Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise, computerized cognitive training and a combined groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited. In this study we report intervention-related changes in plasma biomarkers and structural-MRI and how they (...) related to changes in physical activity and individual variables and their potential role as mediators in the cognitive changes. Our results show that although there were no significant changes in molecular biomarker concentrations in any intervention group, changes in ICAM-1 and SDF1-α were negatively associated with changes in physical activity outcomes in AE and COMB groups. Brain volume changes were found in the CCT showing a significant increase in precuneus volume. Sex moderated the brain volume change in the AE and COMB groups, suggesting that men may benefit more than women. Changes in molecular biomarkers and brain volumes did not significantly mediate the cognitive-related benefits found previously for any group. This study shows crucial initial molecular and brain volume changes related to lifestyle interventions at early stages and highlights the value of examining activity parameters, individual difference characteristics and using a multi-level analysis approach to address these questions. (shrink)

Interest in ethical aspects associated to product acquisition and consumption is a growing trend among consumers. In this context, the concept of “product with ethical attributes” has arisen to refer to products with explicit social and environmental characteristics. However, one of the factors that most hinders the purchasing of these products is certainly price. Given the difficulty of reducing price, the question that arises is the extent to which other product attributes can attenuate the negative impact of price on perceived (...) value. We assume that the special benefits associated to this type of products are, at a different level, attenuators of the relationship between price and perceived value. Focusing on Fair Trade organic coffee, hypotheses are tested regarding survey data from 407 customers. They were interviewed in an actual purchasing scenario. The models are tested using conventional Structural Equation Models and the Latent Moderated Structural Equation method. The results obtained shed some light on a highly generalised belief that the marketing of these products can only be improved by reducing their price. However, although a price reduction could be desirable, albeit complicated in this product category, its effects could be reduced by acting on other variables such as the ethical aspects, quality and healthiness of this product category. (shrink)

Este artículo tiene como objetivo ofrecer una revisión y reinterpretación al problema teórico en la teoría de Darwin en el que se pone en relación el principio de divergencia y la competencia entre los seres vivos. Respecto a este asunto ha habido dos interpretaciones fundamentales. La primera de ellas es la de aquellos que defienden que la divergencia se ve favorecida porque implica una reducción de la competencia a la que se enfrentan los seres vivos que se desplazan de nicho (...) ecológico. Por otro lado, algunos abogan — aunque es una posición menos extendida— por una interpretación en la que la reducción de la competencia no es la ventaja, sino que lo es la especialización y, por tanto, el incremento en la competitividad, es decir, el tener mejores herramientas o capacidades para competir. En este artículo se defiende esta última tesis, fundamentalmente sostenida por William Tammone, pero desde otra perspectiva y sustentada en otros argumentos que se nutren de la propuesta de Trevor Pearce acerca de la noción de economía natural de Darwin. (shrink)

Dreyfus and Dreyfus’ influential phenomenological analysis of skill acquisition proposes that expert performance is guided by non-cognitive responses which are fast, effortless and apparently intuitive in nature. Although this model has been criticised for over-emphasising the role that intuition plays in facilitating skilled performance, it does recognise that on occasions a form of ‘detached deliberative rationality’ may be used by experts to improve their performance. However, Dreyfus and Dreyfus see no role for calculative problem solving or deliberation when performance is (...) going well. In the current paper, we draw on empirical evidence, insights from athletes, and phenomenological description to argue that ‘continuous improvement’ among experts is mediated by cognitive control in three distinct sporting situations. We conclude by arguing that Sutton et al. Journal of the British Society for Phenomenology, 42, 78–103 ‘applying intelligence to the reflexes’ approach may help to elucidate the process by which expert performers achieve continuous improvement through analytical/mindful behaviour during training and competition. (shrink)

Recently in the philosophical literature there has been some effort made to understand the proper application of the theory of utilitarianism to worlds in which there are infinitely many bearers of utility. Here, we point out that one of the best, most inclusive principles proposed to date contradicts fundamental utilitarian ideas, such as the idea that adding more utility makes a better world.

