Membrane proteins possess certain features that make them susceptible to the electric fields generated at the level of the plasma membrane. A reappraisal of cell signalling, taking into account the protein interactions with the membrane electrostatic profile, suggests that an electrical dimension is deeply involved in this fundamental aspect of cell biology. At least three types of potentials can contribute to this dimension: (1) the potential across the compact layer of water adherent to membrane surfaces; this potential is affected by (...) classical inducers of cell differentiation, like dimethylsulfoxide and hexamethylenebisacetamide; (2) the potential across the Gouy‐Chapman double layer, which accounts for the effects of extracellular cations in the modulation of differentiation; and (3) the resting potential. This last potential and its governing ion currents can be exploited in localised mechanisms of cell signalling centred on the functional association of integrin receptors with ion channels. (shrink)

Mental imagery has often been taken to be equivalent to “sensory imagination”, the perception‐like type of imagination at play when, for example, one visually imagines a flower when none is there, or auditorily imagines a music passage while wearing earplugs. I contend that the equation of mental imagery with sensory imagination stems from a confusion between two senses of mental imagery. In the first sense, mental imagery is used to refer to a psychological attitude, which is perception‐like in nature. In (...) the second sense, mental imagery refers to a mental content, which can be grasped via different attitudes. I will show that failure to acknowledge the distinction between these senses of mental imagery has muddled philosophical discussion. This distinction brings much needed clarity to debates where sensory imagination and mental imagery are invoked, shedding light on issues such as the nature of imagistic mental states, and the representational powers and limits of mental imagery. I will conclude by sketching a general attitudinal account of imagination that does justice to both senses of mental imagery, outlining a promising framework for understanding imagination. (shrink)

Aphantasia, a recently labelled spectrum condition affecting mental imagery, has brought to the fore the centrality of imagination in our lives. Intuitively it may seem that we cannot have a normal life without the possession of imaginative abilities. Yet, aphantasics do not seem to be much affected by their condition. Can aphantasia tell us anything about the nature and role of our imaginative abilities? I contend that an important distinction that can shed light on this question has been largely overlooked, (...) namely that between two senses of mental imagery: as a type of mental content (viz., mental imagery strictly speaking), and as a kind of psychological attitude (viz., sensory imagination). Drawing on this distinction, I suggest three possible conditions: (i) impairment in mental imagery only, (ii) impairment in sensory imagination only, (iii) impairment in both mental imagery and sensory imagination. I show that core cases of aphantasia are better understood as impairments in sensory imagination only, but I indicate empirical strategies to investigate whether some cases of aphantasia rather involve impairments in mental imagery, which would point toward a plurality of forms of aphantasia. Sensory imagination, however, does not exhaust the imaginative realm, therefore we shouldn’t jump to the hasty conclusion that aphantasics have no imagination. Most aphantasics lack sensory imagination, but arguably can exploit other forms of imagination. This would explain in which sense they still possess imaginative abilities. (shrink)

Supposition is frequently invoked in many fields within philosophy, including aesthetics, philosophy of mind, philosophy of science and epistemology. However, there is a striking lack of consensus about the nature of supposition. What is supposition? Is supposition a sui generis type of mental state or is it reducible to some other type of mental state? These are the main questions Margherita Arcangeli explores in this book. She examines the characteristic features of supposition, along the dimensions of phenomenology and emotionality, (...) among others, in a journey through the imaginative realm. An informed answer to the question “What is supposition?” must involve an analysis of imagination, since supposition is so often defined in opposition to the latter. She assesses rival explanations of supposition putting forward a novel view, according to which the proper way of seeing supposition is as a primitive type of imaginative state. Supposition and the Imaginative Realm: A Philosophical Inquiry will be of great interest to students of philosophy of psychology, aesthetics, philosophy of mind, philosophy of science and epistemology. (shrink)

La sapienza di partire da sè è una via che si sottrae alle molte contrapposizioni che sono iscritte nel simbolico dominante: quella tra soggettivo e oggettivo, tra individuo e comunità e tra locale e generale: apre un'altra strada.

