Ranging from miniaturized biological robots to organoids, multi-cellular engineered living systems (M-CELS) pose complex ethical and societal challenges. Some of these challenges, such as how to best distribute risks and benefits, are likely to arise in the development of any new technology. Other challenges arise specifically because of the particular characteristics of M-CELS. For example, as an engineered living system becomes increasingly complex, it may provoke societal debate about its moral considerability, perhaps necessitating protection from harm or recognition of positive (...) moral and legal rights, particularly if derived from cells of human origin. The use of emergence-based principles in M-CELS development may also create unique challenges, making the technology difficult to fully control or predict in the laboratory as well as in applied medical or environmental settings. In response to these challenges, we argue that the M-CELS community has an obligation to systematically address the ethical and societal aspects of research and to seek input from and accountability to a broad range of stakeholders and publics. As a newly developing field, M-CELS has a significant opportunity to integrate ethically responsible norms and standards into its research and development practices from the start. With the aim of seizing this opportunity, we identify two general kinds of salient ethical issues arising from M-CELS research, and then present a set of commitments to and strategies for addressing these issues. If adopted, these commitments and strategies would help define M-CELS as not only an innovative field, but also as a model for responsible research and engineering. (shrink)

Social philosophy at the end of the twentieth century must be prefixed by what it follows. It has become commonplace to describe our moment as postmodern and post-structuralist, perhaps also post-Marxian. While true enough, our situation more specifically must be post-Lacan, post-Althusser, post-Foucault, and post-Critical Theory. A number of theorists highlight the context this dissertation places itself in, but Slavoj Žižek and Judith Butler should be emphasized in this regard. The positive project of this dissertation begins with radical doubts about (...) the operation of epistemic truth in subjectivity and in language. The dissertation is a series of case studies in the modes of failure of truth, and of the manner in which ideology functions within the void left by the necessary absence of truth. It has a political project of determining what forms counter-hegemony can take absent a traditional assumption of a solid ground for veracity. (shrink)

The hysteria and misconceptions about AIDS which are fostered and held by the popular press have been accepted uncritically by many bioethicists, who have not bothered to explore popular empirical claims in sufficient depth. As a result, and because ethicists attempt tosell moral problems in a manner not much different from the way the popular press attempt tosell newspapers, artificial dilemmas have been produced in professional journals. We concentrate on just one popular misconception about AIDS-that the hetersexual incidence of the (...) syndrome is widespread-and showhow bioethicists' unreflective acceptance of this myth has led them to make conceptual and practical errors. (shrink)