Subsequently, target genes are physically clustered in close proximity in Cajal body‐containing cells. However, Cajal bodies are observed in only a limited number of human cell types, including neuronal and cancer cells. Ultimately, Cajal body (...) depletion perturbs splicing kinetics by reducing target small nuclear RNA (snRNA) transcription and limiting the levels of spliceosomal snRNPs, including their modification and turnover following each round of RNA splicing. As such, Cajal bodies are capable of shaping the chromatin interaction landscape and the transcriptome by influencing spliceosome kinetics. Future studies should concentrate on characterizing the direct influence of Cajal bodies upon snRNA gene transcriptional dynamics.Also see the video abstract here. (shrink)

Naturalism is a pan-Asian view of the world and way of life. Unlike the atheistic naturalism in the West, Asian naturalism, which rests upon an organic view of the world as represented by key concepts such as the Dao, Heaven, and Emptiness, is basically spiritual. Going beyond the traditional Western antithesis of naturalism and supernaturalism, matter and spirit, it can even be called “supernatural naturalism.” As a living example of Asian naturalism, this article examines the ethics of threefold reverence: reverence (...) toward Heaven, all human beings, and all beings, animate and inanimate. Threefold reverence constitutes the cardinal teaching of Cheondogyo or the Eastern Learning, a native Korean religio-philosophical movement which arose in the latter half of the nineteenth century. The ecological-environmental crisis of our age cannot be overcome without a fundamental change in our attitude toward nature. Recovering humanity’s primal sense of reverence toward all beings in nature is a vital part of this change. (shrink)

1. The definition of subjective materialism: Subjective materialism is not a simple definition, it is a new system of both the conception of the world and the methodology. The definition and the comprehension of the subjective materialism can be much many, but I can definite it with a simple definition after I have grasped it’s core guiding principle: actually, the subjective materialism is a system of both the conception of the world and the methodology which create and illumination the equation (...) material (information)=idea (information) in a materialistic way. 2. The background and condition of subjective materialism come into being: The human society has developed in a information age, but the materialist philosophy still stay in the 19th century of industrial society, which has not fully reflected the spirits of our times and is more difficult to lead the development trend of world philosophy. Materialist philosophy needs to develop. 3. The theory sources of subjective materialism: First of all, subjective materialism is the result of the development of western philosophy, including the modern western philosophy theory. Second, subjective materialism is also undoubtedly a result of development of Marxist philosophy. Third, the subjective materialism is also the result of ancient oriental philosophy. If the subjective materialism must be a definition of western philosophy, then the thinking of “Rune” must be the product of oriental philosophy. 4. Meanings of the new philosophy: Subjective materialism philosophy must be different from modern west philosophy and postmodern philosophy. And it’s essential meaning is rebuild the philosophy and put the metaphysics in our view once again. So, both the conception of the world and the methodology of “Rune” structure are the completely subversion to all the monism philosophy, and are the completely new structure system of philosophy ontology. (shrink)

Subjective Materialism, this new theory has been elaborated thoroughly in the academic book of Philosophy System of Post-modern materialism which was published by Heilongjiang peoples Publishing House in 2003.This article means to open a door to innovation and development of the modern philosophy ofmaterialism in the 21st century.

This study analyses the types and frequencies of ethical dilemmas and the rationale of ethical decision making in student nurses; it also evaluates their decision making. One hundred senior student nurses who were enrolled in a two-credit course in nursing ethics were asked to provide an informal description of a dilemma that they had experienced during their clinical practice. The results were as follows. The ethical dilemmas identified fell into four categories and were of 27 types. Those most frequently experienced (...) were ‘family giving up on a patient because he or she could not be cured’, and ‘not telling the truth to the patient’. The Korean Nurses’ Code of Ethics was applied, in particular the preamble, and the third, fourth, seventh and tenth clauses. The most common rule of ethics and principle applied in these nurses’ ethical decision making were veracity and nonmaleficence. With regard to the moral reasoning process, the primary concern was the welfare of the patients. These students were equipped with the ability to exercise critical and reflective thought when they experienced ethical dilemmas. (shrink)