Awe seems to be a complex emotion or emotional construct characterized by a mix of positive (contentment, happiness), and negative affective components (fear and a sense of being smaller, humbler or insignificant). It is striking that the elicitors of awe correspond closely to what philosophical aesthetics, and especially Burke and Kant, have called “the sublime.” As a matter of fact, awe is almost absent from the philosophical agenda, while there are very few studies on the experience of the sublime as (...) such in the psychological literature. The aim of this paper is to throw light on the complex relationship between awe (as understood by psychologists) and the experience of the sublime (as discussed by philosophers). We distinguish seven ways of conceiving this relationship and highlight those that seem more promising to us. Once we have a clearer picture of how awe and the experience of the sublime are related, we can use it to enhance collaboration between these domains. We would be able to use empirical results about awe in a philosophical analysis of the experience of the sublime, which in turn can help us to design novel experimental hypotheses about the contexts in which we experience awe. (shrink)

A popular view maintains that supposition is a kind of cognitive mental state, very similar to belief in essential respects. Call this view “cognitivism about supposition”. There are at least three grades of cognitivism, construing supposition as (i) a belief, (ii) belief-like imagination or (iii) a species of belief-like imagination. I shall argue against all three grades of cognitivism and claim that supposition is a sui generis form of imagination essentially dissimilar to belief. Since for good reasons (i) is not (...) supported in the literature, I shall dwell on (ii) and (iii). Without further explanation supposition has been very often merely postulated as being nothing but belief-like imagination—that is, (ii). I shall show that at least two considerations undermine (ii). First, supposition and belief-like imagination are governed by different norms, more precisely the former is freer than the latter and requires minimal or no mental effort. Second, contrary to belief-like imagination, supposition is “cold”, in that it is typically dissociated from emotional reactions. Proponents of (iii) face the pressure of explaining these differences between supposition and belief-like imagination too. I shall argue that they have not sufficiently motivated the claim that supposition is belief-like. In particular they fail to accommodate precisely the dimensions of supposition pertaining to its normativity and emotionality. I shall close with a sketch of a new account of supposition. (shrink)

The scientist’s toolkit counts at least three practices: real, thought and numerical experiments. Although a deep investigation of the relationships between these types of experiments should shed light on the nature of scientific enquiry, I argue that it has been compromised by at least four factors: (i) a bias for the epistemological superiority of real experiments; (ii) an almost exclusive focus on the links between either thought or numerical experiments, and real experiments; (iii) a tendency to try and reduce one (...) kind to another; and (iv) an excessive attention to the outputs of these types of experiments, more than to their processes. In this paper I support an unbiased triangular comparative analysis that focuses on the processes involved in real, thought and numerical experiments, and claim that all three types of experimentation are fundamental to scientific research. I do so by clarifying different notions of experimental processes, and by introducing a distinction between two varieties of mental simulation that play a role in them (i.e., mental models and imaginings). I then compare real, thought and numerical experiments in light of this distinction, showing their similarities, but also fundamental differences, which suggest that none of them is dispensable. (shrink)

A widespread claim, which I call ‘the Emotionality Claim’, is that imagination but not supposition is intimately linked to emotion. In more cognitive jargon, imagination is connected to the affect system, whereas supposition is not. EC is open to several interpretations which yield very different views about the nature of supposition. The literature lacks an in-depth analysis of EC which sorts out these different readings and ways to carve supposition and imagination at their joints. The aim of this paper is (...) to fill this gap. I shall argue that existing readings of EC fail to properly account for the emotional asymmetry between imagination and supposition. The tendency is to start from narrow conceptions of both imagination and supposition. I shall argue for a novel interpretation of EC pivoting on different ways a mental state can connect to the affect system. (shrink)

Imagination is widely thought to come in two varieties: perception-like and belief-like imagination. What precisely sets them apart, however, is not settled. More needs to be said about the features that make one variety perception-like and the other belief-like. One common, although typically implicit, view is that they mimic their counterparts along the conceptuality dimension: while the content of belief-like imagination is fully conceptual, the content of perception-like imagination is fully non-conceptual. Such a view, however, is not sufficiently motivated in (...) the literature. I will show that there are good reasons to reject it and I will argue that both varieties of imagination involve fully conceptual contents. I will suggest an alternative way to draw the distinction between perception-like and belief-like imagination along the conceptuality dimension, according to which only perception-like imagination requires observational concepts. (shrink)

