Though genome editing is a powerful technology, germline GE engineering is strongly objectionable for a huge ethical challenge. The after-effects of the genome-edited babies incident have been emerging in China, whether technology or ethics. It is very noticeable that the case has been adverse effects on the application of GE technology in other fields, especially in GE crops. After the incident, research and development of GE crops was affected obviously. It is clear that GE crops and other basic research and (...) application related to GE technology should be encouraged and should not be treated differently. An ethically acceptable development route of GE technology needs to be established in China. (shrink)

Our previous study has shown impaired blood oxygen level-dependent /functional magnetic resonance imaging activation of the visual attention network in strabismic amblyopia. However, there has been no comparison of resting state fMRI activation and functional connectivity in brain regions of interest along the visual attention network including visual cortex, intraparietal sulcus, and frontal eye fields during closed eye resting across the SA, or anisometropic amblyopes groups. Hence, we compared, gray matter volume, amplitude of low frequency fluctuations, regional homogeneity, and FC (...) in the left and right hemisphere ROIs of the visual attention network in SA, AA, and healthy controls. Correlation analyses of corrected visual acuity of amblyopic eye and MRI results were also performed and showed that the LogMAR cVA of the amblyopic eye positively correlated with right zALFF and zReHo FEF of SA and right IPS of AA only. GMV of both left and right hemisphere V1 areas was significantly greater but ALFF was significantly lower for SA compared to AA and HC groups. zALFF and zReHo analyses in the AA and SA groups indicated significantly higher activation than that in the HC group in the right FEF and IPS but lower than that in the HC group in the left FEF, and only the SA group showed lower activation in both V1 areas than the HC group. FC values of the right FEF–left V1, right FEF–right V1, and right FEF–right IPS pathways in the SA and AA groups were also significantly higher than those in the HC group whereas all other FC values were non-significant. Thus, this study indicates that even during resting-state the visual attention network function is impaired in SA and AA participants with only right hemisphere FEF showing significant activation in SA and IPS in AA suggesting that the slower saccade activation times characteristic of amblyopic eyes lead to the dominant eye controlling activation of the visual attention network. (shrink)

Indoor plants can positively impact physical and mental health in daily life. However, the benefits of viewing indoor plants may be enhanced if the plants emit a fragrant aroma. In this crossover-design study, we measured the physiological and psychological effects of fragrant and non-fragrant Primula plants on 50 female college students, and explored whether aroma stimulation had additive benefits for this group. Non-fragrant Primula malacoides Franch was used as a control stimulus, and Primula forbesii Franch, which has a floral fragrance, (...) was used as an experimental stimulus. We measured blood pressure, pulse rate, and electroencephalogram to evaluate physiological responses, and used a mood state profile and the semantic differential method to evaluate psychological responses. We found that mean blood pressure and pulse rate decreased significantly after the experiment in both conditions. EEGs showed that the mean values of high alpha waves, high beta waves, and relaxation scores were significantly higher in the experimental vs. control condition. The average scores on each subscale of the psychological questionnaire improved after the experiment in both conditions, and the vitality subscale and total emotional state scores were significantly better in the experimental vs. control condition. The results of the SD method showed that the sense of relaxation and comfort were significantly higher in the experimental vs. control condition. Compared with the non-fragrant Primula, the fragrant Primula induced relatively better physiological and psychological effects. (shrink)

本书包含了英美基本逻辑教程中应该包含的全部题材,用对话的形式对逻辑的应用、纯逻辑的训练等方面的问题进行了讲解。.

本书是一本汇集古今中外法律名著经典论述并加以简单评点的书,传播先进的法治思想和理念,树立先进的、文明的执法理念。.