Human genomics is a translational field spanning research, clinical care, public health, and direct-to-consumer testing. However, law differs across these domains on issues including liability, consent, promoting quality of analysis and interpretation, and safeguarding privacy. Genomic activities crossing domains can thus encounter confusion and conflicts among these approaches. This paper suggests how to resolve these conflicts while protecting the rights and interests of individuals sequenced. Translational genomics requires this more translational approach to law.

La tesis central de este artículo es que la concepción de la razón pública propuesta por John Rawls, incluso en su versión “inclusiva”, es demasiado restrictiva y viola el principio liberal de legitimidad y la tesis de la neutralidad del estado, que constituyen elementos centrales de la teoría política de Rawls y del liberalismo político en general. Finalmente, se propone una concepción alternativa de la razón pública liberal, centrada únicamente en un deber básico de civilidad, el deber de reciprocidad, a (...) la que denominaré la concepción “abierta” de la razón pública. (shrink)

This article intends to show how the philosophy of Kant supposes a rupture with the doctrines based on a system of absolute rationality, where the most important element is the unity of reason. In this way, it will try to underline the main critiques of the Prussian philosopher to theories based on the unity of reason and direct access to reality, as well as exposing the Kantian proposal of a unitary formal rational structure, but with several irreconcilable uses.

Are species real categories or just conventions? Are species natural kinds? Are teleological statements a distinctive feature of biology? Can life sciences escape from teleology? These are common issues in philosophy of biology. This paper aims to show that in order to answer to each of these questions it is inevitable to take a position respecting the others. Therefore, there is a historical relation between the concept of species and teleological issues. In order to analyse such relation, I will take (...) a historical perspective.After making such historical reconstruction focused on the Aristotle, Linnaeus, Buffon and Lamarck thoughts, I will analyse the Darwinian peculiar view respect teleology and his ideas about species. Although Darwin set out the collapse of teleological essentialisms in biology, there are important vestiges of teleology in his theory. (shrink)

Are species real categories or just conventions? Are species natural kinds? Are teleological statements a distinctive feature of biology? Can life sciences escape from teleology? These are common issues in philosophy of biology. This paper aims to show that in order to answer to each of these questions it is inevitable to take a position respecting the others. Therefore, there is a historical relation between the concept of species and teleological issues. In order to analyse such relation, I will take (...) a historical perspective.After making such historical reconstruction focused on the Aristotle, Linnaeus, Buffon and Lamarck thoughts, I will analyse the Darwinian peculiar view respect teleology and his ideas about species. Although Darwin set out the collapse of teleological essentialisms in biology, there are important vestiges of teleology in his theory. (shrink)

There has been little research on the vocabulary of the Greek novelists. Gasda studied that of Chariton in the last century. He compared some of his terms with those of other authors and he concluded he should be placed in the sixth century A.D. Then Schmid considered that Chariton's language was not Atticist, and dated his novel in the second century or beginning of the third. In 1973 Chariton's language was studied by Papanikolaou. His research dealt above all with several (...) syntactic aspects and the use of some vocabulary, which led him to conclude that this language was closer to the koiné than that of the other novelists. But Papanikolaou went further in his conclusions: finding no trace of Atticism in Chariton, he considered him a pre-Atticist writer and, using extra-linguistic data, such as the citing of the Seres, the Chinese , placed him in the second half of the first century B.C. This chronology has been accepted by some, but already Giangrande has observed that this lack of Atticisms could have been intentional, in which case that date would be questionable. (shrink)

ABSTRACT My aim in this paper is to present a pluralist thesis about the inferential role of logical constants, which embraces classical, relevant, linear and ordered logic. That is, I defend that a logical constant c has more than one correct inferential role. The thesis depends on a particular interpretation of substructural logics' vocabulary, according to which classical logic captures the literal meaning of logical constants and substructural logics encode a pragmatically enriched sense of those connectives. The paper is divided (...) into four parts: first, I introduce the motivation for the pluralist thesis of the paper; second I introduce the calculus for the different logics endorsed in the pluralist thesis; third, I motivate how the different behaviors of the logical vocabulary of these logics can be pragmatically interpreted, and fourth, I motivate how the different inferential roles that each substructural logic attribute to logical constants can coexist, and how we should reason with a logical constant c given this plurality. (shrink)