We attribute the capability of imagination to the madman as to the scientist, to the novelist as to the metaphysician, and last but not least to ourselves. The same, apparently, holds for thought experimentation. Ernst Mach was the first to draw an explicit link between these two mental acts; moreover -in his perspective- imagination plays a pivotal role in thought experimentation. Nonetheless, it is not clear what kind of imagination emerges from Mach’s writings. Indeed, heated debates among cognitive scientists and (...) philosophers turn on the key distinction between sensory and cognitive imagination. Generally speaking, we can say that sensory imagination shares some processes with perception, cognitive imagination with the formation of belief. Both the vocabulary used in the literature on thought experiments and what I refer to as “Machian tradition” indicate imagination as a notion of central importance in the reasoning involved in thought experiments. However, most authors have really focused on sensory (in particular, visual) imagination, but have neglected the second kind. Moreover, some authors attribute to Mach the idea that it is visual imagery that is primarily at work in thought experiments. I claim another interpretation is possible, according to which Mach can be said to deal with cognitive imagination. The main aim of this paper is to retrace Mach’s original arguments and establish a connection with the cognitive literature on imagination. I will argue that imagination tout court could play a role in thought experimentation. Once imagination is seen as the key to the “cognitive black-box” of the thought experiment, we will have moved a step closer to a simulative imagining-based account of thought experimentation. (shrink)

Riassunto La punizione inflitta, nel 211 a. C., ai Campani, municipes sine suffragio, per la loro defezione ad Annibale, era stata assunta da una parte del senato a paradigma anche per i soci Tarentini, nel 208 a. C., rei allo stesso modo. Tale valutazione politica poggiava sull’assunto che la pena dovesse essere commisurata alla colpa, indipendentemente dal differente statuto giuridico dei defezionisti. Questa è espressione della linea rigorista perseguita contro i traditori, tra alti, da Q. Fulvius Flaccus, all’opposto di quella (...) moderata e pragmatica sostenuta da Q. Fabius Maximus. (shrink)

When we remember a past situation, the emotional import of the latter often transpires in a modified form at the phenomenological level of our present memory. When it does, we experience what is sometimes called an “affective memory.” Theorists of memories have disagreed about the status of affective memories. Sceptics claim that the relationship between memory and emotion can only be of two types: either the memory is about a past emotion (the emotion is part of what is remembered), or (...) it causes a present emotion (the emotion is a separable effect of the memory). We argue that there is a third option, which points to an emotional way of representing the past situation. Drawing from Peter Goldie’s account of mental narratives, we show that three levels of mental perspective are involved in memories: the perspective of the represented subject (the character, if there is one), the perspective of the representing subject (the author), and the intermediary perspective of the narrator (who may remain virtual). Affective memories are cases in which the narrator’s emotional perspective has direct implications for the author’s emotional perspective, even if the former typically differs from the latter. (shrink)

Aesthetics, both in its theoretical and empirical forms, has seen a renewed interest in the sublime, an aesthetic category dear to traditional philosophers, but quite neglected by contemporary philosophy. Our aim is to offer a novel perspective on the experience of the sublime. More precisely, our hypothesis is that the latter arises from ‘a radical limit-experience’, which is a metacognitve awareness of the limits of our cognitive capacities as we are confronted with something indefinitely greater or more powerful than us. (...) This hypothesis better explains the negative feelings involved in the experience of the sublime and accounts for its demarcation from other experiences (for example, terrible beauty). Experiences of the sublime have an overall positive valence, though. We will explore different ways in which a subject can try to overcome the negative evaluation involved in radical limit-experiences, and suggest that only one of them is appropriate to experiences of the sublime. (shrink)

Imagination is analysed by contemporary philosophers of mind in order to discover its features and its place in our cognitive architecture. More precisely, the debate has given birth to two competing approaches: simulationism and single-code theory. However, a third, intermediary view, is possible, as Mulligan’s proposal suggests. In this paper I propose a certain type of simulationism, namely a conception of imagination based on a homomorphic functional simulation. Inspired by Mulligan’s position, I will argue that this type of simulationism is (...) in fact neutral with respect to the disagreement between classical simulationists and single-code theorists. It can even be regarded as the common ground of these approaches. (shrink)