Organizational members are likely to harbor different allegiances, values, and identifications that can affect how they respond to their organization’s stigmatization. Drawing on the empirical case of a public broadcaster in South Korea initially stigmatized for its association with an authoritarian government, we focus on the responses of different intra-organizational groups to stigma and their interactions with each other and with external audiences. We find that faced with stigma, groups in the organization were divided about how to respond, with those (...) defying the stigma and advocating a close relationship with the government competing with those who shared the values of stigmatizing audiences. Both groups sought control over journalism work, the organizational attribute for which the broadcaster was stigmatized, allying with external audiences that shared their respective visions. The dominance of the group that defied the stigma led to increased stigmatization of the organization by existing audiences and additionally prompted the participation of initially passive audiences in its denigration, eventually leading to organizational decline. We contribute to the literature on stigma by promoting an understanding of heterogeneity among members in stigmatized organizations and its implications for the consequences of stigma. We also contribute to theorizing stigmatization as a relational process by demonstrating how the heterogeneity of organizational members’ experience of stigma interacted with audience heterogeneity and highlighting the relative roles played by active and passive audiences in bringing about the decline of a stigmatized organization. (shrink)

Background:While nursing ethics education is commonly provided for undergraduate nursing students in most nursing colleges, consensus on the content and teaching modules for these ethics courses have still not been established.Objectives:This study aimed to examine the effects of nursing ethics education on the moral sensitivity and critical thinking disposition of nursing students in Korea.Research design:A one-group pre- and post-test design was used. Moral sensitivity was measured using the Korean version of the Moral Sensitivity Questionnaire. Critical thinking disposition was measured using (...) the Critical Thinking Disposition Questionnaire.Participants and research context:Participants were 70 undergraduate nursing students who were attending a university located in Seoul, Korea. The nursing ethics education was provided 7 times, from September to December 2010, and comprised 90-min sessions each week.Ethical considerations:This study was conducted in accordance with the Human Subject Research Ethics Committee guidelines.Findings:After the education, the levels for the patient-oriented care, a sub-domain of moral sensitivity, and inquisitiveness, a sub-domain of critical thinking disposition, significantly improved. There were no changes in overall scores for moral sensitivity and critical thinking disposition. There were significant positive correlations between moral sensitivity and critical thinking disposition both pre- and post-intervention.Conclusion:These results reflect the need for ongoing efforts to develop innovative content, structure, and instructional methods for undergraduate nursing ethics education programs. (shrink)

Role-based database management systems are most widely used for information storage and analysis but are known as vulnerable to insider attacks. The core of intrusion detection lies in an adaptive system, where an insider attack can be judged if it is different from the predicted role by performing classification on the user’s queries accessing the database and comparing it with the authorized role. In order to handle the high similarity of user queries for misclassified roles, this paper proposes a deep (...) metric neural network with strategic sampling algorithm that properly extracts salient features and directly learns a quantitative measure of similarity. A strategic sampling method of heuristically generating and learning training pairs through Monte Carlo search is proposed to select a training pair that can represent the entire dataset. With the TPC-E–based benchmark data trained with 11,000 queries for 11 roles, the proposed model produces the classification accuracy of 95.41%, which is the highest compared with the previous models. The results are verified through comparison of quantitative and qualitative evaluations, and the feature space modelled in the neural network is analysed by t-SNE algorithm. (shrink)

Public figures’ transgressions attract considerable media attention and public interest. However, little is understood about the impact of celebrity endorsers’ transgressions on associated brands. Drawing on research on moral reasoning, we posit that consumers are not always motivated to separate judgments of performance from judgments of morality or simply excuse a wrongdoer. We propose that consumers also engage in moral coupling, a distinct moral reasoning process which allows consumers to integrate judgments of performance and judgments of morality. In three studies, (...) we demonstrate that moral coupling is prevalent and has unique predictive utilities in explaining consumers’ evaluation of the transgressor. We also show that transgression type has a significant impact on consumers’ choice of moral reasoning strategy. Finally, we demonstrate that consumers’ support for a brand endorsed by a transgressor is a direct function of moral reasoning choice. Findings suggest that public figure’s immoral behavior and its spillover to an extended brand is contingent on consumers’ moral reasoning choices. (shrink)

