Epithelia can be defined morphologically as tissues that line surfaces, and ultrastructurally with reference to their cells' apico‐basal polarity and possession of specific cell‐cell junctions. Defining the epithelial phenotype at a molecular level is more problematic ‐ while it is easy to name proteins (e.g. keratins) expressed by a “typical” epithelium, no known molecules are expressed by every epithelium but by no other tissues. Cells can differentiate to and from the epithelial state as part of normal development, as a response (...) to disease or when manipulated in culture. Many factors (matrix components, adhesion molecules, growth factors, transcription factors) have been identified that can trigger these transitions of phenotype in specific cases, but to date no general master regulators of the epithelial state have been found. The epithelial state may therefore be controlled by multiple regulatory genes so that there is no single molecule responsible for all of the diverse types of epithelium that exist in higher animals. (shrink)

A historically-informed account of the lasting importance of embodied thought in the intellectual trajectory of René Descartes, still remembered today as the founding father of dualism.

Traditional mechanistic accounts of language processing derive almost entirely from the study of monologue. Yet, the most natural and basic form of language use is dialogue. As a result, these accounts may only offer limited theories of the mechanisms that underlie language processing in general. We propose a mechanistic account of dialogue, the interactive alignment account, and use it to derive a number of predictions about basic language processes. The account assumes that, in dialogue, the linguistic representations employed by the (...) interlocutors become aligned at many levels, as a result of a largely automatic process. This process greatly simplifies production and comprehension in dialogue. After considering the evidence for the interactive alignment model, we concentrate on three aspects of processing that follow from it. It makes use of a simple interactive inference mechanism, enables the development of local dialogue routines that greatly simplify language processing, and explains the origins of self-monitoring in production. We consider the need for a grammatical framework that is designed to deal with language in dialogue rather than monologue, and discuss a range of implications of the account. Key Words: common ground; dialogue; dialogue routines; language comprehension; language production; monitoring; perception-behavior link. (shrink)

Currently, production and comprehension are regarded as quite distinct in accounts of language processing. In rejecting this dichotomy, we instead assert that producing and understanding are interwoven, and that this interweaving is what enables people to predict themselves and each other. We start by noting that production and comprehension are forms of action and action perception. We then consider the evidence for interweaving in action, action perception, and joint action, and explain such evidence in terms of prediction. Specifically, we assume (...) that actors construct forward models of their actions before they execute those actions, and that perceivers of others' actions covertly imitate those actions, then construct forward models of those actions. We use these accounts of action, action perception, and joint action to develop accounts of production, comprehension, and interactive language. Importantly, they incorporate well-defined levels of linguistic representation. We show how speakers and comprehenders use covert imitation and forward modeling to make predictions at these levels of representation, how they interweave production and comprehension processes, and how they use these predictions to monitor the upcoming utterances. We show how these accounts explain a range of behavioral and neuroscientific data on language processing and discuss some of the implications of our proposal. (shrink)

How might a human communication system be bootstrapped in the absence of conventional language? We argue that motivated signs play an important role (i.e., signs that are linked to meaning by structural resemblance or by natural association). An experimental study is then reported in which participants try to communicate a range of pre-specified items to a partner using repeated non-linguistic vocalization, repeated gesture, or repeated non-linguistic vocalization plus gesture (but without using their existing language system). Gesture proved more effective (measured (...) by communication success) and more efficient (measured by the time taken to communicate) than non-linguistic vocalization across a range of item categories (emotion, object, and action). Combining gesture and vocalization did not improve performance beyond gesture alone. We experimentally demonstrate that gesture is a more effective means of bootstrapping a human communication system. We argue that gesture outperforms non-linguistic vocalization because it lends itself more naturally to the production of motivated signs. (shrink)

This paper compares two explanations of the process by which human communication systems evolve: iterated learning and social collaboration. It then reports an experiment testing the social collaboration account. Participants engaged in a graphical communication task either as a member of a community, where they interacted with seven different partners drawn from the same pool, or as a member of an isolated pair, where they interacted with the same partner across the same number of games. Participants’ horizontal, pair‐wise interactions led (...) “bottom up” to the creation of an effective and efficient shared sign system in the community condition. Furthermore, the community‐evolved sign systems were as effective and efficient as the local sign systems developed by isolated pairs. Finally, and as predicted by a social collaboration account, and not by an iterated learning account, interaction was critical to the creation of shared sign systems, with different isolated pairs establishing different local sign systems and different communities establishing different global sign systems. (shrink)

