Gene therapy has emerged from the idea of inserting a wild‐type copy of a gene in order to restore the proper expression and function of a damaged gene. Initial efforts have focused on finding the proper vector and delivery method to introduce a corrected gene to the affected tissue or cell type. Even though these first attempts are clearly promising, seveal problems remain unsolved. A major problem is the influence of chromatin structure on transgene expression. To overcome chromatin‐dependent repressive transgenic (...) states, researchers have begun to use chromatin regulatory elements to drive transgene expression. Insulators or chromatin boundaries are able to protect a transgene against chromatin position effects at their genomic integration sites, and they are able to maintain transgene expression for long periods of time. Therefore, these elements may be very useful tools in gene therapy applications for ensuring high‐level and stable expression of transgenes. BioEssays 26:796–807, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This book combines a historical and philosophical study of Russell's theory of descriptions. It defends, develops, and extends the theory as a contribution to natural language semantics while also arguing for a reassessment of the importance of linguistic inquiry to Russell's philosophical project.

Este trabajo se enmarca dentro del análisis de las acciones alternativas a la privación de libertad en adolescentes infractores a la ley penal. Intenta buscar soluciones que eviten la cárcel para quienes cometan pequeños delitos, opción que puede disminuir el índice de reincidencias. El objetivo es promover, desde el Trabajo Social, una doble reflexión: primero, analizando críticamente el concepto de delito, su definición en las diversas corrientes ideológicas y su aplicación en la legislación argentina; y segundo, la importancia de que (...) los jóvenes se responsabilicen de sus actos y experimenten caminos alternativos al delito.This work places inside the analysis of the alternative actions to the privation of freedom in inobservant teenagers to the penal law. It tries to look for solutions that avoid the jail for those who commit small crimes, option that can diminish the index of repetitions. The aim is to promote, from the Social Work, a double reflection: first, analyzing critically the concept of crime, his definition in the diverse ideological currents and his application in the argentine legislation; and second, the importance of which the young men take responsibility of his acts and experience alternative ways to the crime. (shrink)

Disgrace , by J.M. Coetzee, is a story of a rape; more, it is a tale in which the victim of the rape, Lucy Lurie, is silent. She demands neither sympathy nor justice for what happens toher, presenting herself as neither a victim nor someone seeking revenge. Instead she stands as a witness, and does so by adopting an attitude reminiscent of the thinking of Simone Weil—rejecting the possibility of rights, and not looking for explanations. Rape, Coetzee thus suggests, is (...) an act without meaning, a trauma whose reality cannot be exorcised through narration. Fittingly, therefore, the novel ends with a tableau of Lucy growing flowers in her garden; living, like Candide, without rationalisation or consolatory myth. (shrink)

This book brings together three distinct research programs in moral psychology - Moral Foundations Theory, Cognitive Adaptations for Social Exchange and the Linguistic Analogy in Moral Psychology - and shows that they can be combined to create a unified cognitive science of moral intuition. The book assumes evolution has furnished the human mind with two types of judgement: intuitive and deliberative. Focusing on moral intuitions (understood as moral judgments that were not arrived at via a process of conscious deliberation), the (...) book explores the origins of these intuitions, examines how they are produced, and explains why the moral intuitions of different humans differ. Providing a unique synthesis of three separate established fields, this book presents a new research program that will further our understanding of the various different intuitive moral judgements at the heart of some of the moral tensions within human society. (shrink)

Over the past three decades, economic sociology has been revealing how culture shapes economic life even while economic facts affect social relationships. This work has transformed the field into a flourishing and increasingly influential discipline. No one has played a greater role in this development than Viviana Zelizer, one of the world's leading sociologists. Economic Lives synthesizes and extends her most important work to date, demonstrating the full breadth and range of her field-defining contributions in a single volume for (...) the first time. Economic Lives shows how shared cultural understandings and interpersonal relations shape everyday economic activities. Far from being simple responses to narrow individual incentives and preferences, economic actions emerge, persist, and are transformed by our relations to others. Distilling three decades of research, the book offers a distinctive vision of economic activity that brings out the hidden meanings and social actions behind the supposedly impersonal worlds of production, consumption, and asset transfer. Economic Lives ranges broadly from life insurance marketing, corporate ethics, household budgets, and migrant remittances to caring labor, workplace romance, baby markets, and payments for sex. These examples demonstrate an alternative approach to explaining how we manage economic activity--as well as a different way of understanding why conventional economic theory has proved incapable of predicting or responding to recent economic crises. Providing an important perspective on the recent past and possible futures of a growing field, Economic Lives promises to be widely read and discussed. (shrink)