Background Nurses providing care to patients with end-of-life or terminal illnesses often encounter ethically challenging situations leading to moral distress. However, existing quantitative studies have examined moral distress using instruments that address general clinical situations rather than those specific to end-of-life care. Furthermore, qualitative studies have often been limited to participants from a single unit or those experiencing moral distress-induced circumstances. A comprehensive and integrated understanding of the overarching process of moral distress is vital to discern the unique circumstances surrounding (...) end-of-life care and its consequential impacts. Research objectives To explore the moral distress experiences of nurses who are frequently involved in caring for patients with end-of-life or terminal illnesses and apply it to two existing theories: the model of moral distress and the ecological model. Research design A qualitative descriptive approach was employed. Participants and research context Seven focus group interviews involving 30 nurses were performed. The subsequent transcriptions underwent rigorous content analysis. Ethical considerations We obtained Institutional Review Board approval from a university. Focus group interviews were conducted with nurses who agreed to participate and signed the consent form. Findings The moral distress-inducing factors and nurses’ perceived impact of moral distress were identified and categorized based on moral distress theories and ecological models. A total of 15 categories and 30 subcategories across the following 4 domains were derived: (1) intrapersonal, (2) interpersonal, (3) organizational, and (4) structural factors. Conclusions End-of-life-specific circumstances induced moral distress among nurses, with both negative and positive impacts identified. Effective organizational and policy support is essential to manage conflicts, form a healthy organizational culture, provide training, and prevent unnecessary expenses due to the negative consequences of moral distress. (shrink)

This Korean study replicated a previously published American study. The conceptual framework and method combined ethical enquiry and phenomenology. The research questions were: (1) What is nursing students’ experience of ethical problems involving nursing practice? and, (2) What is nursing students’ experience of using an ethical decision-making model? The participants were 97 senior baccalaureate nursing students, each of whom described one ethical problem and chose to use one of five ethical decision-making models. From 97 ethical problems, five content categories emerged, (...) the largest being health professionals (69%). The basic nature of the ethical problems was the students’ experience of conflict, resolution and rationale. Using an ethical decision-making model helped 94% of the students. A comparison of the Korean and American results yields important implications for nursing ethics education, practice and research. (shrink)

This longitudinal study examined how nursing students' moral judgment changes after they become qualified nurses working in a hospital environment. The sample used was a group of 80 nursing students attending a university in Suwon, Korea, between 2001 and 2003. By using a Korean version of the Judgment About Nursing Decisions questionnaire, an instrument used in nursing care research, moral judgment scores based on Ketefian's six nursing dilemmas were determined. The results were as follows: (1) the qualified nurses had significantly (...) higher idealistic moral judgment scores than the nursing students; (2) the qualified nurses showed significantly higher realistic moral judgment scores than the nursing students; and (3) when comparing idealistic and realistic moral judgment scores, both the qualified nurses and the nursing students had higher scores for idealistic moral judgment. Further study is recommended to examine changes in moral judgment. (shrink)

