Autophagy functions in both selective and non‐selective ways to maintain cellular homeostasis. Endoplasmic reticulum autophagy (ER‐phagy) is a subclass of autophagy responsible for the degradation of the endoplasmic reticulum through selective encapsulation into autophagosomes. ER‐phagy occurs both under physiological conditions and in response to stress cues, and plays a crucial role in maintaining the homeostatic control of the organelle. Although specific receptors that target parts of the ER membrane, as well as, internal proteins for lysosomal degradation have been (...) identified, the molecular regulation of ER‐phagy has been elusive. Recent work has uncovered novel regulators of ER‐phagy that involve post‐translational modifications of ER‐resident proteins and functional cross‐talk with other cellular processes. Herein, we discuss how morphology affects the function of the peripheral ER, and how ER‐phagy modulates the turnover of this organelle. We also address how ER‐phagy is regulated at the molecular level, considering implications relevant to human diseases. (shrink)

H. L. A Hart complained about the ambiguity of legal positivism, and proposed a definition that refers to particular explications of the concept of law, to certain theories of legal interpretation, to particular views on the moral problem of a duty to obey the law, and to a sceptical position with regard to the meta-ethical issue of the possibility of moral knowledge. It is said to be restricted to the Thesis of Separation — the contention that there is no necessary (...) connection between law and morals. In this chapter, the Separation Thesis is discussed even further, and has three shortcomings identified: first, that it has been vacillating between object-level contentions about moral qualities of the law; that the precise logical relation between both levels has never been properly accounted for; and that the question of necessary relations between morality and law hinges crucially on the presupposition that the very concept of law itself does not unravel into different sets of convenient stipulations from different epistemological angles, each of which renders the question of such necessary relations trivial. The Separation Thesis is also identified as having two versions: the Fallibility Law and the Neutrality Law. (shrink)

This paper presents an adaptive logic enhancement of conditional logics of normality that allows for defeasible applications of Modus Ponens to conditionals. In addition to the possibilities these logics already offer in terms of reasoning about conditionals, this way they are enriched by the ability to perform default inferencing. The idea is to apply Modus Ponens defeasibly to a conditional and a fact on the condition that it is ‘safe' to do so concerning the factual and conditional knowledge at hand. (...) It is for instance not safe if the given information describes exceptional circumstances: although birds usually fly, penguins are exceptional to this rule. The two adaptive standard strategies are shown to correspond to different intuitions, a skeptical and a credulous reasoning type, which manifest themselves in the handling of so-called floating conclusions. (shrink)

According to the received view the later Wittgenstein subscribed to the thesis that speaking a language requires being guided by rules (thesis RG). In this paper we question the received view. On its most intuitive reading, we argue, (RG) is very much at odds with central tenets of the later Wittgenstein. Giving up on this reading, however, threatens to deprive the notion of rule-following of any real substance. Consequently, the rule-following considerations cannot charitably be read as a deep and subtle (...) defense of (RG) against the threat of paradox, as proponents of the received view are wont to do. Instead, we argue, the rule-following considerations provide Wittgenstein's deep and subtle reasons for rejecting the very idea that speaking a language involves rule-guidance. Although Wittgenstein subscribed to (RG) during his middle period writings, his later remarks on rules, far from being a clarification and elaboration of his earlier views, are directed against the claim of the middle period that speaking a language is an essentially rule-guided activity. (shrink)

ḳunṭres 1. ʼOr ha-emunah --ḳunṭres 2. Śimḥah ṿe-hitḥazḳut, ha-derekh le-hatsalah li-nevukhim.

Donald Davidson denied convention any interesting role in the philosophical theory of meaning: Conventions are neither necessary nor sufficient to account for communication by language. This anticonventionalism is part of Davidson's more general individualism about meaning. According to Davidson, notions such as that of a shared language, shared practices of use, and the attendant notions of standard meaning and linguistic mistake, are as uninteresting to the philosophical theory of meaning as that of convention. The chapter starts with a sketch of (...) the meaning theoretical background for Davidson's anticonventionalism, arguing that Davidson ultimately motivates both anti‐conventionalism and individualism by the social or public nature of language. After quickly taking up Davidson's arguments against attempts to conventionally link semantics to nonsemantic purposes, the chapter then focuses on his attack on the idea that literal meaning is conventional meaning and the surrounding discussion. (shrink)

Donald Davidson famously held that only beliefs provide reasons for belief. Perceptual experiences, he held, are not even propositional attitudes, and thus doubly disqualified from being reason providers. John McDowell and others have tried to restore the intuitive reason-providing role of experience by suggesting that experiences do have contents. However, on McDowell’s account, experiences provide ‘reasons’ in a sense very different from the Davidsonian. In this paper, I argue that there is a better way of rescuing the reason-providing role of (...) experience: Construed as a (special) kind of belief, experience provides reasons for belief in precisely the Davidsonian sense. Moreover, the doxastic account of experience I suggest integrates naturally both with the Davidsonian picture of content determination and, consequently, with Davidsonian anti-skepticism. (shrink)

