IntroductionParkinson’s disease patients have a significantly higher risk of developing dementia in later disease stages, leading to severe impairments in quality of life and self-functioning. Questions remain on how deep brain stimulation affects cognition, and whether we can individualize therapy and reduce the risk for adverse cognitive effects. Our aim in this systematic review is to assess the current knowledge in the field and determine if the findings could influence clinical practice.MethodsWe have conducted a systematic review according to PRISMA guidelines (...) through MEDLINE and Embase databases, with studies being selected for inclusion via a set inclusion and exclusion criteria.ResultsSixty-seven studies were included in this systematic review according to the selected criteria. This includes 6 meta-analyses, 18 randomized controlled trials, 17 controlled clinical trials, and 26 observational studies with no control arms. The total number of PD patients encompassed in the studies cited in this review is 3677, not including the meta-analyses.ConclusionCognitive function in PD patients can deteriorate, in most cases mildly, but still impactful to the quality of life. The strongest evidence is present for deterioration in verbal fluency, while inconclusive evidence is still present for executive function, memory, attention and processing speed. Global cognition does not appear to be significantly impacted by DBS, especially if cognitive screening is performed prior to the procedure, as lower baseline cognitive function is connected to poor outcomes. Further randomized controlled studies are required to increase the level of evidence, especially in the case of globus pallidus internus DBS, pedunculopontine nucleus DBS, and the ventral intermediate nucleus of thalamus DBS, and more long-term studies are required for all respective targets. (shrink)

In this paper we will demonstrate that a computational system can meet the criteria for autonomy laid down by classical enactivism. The two criteria that we will focus on are operational closure and structural determinism, and we will show that both can be applied to a basic example of a physically instantiated Turing machine. We will also address the question of precariousness, and briefly suggest that a precarious Turing machine could be designed. Our aim in this paper is to challenge (...) the assumption that computational systems are necessarily heteronomous systems, to try and motivate in enactivism a more nuanced and less rigid conception of computational systems, and to demonstrate to computational theorists that they might find some interesting material within the enactivist tradition, despite its historical hostility towards computationalism. (shrink)

This paper is dedicated to extending and adapting to modal logic the approach of fractional semantics to classical logic. This is a multi-valued semantics governed by pure proof-theoretic considerations, whose truth-values are the rational numbers in the closed interval $[0,1]$. Focusing on the modal logic K, the proposed methodology relies on three key components: bilateral sequent calculus, invertibility of the logical rules, and stability (proof-invariance). We show that our semantic analysis of K affords an informational refinement with respect to the (...) standard Kripkean semantics (a new proof of Dugundji’s theorem is a case in point) and it raises the prospect of a proof-theoretic semantics for modal logic. (shrink)

Entrevista concedida por Antonio Negri a Homero Santiago e Mario Marino por ocasião do lançamento da segunda edição da tradução brasileira de A anomalia selvagem: poder e potência em Espinosa.

This article presents a new semantics for classical propositional logic. We begin by maximally extending the space of sequent proofs so as to admit proofs for any logical formula; then, we extract the new semantics by focusing on the axiomatic structure of proofs. In particular, the interpretation of a formula is given by the ratio between the number of identity axioms out of the total number of axioms occurring in any of its proofs. The outcome is an informational refinement of (...) traditional Boolean semantics, obtained by breaking the symmetry between tautologies and contradictions. (shrink)

We put forth an account for when to believe causal and evidential conditionals. The basic idea is to embed a causal model in an agent’s belief state. For the evaluation of conditionals seems to be relative to beliefs about both particular facts and causal relations. Unlike other attempts using causal models, we show that ours can account rather well not only for various causal but also evidential conditionals.

