Brieven van de Nederlandse filosoof (1898-1955) uit de periode 1917-1927 aan een vriend.

Inhaltsübersicht: Dankwort, Vorwort, In jedem Augenblick kann ich entscheiden, wer ich bin. Was im Kopf eines anderen vorgeht, können wir nie wissen. Das Erkennen des Erkennens verpflichtet. Wahr ist, was funktioniert. Wir selbst sind Konstrukte. Wir beginnen nie am Anfang. Die Freiheit, das Neue zu wagen. Wir können von der Wirklichkeit nur wissen, was sie nicht ist. Ausgewählte Literaturhinweise. Register. Über den Autor.

Expanding buprenorphine access in the United States requires evidence-based decision-making that considers both the drug's potential dangers and its potential benefits. Risks associated with buprenorphine misuse and diversion highlight the need for careful, ongoing evaluation during each stage of increased access.

This article explores challenges to accessing opioid treatment programs in rural areas, and offers solutions that would ease these problems.

This phenomenological research investigates how it is possible to determine the extent to which a chromatic colour appears white and black in order to use it to build a new Colour Rendering Index. We tested two methods of subjective evaluation; in the first, the perceptual presence of white (and black) in a colour alone was assessed on a unipolar intensity scale, independently for the two attributes. In the second method, evaluations of whiteness (and blackness) were conducted for colours presented in (...) a sequence ordered from the least to the greatest presence of the respective attribute. In both tests evaluations were made either by moving an arrow on a slider from left (minimum) to right (maximum) or by choosing a grey cylinder that matched the same degree of similarity to white (and black) as the test colour. In four experiments, 16 colours of 4 hues and 4 different shades were studied; in a fifth experiment, 48 colours, 12 for each quadrant of the colour wheel, were studied; finally, in another test, 10 greys were studied. In the first three experiments, the results were unexpected, as the evaluations of whiteness and blackness were complementary, adding up to 100%, while in the current NCS, 100% includes not only the evaluation of white and black but also that of chromaticness, therefore white and black are not complementary. In the fourth and fifth experiments, the sum of the evaluations of white and black was always less than 100%, in accordance with the present NCS. In the last experiment, the evaluations of white and black given independently to the 10 greys samples were complementary, confirming the bipolar nature of white-black continuum. Suggestions have been provided to resolve the discrepancy between the results of this research and the structure of the current NCS. (shrink)

Here the author of How to Solve It explains how to become a "good guesser." Marked by G. Polya's simple, energetic prose and use of clever examples from a wide range of human activities, this two-volume work explores techniques of guessing, inductive reasoning, and reasoning by analogy, and the role they play in the most rigorous of deductive disciplines.

2014 Reprint of 1954 American Edition. Full facsimile of the original edition, not reproduced with Optical Recognition Software. This two volume classic comprises two titles: "Patterns of Plausible Inference" and "Induction and Analogy in Mathematics." This is a guide to the practical art of plausible reasoning, particularly in mathematics, but also in every field of human activity. Using mathematics as the example par excellence, Polya shows how even the most rigorous deductive discipline is heavily dependent on techniques of guessing, inductive (...) reasoning, and reasoning by analogy. In solving a problem, the answer must be guessed at before a proof can be given, and guesses are usually made from a knowledge of facts, experience, and hunches. The truly creative mathematician must be a good guesser first and a good prover afterward; many important theorems have been guessed but no proved until much later. In the same way, solutions to problems can be guessed, and a god guesser is much more likely to find a correct solution. This work might have been called "How to Become a Good Guesser."-From the Dust Jacket. (shrink)