My paper proposes the concept of relational work to explain economic activity. In all economic action, I argue, people engage in the process of differentiating meaningful social relations. For each distinct category of social relations, people erect a boundary, mark the boundary by means of names and practices, establish a set of distinctive understandings that operate within that boundary, designate certain sorts of economic transactions as appropriate for the relation, bar other transactions as inappropriate, and adopt certain media for reckoning (...) and facilitating economic transactions within the relation. I call that process relational work. After identifying specific elements of a relational work approach, the paper focuses on the case of monetary differentiation. It compares a relational work theory of earmarking money with behavioral economics’ individually based mental accounting approach. (shrink)

La distinción sexo-género, introducida en la teorización feminista de los años setenta, habría puesto de manifiesto la pertinencia de distinguir entre el sexo y las representaciones socio-culturales e identitarias en las que aquel encontraría su despliegue. De la mano de Judith Butler, la teoría queer parece haber llevado esta distinción hasta el extremo, al sostener que existiría una discontinuidad radical entre los cuerpos sexuados y los géneros culturalmente construidos, y proponer una concepción performativa del género, que pondría de relieve el (...) papel central del sujeto en la configuración de su propia identidad. Sujeto que, sin embargo, ya no sería reconocido como mujer o como hombre, pues toda categoría referente a la distinción entre los sexos o entre los géneros binarios (masculino-femenino) habría sido cuestionada de forma radical. A partir de una aproximación a la distinción inicial sexo-género en el marco del debate feminista y de sus antecedentes, el objeto de este trabajo es indagar cómo se plantea esta distinción en una de las obras emblemáticas y pioneras de la filósofa norteamericana Judith Butler ―Gender Trouble―, a fin de abrir algunas líneas de discusión en torno a las aportaciones y limitaciones que habría traído consigo un discurso que nos confronta con la pregunta fundamental por la configuración de la identidad sexual y de género de la persona. (shrink)

Clinical decision-making within an ethical context -- The ethical self -- Ethical reasoning : a pragmatic approach -- Recognising ethical issues -- Gathering facts and values -- Ethical rules and frameworks -- Ethical theories -- Managing the outcome -- Future development.

The year 1992 is a year for reflection, because whether or not the quincentenary celebration of the arrival of the Europeans to this continent seems justified, one cannot escape thinking about the impact of this event on our land.As archeology is my area of study, my reflections are directed toward the changes that came about in the relationship between man and animals after 1492, specifically toward what occurred in Mexico once the Spaniards established themselves in this territory.

The quest for real democracy is one of the components of sustainable degrowth. But the incipient debate on democracy and degrowth suffers from general definitions and limited connections to political philosophy and democracy theory. This article offers a critical review of democracy theory within the degrowth literature, taking as its focal point a relevant debate between Serge Latouche and Takis Fotopoulos. We argue that the core of their contention can be traced back to the relationship between the concepts of democracy (...) and autonomy as defined by philosopher Cornelius Castoriadis, which both authors and generally the degrowth movement consider as one of their theoretical reference points. We show how both Latouche and Fotopoulos hold a misconception of Castoriadis' notions of autonomy, the social imaginary and politics, which in turn limits their cognisance of democracy and hence confuses their debate concerning the possibilities for a degrowth transition within the confines of a liberal parliamentary democracy. With a clarified theoretical understanding of the interconnected democracy-autonomy assemble, we proceed to an evaluation of the revolutionary potential of the degrowth movement and to a better understanding of a possible relationship between democracy and degrowth. (shrink)

The author demonstrates the validity of the inference of particular sentences from universal sentences through the Aristotelian simple conversion and accidental conversion of categorical propositions.

La llegada del covid-19 a Chile generó un gran cambio en la educación, se implementaron medidas estrictas de confinamiento la cual obligó a la educación presencial ir de manera virtual. La finalidad de este estudio es mostrar la percepción del estudiantado del programa Bachillerato en Ciencias de la Universidad Santo Tomás frente al proceso educativo virtual que se llevo a cabo en los años 2020-21. Se utilizó un cuestionario de tipo cualitativo, con 32 preguntas. Los resultados muestran que la educación (...) virtual en tiempos de pandemia, genero diversos factores de stress, problemas de conectividad, acceso a tecnologías y falta de aprendizaje. (shrink)

Changemaker Education is a collection of practitioner-based case studies that highlight the why, what, and how of empowering educational experiences.

