To ensure accurate chromosome segregation during mitosis, the spindle checkpoint monitors chromosome alignment on the mitotic spindle. Indjeian and colleagues have investigated the precise role of the shugoshin 1 protein (Sgo1p) in this process in budding yeast.1 The Sgo proteins were originally identified as highly conserved proteins that protect cohesion at centromeres during the first meiotic division. Together with other recent findings,2 the study highlighted here has identified Sgo1 as a component that informs the mitotic spindle checkpoint when spindle tension (...) is perturbed. This discovery has provided a molecular link between sister chromatid cohesion and tension‐sensing at the kinetochore–microtubule interface. BioEssays 27:588–591, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

The foundation of the Christian counselling movement -- Christian counselling in the UK -- The aims of Christian counselling -- Integrating psychological and biblical truth -- Sigmund Freud--the founding father of psychotherapy -- The individual psychology of Alfred Adler -- Abraham Maslow--the man with new age tendencies -- Carl Rogers--a man who believed in himself -- Albert Ellis--the aggressive atheist -- The Bible's verdict on psychological 'truth' -- The case against Larry Crabb -- Self-esteem: the secular foundation -- Self-esteem and (...) the Christian counselling movement -- Self-esteem dogma in the light of scripture. (shrink)

William Connolly presents a lucid and concise defense of the thesis of "essentially contested concepts" that can well be read as a general introduction to political theory, as well as for its challenge to the prevailing understanding of political discourse. In Connolly's view, the language of politics is not a neutral medium that conveys ideas independently formed but an institutionalized structure of meanings that channels political thought and action in certain directions. In the new preface he pursues the implications (...) of this perspective for a distinctive conception of ethics and democracy. (shrink)

What the Church teaches and why on issues of euthanasia, invitro fertilization, genetic counseling, assisted suicide, living wills, persistent vegetative state, organ transplants, and more.

This article offers a fresh assessment of the views of the American paleontologist and evolutionary biologist Stephen Jay Gould on the relation of science and religion. Gould is best known for his celebrated notion of “nonoverlapping magisteria,” which is often seen in somewhat negative terms as inhibiting dialogue. However, as a result of his critique of the unificationist approach to knowledge developed in Edward O. Wilson's Consilience, Gould later made increased use of the more positive notion of (...) a “consilience of equal regard,” which recognized the porous nature of disciplinary divides and the propriety of interdisciplinary dialogue. Gould's final views on the relation of science and religion, set out in The Hedgehog, the Fox, and the Magister's Pox, published after his death, affirms the distinctiveness and autonomy of science and religion on the one hand, while encouraging their constructive dialogue and productive interaction on the other. This should now be seen as Gould's definitive statement on this question. (shrink)

But in Why I Am Not a Secularist, distinguished political theorist William E. Connolly argues that secularism, although admirable in its pursuit of freedom and diversity, too often undercuts these goals through its narrow and intolerant ...

Complexity, agency, and time -- The vicissitudes of experience -- Belief, spirituality, and time -- The human predicament -- Capital flows, sovereign decisions, and world resonance machines -- The theorist and the seer.

1 Non-reductive physicalists deny that there is any explanation of mentality in purely physical terms, but do not deny that the mental is entirely determined by and constituted out of underlying physical structures. There are important issues about the stability of such a view which teeters on the edge of explanatory reductionism on the one side and dualism on the other (see Kim 1998). 2 Save perhaps for eliminative materialism (see Churchland 1981 for a classic exposition). In fact, however, while.

In _The Fragility of Things_, eminent theorist William E. Connolly focuses on several self-organizing ecologies that help to constitute our world. These interacting geological, biological, and climate systems, some of which harbor creative capacities, are depreciated by that brand of neoliberalism that confines self-organization to economic markets and equates the latter with impersonal rationality. Neoliberal practice thus fails to address the fragilities it exacerbates. Engaging a diverse range of thinkers, from Friedrich Hayek, Michel Foucault, Hesiod, and Immanuel Kant to (...) Voltaire, Terrence Deacon, Friedrich Nietzsche, and Alfred North Whitehead, Connolly brings the sense of fragility alive as he rethinks the idea of freedom. Urging the Left not to abandon the state but to reclaim it, he also explores scales of politics below and beyond the state. The contemporary response to fragility requires a militant pluralist assemblage composed of those sharing affinities of spirituality across differences of creed, class, gender, sexual orientation, and ethnicity. (shrink)

Paralogismen betreffs der Leibnizschen Prädikatlehre werden aufgezeigt und widerlegt. Enthaltensein heißt die Inverse von Ableitung; den zwei Arten von Ableitung, die Leibniz kennt, entsprechen zwei Arten von Enthaltensein. Die beiden Arten von Enthaltensein bieten Leibniz die Möglichkeit zu der logischen und irreduziblen Unterscheidung zwischen notwendigen und bedingten Wahrheiten. Die Unterscheidung zwischen einem Individuum und einer Eigenschaft wird mit mengentheoretischen Methoden und auch mit Hilfe von epistemologischen Begriffen untersucht. Die besondere kategorische Form des Aussagesatzes impliziert, daß es für alle Aussagesätze nur (...) eine einzige Tiefen-Grammatik gibt, welche wesentlich verschiedene Ausdruckweisen von kategorischen Aussagen umfaßt. (shrink)

In this foundational work in contemporary political theory, William Connolly makes a distinctive contribution to our understanding of the relationship between ...