It has been suggested that iconic graphical signs evolve into symbolic graphical signs through repeated usage. This article reports a series of interactive graphical communication experiments using a ‘pictionary’ task to establish the conditions under which the evolution might occur. Experiment 1 rules out a simple repetition based account in favor of an account that requires feedback and interaction between communicators. Experiment 2 shows how the degree of interaction affects the evolution of signs according to a process of grounding. Experiment (...) 3 confirms the prediction that those not involved directly in the interaction have trouble interpreting the graphical signs produced in Experiment 1. On the basis of these results, this article argues that icons evolve into symbols as a consequence of the systematic shift in the locus of information from the sign to the users' memory of the sign's usage supported by an interactive grounding process. (shrink)

Dialog is a joint action at different levels. At the highest level, the goal of interlocutors is to align their mental representations. This emerges from joint activity at lower levels, both concerned with linguistic decisions (e.g., choice of words) and nonlinguistic processes (e.g., alignment of posture or speech rate). Because of the high‐level goal, the interlocutors are particularly concerned with close coupling at these lower levels. As we illustrate with examples, this means that imitation and entrainment are particularly pronounced during (...) interactive communication. We then argue that the mechanisms underlying such processes involve covert imitation of interlocutors’ communicative behavior, leading to emulation of their expected behavior. In other words, communication provides a very good example of predictive emulation, in a way that leads to successful joint activity. (shrink)

Dialog is a joint action at different levels. At the highest level, the goal of interlocutors is to align their mental representations. This emerges from joint activity at lower levels, both concerned with linguistic decisions (e.g., choice of words) and nonlinguistic processes (e.g., alignment of posture or speech rate). Because of the high‐level goal, the interlocutors are particularly concerned with close coupling at these lower levels. As we illustrate with examples, this means that imitation and entrainment are particularly pronounced during (...) interactive communication. We then argue that the mechanisms underlying such processes involve covert imitation of interlocutors’ communicative behavior, leading to emulation of their expected behavior. In other words, communication provides a very good example of predictive emulation, in a way that leads to successful joint activity. (shrink)

This paper contrasts two influential theoretical accounts of language change and evolution – Iterated Learning and Social Coordination. The contrast is based on an experiment that compares drawings produced with Garrod et al’s ‘pictionary’ task with those produced in an Iterated Learning version of the same task. The main finding is that Iterated Learning does not lead to the systematic simplification and increased symbolicity of graphical signs produced in the standard interactive version of the task. A second finding is (...) that Iterated Learning leads to less conceptual and structural alignment between participants than observed for those in the interactive condition. The paper concludes with a comparison of the two accounts in relation to how each promotes signs that are effi cient, systematic and learnable. (shrink)

Linguistic interaction between two people is the fundamental form of communication, yet almost all research in language use focuses on isolated speakers and listeners. In this innovative work, Garrod and Pickering extend the scope of psycholinguistics beyond individuals by introducing communication as a social activity. Drawing on psychological, linguistic, philosophical and sociological research, they expand their theory that alignment across individuals is the basis of communication, through the model of a 'shared workspace account'. In this workspace, interlocutors are actors (...) who jointly manipulate and control the interaction and develop similar representations of both language and social context, in order to achieve communicative success. The book also explores dialogue within groups, technologies, as well as the role of culture more generally. Providing a new understanding of cognitive representation, this trailblazing work will be highly influential in the fields of linguistics, psychology and cognitive linguistics. (shrink)

This paper contrasts two influential theoretical accounts of language change and evolution – Iterated Learning and Social Coordination. The contrast is based on an experiment that compares drawings produced with Garrod et al’s ‘pictionary’ task with those produced in an Iterated Learning version of the same task. The main finding is that Iterated Learning does not lead to the systematic simplification and increased symbolicity of graphical signs produced in the standard interactive version of the task. A second finding is (...) that Iterated Learning leads to less conceptual and structural alignment between participants than observed for those in the interactive condition. The paper concludes with a comparison of the two accounts in relation to how each promotes signs that are effi cient, systematic and learnable. (shrink)

Garrod, Smith and the contributors of the volume envisage the longue durée poetics of an early modern genre. They interpret its poetics alongside its various epistemic agenda and make a case for the literary status of natural history.