The issue of how to identify the liability of subjects after a traffic accident takes place remains a puzzle regarding the SAE classification system. The SAE system is not good at dealing with the problem of responsibility evaluation; therefore, building a new classification system for self-driving cars from the perspective of the subject's liability is a possible way to solve this problem. This new system divides automated driving into three levels: i) assisted driving based on the will of drivers, ii) (...) automated driving based on the will of the manufacturers, and iii) fully automated driving based on social will. The corresponding responsible subjects for level one, level two, and level three are the drivers, the manufacturers, and society, respectively. (shrink)

The introduction of digital technologies in collective actions seems to have transformed the dynamics of movement organizing and enabled divergent forms of protest organizing. While some studies emphasize “organizationless” organizing in which traditional organizational forms—social movements organizations and formal-bureaucratic structures—have been pushed into the margins, other studies showcase how traditional forms have assumed alternative features, for example, connective leadership and organizations with fluid boundaries. While existing research correctly points out the evolving organizing dynamics and forms in digital activism, few studies (...) have accounted for why digitally enabled protests take certain organizing forms over others among multiple modes of interaction between protesters and digital technologies. Using a case study of a protest campaign organized by Chinese American immigrants, this study illustrates why immigrant activists struggled to keep the campaign “organizationless” on WeChat, a China-based digital platform that afforded other forms of organizing over such an organizing mode. Building on the mechanism-based approach in social movement studies, the findings show that immigrant activists’ emotional–cognitive responses to the changing digital environments became the driving force behind the relational choices to maintain the protest “organizationless.” The study, therefore, may not only inform future studies to explore why certain structures of protest networks emerge and develop but also contribute to the mechanism-based approach by foregrounding emotional–cognitive mechanisms, which mediate environmental and relational mechanisms. (shrink)

In this paper I argue that Leibniz's ethics is a kind of virtue ethics where virtues of the agent are explanatorily primary. I first examine how Leibniz obtained his conception of justice as a kind of love in an early text, Elements of Natural Law. I show that in this text Leibniz's goal was to find a satisfactory definition of justice that could reconcile egoism with altruism, and that this was achieved through the Aristotelian virtue of friendship where friends treat (...) each other as “other selves.” Following this decisive moment, Leibniz adopted an Aristotle‐inspired ethical framework where the virtuous agent is central for moral evaluations. I then show that, despite certain developments, Leibniz's ethics retained this essential feature throughout his career. In Leibniz's later writings, God constitutes the foundation of the moral realm, and the fundamental moral endeavor of human beings consists in the imitation of God. (shrink)

This paper proposes an extended version of the interventionist account for causal inference in the practical context of biological mechanism research. This paper studies the details of biological mechanism researchers’ practices of assessing the evidential legitimacy of experimental data, arguing why quantity and variety are two important criteria for this assessment. Because of the nature of biological mechanism research, the epistemic values of these two criteria result from the independence both between the causation of data generation and the causation in (...) question and between different interventions, not techniques. The former independence ensures that the interventions in the causation in question are not affected by the causation that is responsible for data generation. The latter independence ensures the reliability of the final mechanisms not only in the empirical but also the formal aspects. This paper first explores how the researchers use quantity to check the effectiveness of interventions, where they at the same time determine the validity of the difference-making revealed by the results of interventions. Then, this paper draws a distinction between experimental interventions and experimental techniques, so that the reliability of mechanisms, as supported by the variety of evidence, can be safely ensured in the probabilistic sense. The latter process is where the researchers establish evidence of the mechanisms connecting the events of interest. By using case studies, this paper proposes to use ‘intervention’ as the fruitful connecting point of literature between evidence and mechanisms. (shrink)

di 1 juan. Zheng lun pian -- di 2 juan. Zhe xue pian -- di 3juan. Wen hua pian -- di 4 juan. Shu xin yu sui bi pian.

Ben shu jie shao le gong zi zhen, wei yuan, yan fu, kang you wei, tan si tong, liang qi chao, chen tian hua, zhang bing lin deng wan qing si xiang jia de zhe xue si xiang.

Noted logician and philosopher addresses various forms of mathematical logic, discussing both theoretical underpinnings and practical applications. After historical survey, lucid treatment of set theory, model theory, recursion theory and constructivism and proof theory. Place of problems in development of theories of logic, logic’s relationship to computer science, more. Suitable for readers at many levels of mathematical sophistication. 3 appendixes. Bibliography. 1981 edition.