This article has the purpose of examining the commentation that Sung-ho Yi Ik and Da-san Jung Yak-yong developed of Sa-chil Debate (사칠논쟁) Which was a philosophical debate in Chosun Dynasty. Sa-chil Debate began from Toe-gye Yi Whang and Ko-bong Gi Dae-sung and soon as a result of Yul-gok Yi Yi and Woo-gae Sung Hon repeating the debate, It appeared as a kind of philosophical theme. After that, Yul-gok and Toe-gye's students formed a kind of school. They also (...) made the debate extended and the theory more sophisticated by criticizing a counterpart's argument on base of ideologizing their teacher's theory. About 200 years after Toe-gye died, Sung-ho Yi Ik was born and after about 250 years, Da-san Jung Yak-yong was born. Both they experienced a western naturalscience and a catholic theory as Silhak Scholars (실학자). Therefore their this kind of interpretation about Sung-li Debate must be offering a deeply interesting investigation to us. In conclusion, Sung-ho advocated Toe-gye's theory at all, adding more explanation to it and Da-san evaluated all of Toe-gye's and Yul-gok's theory to be right because their theories have a unique logicality of making a sense. Sung-ho stood on a Shilhak view point gave up a organic cosmology ofSung-li theory which has a continuity to cosmology and moral theory, arguing Sa-chil-Li bal-Yil-lo Theory (四七理發一路說) by understanding Sa-chil Debate based on only moral perspective. Even though Da-san also said Yang-si Theory (兩是論) that both their theories are all right, he argued that Toe-gye's theory is much more important in the aspect of moral practice owing to his religious opinion by a catholic affect. By the way, Sung-ho supplemented and explained Toe-gye's theory, but he had not a sufficient logic and was not objective because of his leaning into advocating Toe-gye's theory much further. Da-san had an advantage of evaluating both Toe-gye's and Yul-gok's theory to be all right, but came to argue an insufficient philosophy on account of its simplicity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 20 (2000) 95-113 [Access article in PDF] Further Buddhist Christian Dialogue: A Review Article of Hee Sung Keel's Understanding Shinran: A Dialogical Approach Alfred BloomUniversity of Hawai'iIt was my original intention to write a review of Professor Keel's book. The exceptional quality of the book itself, however, and the issues it raises concerning Shin Buddhism call for a more detailed exploration and discussion. Therefore, this essay (...) is a review article offered in the interests of promoting the dialogue which Professor Keel has so eloquently and capably initiated.With the appearance of Professor Keel's book the development of Shin studies has reached a major milestone. Aspects of Shinran's (1173-1262) life and thought have occasionally been discussed by scholars in the West and by participants in Buddhist-Christian dialogue conferences. In this work we have a detailed analysis of Shinran's thought and the problems and questions that emerge from his interpretation of Mahayana Buddhism and Pure Land teaching. The breadth of Professor Keel's knowledge of Shinran and the depth of his insight into the teaching will carry Buddhist-Christian dialogue into the relatively unexplored area of Shin Buddhist-Christian dialogue.Professor Keel underscores the fact that the translation of Shinran's writings into English has significantly advanced Shin studies by making the teachings available to a wider range of inquirers. It also demonstrates the great responsibility shouldered by Shin scholars who have produced these texts. They must respond substantively and positively to the issues raised by Professor Keel.Though he is clearly Christian, he offers a lucid, sensitive, and fair summation of Shinran's religious experience and thought. He has opened the door of dialogue by presenting an interpretation of Shinran which requires a response. He does not take the position that he possesses the truth, nor does he attempt to refute Shinran in favor of Christianity. He does not judge Shinran to be in error, so much as to point to the paradoxes and dilemmas that are implied in his thought. We shall focus on these later.His volume addresses features of the study of Shinran. Chapter One, entitled The Easy Path, takes up the social and religious background and context of Pure Land [End Page 95] teaching out of which Shinran emerged. Particularly important is the teaching of Honen (1133-1212) whose interpretation of the sole practice of nembutsu (recitation of Amida Buddha's name) threatened the traditional Buddhist establishment. Honen taught that the nembutsu recitation was fully sufficient to realize birth in the Pure Land and ultimate enlightenment without depending on the elaborate, complex Buddhist institutions which offered arduous, rigorous methods for attaining liberation from the bondage of finitude. The elevation of a single practice as the way to enlightenment characterizes the new forms of Buddhism in the Kamakura period (1185-1332).The emphasis on the sole practice of nembutsu devotion marking Honen's Pure Land teaching, Dogen's dedication to zazen meditation alone, and Nichiren's insistence on the recitation of the title of the Lotus Sutra [Saddharma-pundarika-sutra] all countered the worldliness and decline of the contemporary Buddhist order of the period, as well as responded to the social turbulence and disorder arising from social change and shifts of power in Japan at that time. These developments also provided the background of Shinran's religious search and inspired his interpretation of Pure Land teaching which, while trying to clarify Honen against his critics, went beyond the master in significant areas.In Chapter Two, Shinran the Bonpu, Keel takes up Shinran's religious development and life. Bonpu means a foolish, common mortal, an ordinary person. As Keel points out, religion begins with problems intrinsic to human life. In the case of Shinran, he became deeply aware of the great evils of ignorance, greed, and anger within himself and in his world. Shinran's existential seriousness and honesty led him to draw "the ultimate conclusion from the message of his master [Honen] and [push] it to the extremity of paradoxicality, giving... (shrink)