The purpose of this article is to construct a critique of some works by the French artist Lucy Schwob, better known as Claude Cahun, who was active between 1910 and 1950. A writer and photographer, Cahun was at first very close to symbolist positions; later she was closer to the surrealist movement. Her work and her life, continually suspended between genders, and between ‘normality’ and ‘deviance’, have so far been analysed mainly through gender studies. This article attempts to restore the (...) inherent complexity of her poetic work and aesthetic. It tries to widen the field of study to deal with the representation of alterity, through reversing the stereotypical representation. (shrink)

This revised and considerably expanded 2nd edition brings together a wide range of topics, including modal, tense, conditional, intuitionist, many-valued, paraconsistent, relevant, and fuzzy logics. Part 1, on propositional logic, is the old Introduction, but contains much new material. Part 2 is entirely new, and covers quantification and identity for all the logics in Part 1. The material is unified by the underlying theme of world semantics. All of the topics are explained clearly using devices such as tableau proofs, and (...) their relation to current philosophical issues and debates are discussed. Students with a basic understanding of classical logic will find this book an invaluable introduction to an area that has become of central importance in both logic and philosophy. It will also interest people working in mathematics and computer science who wish to know about the area. (shrink)

The European framework surrounding clinical trials on medicinal products for human use is going to change as demonstrated by the large debate at European institutional level. One of the major challenges is to overcome the lack of harmonisation of clinical trial procedures among countries. This aspect is gaining more and more importance, considering the increasing number of multicentre and multinational studies. In this work, the actual European rules governing the Clinical Trial Application have been analysed throughout the different steps including (...) the registration of the trial in the European database; the preparation of documents to be submitted and their contents; the preparation of documents related to the information and consent process; the submission to competent bodies. Specific issues related to paediatric research and trials involving non EU/EEA countries have been addressed as well. Results reveal that the European legislation offers a well defined set of European rules covering different aspects of a Clinical Trial Application. However, these are not suitable to meet the challenges from multicentre and multinational clinical studies. A stronger set of rules, such as is available in a composite European Regulation has been adopted and is expected to harmonise practices and enable sponsors to carry out well conducted trials. But will the new regulation overcome the existing criticisms of Directive 2001/20/EC? (shrink)

Las estrategias de adquisición léxica implementadas en formato multimedia han sido poco estudiadas, especialmente las que se utilizan en documentos diseñados para estudiantes en nivel preescolar. El objetivo de este artículo es identificar estrategias de adquisición léxica presentes en el documento digital que complementa al libro de texto de inglés para Kínder “Calibot 2”, único en su tipo de editorial chilena. Para esto, se llevó a cabo un estudio cualitativo de diseño análisis documental a la luz de la propuesta de (...) Nation (2007) conocida como las Four strands o cuatro hebras a partir de la que se levantaron categorías de análisis que fueron aplicadas por medio del software Nvivo12. Se encontraron 11 estrategias de adquisición léxica presentadas de forma multimedia que apoyarían la adquisición efectiva de léxico en una L2. Si bien los resultados aportan al ámbito pedagógico al promover el conocimiento de estrategias de adquisición léxica de L2 que pueden ser implementadas en formato multimedia, la presencia de estas estrategias se limita al documento analizado y sus resultados no pueden ser generalizados. (shrink)

The goal of this research is to know and compare the emotions and reactions to confinement due to the COVID-19 pandemic in children and adolescents with high abilities and community samples. This is a mixed study with an exploratory reach that is descriptive, and which combines survey and qualitative methodologies to examine the emotions and reactions to confinement experiences of children and adolescents aged between 5 and 14 years. An online poll was designed with 46 questions, grouped into three sections: (...) General Data, Reactions to the health contingencies of COVID-19, and Positive and negative emotions. This last section was included the Oros’ positive emotions questionnaire and the scales of the negative effect of the PANAS Schedule positive and negative affect on children and adolescents between 8 and 14 years old. Data were collected online with a convenience sample. Quantitative data were analyzed with the SPSS statistics program and qualitative data with Alceste software. Among the main findings is the fact that there are no significant differences between the groups by ability in terms of reactions and emotions; however, there are differences between age groups and sex. The study discusses the implications for educational intervention in situations like the current pandemic. (shrink)

En esta breve reflexión nos centraremos en dos aspectos de la frase poética, el primero es el ritmo y el segundo, la metáfora. Nos referiremos al ritmo como imagen, musicalidad y sentido que trasciende la métrica, y a la metáfora como figura de pensamiento y vehículo para ingresar en una nueva percepción del mundo. El análisis de estos dos elementos propicia un acercamiento hermenéutico al poema como un devenir.