Over the past twenty years the expression “thought experiment” (Gedankenexperiment) has become part of the philosophical vocabulary. Galileo’s thought experiment on the fall of bodies is an example that shows how thought experimentation might be an important scientific tool in order to acquire new knowledge. Nonetheless, the epistemological validity of thought experiments is still questioned in the domains different from physics. The paper aims to investigate whether the thought experimentation is really proper to physics. For this sake, biology will be (...) our testbed. The skeptical view on biological thought experiments, e.g. Snooks, implies that the thought experiment is not an experiment; it is just the copy of a real one. We adopt a more positive view, inspired by Bokulich and Lennox, and we apply it to some Darwinian thought experiments. This analysis points to the fact that, much alike thought experiments in physics, Darwin’s ones in biology test the non-empirical criteria of a theory. Therefore, we advance the hypothesis that even biological thought experiments participate to such a re-ordering of processes and mechanisms, as to push a theory beyond its time. (shrink)

The idea of the present Issue originated in a workshop held at the University of Urbino, Italy, in June 2014, and subsequently developed into an independent editorial project by including contributions that were not initially presented at the workshop. The eight essays that follow authored by young and emerging philosophers as well as fully accomplished ones—touch upon various aspects of the most recent debate surrounding TEs, closely engaging with many influential proposals that have been put forward over the last few (...) years. They can be organised around three main areas of concern. The first group deals with general issues raised by the use of TEs, such as the possibility of drawing a principled distinction between scientific and philosophical TEs (Marco Buzzoni), the role played by intuitions within philosophical TEs (Julia Langkau), and the different ways in which the intended conclusion of a TE can be resisted (Roy Sorensen). The second group focuses on the logical form of philosophical TEs (Sören Häggqvist; Daniele Sgaravatti), and on the kind of access to modal knowledge they are standardly taken to provide (Vittorio Morato). The third and last group explores the virtues and limits of TEs used in two specific philosophical areas, namely the philosophy of science (Margherita Benzi), and the philosophy of mind (Elizabeth Schier). (shrink)

A review of Anežka Kuzmičová´s Mental Imagery in the Experience of Literary Narrative: Views from Embodied Cognition (Stockholm: Stockholm University, 2013, 177 pp. ISBN 978-91-7447-660-6).

The e-mail address of the second author was incorrectly published in the original article. The author’s correct e-mail address is given in this correction.

Dialectica, Volume 73, Issue 4, Page 598-602, December 2019.

Contents: 1) Peter Kung, Why We Need Something Like Imagery; 2) Derek Lam, An Imaginative Person’s Guide to Objective Modality; 3) Rebecca Hanrahan, Crossing Rivers: Imagination and Real Possibilities; 4) Michael Omoge, Imagination, Metaphysical Modality, and Modal Psychology; 5) Joshua Myers, Reasoning with Imagination; 6) Franz Berto, Equivalence in Imagination; 7) Christopher Badura, How Imagination Can Justify; 8) Antonella Mallozzi, Imagination, Inference, and Apriority; 9) Margherita Arcangeli, Narratives and Thought Experiments: Restoring the Role of Imagination; 10) Margot Strohminger, Two (...) Ways of Imagining Galileo’s Experiment; 11) Eric Peterson, Attention to Details: Imagination, Attention, and Epistemic Significance; 12) Amy Kind, Bridging the Divide: Imagining Across Experiential Perspectives; 13) Julia Langkau, On Imagining Being Someone Else; 14) Luke Roelofs, “Imagine If They Did That to You!”: The Complexity of Empathy; 15) Nick Wiltsher and Bence Nanay, Imagination, Selves, and Knowledge of Self: Pessoa’s Dreams in The Book of Disquiet . (shrink)