This paper examines a fundamental philosophical difference between two radical postcognitivist theories that are usually assumed to offer the same view of cognition; namely the autopoietic theory and the enactive approach. The ways these two theories understand cognition, it is argued, are not compatible nor incompatible but rather incommensurable. The reason, so it is argued, is that while enactivism, following the traditional stance held by most of the cognitive theories, understands cognitive systems as constituting a natural kind, the autopoietic theory (...) understands them as constituting only a conventional kind. Additionally, the paper shows that AT’s conventionalist stance about cognition, far from being an undesirable or useless position, offers some methodological virtues that might be timely and welcome in the agitated and revolutionary climate of current cognitive science. (shrink)

We propose a method of learning indicative conditional information. An agent learns conditional information by Jeffrey imaging on the minimally informative proposition expressed by a Stalnaker conditional. We show that the predictions of the proposed method align with the intuitions in Douven, 239–263 2012)’s benchmark examples. Jeffrey imaging on Stalnaker conditionals can also capture the learning of uncertain conditional information, which we illustrate by generating predictions for the Judy Benjamin Problem.

El propósito de este artículo consiste en mostrar el carácter social del contractualismo de Fichte. Para realizar ese propósito se comienza examinando la conexión entre trabajo y ciudadanía como una condición de la legitimidad política. Luego se presenta esa conexión en el marco del siempre posible desarrollo histórico de la naturaleza humana. Por último, se indican las razones de la recepción de Fichte como un precursor del socialismo germánico.

Originally published as Scientific Research, this pair of volumes constitutes a fundamental treatise on the strategy of science. Mario Bunge, one of the major figures of the century in the development of a scientific epistemology, describes and analyzes scientific philosophy, as well as discloses its philosophical presuppositions. This work may be used as a map to identify the various stages in the road to scientific knowledge. Philosophy of Science is divided into two volumes, each with two parts. Part 1 (...) offers a preview of the scheme of science and the logical and semantical took that will be used throughout the work. The account of scientific research begins with part 2, where Bunge discusses formulating the problem to be solved, hypothesis, scientific law, and theory. The second volume opens with part 3, which deals with the application of theories to explanation, prediction, and action. This section is graced by an outstanding discussion of the philosophy of technology. Part 4 begins with measurement and experiment. It then examines risks in jumping to conclusions from data to hypotheses as well as the converse procedure. Bunge begins this mammoth work with a section entitled "How to Use This Book." He writes that it is intended for both independent reading and reference as well as for use in courses on scientific method and the philosophy of science. It suits a variety of purposes from introductory to advanced levels. Philosophy of Science is a versatile, informative, and useful text that will benefit professors, researchers, and students in a variety of disciplines, ranging from the behavioral and biological sciences to the physical sciences. (shrink)

A discussion concerning whether to conceive Artificial Intelligence systems as responsible moral entities, also known as “artificial moral agents”, has been going on for some time. In this regard, we argue that the notion of “moral agency” is to be attributed only to humans based on their autonomy and sentience, which AI systems lack. We analyze human responsibility in the presence of AI systems in terms of meaningful control and due diligence and argue against fully automated systems in medicine. With (...) this perspective in mind, we focus on the use of AI-based diagnostic systems and shed light on the complex networks of persons, organizations and artifacts that come to be when AI systems are designed, developed, and used in medicine. We then discuss relational criteria of judgment in support of the attribution of responsibility to humans when adverse events are caused or induced by errors in AI systems. (shrink)

With special relativity, we seem to be facing a conundrum. It is a very well-tested theory; in this way, the Minkowski spacetime must be “capturing” essential features of space and time. However, its geometry seems to be incompatible with any sort of global notion of time. We might only have local notions of now (present moment) and time flow, at best. In this note, we will explore the possibility that a pretty much global notion of now (and time flow) might (...) be hiding in plain sight in the geometry of the Minkowski spacetime. (shrink)