BackgroundThe therapeutic effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) is related to the modulation of pathological neural activities, particularly the synchronization in the β band (13–35 Hz). However, whether the local β activity in the STN region can directly predict the stimulation outcome remains unclear.ObjectiveWe tested the hypothesis that low-β (13–20 Hz) and/or high-β (20–35 Hz) band activities recorded from the STN region can predict DBS efficacy.MethodsLocal field potentials (LFPs) were recorded in (...) 26 patients undergoing deep brain stimulation surgery in the subthalamic nucleus area. Recordings were made after the implantation of the DBS electrode prior to its connection to a stimulator. The maximum normalized powers in the theta (4–7 Hz), alpha (7–13 Hz), low-β (13–20 Hz), high-β (20–35 Hz), and low-γ (40–55 Hz) subbands in the postoperatively recorded LFP were correlated with the stimulation-induced improvement in contralateral tremor or bradykinesia–rigidity. The distance between the contact selected for stimulation and the contact with the maximum subband power was correlated with the stimulation efficacy. Following the identification of the potential predictors by the significant correlations, a multiple regression analysis was performed to evaluate their effect on the outcome.ResultsThe maximum high-β power was positively correlated with bradykinesia–rigidity improvement (rs = 0.549, p < 0.0001). The distance to the contact with maximum high-β power was negatively correlated with bradykinesia–rigidity improvement (rs = −0.452, p < 0.001). No significant correlation was observed with low-β power. The maximum high-β power and the distance to the contact with maximum high-β power were both significant predictors for bradykinesia–rigidity improvement in the multiple regression analysis, explaining 37.4% of the variance altogether. Tremor improvement was not significantly correlated with any frequency.ConclusionHigh-β oscillations, but not low-β oscillations, recorded from the STN region with the DBS lead can inform stimulation-induced improvement in contralateral bradykinesia–rigidity in patients with PD. High-β oscillations can help refine electrode targeting and inform contact selection for DBS therapy. (shrink)

Philosophical naturalism faces a dilemma: take it as an ideology, and you face charges of internal incoherence, since the ideological stance itself does not look to be a deliverance of science. Forgo the ideological aspect, on the other hand, and naturalism becomes a merely subjective assessment, a cry of “yay for science!” that carries no normative weight for those who are not inclined to agree. I first argue that both horns of this dilemma are sharp, and that current attempts to (...) negotiate them have failed. I then give a plausible construal of methodological naturalism that is both ideological and internally coherent, and so threads this dilemma. Finally, I consider objections to this formulation of naturalism. (shrink)

Humanely raised farm animals have lives worth living, and their existence is contingent upon human actions. Do these facts render the act of humanely slaughtering such animals permissible? I identify two ethical principles that may seem to connect these facts to the permissibility of humane animal slaughter. The first principle, inspired by the non-identity problem, exonerates some actions that maximize an individual’s well-being, but it is often inapplicable to animal slaughter. The second principle, which exonerates actions that are part of (...) a practice that makes the animal better off, does apply to animal slaughter; but this principle is false. (shrink)

Are there objective moral truths, i.e. things that are morally right, wrong, good, or bad independently of what anybody thinks about them? To answer this question more and more scholars have recently turned to evidence from psychology, neuroscience, cultural anthropology, and evolutionary biology. This book investigates this novel scientific approach in a comprehensive, empirically-focused, and partly meta-theoretical way. It suggests that while it is possible for the empirical sciences to contribute to the moral realism/anti-realism debate, most arguments that have so (...) far been proposed fail (because they misrepresent, cherry-pick, or overlook the invalidity of (parts of) the available scientific evidence). The book’s main chapters address five prominent science-based arguments for or against the existence of objective moral truths: the argument from moral disagreement, the evolutionary debunking argument, the sentimentalist argument, the presumptive argument, and the projectivist argument. Thomas Pölzler investigates in which sense the underlying empirical hypotheses would have to be true in order for these arguments to work, and then shows how the available scientific evidence fails to support them. Finally, he makes suggestions as to how to test these hypotheses in a more valid way. Moral Reality and the Empirical Sciences is an important contribution to the moral realism/anti-realism debate that will appeal to philosophers and scientists interested in moral psychology and metaethics. (shrink)

Previous studies have focused on individuals learning from observing a model to be able to produce the modeled behavior. However, there is a lack of studies emphasizing the perspective of being observed to understand the role of perceived value and stress when teachers act as a teaching model. To address this gap, the present study explored the correlates between teachers’ teaching beliefs, perceived value, psychosocial stress, and continuous intention to be the observed teaching model in classroom observations. Data of 349 (...) respondents were usefully collected, and confirmatory factor analysis with structural equation modeling was performed. Results showed that teachers’ constructivist belief in teaching was positively related to perceived value of being observed and getting feedback, but was negatively related to psychosocial stress. Perceived value was positively related to continuous intention to be observed in future classroom observations, but perceived psychosocial stress was not significantly related to continuous intention. The results of this study can be applied to encourage those who are resistant to presenting their teaching experience in classroom observations. (shrink)