A good edition of the Catalepton has long been wanted: and Birt's recently Published ‘Erklärung,’ despite some obvious defects, may fairly be regarded as good book. It is at any rate fresh, interesting, and stimulating. The text is the whole, though not always, sensible. The commentary is full without being too full. But, more valuable still, both commentary and introduction constantly bring home to one the probability that nearly all the poems in this collection are genuinely Vergilian— ‘Jugendverse und Heimatpoesie (...) Vergils.’ No editor before Birt has brought before us so clearly the environment out of which these poems came. (shrink)

The Oxford Classical Texts, or Scriptorum Classicorum Bibliotheca Oxoniensis, are renowned for their reliability and presentation. The series consists of a text without commentary but with a brief apparatus criticus at the front of each page. There are now over 100 volumes, representing the greater part of classical Greek and Latin literature. The aim of the series remains that of including the works of all the principal classical authors. Although this has been largely accomplished, new volumes are still being published (...) to fill the remaining gaps, and old editions are being revised in the light of recent research or replaced. (shrink)

Foundations of Language sets out to reconcile generative accounts of language structure with psychological accounts of language processing. We argue that Jackendoff's “parallel architecture” is a particularly appropriate linguistic framework for the interactive alignment account of dialogue processing. It offers a helpful definition of linguistic levels of representation, it gives an interesting account of routine expressions, and it supports radical incrementality in processing.

Since P. Thielscher, in Philologus, 1907, pp. 117, 128, supplies us with information about the Manilian MS. Palatinus 1711 , the importance of which he himself does not seem to comprehend, I should like to point out what an interesting MS. this is. ‘It is to be suspected,’ says Thielscher, ‘that it offers interpolated readings.’ It is not a matter of ‘suspicion’ at all. If Thielscher did not know it for himself, he could have learnt from Scaliger , from Bentley, (...) from Jacob, that the readings of P long ago received sufficient publicity to enable scholars to assign it to the ‘ interpolated’ class of MSS. The Variae Lectiones of Junius is mostly occupied with the readings of P, and tells us all about P that we need know, save what Thielscher has himself added. From Thielscher we for the first time learn that P belonged to ‘Johannes Archiepiscopus Strigoniensis,’ and that it contains this subscription: ‘legi et emendaui cum magistro Galeotto 1469.’ Now just as Thielscher seems to know nothing of Junius, so he seems to have no idea who Johannes Strigoniensis is, though the reference to Galeotto and the year 1469 should at once have told him. If he had troubled to look at Schmitt's Archiepiscopi he would have found that, while Schmitth enumerates no less than six archbishops of Gran who bore the name John, yet the only one of them who fits the date 1469 is John IV. And John IV. is a famous person, being none other than that leader of the Hungarian Renaissance whom we commonly call Vitezius. (shrink)

In the Classical Quarterly, vol. ii. No. 2, reviewing Breiter's recent text of the Astronomica, together with Housman's edition of Book i, I made a number of suggestions of my own on some of the principal difficulties in the text and interpretation of Manilius. I did not, however, bring my notes down beyond Book i. In the present paper I propose to traverse some of the more thorny places of ii. and iii. I shall try to make what I have (...) to say to some extent a continued review of Breiter. (shrink)

Pierre Viret (1511–1571), one of the leaders of the Calvinist Reformation, claims that the natural theology of his Instruction Chrestienne (1564) dedicated to the Faculty of Medicine of Montpellier, is a spiritual medicine. This paper shows that such spiritual medicine amounts to a specific expression of Calvinist pastoralism. Viret's natural theology uses natural-historical data as moral examples, thus transforming them into the material fit for his pastoral cure. This cure consists in exhorting his audience to bear the trials of divine (...) Providence by meditating on their own sinful state: such medicine asserts the limits of human reason. (shrink)

The spaced words are commonly rendered either ‘desiring to ward off from his head,’ or ‘expecting to strike his head.’ Of these two renderings the first gives to κεφαλxs22EFς βαλεxs1FD6ν a sense which is seemingly without example and which the two words can hardly bear, if they can also bear the meaning given to them by the second rendering. The meaning which this second rendering gives to them is their natural meaning : on the other hand μενοινxs22EFν does not mean, (...) and cannot mean, ‘expecting.’ It means ‘strongly desiring.’ ‘Expecting it to strike his head’ would be μένωνοxs1F31 κεφαλxs22EFς βαλεxs1FD6ν, and this, I suggest, is what Pindar wrote. (shrink)