Lou Goble proposed powerful conditional deontic logics (CDPM) that are able to deal with deontic conflicts by means of restricting the inheritance principle. One of the central problems for dyadic deontic logics is to properly treat the restricted applicability of the principle “strengthening the antecedent”. In most cases it is desirable to derive from an obligation A under condition B, that A is also obliged under condition B and C. However, there are important counterexamples. Goble proposed a weakened rational monotonicity (...) principle to tackle this problem. This solution is suboptimal as it is for some examples counter-intuitive or even leads to explosion. The paper identifies also other problems of Goble’s systems. For instance, to make optimal use of the restricted inheritance principle, in many cases the user has to manually add certain statements to the premises. An adaptive logic framework based on CDPM is proposed which is able to tackle these problems. It allows for certain rules to be applied as much as possible. In this way counter-intuitive consequences as well as explosion can be prohibited and no user interference is required. Furthermore, for non-conflicting premise sets the adaptive logics are equivalent to Goble’s dyadic version of standard deontic logic. (shrink)

In this article, we present an argumentative approach to normative reasoning. Special attention is paid to deontic conflicts, contrary-to-duty and specificity cases, which are modelled by means of argumentative attacks. For this, we adopt a recently proposed framework for logical argumentation in which arguments are generated by a sequent calculus of a given base logic of Argument & Computation ), and use standard deontic logic as our base logic. Argumentative attacks are realized by elimination rules that allow to discharge specific (...) sequents. We demonstrate the usefulness of our approach by means of various well-known benchmark examples, and show that this approach is rich enough to capture a variety of paradigms for handling conflicting norms such as reasoning with maximally consistent sets, prioritized norms and deontic formalisms based on I/O logic. (shrink)

Den Bildbegriff verwendet die unterschätzte US-amerikanische Philosophin Susanne Langer argumentativ in allen drei Phasen ihres Denkens, ohne den Begriff bildtheoretisch zu fundieren. Versucht man nun diesen Bildbegriff vergleichend mit semiotischen oder phänomenologischen Bildtheorien zu diskutieren, so erlangt ihre Philosophie des Bildes nur dann die erforderliche Stringenz, wenn man die gegenwärtigen Bildtheorien einer grundlegenden Kritik unterzieht. Mit Langer erscheint u.a. Husserls Bildkonstitutionstheorie in einem neuen, aber ursprünglicheren Licht, wodurch sich eine komplementäre Bildtheorie abzeichnet, in der semiotische und phänomenologische Aspekte konstitutiv sind.

We translate unconstrained and constrained input/output logics as introduced by Makinson and van der Torre to modal logics, using adaptive logics for the constrained case. The resulting reformulation has some additional benefits. First, we obtain a proof-theoretic characterization of input/output logics. Second, we demonstrate that our framework naturally gives rise to useful variants and allows to express important notions that go beyond the expressive means of input/output logics, such as violations and sanctions.

COVID‐19 caused an imbalance between medical resources and the number of patients in Türkiye like in many countries. There was not pandemic‐triage system, and this situation led to decision making based on experience, intuition, and judgment of allocation of scarce resources. The research explains the guiding criteria that healthcare professionals used to prioritize the distribution of scarce medical resources during the COVID‐19 pandemic. The criteria preferred by 928 healthcare professionals were evaluated when preventive measures for COVID‐19 were reduced and so (...) the number of cases increased rapidly. The results indicate that Turkish healthcare professionals largely support the utilitarian approach, which focuses on medical benefit in pandemic. The main problem was that some criteria not approved in COVID‐19 triage guidelines were considered important by healthcare professionals. These criteria, which cause discrimination by preventing the provision of fair and equal medical care to patients, are a prominent issue in the study. (shrink)

We introduce a general approach for representing and reasoning with argumentation-based systems. In our framework arguments are represented by Gentzen-style sequents, attacks between arguments are represented by sequent elimination rules, and deductions are made according to Dung-style skeptical or credulous semantics. This framework accommodates different languages and logics in which arguments may be represented, allows for a flexible and simple way of expressing and identifying arguments, supports a variety of attack relations, and is faithful to standard methods of drawing conclusions (...) by argumentation frameworks. Altogether, we show that argumentation theory may benefit from incorporating proof theoretical techniques and that different non-classical formalisms may be used for backing up intended argumentation semantics. (shrink)

We present the inconsistency-adaptive deontic logic DP r , a nonmonotonic logic for dealing with conflicts between normative statements. On the one hand, this logic does not lead to explosion in view of normative conflicts such as O A ∧ O ∼A, O A ∧ P ∼A or even O A ∧ ∼O A. On the other hand, DP r still verifies all intuitively reliable inferences valid in Standard Deontic Logic (SDL). DP r interprets a given premise set ‘as normally (...) as possible’ with respect to SDL. Whereas some SDL-rules are verified unconditionally by DP r , others are verified conditionally. The latter are applicable unless they rely on formulas that turn out to behave inconsistently in view of the premises. This dynamic process is mirrored by the proof theory of DP r. (shrink)

本书讨论的内容有:生存的背景、生存的误区、生存的悖谬、现实生存、社会生存、细节生存、我的境界就是我的生存等。.

Mador ʻinyene teshuvah -- Mador ʻinyene ha-moʻadim -- Mador maʻalot ha-Torah -- Mador ʻinyene emunah -- Mador Torah u-maʻalote' -- Mador ʻinyene ha-musar ṿe-tiḳun ha-midot -- Mador zikhron ḳedoshim -- Mador be-shule ha-mesilah.