This paper assesses the novelty of NSMs - or better, of any social and political movement in contemporary Western societies - in the light of their capacity to develop systems of relationships which cut across established social and political cleavages. It illustrates first the relational bases of Rokkan's concept of cleavage, and its contribution to the understanding of social movements; it then shows how Simmel's concept of the intersection of social circles and his distinction between concentric and crosscutting circles may (...) be fruitfully applied to the analysis of political cleavages and their changing forms. In the conclusions, the elements of an approach to the study of the newness of social movements, based on the integration of Rokkan's and Simmel's principles, are introduced. (shrink)

The question of the animal is one of the most intensely debated in the contemporary philosophical arena. The present article makes the case that Husserl’s phenomenological approach offers a stimulating and open-ended perspective on this discussion. The animal, indeed, is an instance of extreme otherness, which pushes phenomenology to its limits. The paper opens with an outline of the methodological issues raised by the question of the animal. It then examines what the animal—at this point, taken as a whole—and the (...) human being have in common and what Husserl sees as the main differences between them. A critical aspect here is the question of personhood. Finally, Sect. 3 traces Husserl’s progression from a general concept of animality to detailed and nuanced phenomenological descriptions of different animals and their intra- and inter-specific relationships. Husserl understands that the threshold that joins and divides human beings and animals is difficult to pin down, because there is more than one threshold: it is plural. (shrink)

One of the open questions in Bayesian epistemology is how to rationally learn from indicative conditionals (Douven, 2016). Eva et al. (Mind 129(514):461–508, 2020) propose a strategy to resolve this question. They claim that their strategy provides a “uniquely rational response to any given learning scenario”. We show that their updating strategy is neither very general nor always rational. Even worse, we generalize their strategy and show that it still fails. Bad news for the Bayesians.

Different methods are available in clinical ethics consultation. In our experience as ethics consultants, certain individual methods have proven insufficient, and so we use a combination of methods. Based on these considerations, we first critically analyze the pros and cons of two well-known methods in the working field of clinical ethics, namely Beauchamp and Childress’s four-principle approach and Jonsen, Siegler, and Winslade’s four-box method. We then present the circle method, which we have used and refined during several clinical ethics consultations (...) in the hospital setting. (shrink)

In this paper, it is presented a historical account of the formulation of the quantum relativistic wave equation of an electron – the Dirac equation, issues regarding its interpretation that arose from the very beginning, and the later formulation of this equation in relation to a quantized electron-positron field, which implies a new interpretation. The way in which solutions obtained under each interpretation of the equation relate to one another is also considered for the simple case of hydrogen-like problems.

At the beginning of the third section of Book II of Capital, Marx distinguishes between the direct process of the production of capital and the total process of its reproduction. The former includes both the work process as well as the value-creating process. As we shall see, the latter includes both the process of consumption mediated by circulation, as well as the process of reproduction of capital itself. In the different forms assumed by capital within its cycle, and even more (...) in the different forms assumed by this cycle, the movement of individual capital turns out to be a part of the total movement of social capital. (shrink)

The Italian debate about the role of clinical ethics and ethics consultation has brought about the need to create a working group of Healthcare Ethics Consultation. The group began to take shape an...

Among the influential contributions of Alfred Tarski to logic and philosophy, and close in importance to his widely applied and discussed definition of truth, one finds his definition of logical consequence for formal languages. Like his definition of truth, Tarski's definition of logical consequence has been widely and fruitfully applied. Unlike the definition of truth, that of logical consequence has been rarely discussed philosophically. The main aim of this dissertation is to offer a thorough discussion of some philosophical issues arising (...) from the neglected definition. ;The point of departure is an interpretative reading of the relevant writings by Tarski. This reading yields historically interesting data that refute other recent readings. It also provides philosophical illumination, by clarifying how Tarski thought that his definition satisfied some pretheoretic desiderata. ;Next it is discussed whether Tarski's definition satisfies other pretheoretic desiderata, not stated by Tarski and in some cases not endorsed by him, but which are desiderata nonetheless from reasonable standpoints. These include the desiderata that all instances of logical consequence in Tarski's defined sense be instances of analytical implication, and that they be instances of valid implication. The conclusion of this part of the dissertation is that, under reasonable assumptions regarding the field of applicability of the definition and the concepts used in it, there are reasons to believe that these desiderata are met, and none to believe they are not. ;Finally, the problem of logical constants is examined. The concept of a "logical constant" is the only concept not taken from logic and mathematics that appears in Tarski's definition. The problem of logical constants is that of replacing the primitive 'logical constant' with a defined, better understood concept, and in a such a way that the resulting defined concept of logical consequence meets the previously discussed desiderata. The main conclusion of this part is that some attempts to do this replace the obscure with the more obscure, while other attempts that seem to be in the right spirit have shortcomings of their own. (shrink)