Este trabajo se propone examinar algunas características de la máscara del coquus en el corpus plautino. En primer término, se estudia el modo en que este personaje, a partir de las referencias al castigo físico y a la pasividad sexual, es construido como un cuerpo subordinado al servicio de otros. Luego, se consideran sus apariciones como ladrón y como proveedor de placeres corporales. Proponemos que la forma en que los cocineros son representados en la palliata de Plauto pone en evidencia (...) el vínculo que la axiología republicana establece entre actores sociales subalternos, corporalidad y amenaza a los mores maiorum. This paper examines some characteristics of the coquus mask in the plautine corpus. First, we study how this character, from references to physical punishment and sexual passivity, is built as a subordinate body to the service of others. Then, we consider his appearances as a thief and a provider of bodily pleasures. We propose that the way cooks are represented in Plautus' palliata shows us the link established by Republican axiology between subaltern social actors, body and threat to mores maiorum. (shrink)

Las nuevas prácticas pedagógicas buscan un camino donde el educador se encuentre con el educando de manera horizontal, debido a que el conocimiento no se limita a un aula. Por ello surge el término de educación expandida, que apoya la idea de que la educación trasciende y traspasa la escuela y empatiza con los nuevos escenarios tecnológicos de comunicación. El objetivo de la investigación consistió en diagnosticar y categorizar la educación expandida en tres casos de la Universidad UNIMINUTO, los cuales (...) tuvieron impacto en la transformación dentro de la interacción e intercambio de saberes de las practicas pedagógicas. (shrink)

Sebbene la ricchezza espressiva e la versatilità della scrittura di J.M. Coetzee si prestino ad una varietà di studi e considerazioni che riescono a coinvolgere molteplici discipline, solo i saggi che compongono il presente volume si impongono come un primo importante studio volto a comprendere, in maniera più sistematica, l’ampia pluralità di voci che caratterizza la critica coetziana. Il volume, dunque, riesce a superare le analisi meramente settoriali e unilaterali perché, cogliendo le pro...

Questo studio investiga quali siano i punti di contatto tra il filosofo tedesco Friedrich Nietzsche e lo scrittore svedese Hjalmar Söderberg nel romanzo di quest’ultimo Doktor Glas. L’articolo prende in esame due testi nietzschiani finora poco messi in relazione con l’opera söderberghiana, Über Wahrheit und Lüge im außermoralischen Sinne e Die fröhliche Wissenschaft, evidenziando gli influssi che il pensiero del filosofo tedesco ha esercitato sulla concezione del Doktor Glas. L’analisi prende le mosse dai concetti di menzogna e conoscenza così come (...) formulati in Über Wahrheit und Lüge im außermoralischen Sinne e dal concetto di “morte di Dio”, identificando in quest’ultimo il crollo della metafisica nel pensiero filosofico europeo a partire dalla rivoluzione copernicana. Il saggio illustra come a questo cambiamento sia sopraggiunto lo svilupparsi di una nuova sensibilità tecnico-scientifica legata alla physis, cambiamento che vede nella figura del medico il suo massimo esponente. L’articolo mette dunque in luce come nel Doktor Glas il passaggio dalla metafisica alla physis venga rappresentato come un momento di crisi esistenziale, non avendo il medico la capacità di superare il trauma della perdita della metafisica. Quest’incapacità è causata dalla conoscenza, la quale se offre la possibilità di scoprire le menzogne usate dalla società, non consente però di trovare lo stimolo per superare la condizione di vuoto causata dalla “morte di Dio”. Söderberg fornisce dunque nel suo romanzo un’interpretazione pessimistica della crisi di Fin de siècle, inquadrando nella paralisi interiore del dottor Tyko Gabriel Glas e l’omicidio inconcludente del pastore Gregorius il fallimento del passaggio dal paradigma metafisico al paradigma della physis e l’impossibilità di superare la crisi tramite una metamorfosi nella condizione di Übermensch. (shrink)