By the start of the twenty-first century, the notion of ‘the sublime’ had come to seem incoherent. In the last ten years or so considerable light has been shed by empirical psychologists on a related notion of ‘awe’, and a fruitful dialogue between aestheticians and empirical psychologists has ensued. It is the aim of this paper to synthesize these advances and to offer what I call a ‘two-tiered’ theory of the sublime that shows it to be a coherent aesthetic category. (...) On this theory, sublime experiences begin in an ‘awe response’ (the ‘thin sublime’) and might, with the additional element of temporally-extended reflection, turn into a ‘thick sublime’ response. Building on accounts of the sublime as a species of ‘aesthetic awe’ (Clewis, 2019a and 2019b; Arcangeli, et al., 2020) I aim to show that this two-tiered theory helps to explain why sublime experiences seem to have a basic, primordial core, but also seem to be historically and culturally quite variable (as Nicolson, 1963 [1959]; Battersby, 2007; and McMahon, 2017 have stressed). On this model, the cultural and historical variability comes in largely at the point of the temporally-extended reflection characteristic of the thick sublime, due to the cognitive stock that the subject brings to the encounter. Thus, sublime experiences really lend themselves to being interpreted quite variously by the subject (as well as by the theorist) of these experiences, as, for example, affording insight into the Divine, our moral vocation, or our metaphysical unity with the entire universe, among other lofty thoughts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Latin Lay Piety in an Islamic Context:The Development of the Third Order Community of St. Mary's of Mt. Sion in Mamluk Jerusalem1Jon Paul Heyne (bio)In the spring of 1353, roughly half a century after the Latin world's loss of Acre, the Florentine lady Sofia degli Arcangeli purchased lands in Mamluk Jerusalem for the establishment of a pilgrim hospital run by a group of select companions.2 Thus began the (...) Latin hospice of St. Mary's of Mt. Sion. For twenty years under Sofia's direction, the foundation obtained numerous privileges from the popes until suddenly, in 1375, Gregory XI denounced Sofia, forbidding her continued association with the hospital. Shortly thereafter, care of St. Mary's fell into the hands of a community of Franciscan friars living in Jerusalem—members of the recently formed Franciscan Custody of the Holy Land—who in turn established various regulations for the workers at the hospital, identified simply as women (mulieres) of the hospice.3 By the fifteenth century, the community at St. Mary's was transformed into a female house of Third Order Franciscans directly under the authority of the Custody, which, [End Page 33] for its own part, had adopted the regular Observance sub vicariis of the Franciscan order.The story of Sofia's hospital and its associated house of workers raises important questions regarding the relationship of penitential lay communities to the papacy and to the mendicant orders in the late medieval period. At first glance, St. Mary's appears simply to have encountered the same fate of many quasi-religious groups in the fourteenth and fifteenth centuries; driven by papal, clerical, and Observant efforts to establish uniformity and avoid heresy among lay penitents, the hospice fell under the supervision of the Franciscans, and the women living and working there were made tertiary members of the friars' order. Was, however, this clerical interest in regulating penitential groups the primary driving force in the development and transformation of Sofia's hospital? How did the hospital's location in Jerusalem, a city under Islamic rule, influence the dynamics that formed between Sofia and the popes and between the community at St. Mary's and the nearby Franciscan monastery? I argue that both the popes' changing relationship with Sofia and the formation of closer ties between the hospice community in Jerusalem and the Franciscan Custody had as much or more to do with the opportunities and challenges presented by the hospital's position as a Latin establishment in the Mamluk Empire as it did with clerical preoccupations to promote uniformity in the late medieval Church. Thus, the history of St. Mary's expands upon recent scholarly understandings of the creation of the third orders, offering a view of these tertiary communities within the wider scope of Muslim-Christian relations in the Mediterranean.Before examining the history of St. Mary's, I offer a brief overview of recent scholarship on female tertiary communities.4 Traditional narratives on the Franciscan Third Order assert that the tertiaries officially began with St. Francis or at the very least with the creation of an "order of penitents" through the 1289 bull Supra montem.5 Several studies have challenged this older interpretation, describing the formation of the Third [End Page 34] Order Franciscans as a much messier and less coherent process spanning the thirteenth through sixteenth centuries.6 According to some of the most recent revisionist approaches, female penitential establishments first fell under increased clerical scrutiny and canonical regulation in the late thirteenth century and early fourteenth centuries.7 Nonetheless, despite such ecclesiastical efforts to conform penitential groups to more traditional forms of religious life—by requiring enclosure, a rule, and the direct association with an existing order—many lay communities remained merely quasi-religious and even those that adopted Supra montem as a "rule" were only superficially connected to the Franciscan friars. Indeed neither the lay communities nor the friars were typically interested in a more official or direct association, and the adoption of Supra montem was primarily a means by which female penitents put on the façade of a regulated monastic lifestyle so as to evade potential accusations that they were inappropriately... (shrink)