Review of: Communauté (Gemeinschaft), Martin Buber (2018) Paris: Éditions de l’éclat, 157 pp., ISBN 978-2-84162-432-4, p/bk, €10.

Recently, Michael Wheeler has argued that despite its sometimes revolutionary rhetoric, the so called 4E cognitive movement, even in the guise of ‘radical’ enactivism, cannot achieve a full revolution in cognitive science. A full revolution would require the rejection of two essential tenets of traditional cognitive science, namely internalism and representationalism. Whilst REC might secure antirepresentationalism, it cannot do the same, so Wheeler argues, with externalism. In this paper, expanding on Wheeler’s analysis, we argue that what compromises REC’s externalism is (...) the persistence of cognitively relevant asymmetries between its purported cognitive systems and the environment. Complementarily, we argue that an antirepresentationalist ancestor of enactivism, the autopoietic theory of cognition, is able to deliver and secure externalism, thus offering the explosive combination that Wheeler claims us needed for a revolution in cognitive science. (shrink)

El propósito del presente escrito es hacer un análisis de algunas defensas universalistas sobre el segundo argumento de Z13 el cual niega que el universal pueda ser forma y, de esta manera, que pueda ser substancia primera. El análisis tiene dos momentos: en el primero se sostiene que, basado en la evidencia textual de Z, hay una premisa falsa y esto conduce a que la estructura general de uno de los principales argumentos universalistas sea inconsistente. El segundo momento del análisis (...) consiste en mostrar una serie de distinciones importantes no trazadas del segundo argumento que conducen, nuevamente, a que el argumento universalista no sea consistente. (shrink)

Considering Butler's "tragic trilogy"-a set of interventions on Sophocles' Antigone, Euripides' Bacchae, and Aeschylus's Eumenides-this book seeks to understand not just how Butler uses and interprets Greek tragedy, but also how tragedy shapes Butler's thinking, even when their gaze is directed elsewhere. Through close readings of these tragedies, this book brings to light the tragic quality of Butler's writing. It shows how Butler's mode of reading tragedy-and, crucially, reading tragically-offers a distinctive ethico-political response to the harrowing dilemmas of our current (...) moment. (shrink)

In this article we will put forward the proposal that the concept of functional diversity can be considered as a relevant analytical category necessarily applicable as a perspective of analysis to the social sphere. To this end, we will situate the idea of functional diversity in six different and interrelated dimensions of human experience, which we call: body dimension, relational, political, ethical, social and cultural dimension, in relation to the corresponding dimensions of the social sphere. The idea of functional diversity (...) will appear as a fundamental element in each of these six dimensions, extending from the body to culture. We consider this breadth in the scope of the idea’s presence to be essential as an argument in favour of its conceptual importance. This approach to the idea of functional diversity will involve, at the same time, a deconstructive examination of the discourse of ableism, which we consider to be opposed to the discourse emanating from the anti-ableist perspective of functional diversity. If, as such a category, functional diversity manages to embrace such a wide spectrum of dimensions of human experience and social life, the possibility of beginning to include it in an epistemic-political sense as a necessary analytical perspective in the social sphere acquires value, perhaps as relevant in the future as the gender perspective is at present. (shrink)