Dutch euthanasia legislation states that an act of euthanasia is only permissible if it is based on a voluntary request made in a situation of unbearable suffering to which there are no alternatives.The central question of this article is whether these criteria can be satisfied simultaneously. In an analysis of several (partly overlapping) definitions of voluntariness it is argued that there are circumstances in which this question should be answered negatively.The possible incompatibility of the criteria reveals a tension between different (...) defences of the permissibility of euthanasia. (shrink)

Enlightened experience (i.e. awakened to the truth) is the most valuable one in most religions including Christianity and Buddhism. As well-known cases of such experience are Apocalypse St. Paul and many Grand Zen masters in Zen Buddhism, it is natural for us to believe that the enlighten is for very talented or speciallytrained ones. However, applying the complexity theory on the structure of enlightenment, based on the power law function, selforganized criticality, phase transition, and emergence, it is clear that the (...) full awakening can be experienced by everyone in daily life. Furthermore, such experiences are not necessary to be limited in religious one. Rediscovering the path to full awakening by complexity theory leads to the demythologization of the enlightenment in Korean Zen Buddhism, which emphasizes a hard apprenticeship in temple for long periods for the purpose. (shrink)

In 'Yeogi (禮記)', the Chinese scriptures of Confucianism, they recoded the solar calendar of modern viewpoints. According to the ancient document, the 24 solar terms was one of seasonal divisions in a year. The regularly change of the four seasons play an important part in the national economic project. For a national economy depended on agriculture in East Asia of ancient times, the administration to pay no regard to the change of the season was directly connected to the fall of (...) the nation. And then the legislator must enact laws to reflect the change of the season. According to the 'Wolryeong (月令)' in 'Yeogi (禮記)', there is recoded national regulations to suit with the each twelve momth. The first month of spring is the prime of the year (February). The month shows sign of new livingthings. The ruler take order to protect the first breath of spring and ought to put a ban on the military training and labor mobilization. The reasons are to safeguard the new life and not to interrupt the preparation for farming. Confucian attach value to the nature within a human’s way of life. Therefore the norm of human do correlate closely with the principle of nature. The rule of Wuju (宇宙) was not a simple concept of the natural phenomenon and Cheon (天) was not the Almighty for himself. Cheon was just the existence of virtue and moral influence in the confidence of man. And Ji (地) was the Mother of all things. In this space man had to manage the world in sympathy with the process of cheonJi (天地); Cheonsi (天時), JIri (地利), Inhwa (人和). (shrink)

The study reveals the political and ideological journey of Beom-do Hong, a Korean independence fighter and general as reflected in the historical novel of Soviet Korean writer Kim Se-il. Due to to the lack of historical records on Beom-do Hong, stories on his deeds before and after the Japan's annexation of Korea remained at the level of legends. In Korean society, his figure is seen within opposing positions and discourses; to some he is a national hero; to others a communist (...) collaborator. This investigation of the historical novel as a medium for the transmission of shared memories based on the protagonist's battle diary and the recollections of his comrades will fill the gap in the historical memory and contribute to alleviating social political conflicts. Memorial heritage is closely linked to the intangible aspects of heritage, which is an essential driver of development. (shrink)

Purpose: The purpose of this study was to verify the long-term effect of adverse childhood experiences, school disengagement, and the reasons for leaving school on adolescent delinquency while adjusting for sex.Methods: Data were collected from 663 teenagers [male 368, female 295; mean age = 16.81 ; age range = 13–19 years] through a Longitudinal Survey and Support Plan for Dropouts.Results: Multivariate latent growth modeling demonstrated that ACEs and school disengagement are positively associated with delinquency and the mediating effect of school (...) disengagement on association between ACEs and delinquency was verified. Teenagers who quit school for personal reasons reported fewer instances of delinquent behavior than adolescents who left because of school reasons.Conclusion: This study suggests that researchers and teachers need to consider ACEs and school disengagement as a warning index for delinquency with school dropout. In addition, the reason for leaving school should be considered to clarify the effect of school dropout on delinquency in adolescents who dropout. (shrink)