My paper, written in 1911, was something of a ballon d'essai, and I acknowledge frankly one or two mistakes. Thus I did not know that Euripides wrote a Thyestes; and again one or two of my references were wrong: in excuse I may perhaps plead that I have not had access to a Latin book for nearly two years. Apart from this I will now make only two observations:1. I set aside the evidence of Cod. Paris. Lat. 7530 because I (...) was dealing with evidence of saec. i.-iv. Cod. Paris. Lat. 7530 shows that some persons at the end of saec. viii. ascribed the Thyestes to L. Varius Rufus. So did persons in saec. iv. In addition, Cod. Paris. Lat. 7530 gives a date for the Thyestes. To Mr. Housmanthis date is certain; if it is uncertain a large part of his argument comes to nothing. But who can think it certain ? It comes to us from the end of the eighth century. If it came to us from Jerome's Chronicle we could still not think it certain, though we should know whence Jerome derived it. We do not now whence Cod. Paris. Lat. 7530 derived it. The reference to Actium may have no better source than the wish to connect a great literary and a great political event: and the gossip about the playwright's profits seems to me in itself suspicious.2. The main contention of the early part of my paper was that the evidence of the relevant MSS. as between Vari and Varii, etc., amounts to nothing either way. I do not think Mr. Housman is prepared seriously to contest this proposition. (shrink)

This chapter examines the role of the situation model in referential processing and how it can link what appear to be incompatible results from studies of monologue and dialogue as well as studies of reading and visual-world eye tracking. It shows that data from experiments on pronoun resolution in reading indicate a two-step model, in which candidate antecedents for an anaphor are first identified on the basis of gender matching and number matching, then evaluated with respect to the overall situation (...) model. In similar visual-world studies, these stages are seemingly collapsed together, which can be explained in terms of differences in how the situation model is related to the text versus the visual display of potential referents. The chapter suggests that comparing these different types of studies can elucidate the processes of reference resolution. (shrink)

In what has preceded I have travelled a good deal beyond Simonides. But I have done so in order to illustrate the fact that the remains of ancient lyric cannot be interpreted in isolation. I come back now to the extant fragments of Simonides.

Bücheler assigns this epitaph to the Caesarian epoch: and it is clearly not of later date. The fifth line is corrupt. Bücheler suggests tentatively the insertion of the word dilecto after Cadmo. That will indeed give us a verse of six feet. But we shall not be much the happier. We shall still have to believe that a member of the gens Heluia married, circa 100&50 B.C, a husband of the name of Cadmus Scrateius. He must have been the public (...) executioner: for I know of no other Cadmus in Rome; and he bore no very good reputation, and very little deserved the epithet dilectus, for the commentators upon Horace 5. i. 6. 39 speak of him as ‘ notae crudelitatis.’ He must be supposed to have taken the name Scrateius to make himself more terrible. But where in all the Graeco-Roman world he found it, it is impossible to guess. (shrink)

These are not two adjectives. They are two men—or, rather, two shadows. If I said that they were two names I should be speaking inexactly. The name of Varus occurs five times in Vergil: and twice out of these five times the oldest Latin MSS. which we possess have confounded it with that of Varius. In the Vitae Vergilianae, recently edited with an adequate Apparatus Criticus, the names Varus and Varius are found, I think, twenty-eight times; and twenty-two times out (...) of these twenty-eight all, or most, of our MSS. have confused them—and that though in thirteen cases we are dealing with codices of saec. IX.–X. The same names occur four times in Quintilian, and in one case all, in another all the respectable, MSS. have got them wrong. They occur thrice in Martial—twice right, once wrong. I have selected these particular writers for a reason that will appear later. But the MSS. of Horace tell a like tale. (shrink)

Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes. Both are characterised at the ultrastructural level by dense cytoplasmic plaques which are linked to the intermediate filament cytoskeleton of the cells. The plaques strongly resemble each other suggesting a relationship between the two kinds of junctions, as implied by their names. Recent characterisation of the molecular components of the junctions shows they are, in fact, quite unrelated implying (...) that structural similarity is fortuitous. The molecular biology raises many fascinating problems relating to their structure and function. (shrink)