Purpose – This study aims to investigate the perceptions, acceptance, usage and access to social media by students and academics in higher education in informatics programs in Malaysia. A conceptual model based on Connectivism and communities of practice learning theory was developed and were used as a basis of mapping the research questions to the design frameworks and the research outcomes. A significant outcome of this study will be the development of a design framework for implementing social media as supporting (...) tools for student engagement and teaching and learning of informatics programs in higher education institutions in Malaysia. Design/methodology/approach – A mixed-method research methodology with a significant survey research component was employed for this research. This methodology focused on collecting and analyzing quantitative and qualitative data to better understand the research problems. For this study, a mixed-method sequential transformative research strategy based on a QUAN-Qual model was used in the data collection process. Mixed-method research methodology is considered to be most appropriate for this study, as it allows the researcher to gather multiple forms of data from diverse audiences such as educators, administrators and students. Findings – The findings show the close matched of the ownership, amount of hours spent online, types of social media technologies used and pattern of usage between informatics and non-informatics students. It also shows that many students and instructors have started to explore and accept the use of SMTs as a tool for engaging with their institution and their peers as well as for teaching and learning purposes. Innovative institutions need to understand the critical success factors and the barriers that restrict the implementation of SMTs within the HEI to take advantage of the opportunities offered by SMTs in higher education. Research limitations/implications – The surveys and interview participant, in part, are self-selecting, so the data collected cannot be claimed to be representative of the population. However, because of the relatively large number of participants, it can be considered that the findings are indicative. Other limitation includes the depth of data that can be collected using this methodology. Practical implications – There is wide range of social media usage in educational settings now being reported, but many issues are still unexamined. Limited studies have been focusing on the educators’ readiness, acceptance or refusal in integrating social media into their courses, the perceived effectiveness of the tools and student outcomes for their learning. The central outcome of this research will be the development of a design framework that will be used as a guide for Malaysian HEIs and informatics academics to engage students using SMTs in creating effective learning communities for informatics programs. Social implications – The framework will have implication for the social interaction and engagement of students with their institution. Originality/value – Very little work has been reported on student and academic engagement, their perspectives and perceived effectiveness of social media usage in higher education, especially in the Malaysia context. Most of the research focused only on the quantitative research with students from universities in the USA and Australia, with an emphasis mainly on student’s perception and acceptance. There are calls for more research to examine how social media is perceived and accepted by students and academics for teaching and learning, especially in Malaysia. (shrink)

本书是对由“教”而“学”的单向度教学,向教师引导与学生自主间的双向度转变进行的探索,论述了这种教育理想的生成、当代教育理想的建构等。.

In this paper I argue that there is a structural parallelism between law and physics in Leibniz since his early years, which has significant influence on the formation of his views. I start by examining Leibniz's early physical system and an analogy with juridical laws that he uses to explain the structure of physical laws. Then, I argue that this analogy stems from an envisioned parallelism between law and physics. Finally, I illustrate the significance of this legal-physical parallelism by arguing (...) that it underlies some of Leibniz's mature views. Most importantly, I argue that the parallelism explains the origin of architectonic principles or optimality principles in Leibniz's mature physics. (shrink)

The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct.

This paper aims both to tackle the technical issue of deciphering Hobbes’s derivation of the sine law of refraction and to throw some light to the broader issue of Hobbes’s mechanical philosophy. I start by recapitulating the polemics between Hobbes and Descartes concerning Descartes’ optics. I argue that, first, Hobbes’s criticisms do expose certain shortcomings of Descartes’ optics which presupposes a twofold distinction between real motion and inclination to motion, and between motion itself and determination of motion; second, Hobbes’s optical (...) theory presented in Tractatus Opticus I constitutes a more economical alternative, which eliminates the twofold distinction and only admits actual local motion, and Hobbes’s derivation of the sine law presented therein, which I call “the early model” and which was retained in Tractatus Opticus II and First Draught, is mathematically consistent and physically meaningful. These two points give Hobbes’s early optics some theoretical advantage over that of Descartes. However, an issue that has baffled commentators is that, in De Corpore Hobbes’s derivation of the sine law seems to be completely different from that presented in his earlier works, furthermore, it does not make any intuitive sense. I argue that the derivation of the sine law in De Corpore does make sense mathematically if we read it as a simplification of the early model, and Hobbes has already hinted toward it in the last proposition of Tractatus Opticus I. But now the question becomes, why does Hobbes take himself to be entitled to present this simplified, seemingly question-begging form without having presented all the previous results? My conjecture is that the switch from the early model to the late model is symptomatic of Hobbes’s changing views on the relation between physics and mathematics. (shrink)