Die vorliegenden Bande folgen dem gefeierten Heidegger- und Hegelkenner Otto Poggeler in seinen Fragestellungen uber die Beziehung zwischen Philosophie und Poesie. In 36 Beitragen werden Funktion und Form der Philosophie, Asthetik und Politik im deutschen Idealismus, die Einheit von Denken und Poesie bei Heidegger und die philosophische Dimension der Poesie diskutiert. - Der erste Band behandelt die Moglichkeit von Philosophie nach der Entdeckung der Geschichtlichkeit von menschlichem Wissen durch die hermeneutische Philosophie. Der zweite Band fuhrt diese Diskussion fort und entwickelt (...) die Beziehung zwischen Poggeler und Heidegger und dessen Kommentatoren und Gegnern. Hier wird das Verhaltnis von Philosophie und Poesie auch aus Sicht der Kunst verhandelt. - Mit Beitragen u.a. von Gadamer, Apel, Siep, Tilliette, Dusing und Lucas bieten die Bande in ihrer Reichhaltigkeit geradezu ein philosophisches Forum zum Thema Asthetik. (shrink)

In this paper, I criticize the view that non-conscious entities—such as plants and bacteria—have well-being. Plausible sources of well-being include pleasure, the satisfaction of consciously held desires, and achievement. Since nonconscious entities cannot obtain well-being from these sources, the most plausible source of well-being for them is the exercise of natural capacities. Plants and bacteria, for example, certainly do exercise natural capacities. But I argue that exercising natural capacities does not in fact contribute (in a non-instrumental way) to well-being. I (...) do so by presenting cases in which human beings exercise natural capacities that they do not enjoy exercising and that they do not desire (non-instrumentally) to exercise. I also argue that plausible views about fortune—how one’s well-being ranks on an appropriate scale—do not support the claim that exercising natural capacities contributes to well-being. (shrink)

This article examines whether and to what extent Confucianism as a resilient Chinese cultural tradition can be used as a sound basis of business practice and management model for Chinese corporations in the twenty-first century. Using the core elements of Confucianism, the article constructs a notion of a Confucian Firm with its concepts of the moral person ( Junzi ), core human morality ( ren, yi, li ) and relationships ( guanxi ), as well as benign social structure (harmony), articulated (...) in corporate and organizational terms. The basic character of the Confucian Firm is described, and its philosophical and cultural foundation is critically assessed with respect to its moral legitimacy and relevant to today’s China. China’s recent Corporate Social Responsibility (CSR) development is a high profile response to global business ethics concerns. Efforts have been made to emulate and develop good business practice fashioned in CSR norms and visions. The so-called “human-based” and “virtue-based” business practices rooted in local cultural heritage have been touted as a Chinese response to this problem. This investigation is particularly relevant in the context of the increasingly prominence of the Chinese corporations (China Inc.) in the wake of the rise of China as a global power. How relevant is Confucianism to the building of a modern Chinese corporation that is willing and able to practice reasonable norms of business ethics? The findings of this discussion, which include the organizational implications of the Confucian familial collectivism, have implications for other Chinese communities (Taiwan, Hong Kong, and Singapore) where Confucian tradition is endorsed and practiced. (shrink)

Over the past few years several drugs that target epigenetic modifications have shown clinical benefits, thus seemingly validating epigenetic cancer therapy. More recently, however, it has become clear that these drugs are either characterized by low specificity or that their target enzymes have low substrate specificity. As such, clinical proof‐of‐concept for epigenetic cancer therapies remains to be established. Human cancers are characterized by widespread changes in their genomic DNA methylation and histone modification patterns. Epigenetic cancer therapy aims to restore normal (...) epigenetic modification patterns through the inhibition of epigenetic modifier enzymes. In this review, we provide an overview about the known functional roles of DNA methyltransferases, histone deacetylases, histone methyltransferases, and demethylases in cancer development. The available data identify several examples that warrant further consideration as drug targets. Future research should be directed toward targeted enzyme inhibition and toward exploring interactions between epigenetic pathways to maximize cancer specificity. (shrink)

In this article, I will identify an argument for the conclusion that all human moral agents have stronger moral reasons regarding other human beings than they do regarding nonhuman animals, and I will explain why I think this argument is unsound. The argument employs an empirical claim, that all human beings are more closely genealogically related to all other humans than they are to any nonhuman animals, and a moral claim, that one’s genealogical relationship to an individual is a morally (...) relevant consideration. The moral claim is supported by a comparison between genealogically related individuals and a family. (shrink)

This book offers a rich introduction to Heidegger that reveals Poggeler's sound scholarship and philosophical criticism.