Human cognition and behavior are dominated by symbol use. This paper examines the social learning strategies that give rise to symbolic communication. Experiment 1 contrasts an individual-level account, based on observational learning and cognitive bias, with an inter-individual account, based on social coordinative learning. Participants played a referential communication game in which they tried to communicate a range of recurring meanings to a partner by drawing, but without using their conventional language. Individual-level learning, via observation and cognitive bias, was sufficient (...) to produce signs that became increasingly effective, efficient, and shared over games. However, breaking a referential precedent eliminated these benefits. The most effective, most efficient, and most shared signs arose when participants could directly interact with their partner, indicating that social coordinative learning is important to the creation of shared symbols. Experiment 2 investigated the contribution of two distinct aspects of social interaction: behavior alignment and concurrent partner feedback. Each played a complementary role in the creation of shared symbols: Behavior alignment primarily drove communication effectiveness, and partner feedback primarily drove the efficiency of the evolved signs. In conclusion, inter-individual social coordinative learning is important to the evolution of effective, efficient, and shared symbols. (shrink)

I have not read the Thebais more than three times, nor ever with intent care and interest; and although in putting these notes together I have consulted a large number of editions—Bernartius, Tiliobroga, Geuartius, Cruceus, Gronouius, Barthius, Veenhusen, Beraldus , ed. Bipontina, Lemaire , Queck, O. Mueller , Kohlmann, Wilkins, Garrod, Klotz, and the translations of Marolles, Nisard, and Mozley —it may well be that profitable matter has escaped me and that some of my comments have been made before.

Natural language involves both speaking and listening. Recent models claim that production and comprehension share aspects of processing and are linked within individuals (Dell & Chang, 2014; MacDonald, 2013; Pickering & Garrod, 2004; 2013a). Evidence for this claim has come from studies of cross-modality structural priming, mainly examining processing in the direction of comprehension to production. The current study replicated these comprehension to production findings and developed a novel cross-modal structural priming paradigm from production to comprehension using a temporally-sensitive (...) online measure of comprehension, Event-Related Potentials. For Comprehension-to-Production priming, participants first listened to active or passive sentences and then described target pictures using either structure. In Production-to-Comprehension priming, participants first described a picture using either structure and then listened to target passive sentences while EEG was recorded. Comprehension-to-Production priming showed the expected passive sentence priming for syntactic choice, but not response time or average syllable duration. In Production-to-Comprehension priming, primed, versus unprimed, passive sentences elicited a reduced N400. These effects support the notion that production and comprehension share aspects of processing and are linked within the individual. Moreover, this paradigm can be used for the exploration priming at different linguistic levels as well as the influence of extra-linguistic factors on natural language use. (shrink)

The most reliable manuscript of Statius' Achilleid is the Puteaneus , and its authority, against the group QKC, is frequently upheld only by the Codex Etonensis . The readings of this manuscript , which contains, apart from the Achilleid, Maximian, Ovid's Remedium Atnoris and other poems, were collated by C. Schenkl, Wiener Studien, iv , 96 ff., and were used by H. W. Garrod for the O.C.T. of Statius: Klotz in the Teubner 2nd edition merely notes the readings of (...) Schenkl and of the Oxford text. Unfortunately these are neither complete nor always accurate; and the latter should be corrected as follows: 1. In three passages the Oxford text differs from the reading of PEKQ without noting the fact: Ach. i. 145 Non superant is not, as implied, the MS. reading, but Havet's conjecture: PEKQ have nam superant. 306 PEKQ have impulsam , not impulsum. 680 PEKQ ibi, not ubi. (shrink)

Pickering & Garrod's (P&G's) call to study language processing in dialogue context is an appealing one. Their interactive alignment model is ambitious, aiming to explain the converging behavior of dialogue partners via both intra- and interpersonal priming. However, they ignore the flexible, partner-specific processing demonstrated by some recent dialogue studies. We discuss implications of these data.

Review of Garrod, R., & Marr, A. (Eds.). (2021). Descartes and the ingenium: the embodied soul in Cartesianism. Leiden: Brill.

Starting from the conceptual premises of Garrod, who as long ago as 1902 spoke of chemical individuality, and of Burnet (1949), who recognized as self one's own molecular antigenic structures (as opposed to the antigenic alien: the non- self), the discovery and understanding of HLA antigens and of their extraordinarily individual and differentiated polymorphisms have gained universal recognition. Transplant medicine has now dramatically stressed, within man's knowledge of himself, the characteristic of his biological uniqueness. Today man, having become aware (...) of being a biological antigenic-molecular individuality which is unique and different from that of all of his fellow men (except for monozygotic twins), can therefore easily consider himself a true biological Ego. (shrink)