Gender roles are anti-dichotomous and malleable social constructs that should theoretically be constructed independently from biological sex. However, it is unclear whether and how the factor of sex is related to neural mechanisms involved in social constructions of gender roles. Thus, the present study aimed to investigate sex specificity in gender role constructions and the corresponding underlying neural mechanisms. We measured gender role orientation using the Bem Sex-Role Inventory, used a voxel-based global brain connectivity method based on resting-state functional magnetic (...) resonance imaging to characterize the within-network connectivity in the brain reward network, and analyzed how the integration of the reward network is related to gender role scores between sex groups. An omnibus analysis of voxel-wise global brain connectivity values within a two-level linear mixed model revealed that in female participants, femininity scores were positively associated with integration in the posterior orbitofrontal cortex and subcallosal cortex, whereas masculinity scores were positively associated with integration in the frontal pole. By contrast, in male participants, masculinity was negatively correlated with integration in the nucleus accumbens and subcallosal cortex. For the first time, the present study revealed the sex-specific neural mechanisms underlying distinct gender roles, which elucidates the process of gender construction from the perspective of the interaction between reward sensitivity and social reinforcement. (shrink)

Distinct from nominal metaphors, predicate metaphors entail metaphorical abstraction from concrete verbs, which generally involve more action and stronger motor simulation than nouns. It remains unclear whether and how the concrete, embodied aspects of verbs are connected with abstract, disembodied thinking in the brains of L2 learners. Since English predicate metaphors are unfamiliar to Chinese L2 learners, the study of embodiment effect on English predicate metaphor processing may provide new evidence for embodied cognition and categorization models that remain controversial, and (...) offer practical insights into L2 metaphor processing and pedagogy. Hence, we aim to investigate whether the embodiment of verbs, via the activation of sensorimotor information, influences two groups of L2 learners during their comprehension of conventional and novel predicate metaphors. The results show a significant effect of embodiment: a stronger facilitation for novel predicate metaphors in both higher-level and lower-level groups, and a weaker facilitation for conventional predicate metaphors in the lower-level group. The findings demonstrate preliminary evidence for a graded effect of embodiment on predicate metaphors processing, modulated by L2 proficiency and metaphor novelty. The study supports a hybrid view of embodied cognition and reveals that sensorimotor aspects of verbs may be the intermediate entity involved in the indirect categorization. (shrink)

WANG Bi 王弼 develops a metaphysic of Dao 道 in his Commentary on Laozi and “The Structure of Laozi’s Subtle Pointers.” I summarize this metaphysic as the following thesis: Dao is featureless and is the ultimate reason why the myriad things exist and are the ways they are. I develop a systematic account of this thesis: I provide an interpretation of the featurelessness of Dao and show how Dao’s featurelessness relates to its fundamental explanatory role as the ontological ground for (...) the myriad things. (shrink)