PurposeThis study aimed to examine the long-term association between social activity, physical function decline and cognitive function, as well as verify the long-term mediating effect of physical function decline on the relationship between social activity and cognitive function.MethodsData from the Korean Longitudinal Study of Aging that was collected over 10 years was analyzed. The sample included 10,240 adults aged 45–93 years. Multivariate latent growth modeling was applied to verify the long-term effect of social activity and physical function on cognitive function.ResultsThe (...) results revealed that social activity had a positive impact on cognitive function and negative impact on physical function decline after controlling for age and education level. Additionally, physical function decline negatively influenced cognitive function. Finally, social activity indirectly affected cognitive function through physical function decline.ConclusionThe contribution of this study was to test the long-term effect social activity on physical and cognitive function. (shrink)

This paper intends to highlight how the Kazakhs, the indigenous ethnic group that emerged as the leading subject of society in Kazakhstan after independence from the former Soviet Union, reclassify and remodel their self-culture in the new socio-political context. Despite the craving for resuscitating the Islamic tradition, shrunk under colonial domination, rather the indigenous folklorized Islam came to be classified as a pure national tradition under the fear of radical Islamism, causing the exclusion of the orthodox Muslims. This paper looks (...) at hijabed Muslim women, considered to be outside the reclassified boundary of national tradition, and efficiently controlled and marginalized by the discourse produced by the ruling powers. The authors include field research and interviews from a number of participants, making visible the strategies of exclusion and the political narratives constructed around what people should remember and learn. These narratives recollect forms of imperialism which continue to be, in one way or another. (shrink)

This paper investigates the contexts on the grand narrative and the memory manipulation of the media in the case of Soviet Korean migrants. The study focuses on the forced migration of Soviet Koreans and how their memories were covered up by dominant Soviet narratives. Specifically, the paper explores LeninKichi, a Korean newspaper that became the mouth of institutional power. The research brings to light part of the history of Soviet Koreans migrants, whose memories were buried by a socio-cultural system that (...) encouraged narratives of victory and progress through an oppositional symbolism of glorious patriots versus enemies and traitors. (shrink)

This paper investigates microcultural imperialism upon Eastern cultural heritage. In particular, it exposes the loss of Korean cultural artifacts during wars, and also during imperial cultural expeditions, visits of scholarly research groups, and diplomatic encournters. The paper argues that imperialist domination is sometimes concealed in the name of Oriental Studies projects and the assumed superiority of certain nations in terms of knowledge and technology.

The main purpose of this study was to validate a scale to examine the moral sensitivity of Korean nurses. A pre-existing scale, the Moral Sensitivity Questionnaire (MSQ), developed by Lützén, was used after deletion of three items. The reliability and validity of the scale were examined by using Cronbach’s alpha and factor analysis, respectively. According to the results, reliability of the scale was adequate but its construct validity was not fully supported. Through discussion on evidence of validity, five subconstructs emerged. (...) In particular, unlike the factor structure of the MSQ, two subconstructs, patient-oriented care and professional responsibility, were newly extracted. It was assumed that the other three MSQ subconstructs, conflict, meaning and benevolence (expressed as nurses being ethically good), would not be sensitive to cultural background. Given these findings, interpretations about the meaning of moral sensitivity of Korean nurses are discussed. (shrink)

This paper presents a non-preference-based approach to the analysis of negative freedom. It is argued that a proper understanding of (different conceptions of) negative freedom necessitates an examination of the consequences of changes in the set of feasible alternatives. For this reason the paper does not focus on freedom rankings of opportunity sets but on freedom rankings of opportunity situations, i.e., pairs consisting of a feasible set and an opportunity set. Three different freedom rankings of opportunity situations are axiomatically characterised. (...) Each of the three rankings forms a generalisation of the purely cardinality-based freedom ranking of opportunity sets presented by Pattanaik and Xu (1990). (shrink)