BackgroundThe therapeutic effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) is related to the modulation of pathological neural activities, particularly the synchronization in the β band (13–35 Hz). However, whether the local β activity in the STN region can directly predict the stimulation outcome remains unclear.ObjectiveWe tested the hypothesis that low-β (13–20 Hz) and/or high-β (20–35 Hz) band activities recorded from the STN region can predict DBS efficacy.MethodsLocal field potentials (LFPs) were recorded in (...) 26 patients undergoing deep brain stimulation surgery in the subthalamic nucleus area. Recordings were made after the implantation of the DBS electrode prior to its connection to a stimulator. The maximum normalized powers in the theta (4–7 Hz), alpha (7–13 Hz), low-β (13–20 Hz), high-β (20–35 Hz), and low-γ (40–55 Hz) subbands in the postoperatively recorded LFP were correlated with the stimulation-induced improvement in contralateral tremor or bradykinesia–rigidity. The distance between the contact selected for stimulation and the contact with the maximum subband power was correlated with the stimulation efficacy. Following the identification of the potential predictors by the significant correlations, a multiple regression analysis was performed to evaluate their effect on the outcome.ResultsThe maximum high-β power was positively correlated with bradykinesia–rigidity improvement (rs = 0.549, p < 0.0001). The distance to the contact with maximum high-β power was negatively correlated with bradykinesia–rigidity improvement (rs = −0.452, p < 0.001). No significant correlation was observed with low-β power. The maximum high-β power and the distance to the contact with maximum high-β power were both significant predictors for bradykinesia–rigidity improvement in the multiple regression analysis, explaining 37.4% of the variance altogether. Tremor improvement was not significantly correlated with any frequency.ConclusionHigh-β oscillations, but not low-β oscillations, recorded from the STN region with the DBS lead can inform stimulation-induced improvement in contralateral bradykinesia–rigidity in patients with PD. High-β oscillations can help refine electrode targeting and inform contact selection for DBS therapy. (shrink)

The structure of pluralist arguments -- The inadequacy of multiculturalism -- The incompatibility of subsidiarity -- Associative democracy and the corporatist temptation -- Two conceptions of sovereignty -- A positivist pluralism? -- Law as intelligibility -- Pluralist authority -- This unity of life and action -- The personality of associations -- Property, personality, and public justification -- The spectre of intractability.

황우석 교수 사건을 종합적으로 분석한 책이 나왔다. 『황우석의 나라』는 황 교수 사태가 요동칠 때 에서 기자생활을 한 이성주가 현장을 지켜보고 이를 분석한 책이다. 저자는 7년 동안 의학팀장을 맡았고 2004년 8월부터 1년 동안 미국 존스홉킨스대에서 연수를 하고 귀국한 뒤 4개월 동안 과학 및 의학 분야의 곁에서 황 교수 사태가 요동치는 현장을 지켜보았다. 이 책은 황우석 사건 보도와 관련해 알려지지 않은 언론계의 현장 이야기, 과학계의 분위기, 황우석의 로비 실태 등을 생생하게 보여준다. 또 이번 사태가 발생하기 이전의 각종 기사를 분석해 언론이 무비판적으로 보도한 (...) 황 교수의 업적이 얼마나 허점투성이인지 설득력 있게 제시하고 있다. 동시에 19세기 말 프랑스를 뒤흔들었던 ‘드레퓌스 사건’과 마찬가지로 언론이 줄기세포처럼 똬리를 틀고 있다고 진단하고 언론의 본질과 역할에 대해 문제를 제기한다. 저자는 제2의 황우석 사건을 예방하기 위해 연구비 심사제도 개선, 연구비에서 간접비의 비중 강화, 언론의 에디터제 도입 등 세세한 대안도 내놓고 있다. (shrink)

国家社会科学基金项目获“高等学校优秀青年教师教学科研奖励计划资助”(TRAPOYT).

1. Sae sidae rŭl yŏrŏ gan saramdŭl -- 2. Ŏdum ŭi sidae.

Geography and religion -- Landscape of anxiety and fear -- Chinese cosmic space and places -- European sacred space and places -- A comparison with American Indian world-view -- Similar, yet different -- Apartness -- Order -- Wholeness and completion -- Sacred state -- Violence -- Ironies of piety -- God and morality -- From amoral energy to power for good -- Rise and fall of place specificity -- Traders and pilgrims -- Religious geography; or just human geography -- The (...) aesthetic sublime : vastness, place, and space -- Space vs. local place and custom -- Unbounded vastness and placelessness -- The aesthetic sublime : transiency and the eternal -- The ethical sublime : Buddhism -- The ethical sublime : Christianity -- Falling standard -- Geography and religion : fundamental questions -- From architectural and ritual to storytelling -- Community, self, and selflessness -- Placelessness and ethereality -- Religion of fear and privilege -- True religion -- Progress -- The ultimate test. (shrink)

A plurality or plural object is a single object that is also many, and pluralitism is the thesis that there is such an object. This paper argues that pluralitism and closely related theses (e.g., the many-one identity thesis and the composition as identity thesis) violate logic. To do so, it formulates an approach to the logic and semantics of plural constructions that results in plural logic and relates treatments of plural constructions to accounts of natural number. And it gives a (...) critical examination of Frege’s views of numbers and plural constructions, and sketches the view of plural constructions as devices for talking about the many (as such), and an account of natural numbers as properties of a special kind, plural properties. (shrink)

Sanskrit text with Hindi translation on Jaina monasticism and ethics.

Mal ŭi him -- Kŏjinmal ch'ammal kŭrigo ch'immuk.

In this essay, I develop the concept of episodic value, which describes a form of value connected to a particular object or individual expressed and delivered through a narrative. Narrative can bestow special kinds of value on objects, as exemplified by auction articles or museum collections. To clarify the nature of episodic value, I show how the notion of episodic value fundamentally differs from the traditional axiological picture. I extend my discussion of episodic value to argue that the notion of (...) episodic value readily incorporates the role of narratives into the construction of identity in personal and social contexts. My main contentions are twofold. First, events or experiences from our personal narratives are episodically valuable insofar as they contribute to shaping our narrative identities. Second, when engaged in a collective action, we write a joint narrative with other participants that confers special meanings on the actions of each participant. (shrink)

As the scope of innovative technologies is expanding, their implications and applications are increasingly intersecting with various facets of society, including the deeply rooted traditions of religion. This paper embarks on an exploratory journey to bridge the perceived divide between advancements in technology and faith, aiming to catalyze a dialogue between the religious and scientific communities. The former often views technological progress through a lens of conflict rather than compatibility. By utilizing a technology-centric perspective, we draw metaphorical parallels between the (...) functionalities of new technologies and some theological concepts of Islam. The purpose is not to reinterpret religious concepts but to illustrate how these two domains can coexist harmoniously. This comparative analysis serves as a conversation starter with an intention to mitigate any apprehensions towards technology by highlighting its potential to align with religious concepts. By fostering an environment where technological innovations are seen as tools for enhancement rather than threats to tradition, we contribute to a more inclusive discourse that encourages the religious community to engage with and potentially embrace contemporary technological advancements. (shrink)

This book discusses political change in the view of Confucian thought. This study focuses on the Book of Change, which is one of the nine basic books of Confucius School, and has dominated oriental thought in this field for more than three thousand years.