Media guidelines on safe suicide-related reporting are within the suicide prevention armamentarium. However, implementation issues beleaguer real-world practice. This study evaluated the perspectives of the Malaysian media community, persons with lived experience of suicidal behavior, and mental health professionals on suicide-related reporting in terms of the impact, strategies, challenges, and the implementation of guidelines on safe reporting. Three focus group discussions of purposively sampled Malaysian media practitioners, PLE, and MHP were audio-recorded, transcribed, coded and thematically analyzed. Inclusion criteria were: English (...) fluency, no clinical depression or suicidal ideation, no recent previous suicide attempts or suicide bereavement. Three major themes emerged: Unsafe Reporting; Impact; and Safe Reporting. Most described current reporting as unsafe by being potentially triggering to media users and may contribute to contagion effect. Positive impacts identified included raised awareness toward suicide and its prevention. Unsafe reporting was attributed to inadequate awareness, knowledge, and guidance, lack of empathy and accountability, job-related factors, popularity-seeking, lack of monitoring and governance, and information source with unsafe content. Majority agreed on how suicide stories should be framed to produce a safe report. The media community diverged on how detailed a suicide story should be. Safe reporting challenges included difficulties in balancing beneficial versus harmful details, social media ubiquity and its citizen reporters. Participants suggested these safe reporting strategies: stakeholder engagement, educational approaches, improving governance and surveillance, and guidelines revision. Most acknowledged the relevance of guidelines but were unaware of the existence of local guidelines. Implementation challenges included the dilemma in balancing media industry needs vis-à-vis safe reporting requirements, stakeholder engagement difficulties and social media regulation. There is poor awareness regarding safe suicide-related reporting across all groups. PLE and MHP were negatively impacted by current unsafe messaging which aggravated trauma and grief reactions. Postvention support gaps for mental health professionals were highlighted. Safe reporting promotion strategies should include stakeholder engagement to increase awareness on minimizing Werther and maximizing Papageno effects. Strategic re-examination and dissemination of local media guidelines to address new media issues, and effective surveillance mechanisms, are crucial in sustainable improvement of safe reporting practices. (shrink)

Preparative and analytical methods developed by separation scientists have played an important role in the history of molecular biology. One such early method is gel electrophoresis, a technique that uses various types of gel as its supporting medium to separate charged molecules based on size and other properties. Historians of science, however, have only recently begun to pay closer attention to this material epistemological dimension of biomolecular science. This paper substantiates the historiographical thread that explores the relationship between modern laboratory (...) practice and the production of scientific knowledge. It traces the historical development of gel electrophoresis from the mid-1940s to the mid-1960s, with careful attention to the interplay between technical developments and disciplinary shifts, especially the rise of molecular biology in this time-frame. Claiming that the early 1950s marked a decisive shift in the evolution of electrophoretic methods from moving boundary to zone electrophoresis, I reconstruct various trajectories in which scientists such as Oliver Smithies sought out the most desirable solid supporting medium for electrophoretic instrumentation. Biomolecular knowledge, I argue, emerged in part from this process of seeking the most appropriate supporting medium that allowed for discrete molecular separation and visualization. The early 1950s, therefore, marked not only an important turning point in the history of separation science, but also a transformative moment in the history of the life sciences as the growth of molecular biology depended in part on the epistemological access to the molecular realm available through these evolving technologies. (shrink)

殷海光―― 臺灣自由主義的奠基者與啟迪者 他用他的筆，對抗一整個時代的黑暗； 更用他的生命，為知識分子留下最鮮明的形象。 臺大版《殷海光全集》蒐羅殷海光先生所有中英文著作、文章、譯作、書序、隨筆、書信，是殷先生所撰文字最完整的紀錄。殷海光畢生筆耕不輟，或以筆言志，或藉紙抒懷，他的眾多文字遺產，既是自身思想言行的展現，也是 後人理解探討他的生命思想的最主要依據。 正因為殷海光先生的撰述繁多，清查檢索，好似永無止境的學術工程。機緣巧合，編者從各種管道陸續發現殷海光的著述，尚未匯編，故特編印《殷海光全集‧補遺》，以彌補前此的闕失，履踐讓臺大版《殷海光全集》總匯殷海 光之一切著述的期望。我們更誠懇希望，學界方家繼續提供助力，讓臺大版《殷海光全集》愈趨理想之境。 本書分為三部分： 第一部分「補遺」。收錄新始發現之殷海光先生著作，包括十五篇中文著作、兩篇英文著作及三封殷海光致夏君璐之書信；整理編輯之原則，率皆依循前例。 第二部分「殷海光先生著述目錄」。依初次發表年排序，編錄殷海光先生生平著作。發表時間相同者，依文章篇名筆畫順序排列；僅知發表年代、未知月日者，置於該年最末；僅知發表年月、未知日者，置於該年該月最末；撰作 時間不詳者，置於本篇最末。 第三部分「《殷海光全集》簡目」。依序展列臺大版《殷海光全集》各卷目錄，以便查詢對照。.