The challenge of developing a business ethics in China in response to today's increasing demands of Corporate Social Responsibility (CSR) is examined within the context of recent business scandals, food scare, labor issues, and environmental degradations the country is now experiencing. Two surveys on CSR are reported. This paper reports the recent CSR development in China and oudines the profile of a prospective business ethics for China. The formal constraints and substantive components of this business ethics are proposed against the (...) background of China's cultural and ideological heritage. (shrink)

Corporate social responsibility (CSR) has become increasingly popular in advanced economies in the West. In contrast, CSR awareness in Asia is rather low, both on the corporate and state level. However, recent events have shown that the CSR is receiving more attention by corporations in Asia. Recent development in CSR in Taiwan is one example of such a trend. A 2005 survey on the 700 publicly listed companies in Taiwan on␣CSR has highlighted the current CSR situation. Concurrently, the numbers of (...) corporate scandals and corruption have dramatically increased over the past 6 years. Corporate CSR activities co-existing with pervasive corporate scandals create a phenomenon of contradictions. This article aims to report via the survey findings the current development of business ethics in corporate Taiwan; and to interpret the findings in context of Taiwan’s business ethos, especially its Confucian familism and crony capitalism. (shrink)

Queer theorists have considered the problems concerning the political strategy of using LGBT rights to justify racist xenophobia and using homo/transphobia to consolidate heterosexist nationalism. Their timely interventions are important in exposing state violence in the name of human rights and sovereign equality, but they have offered no alternative. They may also have reinforced the assumption of state science. This assumption is based on a trinity structure of the nation-state-sovereignty of ‘modern, self-determining men’, who are against each other and thereby (...) co-built the so-called ‘international’. State-centric internationalism produces exclusionary effects that undermine the rights of sexual and gender minorities. To address this, I first consider the debate over ‘LGBT rights as human rights’, and identify two types of cultural relativism (epistemological and political) as the categories to formulate a decolonial response to the debate. In this article, queer political theorising is pushed forward to: 1) critically evaluate universalism, 2) differentiate cultural relativism (opposing the political version of it) and 3) revise the epistemological version with decolonial-queer praxis. I propose a pluralist approach to sovereignty and human rights; informed by this approach, the lack of international consensus is remedied by recognising the polyvocality within transnational queer activism beyond the monopoly of states’ representation of their own peoples. This proposal also aims to decentre modern statecraft from the political imagination of contemporary international studies scholarship. (shrink)

A one-day educational intervention with multiple activities was developed and operationalized with a sample of Chinese business students in Hong Kong, China. Its effectiveness in influencing students’ corporate social responsibility orientation was measured with a Chinese version of a forced choice scale using Economic, Legal, Ethical, and Discretionary dimensions by Carroll. A repeated measures multivariate analysis of variance showed significant differences in the Legal and Discretionary dimensions between the post-test Experimental group and Control group ; in the Legal, Ethical, and (...) Discretionary dimensions within the pre-post X group. Such significant differences may be explained by the content of the activities, especially the service learning component. Overall, the intervention appeared effective in influencing students’ CSRO within a Chinese context. Since it was designed upon Western CSR literature, its applicability goes beyond the Chinese community. (shrink)

Since China's Reform Era began in 1979, corporations of all shapes and sizes mushroomed in the economic landscape. Among these companies, a few have distinguished themselves by their unique corporate cultures and financial performance. The Chinese state–owned enterprises (SOEs) are notorious for their inefficiency, conservatism, bloated bureaucracy, and obsoleteness. However, a few good SOEs stand out as corporations of excellence with commitment to business ethics. Very little study has been done on SOE corporate cultures and business ethics, especially in the (...) western literature. This paper provides an insight into one such organisation – the Double Star Group of Qingdao. This paper includes the results of an empirical survey on Double Star's employees’ perception of its corporate culture and business ethics. (shrink)

Since China's Reform Era began in 1979, corporations of all shapes and sizes mushroomed in the economic landscape. Among these companies, a few have distinguished themselves by their unique corporate cultures and financial performance. The Chinese state–owned enterprises (SOEs) are notorious for their inefficiency, conservatism, bloated bureaucracy, and obsoleteness. However, a few good SOEs stand out as corporations of excellence with commitment to business ethics. Very little study has been done on SOE corporate cultures and business ethics, especially in the (...) western literature. This paper provides an insight into one such organisation – the Double Star Group of Qingdao. This paper includes the results of an empirical survey on Double Star's employees’ perception of its corporate culture and business ethics. (shrink)