El objetivo de este estudio es evaluar la percepción de la inclusión educativa en sus dimensiones de políticas, prácticas y cultura de los directivos, docentes y asistentes de la educación, considerando las variables rol y género, en centros educativos de nivel secundario de la octava región del Biobío de Chile. La metodología es cuantitativa de carácter descriptivo, con un diseño no experimental transaccional, la muestra está compuesta de 346 profesionales. Los resultados generales arrojan una percepción muy favorable hacia la dimensión (...) prácticas inclusivas, tanto en la variable rol los directivos y en género las mujeres. (shrink)

Este artículo presenta un análisis teórico de la incorporación del concepto de interseccionalidad en el discurso jurídico, para posteriormente, adentrarse al estudio de las iniciativas de norma constitucional que buscan consagrarlo en la propuesta de nueva Constitución de Chile.

This article addresses, experimentally, the question of how presuppositions are cognitively processed and retrieved in discourse. In the proposed research, we have administered tweets produced by Italian politicians to native speakers so as to assess how easily they could retrieve the presupposed content of two presupposition triggers (definite descriptions and change of state verbs), as opposed to their explicit paraphrase, by answering verification questions. Results showed that content presupposed by change of state verbs was likely to receive more attention than (...) content conveyed by definite descriptions; this could possibly be due to the greater effort involved in mentally representing the event taken for granted by the predicates. Definite descriptions, on the contrary, seem to instruct to a shallower processing modality, which means that their content is processed less attentively or in a ‘good-enough’ way. (shrink)

Teniendo en cuenta la relevancia que Aristóteles le atribuye a la educación musical en _Política_ VII-VIII resulta extraño que no haga mención a ella ni en sus obras éticas ni, sobre todo, en la _Poética_. En los últimos treinta años los intérpretes han recurrido a diversas explicaciones para elucidar el silencio político de su _Poética_. Sin embargo, la principal conexión la ofrece el propio Aristóteles cuando en _Pol_. VIII 7, 1341 b 36-40 promete explicar con mayor claridad qué entiende por (...) _kátharsis_ en sus escritos sobre poética. La continuidad implícita que traza entre ambas obras revela a la vez semejanzas y diferencias en lo que respecta a las emociones que, en cada caso, están involucradas en la _kátharsis_. El propósito del presente artículo es señalar los principales puntos de contacto entre el programa de educación musical que bosqueja en _Política_ y las consideraciones que expone en _Poética_, atendiendo no solo a los distintos aspectos destacados por las interpretaciones más recientes, sino en especial al vínculo que el propio Estagirita establece y que permite pensar dicha conexión a partir de las emociones que la _kátharsis_ pone en juego. (shrink)

El artículo se propone caracterizar la Extensión Crítica, como una alternativa modalidad emergente, desde una perspectiva epistemológica. Caracteriza al conocimiento propio de la misma como orientado por un interés emancipador, lo que supone procesos de autorreflexión, concientización, crítica ideológica y praxis. Es un conocimiento práctico para la acción y que se construye en y desde la acción. Su modo de producción propone una epistemología que reconoce al otro como sujeto cognoscente y legitima reflexivamente sus saberes silenciados, proponiendo incluir el punto (...) de visa de los excluidos y, por lo tanto, una epistemología extendida, que articula conocimientos experienciales, proposicionales, representacionales y prácticos, así como científicos, populares, cotidianos y nativos. La complejidad de los problemas socio-políticos abordados desde la Extensión Crítica interpela a abordajes interdisciplinares y a la conformación de comunidades de prácticas. Finalmente, se proponen otros criterios de validación de este tipo de conocimiento, diferentes a los considerados en el campo de la extensión clásica: validez comunicativa, operatividad pragmática, empoderamiento, congruencia entre diferentes tipos de conocimiento y credibilidad. (shrink)

Indirect speech is a remarkable trait of human communication. The present paper tackles the sociobiological underpinnings of communicative indirectness discussing both socio-interactional and cognitive rationales behind its manifestation in discourse. From a social perspective, the use of indirect forms in interactions can be regarded as an adaptive response to the epistemic implications of transacted new information in small primary groups, representing – in Givón’s terms – our “bio-cultural” descent. The design features of indirect strategies today may therefore be explained in (...) terms of a form-function mapping in which indirect communicative expressions allowed a “safer” transaction of contents and a more cooperative attitude of speakers in both face-to-face and public contexts of communication. The unchallengeability effects notably induced by underencoded meanings have now received extensive experimental backing, unveiling intriguing underlying cognitive mechanisms such as the well-known cognitive illusions or fallacies. (shrink)