RESUMEN El objetivo de este artículo es proponer una reinterpretación del concepto de comunidad a la luz de las transformaciones tecnológicas y de las formas de comunicación recientes, las cuales ponen la idea de lo social no como precepto teórico, sino como elemento a descubrir en los diferentes estudios planteados. Se busca una transversalización teórica de los tres autores, tomando elementos esenciales de sus obras para proponer una nueva clave interpretativa que permita tomar el concepto de comunidad no como un (...) presupuesto teórico, sino como un producto inmanente, resultado de las conexiones cotidianas que se realizan entre los sujetos de manera espontánea en el campo de lo social. ABSTRACT Taking as a starting point the objective of this article is the reinterpretation of the concept, forced by the technological and communication transformations that place the ideas of social and community, not as theoretical precepts, but as elements to discover on the studies proposed. A theoretical transversalization of the three authors will be sought, taking essential elements from their works to propose a new interpretative key that allows us to take the concept of community, not as a theoretical presupposition, but as an immanent product resulting from the daily connections made between the subjects, spontaneously, on the social field. (shrink)

Aquí nos dedicamos al problema central de pensar cuál sería el motivo de recuperar los vínculos sociales en escenarios de reconciliación, perdón y justicia. Vamos a tratar de mostrar que hacerle frente a la posibilidad de vivir juntos, con todo lo ocurrido en el pasado, es un asunto que compromete criterios de composición social y fuentes de confluencia local que necesitan ser caracterizados teóricamente. Así, pues, nos preguntamos de qué son capaces los sujetos cuando se unen, se organizan, piensan y (...) deciden juntos. ¿Qué es aquello de lo que son capaces los colectivos para superar el pasado? La hipótesis de trabajo es la siguiente: la fraternidad de la existencia alegre, justo en el seno de los dilemas asociados al Terror y la Dolor, constituye la empresa de salvar la vida y las posibilidades que contiene. Al pensamiento de lo colectivo y al élan de la fraternidad nos apegamos para decir que es en el problema de la composición y de la celebración de las capacidades que vamos a encontrar el camino a los motivos de vivir juntos. (shrink)

En este ensayo se destaca fundamentalmente las aportaciones de T.S. Kuhn, quien al aproximarse al conocimiento científico a partir del quehacer o práctica científica, observando a los observadores científicos, apunta a dos aspectos centrales sobre el cambio radical que ha experimentado la concep..

Isidore of Seville did not leave behind any specifically trinitarian, Christological or pneumatological treatises. We find his theological doctrine evident in sections throughout his works although, as a result of the effort of a good compiler and synthesizer, it is not difficult to trace the passages in which the bishop of Seville deals with each one of these subjects. With regard to the doctrine on the Holy Spirit, the chapter dedicated to the third person of the Trinity in the first (...) book of the Sententiae offers a fairly complete summary of the matter. The following pages are intended to present the content of that chapter and to place it within the context of the rest of Isidore’s theological output. Therefore, in addition to paying close attention to the text of the Sententiae, we will seek its dependence or influence, as the case may be, on other treatises of Isidore, mainly in these three: Etymologiae, De fide catholica and Liber differentiarum [II]. Augustine, Gregory the Great and the theological contribution of the Spanish councils are presented as Isidore’s main sources. (shrink)

El presente artículo pretende hacer un recorrido por las prescripciones sobre el estudio de las lenguas bíblicas en el magisterio pontificio. No solo desvela los lugares concretos en los que se hallan, sino que, sobre todo, explica el contexto teológico que justifica su prescripción. El análisis aporta perspectivas que hacen del conocimiento de estas lenguas un instrumento irrenunciable para el recto ejercicio de la exégesis católica. También se añade una serie de consecuencias a partir de las perspectivas extraídas.